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Q9EST2 (HNMT_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Histamine N-methyltransferase
Short name=HMT
EC=2.1.1.8
Gene names
Name:HNMT
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length292 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.

Catalytic activity

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Tissue specificity

Expressed in jejunum, brain > lung, spleen, stomach > liver, kidney. Ref.1

Sequence similarities

Belongs to the methyltransferase superfamily. HNMT family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: Compara

   Molecular_functionhistamine N-methyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 292292Histamine N-methyltransferase
PRO_0000084020

Sites

Binding site281Substrate By similarity
Binding site601S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site891S-adenosyl-L-methionine By similarity
Binding site941S-adenosyl-L-methionine By similarity
Binding site1201S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding site1421S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site2831Substrate By similarity

Amino acid modifications

Modified residue31Phosphoserine By similarity
Modified residue101Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9EST2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 1D7F79D84C11BF40

FASTA29233,712
        10         20         30         40         50         60 
MASSMRSLFS DHGRYFEAFR RFLNNSTEYQ CMREFMDKQL PGIIARIGGS KSEIKVLSIG 

        70         80         90        100        110        120 
GGAGEMDLHI LSKVKAQYPG VHIINEVVEP SAEQITKYKE LVAKTSNLEN IKFAWHKETS 

       130        140        150        160        170        180 
SEYQNRVMEQ KEIQKWDFIH MIQMLYYVDD IPATLKFFHS LLATNAKILI ILVSGKSGWL 

       190        200        210        220        230        240 
KFWKKYRSRL PQNDLCQYVT SFDIIQMLDS LGIKYQCYDL LSTMDITDCF IDGNENGELL 

       250        260        270        280        290 
WDFLTETCNF LTTAPPDLRA EIMKDLQGPE FIVRKEGKIL FDNSLSFITI EA

« Hide

References

[1]"Guinea pig histamine N-methyltransferase: cDNA cloning and mRNA distribution."
Kitanaka J., Kitanaka N., Tsujimura T., Kakihana M., Terada N., Takemura M.
Jpn. J. Pharmacol. 85:105-108(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: Hartley.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB032693 mRNA. Translation: BAB13758.1.
RefSeqNP_001166431.1. NM_001172960.2.

3D structure databases

ProteinModelPortalQ9EST2.
SMRQ9EST2. Positions 5-292.
ModBaseSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000002230.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000002482; ENSCPOP00000002230; ENSCPOG00000002449.
GeneID100135537.

Organism-specific databases

CTD3176.

Phylogenomic databases

eggNOGNOG39680.
GeneTreeENSGT00390000002862.
HOGENOMHOG000231790.
HOVERGENHBG051914.
InParanoidQ9EST2.
OMAWKKYGSR.
OrthoDBEOG4NCMDJ.

Family and domain databases

InterProIPR016673. Histamine_N-methyltransferase.
[Graphical view]
PANTHERPTHR32330. PTHR32330. 1 hit.
PIRSFPIRSF016616. HHMT. 1 hit.
ProtoNetSearch...

Other

ChEMBLCHEMBL4485.

Entry information

Entry nameHNMT_CAVPO
AccessionPrimary (citable) accession number: Q9EST2
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2001
Last modified: April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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