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Q9EST2

- HNMT_CAVPO

UniProt

Q9EST2 - HNMT_CAVPO

Protein

Histamine N-methyltransferase

Gene

HNMT

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + histamine = S-adenosyl-L-homocysteine + N(tau)-methylhistamine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei28 – 281SubstratePROSITE-ProRule annotation
    Binding sitei60 – 601S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
    Binding sitei89 – 891S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei94 – 941S-adenosyl-L-methioninePROSITE-ProRule annotation
    Binding sitei120 – 1201S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation
    Binding sitei142 – 1421S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation
    Binding sitei283 – 2831SubstratePROSITE-ProRule annotation

    GO - Molecular functioni

    1. histamine N-methyltransferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histamine N-methyltransferase (EC:2.1.1.8)
    Short name:
    HMT
    Gene namesi
    Name:HNMT
    OrganismiCavia porcellus (Guinea pig)
    Taxonomic identifieri10141 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
    ProteomesiUP000005447: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 292292Histamine N-methyltransferasePRO_0000084020Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in jejunum, brain > lung, spleen, stomach > liver, kidney.1 Publication

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi10141.ENSCPOP00000002230.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9EST2.
    SMRiQ9EST2. Positions 5-292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG39680.
    GeneTreeiENSGT00390000002862.
    HOGENOMiHOG000231790.
    HOVERGENiHBG051914.
    InParanoidiQ9EST2.
    OMAiMDISDCF.
    OrthoDBiEOG7Z69CQ.
    TreeFamiTF331080.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR016673. Histamine_N-methyltransferase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PIRSFiPIRSF016616. HHMT. 1 hit.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS51597. SAM_HNMT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9EST2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASSMRSLFS DHGRYFEAFR RFLNNSTEYQ CMREFMDKQL PGIIARIGGS    50
    KSEIKVLSIG GGAGEMDLHI LSKVKAQYPG VHIINEVVEP SAEQITKYKE 100
    LVAKTSNLEN IKFAWHKETS SEYQNRVMEQ KEIQKWDFIH MIQMLYYVDD 150
    IPATLKFFHS LLATNAKILI ILVSGKSGWL KFWKKYRSRL PQNDLCQYVT 200
    SFDIIQMLDS LGIKYQCYDL LSTMDITDCF IDGNENGELL WDFLTETCNF 250
    LTTAPPDLRA EIMKDLQGPE FIVRKEGKIL FDNSLSFITI EA 292
    Length:292
    Mass (Da):33,712
    Last modified:March 1, 2001 - v1
    Checksum:i1D7F79D84C11BF40
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032693 mRNA. Translation: BAB13758.1.
    RefSeqiNP_001166431.1. NM_001172960.2.

    Genome annotation databases

    EnsembliENSCPOT00000002482; ENSCPOP00000002230; ENSCPOG00000002449.
    GeneIDi100135537.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032693 mRNA. Translation: BAB13758.1 .
    RefSeqi NP_001166431.1. NM_001172960.2.

    3D structure databases

    ProteinModelPortali Q9EST2.
    SMRi Q9EST2. Positions 5-292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10141.ENSCPOP00000002230.

    Chemistry

    ChEMBLi CHEMBL4485.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSCPOT00000002482 ; ENSCPOP00000002230 ; ENSCPOG00000002449 .
    GeneIDi 100135537.

    Organism-specific databases

    CTDi 3176.

    Phylogenomic databases

    eggNOGi NOG39680.
    GeneTreei ENSGT00390000002862.
    HOGENOMi HOG000231790.
    HOVERGENi HBG051914.
    InParanoidi Q9EST2.
    OMAi MDISDCF.
    OrthoDBi EOG7Z69CQ.
    TreeFami TF331080.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR016673. Histamine_N-methyltransferase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    PIRSFi PIRSF016616. HHMT. 1 hit.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS51597. SAM_HNMT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Guinea pig histamine N-methyltransferase: cDNA cloning and mRNA distribution."
      Kitanaka J., Kitanaka N., Tsujimura T., Kakihana M., Terada N., Takemura M.
      Jpn. J. Pharmacol. 85:105-108(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Hartley.
      Tissue: Brain.

    Entry informationi

    Entry nameiHNMT_CAVPO
    AccessioniPrimary (citable) accession number: Q9EST2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3