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Q9EST2

- HNMT_CAVPO

UniProt

Q9EST2 - HNMT_CAVPO

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Protein

Histamine N-methyltransferase

Gene
HNMT
Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.

Catalytic activityi

S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei28 – 281Substrate By similarity
Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei89 – 891S-adenosyl-L-methionine By similarity
Binding sitei94 – 941S-adenosyl-L-methionine By similarity
Binding sitei120 – 1201S-adenosyl-L-methionine; via amide nitrogen By similarity
Binding sitei142 – 1421S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding sitei283 – 2831Substrate By similarity

GO - Molecular functioni

  1. histamine N-methyltransferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine N-methyltransferase (EC:2.1.1.8)
Short name:
HMT
Gene namesi
Name:HNMT
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Histamine N-methyltransferasePRO_0000084020Add
BLAST

Expressioni

Tissue specificityi

Expressed in jejunum, brain > lung, spleen, stomach > liver, kidney.1 Publication

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000002230.

Structurei

3D structure databases

ProteinModelPortaliQ9EST2.
SMRiQ9EST2. Positions 5-292.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG39680.
GeneTreeiENSGT00390000002862.
HOGENOMiHOG000231790.
HOVERGENiHBG051914.
InParanoidiQ9EST2.
OMAiMDISDCF.
OrthoDBiEOG7Z69CQ.
TreeFamiTF331080.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PIRSFiPIRSF016616. HHMT. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51597. SAM_HNMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9EST2-1 [UniParc]FASTAAdd to Basket

« Hide

MASSMRSLFS DHGRYFEAFR RFLNNSTEYQ CMREFMDKQL PGIIARIGGS    50
KSEIKVLSIG GGAGEMDLHI LSKVKAQYPG VHIINEVVEP SAEQITKYKE 100
LVAKTSNLEN IKFAWHKETS SEYQNRVMEQ KEIQKWDFIH MIQMLYYVDD 150
IPATLKFFHS LLATNAKILI ILVSGKSGWL KFWKKYRSRL PQNDLCQYVT 200
SFDIIQMLDS LGIKYQCYDL LSTMDITDCF IDGNENGELL WDFLTETCNF 250
LTTAPPDLRA EIMKDLQGPE FIVRKEGKIL FDNSLSFITI EA 292
Length:292
Mass (Da):33,712
Last modified:March 1, 2001 - v1
Checksum:i1D7F79D84C11BF40
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032693 mRNA. Translation: BAB13758.1.
RefSeqiNP_001166431.1. NM_001172960.2.

Genome annotation databases

EnsembliENSCPOT00000002482; ENSCPOP00000002230; ENSCPOG00000002449.
GeneIDi100135537.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB032693 mRNA. Translation: BAB13758.1 .
RefSeqi NP_001166431.1. NM_001172960.2.

3D structure databases

ProteinModelPortali Q9EST2.
SMRi Q9EST2. Positions 5-292.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000002230.

Chemistry

ChEMBLi CHEMBL4485.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000002482 ; ENSCPOP00000002230 ; ENSCPOG00000002449 .
GeneIDi 100135537.

Organism-specific databases

CTDi 3176.

Phylogenomic databases

eggNOGi NOG39680.
GeneTreei ENSGT00390000002862.
HOGENOMi HOG000231790.
HOVERGENi HBG051914.
InParanoidi Q9EST2.
OMAi MDISDCF.
OrthoDBi EOG7Z69CQ.
TreeFami TF331080.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR016673. Histamine_N-methyltransferase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
PIRSFi PIRSF016616. HHMT. 1 hit.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS51597. SAM_HNMT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Guinea pig histamine N-methyltransferase: cDNA cloning and mRNA distribution."
    Kitanaka J., Kitanaka N., Tsujimura T., Kakihana M., Terada N., Takemura M.
    Jpn. J. Pharmacol. 85:105-108(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Hartley.
    Tissue: Brain.

Entry informationi

Entry nameiHNMT_CAVPO
AccessioniPrimary (citable) accession number: Q9EST2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2001
Last modified: June 11, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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