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Protein

Histamine N-methyltransferase

Gene

HNMT

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.By similarity

Catalytic activityi

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotationBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei28SubstratePROSITE-ProRule annotation1
Binding sitei60S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei89S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei94S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei120S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
Binding sitei142S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
Binding sitei283SubstratePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine N-methyltransferase (EC:2.1.1.8By similarity)
Short name:
HMT
Gene namesi
Name:HNMT
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4485

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000840201 – 292Histamine N-methyltransferaseAdd BLAST292

Expressioni

Tissue specificityi

Expressed in jejunum, brain > lung, spleen, stomach > liver, kidney.1 Publication

Gene expression databases

BgeeiENSCPOG00000002449

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000002230

Chemistry databases

BindingDBiQ9EST2

Structurei

3D structure databases

ProteinModelPortaliQ9EST2
SMRiQ9EST2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IGS0 Eukaryota
ENOG410ZU1D LUCA
GeneTreeiENSGT00390000002862
HOGENOMiHOG000231790
HOVERGENiHBG051914
InParanoidiQ9EST2
OMAiMDISDCF
OrthoDBiEOG091G0DY6
TreeFamiTF331080

Family and domain databases

InterProiView protein in InterPro
IPR016673 HHMT-like
IPR029063 SAM-dependent_MTases
PIRSFiPIRSF016616 HHMT, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51597 SAM_HNMT, 1 hit

Sequencei

Sequence statusi: Complete.

Q9EST2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSMRSLFS DHGRYFEAFR RFLNNSTEYQ CMREFMDKQL PGIIARIGGS
60 70 80 90 100
KSEIKVLSIG GGAGEMDLHI LSKVKAQYPG VHIINEVVEP SAEQITKYKE
110 120 130 140 150
LVAKTSNLEN IKFAWHKETS SEYQNRVMEQ KEIQKWDFIH MIQMLYYVDD
160 170 180 190 200
IPATLKFFHS LLATNAKILI ILVSGKSGWL KFWKKYRSRL PQNDLCQYVT
210 220 230 240 250
SFDIIQMLDS LGIKYQCYDL LSTMDITDCF IDGNENGELL WDFLTETCNF
260 270 280 290
LTTAPPDLRA EIMKDLQGPE FIVRKEGKIL FDNSLSFITI EA
Length:292
Mass (Da):33,712
Last modified:March 1, 2001 - v1
Checksum:i1D7F79D84C11BF40
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032693 mRNA Translation: BAB13758.1
RefSeqiNP_001166431.1, NM_001172960.2

Genome annotation databases

EnsembliENSCPOT00000002482; ENSCPOP00000002230; ENSCPOG00000002449
GeneIDi100135537

Similar proteinsi

Entry informationi

Entry nameiHNMT_CAVPO
AccessioniPrimary (citable) accession number: Q9EST2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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