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Q9ESV0

- DDX24_MOUSE

UniProt

Q9ESV0 - DDX24_MOUSE

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Protein

ATP-dependent RNA helicase DDX24

Gene
Ddx24
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

ATP-dependent RNA helicase Reviewed prediction.

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi238 – 2458ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATP-dependent helicase activity Source: InterPro
  3. RNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX24 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 24
Gene namesi
Name:Ddx24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:1351337. Ddx24.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 857857ATP-dependent RNA helicase DDX24PRO_0000055030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei80 – 801Phosphoserine2 Publications
Modified residuei92 – 921Phosphoserine By similarity
Modified residuei288 – 2881Phosphoserine By similarity
Modified residuei296 – 2961Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ESV0.
PRIDEiQ9ESV0.

PTM databases

PhosphoSiteiQ9ESV0.

Expressioni

Gene expression databases

ArrayExpressiQ9ESV0.
BgeeiQ9ESV0.
CleanExiMM_DDX24.
GenevestigatoriQ9ESV0.

Interactioni

Protein-protein interaction databases

BioGridi205146. 2 interactions.
IntActiQ9ESV0. 1 interaction.
MINTiMINT-4092963.
STRINGi10090.ENSMUSP00000040890.

Structurei

3D structure databases

ProteinModelPortaliQ9ESV0.
SMRiQ9ESV0. Positions 195-252, 340-744.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini225 – 528304Helicase ATP-bindingAdd
BLAST
Domaini576 – 723148Helicase C-terminalAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi193 – 22129Q motifAdd
BLAST
Motifi471 – 4744DEAD box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi81 – 877Poly-Glu
Compositional biasi755 – 7584Poly-Ala

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0513.
GeneTreeiENSGT00550000074847.
HOGENOMiHOG000290702.
HOVERGENiHBG104200.
InParanoidiQ7TM97.
KOiK14805.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESV0-1 [UniParc]FASTAAdd to Basket

« Hide

MKVKETNSKP KLASRGTFQR KGIKIVGKWK QVTIDPNLFA DGQMDDLVCF    50
EELTDYRLVK NPSRLFSSEE TKKRKAQAVS EEEEEEEGQS SSPKKKIKLK 100
KQRDAARAAE GAAAQNEYEV KASEPEAQGE VTACSDQKVG GAKSESLAQA 150
APRKKKNKGK KKLDTFQSTS PKLPKKSKKT WMAEVHDQKA DVSAWRDLFV 200
PKAVLRALSF LGFSAPTPIQ ALTLAPAIRD KLDILGAAET GSGKTLAFAI 250
PMIHSVLQWH KMKAPPIPRS TGMPPREMRF GATAHLGSPC KDRTESGVLP 300
EEARIETEAQ PSDSGVQATP ETSASASAQT LLVCDDDAGE GPSSLEEKPV 350
PKQNEDGEEK FDAEQAGKLK QELCDQIAIY KVHPRRPLLG LVLTPTRELA 400
IQVRQHIDAV AKFTGINTAI LVGGMSTQKQ QRMLNRHPEI VIATPGRLWE 450
LVKEKHPHLS NLRQLRCLVI DEADRMVEKG HFAELSQLLE MLNDSQYNPS 500
RQTLVFSATL TLVHQAPARI LHKKHVKKMD KTDKLDLLMQ KVGMRGKPKV 550
IDLTRNEGTV ETLTETKIHC ETDEKDLYLY YFLMQYPGRS LVFANSISCI 600
KRLSGLLKVL DVMPLTLHAC MHQKQRLRNL EQFARLQDCV LLATDVAARG 650
LDIPKVQHVI HYQVPRTSEI YIHRSGRTAR AASEGLSLML IGPEDVINFK 700
KIYKTLQKDE DIPLFPVQSK YMDVVKERIR LARQIEKAEY RNFQACLHNS 750
WIEQAAAALE IELEEEMYKG GKADQQEERR RQKQMKMLKQ ELRHLLSQPL 800
FQENLKTRYP TQSGRPPQPV LASRNIESAL SCLSRQKRRR KKPKEPRAPP 850
QPGSSTS 857
Length:857
Mass (Da):96,429
Last modified:July 27, 2011 - v2
Checksum:iF3DCF47E9F27CAEC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti556 – 5572NE → ER in AAG02170. 1 Publication
Sequence conflicti556 – 5572NE → ER in AAB01091. 1 Publication
Sequence conflicti616 – 6161T → N in AAB01091. 1 Publication
Sequence conflicti710 – 7101E → EDIPLFPVHFKKIYKTLQKD E in AAB01091. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF214732 mRNA. Translation: AAG02170.1.
CH466549 Genomic DNA. Translation: EDL18835.1.
BC055048 mRNA. Translation: AAH55048.1.
BC055317 mRNA. Translation: AAH55317.1.
U46690 mRNA. Translation: AAB01091.1.
CCDSiCCDS26129.1.
RefSeqiNP_001152974.1. NM_001159502.1.
NP_065240.2. NM_020494.3.
XP_006515995.1. XM_006515932.1.
XP_006515996.1. XM_006515933.1.
UniGeneiMm.3935.
Mm.475067.

Genome annotation databases

EnsembliENSMUST00000044923; ENSMUSP00000040890; ENSMUSG00000041645.
GeneIDi27225.
KEGGimmu:27225.
UCSCiuc007ovj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF214732 mRNA. Translation: AAG02170.1 .
CH466549 Genomic DNA. Translation: EDL18835.1 .
BC055048 mRNA. Translation: AAH55048.1 .
BC055317 mRNA. Translation: AAH55317.1 .
U46690 mRNA. Translation: AAB01091.1 .
CCDSi CCDS26129.1.
RefSeqi NP_001152974.1. NM_001159502.1.
NP_065240.2. NM_020494.3.
XP_006515995.1. XM_006515932.1.
XP_006515996.1. XM_006515933.1.
UniGenei Mm.3935.
Mm.475067.

3D structure databases

ProteinModelPortali Q9ESV0.
SMRi Q9ESV0. Positions 195-252, 340-744.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 205146. 2 interactions.
IntActi Q9ESV0. 1 interaction.
MINTi MINT-4092963.
STRINGi 10090.ENSMUSP00000040890.

PTM databases

PhosphoSitei Q9ESV0.

Proteomic databases

PaxDbi Q9ESV0.
PRIDEi Q9ESV0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000044923 ; ENSMUSP00000040890 ; ENSMUSG00000041645 .
GeneIDi 27225.
KEGGi mmu:27225.
UCSCi uc007ovj.2. mouse.

Organism-specific databases

CTDi 57062.
MGIi MGI:1351337. Ddx24.

Phylogenomic databases

eggNOGi COG0513.
GeneTreei ENSGT00550000074847.
HOGENOMi HOG000290702.
HOVERGENi HBG104200.
InParanoidi Q7TM97.
KOi K14805.

Miscellaneous databases

NextBioi 305144.
PROi Q9ESV0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9ESV0.
Bgeei Q9ESV0.
CleanExi MM_DDX24.
Genevestigatori Q9ESV0.

Family and domain databases

Gene3Di 3.40.50.300. 3 hits.
InterProi IPR011545. DNA/RNA_helicase_DEAD/DEAH_N.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view ]
Pfami PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view ]
SMARTi SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
PROSITEi PS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of human DDX24 and mouse Ddx24, two novel putative DEAD-box proteins, and mapping DDX24 to human chromosome 14q32."
    Zhao Y., Yu L., Fu Q., Chen W., Jiang J., Gao J., Zhao S.
    Genomics 67:351-355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N-3.
    Tissue: Mammary tumor.
  4. "Identification of a lipopolysaccharide inducible gene in murine macrophages that putatively encodes an ATP-dependent RNA helicase."
    Drysdale B., Howard D.L., Johnson R.J.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 399-857.
    Strain: BALB/c.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-80, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDDX24_MOUSE
AccessioniPrimary (citable) accession number: Q9ESV0
Secondary accession number(s): Q61119, Q7TM97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi