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Q9ESV0

- DDX24_MOUSE

UniProt

Q9ESV0 - DDX24_MOUSE

Protein

ATP-dependent RNA helicase DDX24

Gene

Ddx24

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    ATP-dependent RNA helicase.Curated

    Catalytic activityi

    ATP + H2O = ADP + phosphate.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi238 – 2458ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. ATP-dependent helicase activity Source: InterPro
    3. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Helicase, Hydrolase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding, RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent RNA helicase DDX24 (EC:3.6.4.13)
    Alternative name(s):
    DEAD box protein 24
    Gene namesi
    Name:Ddx24
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:1351337. Ddx24.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 857857ATP-dependent RNA helicase DDX24PRO_0000055030Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei80 – 801Phosphoserine2 Publications
    Modified residuei92 – 921PhosphoserineBy similarity
    Modified residuei288 – 2881PhosphoserineBy similarity
    Modified residuei296 – 2961PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9ESV0.
    PRIDEiQ9ESV0.

    PTM databases

    PhosphoSiteiQ9ESV0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ESV0.
    BgeeiQ9ESV0.
    CleanExiMM_DDX24.
    GenevestigatoriQ9ESV0.

    Interactioni

    Protein-protein interaction databases

    BioGridi205146. 2 interactions.
    IntActiQ9ESV0. 1 interaction.
    MINTiMINT-4092963.
    STRINGi10090.ENSMUSP00000040890.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ESV0.
    SMRiQ9ESV0. Positions 195-252, 340-744.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini225 – 528304Helicase ATP-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini576 – 723148Helicase C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi193 – 22129Q motifAdd
    BLAST
    Motifi471 – 4744DEAD box

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi81 – 877Poly-Glu
    Compositional biasi755 – 7584Poly-Ala

    Sequence similaritiesi

    Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
    Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0513.
    GeneTreeiENSGT00550000074847.
    HOGENOMiHOG000290702.
    HOVERGENiHBG104200.
    InParanoidiQ7TM97.
    KOiK14805.

    Family and domain databases

    Gene3Di3.40.50.300. 3 hits.
    InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view]
    PfamiPF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 3 hits.
    PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ESV0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVKETNSKP KLASRGTFQR KGIKIVGKWK QVTIDPNLFA DGQMDDLVCF    50
    EELTDYRLVK NPSRLFSSEE TKKRKAQAVS EEEEEEEGQS SSPKKKIKLK 100
    KQRDAARAAE GAAAQNEYEV KASEPEAQGE VTACSDQKVG GAKSESLAQA 150
    APRKKKNKGK KKLDTFQSTS PKLPKKSKKT WMAEVHDQKA DVSAWRDLFV 200
    PKAVLRALSF LGFSAPTPIQ ALTLAPAIRD KLDILGAAET GSGKTLAFAI 250
    PMIHSVLQWH KMKAPPIPRS TGMPPREMRF GATAHLGSPC KDRTESGVLP 300
    EEARIETEAQ PSDSGVQATP ETSASASAQT LLVCDDDAGE GPSSLEEKPV 350
    PKQNEDGEEK FDAEQAGKLK QELCDQIAIY KVHPRRPLLG LVLTPTRELA 400
    IQVRQHIDAV AKFTGINTAI LVGGMSTQKQ QRMLNRHPEI VIATPGRLWE 450
    LVKEKHPHLS NLRQLRCLVI DEADRMVEKG HFAELSQLLE MLNDSQYNPS 500
    RQTLVFSATL TLVHQAPARI LHKKHVKKMD KTDKLDLLMQ KVGMRGKPKV 550
    IDLTRNEGTV ETLTETKIHC ETDEKDLYLY YFLMQYPGRS LVFANSISCI 600
    KRLSGLLKVL DVMPLTLHAC MHQKQRLRNL EQFARLQDCV LLATDVAARG 650
    LDIPKVQHVI HYQVPRTSEI YIHRSGRTAR AASEGLSLML IGPEDVINFK 700
    KIYKTLQKDE DIPLFPVQSK YMDVVKERIR LARQIEKAEY RNFQACLHNS 750
    WIEQAAAALE IELEEEMYKG GKADQQEERR RQKQMKMLKQ ELRHLLSQPL 800
    FQENLKTRYP TQSGRPPQPV LASRNIESAL SCLSRQKRRR KKPKEPRAPP 850
    QPGSSTS 857
    Length:857
    Mass (Da):96,429
    Last modified:July 27, 2011 - v2
    Checksum:iF3DCF47E9F27CAEC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti556 – 5572NE → ER in AAG02170. (PubMed:10936056)Curated
    Sequence conflicti556 – 5572NE → ER in AAB01091. 1 PublicationCurated
    Sequence conflicti616 – 6161T → N in AAB01091. 1 PublicationCurated
    Sequence conflicti710 – 7101E → EDIPLFPVHFKKIYKTLQKD E in AAB01091. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF214732 mRNA. Translation: AAG02170.1.
    CH466549 Genomic DNA. Translation: EDL18835.1.
    BC055048 mRNA. Translation: AAH55048.1.
    BC055317 mRNA. Translation: AAH55317.1.
    U46690 mRNA. Translation: AAB01091.1.
    CCDSiCCDS26129.1.
    RefSeqiNP_001152974.1. NM_001159502.1.
    NP_065240.2. NM_020494.3.
    XP_006515995.1. XM_006515932.1.
    XP_006515996.1. XM_006515933.1.
    UniGeneiMm.3935.
    Mm.475067.

    Genome annotation databases

    EnsembliENSMUST00000044923; ENSMUSP00000040890; ENSMUSG00000041645.
    GeneIDi27225.
    KEGGimmu:27225.
    UCSCiuc007ovj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF214732 mRNA. Translation: AAG02170.1 .
    CH466549 Genomic DNA. Translation: EDL18835.1 .
    BC055048 mRNA. Translation: AAH55048.1 .
    BC055317 mRNA. Translation: AAH55317.1 .
    U46690 mRNA. Translation: AAB01091.1 .
    CCDSi CCDS26129.1.
    RefSeqi NP_001152974.1. NM_001159502.1.
    NP_065240.2. NM_020494.3.
    XP_006515995.1. XM_006515932.1.
    XP_006515996.1. XM_006515933.1.
    UniGenei Mm.3935.
    Mm.475067.

    3D structure databases

    ProteinModelPortali Q9ESV0.
    SMRi Q9ESV0. Positions 195-252, 340-744.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 205146. 2 interactions.
    IntActi Q9ESV0. 1 interaction.
    MINTi MINT-4092963.
    STRINGi 10090.ENSMUSP00000040890.

    PTM databases

    PhosphoSitei Q9ESV0.

    Proteomic databases

    PaxDbi Q9ESV0.
    PRIDEi Q9ESV0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000044923 ; ENSMUSP00000040890 ; ENSMUSG00000041645 .
    GeneIDi 27225.
    KEGGi mmu:27225.
    UCSCi uc007ovj.2. mouse.

    Organism-specific databases

    CTDi 57062.
    MGIi MGI:1351337. Ddx24.

    Phylogenomic databases

    eggNOGi COG0513.
    GeneTreei ENSGT00550000074847.
    HOGENOMi HOG000290702.
    HOVERGENi HBG104200.
    InParanoidi Q7TM97.
    KOi K14805.

    Miscellaneous databases

    NextBioi 305144.
    PROi Q9ESV0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ESV0.
    Bgeei Q9ESV0.
    CleanExi MM_DDX24.
    Genevestigatori Q9ESV0.

    Family and domain databases

    Gene3Di 3.40.50.300. 3 hits.
    InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    [Graphical view ]
    Pfami PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 3 hits.
    PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-box proteins, and mapping DDX24 to human chromosome 14q32."
      Zhao Y., Yu L., Fu Q., Chen W., Jiang J., Gao J., Zhao S.
      Genomics 67:351-355(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6 and FVB/N-3.
      Tissue: Mammary tumor.
    4. "Identification of a lipopolysaccharide inducible gene in murine macrophages that putatively encodes an ATP-dependent RNA helicase."
      Drysdale B., Howard D.L., Johnson R.J.
      Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 399-857.
      Strain: BALB/c.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    6. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDDX24_MOUSE
    AccessioniPrimary (citable) accession number: Q9ESV0
    Secondary accession number(s): Q61119, Q7TM97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3