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Q9ESV0 (DDX24_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent RNA helicase DDX24

EC=3.6.4.13
Alternative name(s):
DEAD box protein 24
Gene names
Name:Ddx24
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length857 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

ATP-dependent RNA helicase Potential.

Catalytic activity

ATP + H2O = ADP + phosphate.

Sequence similarities

Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.

Contains 1 helicase ATP-binding domain.

Contains 1 helicase C-terminal domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 857857ATP-dependent RNA helicase DDX24
PRO_0000055030

Regions

Domain225 – 528304Helicase ATP-binding
Domain576 – 723148Helicase C-terminal
Nucleotide binding238 – 2458ATP By similarity
Motif193 – 22129Q motif
Motif471 – 4744DEAD box
Compositional bias81 – 877Poly-Glu
Compositional bias755 – 7584Poly-Ala

Amino acid modifications

Modified residue801Phosphoserine Ref.5 Ref.6
Modified residue921Phosphoserine By similarity
Modified residue2881Phosphoserine By similarity
Modified residue2961Phosphoserine By similarity

Experimental info

Sequence conflict556 – 5572NE → ER in AAG02170. Ref.1
Sequence conflict556 – 5572NE → ER in AAB01091. Ref.4
Sequence conflict6161T → N in AAB01091. Ref.4
Sequence conflict7101E → EDIPLFPVHFKKIYKTLQKD E in AAB01091. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9ESV0 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: F3DCF47E9F27CAEC

FASTA85796,429
        10         20         30         40         50         60 
MKVKETNSKP KLASRGTFQR KGIKIVGKWK QVTIDPNLFA DGQMDDLVCF EELTDYRLVK 

        70         80         90        100        110        120 
NPSRLFSSEE TKKRKAQAVS EEEEEEEGQS SSPKKKIKLK KQRDAARAAE GAAAQNEYEV 

       130        140        150        160        170        180 
KASEPEAQGE VTACSDQKVG GAKSESLAQA APRKKKNKGK KKLDTFQSTS PKLPKKSKKT 

       190        200        210        220        230        240 
WMAEVHDQKA DVSAWRDLFV PKAVLRALSF LGFSAPTPIQ ALTLAPAIRD KLDILGAAET 

       250        260        270        280        290        300 
GSGKTLAFAI PMIHSVLQWH KMKAPPIPRS TGMPPREMRF GATAHLGSPC KDRTESGVLP 

       310        320        330        340        350        360 
EEARIETEAQ PSDSGVQATP ETSASASAQT LLVCDDDAGE GPSSLEEKPV PKQNEDGEEK 

       370        380        390        400        410        420 
FDAEQAGKLK QELCDQIAIY KVHPRRPLLG LVLTPTRELA IQVRQHIDAV AKFTGINTAI 

       430        440        450        460        470        480 
LVGGMSTQKQ QRMLNRHPEI VIATPGRLWE LVKEKHPHLS NLRQLRCLVI DEADRMVEKG 

       490        500        510        520        530        540 
HFAELSQLLE MLNDSQYNPS RQTLVFSATL TLVHQAPARI LHKKHVKKMD KTDKLDLLMQ 

       550        560        570        580        590        600 
KVGMRGKPKV IDLTRNEGTV ETLTETKIHC ETDEKDLYLY YFLMQYPGRS LVFANSISCI 

       610        620        630        640        650        660 
KRLSGLLKVL DVMPLTLHAC MHQKQRLRNL EQFARLQDCV LLATDVAARG LDIPKVQHVI 

       670        680        690        700        710        720 
HYQVPRTSEI YIHRSGRTAR AASEGLSLML IGPEDVINFK KIYKTLQKDE DIPLFPVQSK 

       730        740        750        760        770        780 
YMDVVKERIR LARQIEKAEY RNFQACLHNS WIEQAAAALE IELEEEMYKG GKADQQEERR 

       790        800        810        820        830        840 
RQKQMKMLKQ ELRHLLSQPL FQENLKTRYP TQSGRPPQPV LASRNIESAL SCLSRQKRRR 

       850 
KKPKEPRAPP QPGSSTS 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-box proteins, and mapping DDX24 to human chromosome 14q32."
Zhao Y., Yu L., Fu Q., Chen W., Jiang J., Gao J., Zhao S.
Genomics 67:351-355(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 and FVB/N-3.
Tissue: Mammary tumor.
[4]"Identification of a lipopolysaccharide inducible gene in murine macrophages that putatively encodes an ATP-dependent RNA helicase."
Drysdale B., Howard D.L., Johnson R.J.
Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 399-857.
Strain: BALB/c.
[5]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[6]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF214732 mRNA. Translation: AAG02170.1.
CH466549 Genomic DNA. Translation: EDL18835.1.
BC055048 mRNA. Translation: AAH55048.1.
BC055317 mRNA. Translation: AAH55317.1.
U46690 mRNA. Translation: AAB01091.1.
RefSeqNP_001152974.1. NM_001159502.1.
NP_065240.2. NM_020494.3.
XP_006515995.1. XM_006515932.1.
XP_006515996.1. XM_006515933.1.
UniGeneMm.3935.
Mm.475067.

3D structure databases

ProteinModelPortalQ9ESV0.
SMRQ9ESV0. Positions 194-744.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid205146. 1 interaction.
IntActQ9ESV0. 1 interaction.
MINTMINT-4092963.
STRING10090.ENSMUSP00000040890.

PTM databases

PhosphoSiteQ9ESV0.

Proteomic databases

PaxDbQ9ESV0.
PRIDEQ9ESV0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000044923; ENSMUSP00000040890; ENSMUSG00000041645.
GeneID27225.
KEGGmmu:27225.
UCSCuc007ovj.2. mouse.

Organism-specific databases

CTD57062.
MGIMGI:1351337. Ddx24.

Phylogenomic databases

eggNOGCOG0513.
GeneTreeENSGT00550000074847.
HOGENOMHOG000290702.
HOVERGENHBG104200.
InParanoidQ7TM97.
KOK14805.

Gene expression databases

ArrayExpressQ9ESV0.
BgeeQ9ESV0.
CleanExMM_DDX24.
GenevestigatorQ9ESV0.

Family and domain databases

Gene3D3.40.50.300. 3 hits.
InterProIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 3 hits.
PROSITEPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio305144.
PROQ9ESV0.
SOURCESearch...

Entry information

Entry nameDDX24_MOUSE
AccessionPrimary (citable) accession number: Q9ESV0
Secondary accession number(s): Q61119, Q7TM97
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot