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Protein

ATP-dependent RNA helicase DDX24

Gene

Ddx24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

ATP-dependent RNA helicase.Curated

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi238 – 245ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX24 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 24
Gene namesi
Name:Ddx24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1351337. Ddx24.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550301 – 857ATP-dependent RNA helicase DDX24Add BLAST857

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei80PhosphoserineCombined sources1
Modified residuei92PhosphoserineCombined sources1
Modified residuei170PhosphoserineCombined sources1
Modified residuei288PhosphoserineBy similarity1
Modified residuei296PhosphoserineBy similarity1
Cross-linki370Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki624Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9ESV0.
MaxQBiQ9ESV0.
PaxDbiQ9ESV0.
PRIDEiQ9ESV0.

PTM databases

iPTMnetiQ9ESV0.
PhosphoSitePlusiQ9ESV0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041645.
CleanExiMM_DDX24.
ExpressionAtlasiQ9ESV0. baseline and differential.
GenevisibleiQ9ESV0. MM.

Interactioni

Protein-protein interaction databases

BioGridi205146. 2 interactors.
IntActiQ9ESV0. 1 interactor.
MINTiMINT-4092963.
STRINGi10090.ENSMUSP00000105628.

Structurei

3D structure databases

ProteinModelPortaliQ9ESV0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini225 – 528Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST304
Domaini576 – 723Helicase C-terminalPROSITE-ProRule annotationAdd BLAST148

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi193 – 221Q motifAdd BLAST29
Motifi471 – 474DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi81 – 87Poly-Glu7
Compositional biasi755 – 758Poly-Ala4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0347. Eukaryota.
ENOG410XS03. LUCA.
GeneTreeiENSGT00550000074847.
HOGENOMiHOG000290702.
HOVERGENiHBG104200.
InParanoidiQ9ESV0.
KOiK14805.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiView protein in PROSITE
PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ESV0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKETNSKP KLASRGTFQR KGIKIVGKWK QVTIDPNLFA DGQMDDLVCF
60 70 80 90 100
EELTDYRLVK NPSRLFSSEE TKKRKAQAVS EEEEEEEGQS SSPKKKIKLK
110 120 130 140 150
KQRDAARAAE GAAAQNEYEV KASEPEAQGE VTACSDQKVG GAKSESLAQA
160 170 180 190 200
APRKKKNKGK KKLDTFQSTS PKLPKKSKKT WMAEVHDQKA DVSAWRDLFV
210 220 230 240 250
PKAVLRALSF LGFSAPTPIQ ALTLAPAIRD KLDILGAAET GSGKTLAFAI
260 270 280 290 300
PMIHSVLQWH KMKAPPIPRS TGMPPREMRF GATAHLGSPC KDRTESGVLP
310 320 330 340 350
EEARIETEAQ PSDSGVQATP ETSASASAQT LLVCDDDAGE GPSSLEEKPV
360 370 380 390 400
PKQNEDGEEK FDAEQAGKLK QELCDQIAIY KVHPRRPLLG LVLTPTRELA
410 420 430 440 450
IQVRQHIDAV AKFTGINTAI LVGGMSTQKQ QRMLNRHPEI VIATPGRLWE
460 470 480 490 500
LVKEKHPHLS NLRQLRCLVI DEADRMVEKG HFAELSQLLE MLNDSQYNPS
510 520 530 540 550
RQTLVFSATL TLVHQAPARI LHKKHVKKMD KTDKLDLLMQ KVGMRGKPKV
560 570 580 590 600
IDLTRNEGTV ETLTETKIHC ETDEKDLYLY YFLMQYPGRS LVFANSISCI
610 620 630 640 650
KRLSGLLKVL DVMPLTLHAC MHQKQRLRNL EQFARLQDCV LLATDVAARG
660 670 680 690 700
LDIPKVQHVI HYQVPRTSEI YIHRSGRTAR AASEGLSLML IGPEDVINFK
710 720 730 740 750
KIYKTLQKDE DIPLFPVQSK YMDVVKERIR LARQIEKAEY RNFQACLHNS
760 770 780 790 800
WIEQAAAALE IELEEEMYKG GKADQQEERR RQKQMKMLKQ ELRHLLSQPL
810 820 830 840 850
FQENLKTRYP TQSGRPPQPV LASRNIESAL SCLSRQKRRR KKPKEPRAPP

QPGSSTS
Length:857
Mass (Da):96,429
Last modified:July 27, 2011 - v2
Checksum:iF3DCF47E9F27CAEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti556 – 557NE → ER in AAG02170 (PubMed:10936056).Curated2
Sequence conflicti556 – 557NE → ER in AAB01091 (Ref. 4) Curated2
Sequence conflicti616T → N in AAB01091 (Ref. 4) Curated1
Sequence conflicti710E → EDIPLFPVHFKKIYKTLQKD E in AAB01091 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214732 mRNA. Translation: AAG02170.1.
CH466549 Genomic DNA. Translation: EDL18835.1.
BC055048 mRNA. Translation: AAH55048.1.
BC055317 mRNA. Translation: AAH55317.1.
U46690 mRNA. Translation: AAB01091.1.
CCDSiCCDS26129.1.
RefSeqiNP_001152974.1. NM_001159502.1.
NP_065240.2. NM_020494.3.
XP_006515995.1. XM_006515932.3.
XP_006515996.1. XM_006515933.1.
UniGeneiMm.3935.
Mm.475067.

Genome annotation databases

EnsembliENSMUST00000044923; ENSMUSP00000040890; ENSMUSG00000041645.
GeneIDi27225.
KEGGimmu:27225.
UCSCiuc007ovj.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiDDX24_MOUSE
AccessioniPrimary (citable) accession number: Q9ESV0
Secondary accession number(s): Q61119, Q7TM97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: August 30, 2017
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families