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Q9ESS9

- Q9ESS9_RAT

UniProt

Q9ESS9 - Q9ESS9_RAT

Protein
Submitted name:

Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1

Gene

Herpud1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: RGD
    2. endoplasmic reticulum unfolded protein response Source: RGD
    3. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: RGD
    4. positive regulation of protein binding Source: Ensembl
    5. regulation of protein ubiquitination Source: Ensembl
    6. ubiquitin-dependent protein catabolic process Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_100810. ATF4 activates genes.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1Imported
    Submitted name:
    Homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1, isoform CRA_aImported
    Submitted name:
    Protein Herpud1Imported
    Submitted name:
    SUPImported
    Gene namesi
    Name:Herpud1Imported
    Synonyms:SUPImported
    ORF Names:rCG_39087Imported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 19

    Organism-specific databases

    RGDi620818. Herpud1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. endoplasmic reticulum membrane Source: RGD
    3. integral component of membrane Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ESS9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000025559.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG259558.
    GeneTreeiENSGT00390000017671.
    HOGENOMiHOG000252989.
    HOVERGENiHBG051899.
    InParanoidiQ9ESS9.
    KOiK14027.
    OMAiLSGDRSW.
    OrthoDBiEOG7QRQWK.
    TreeFamiTF324319.

    Family and domain databases

    InterProiIPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF00240. ubiquitin. 1 hit.
    [Graphical view]
    SMARTiSM00213. UBQ. 1 hit.
    [Graphical view]
    SUPFAMiSSF54236. SSF54236. 1 hit.
    PROSITEiPS50053. UBIQUITIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ESS9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPEPQPEPV TLLVKSPNQR HRDLELSGDR GWSVSRLKAH LSRVYPERPR    50
    PEDQRLIYSG KLLLDHQCLQ DLLPKQEKRH VLHLVCNVRS PSKKPEASTK 100
    GAESTEQPDN TSQAQYPGDS SSDGLREREV LRNLPPSGWE NVSRPEAVQQ 150
    TFQGLGPGFS GYTTYGWLQL SWFQQIYARQ YYMQYLAATA ASGAFGPTPS 200
    AQEIPVVSTP APAPIHNQFP AENQPANQNA AAQAVVNPGA NQNLRMNAQG 250
    GPLVEEDDEI NRDWLDWTYS AATFSVFLSI LYFYSSLSRF LMVMGATVVM 300
    YLHHVGWFPF RQRPVQNFPD DGPPQEAANQ DPNNNLQGGL DPEMEDPNRL 350
    PVGREVLDPE HTSPSFMSTA WLVFKTFFAS LLPEGPPALA N 391
    Length:391
    Mass (Da):43,705
    Last modified:March 1, 2001 - v1
    Checksum:iFE69D02F3CAA3D1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06097123 Genomic DNA. No translation available.
    BC061849 mRNA. Translation: AAH61849.1.
    AB033771 mRNA. Translation: BAB16047.1.
    CH474006 Genomic DNA. Translation: EDL87344.1.
    RefSeqiNP_445975.1. NM_053523.1.
    UniGeneiRn.4028.

    Genome annotation databases

    EnsembliENSRNOT00000025559; ENSRNOP00000025559; ENSRNOG00000018796.
    GeneIDi85430.
    KEGGirno:85430.
    UCSCiRGD:620818. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AABR06097123 Genomic DNA. No translation available.
    BC061849 mRNA. Translation: AAH61849.1 .
    AB033771 mRNA. Translation: BAB16047.1 .
    CH474006 Genomic DNA. Translation: EDL87344.1 .
    RefSeqi NP_445975.1. NM_053523.1.
    UniGenei Rn.4028.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000025559.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000025559 ; ENSRNOP00000025559 ; ENSRNOG00000018796 .
    GeneIDi 85430.
    KEGGi rno:85430.
    UCSCi RGD:620818. rat.

    Organism-specific databases

    CTDi 9709.
    RGDi 620818. Herpud1.

    Phylogenomic databases

    eggNOGi NOG259558.
    GeneTreei ENSGT00390000017671.
    HOGENOMi HOG000252989.
    HOVERGENi HBG051899.
    InParanoidi Q9ESS9.
    KOi K14027.
    OMAi LSGDRSW.
    OrthoDBi EOG7QRQWK.
    TreeFami TF324319.

    Enzyme and pathway databases

    Reactomei REACT_100810. ATF4 activates genes.

    Miscellaneous databases

    NextBioi 617534.
    PROi Q9ESS9.

    Gene expression databases

    Genevestigatori Q9ESS9.

    Family and domain databases

    InterProi IPR000626. Ubiquitin-like.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF00240. ubiquitin. 1 hit.
    [Graphical view ]
    SMARTi SM00213. UBQ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54236. SSF54236. 1 hit.
    PROSITEi PS50053. UBIQUITIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: ProstateImported.
    3. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Rat Genome Sequencing Project Consortium
      Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
      , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
      Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Brown NorwayImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    5. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BNImported.
    6. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: Brown NorwayImported.

    Entry informationi

    Entry nameiQ9ESS9_RAT
    AccessioniPrimary (citable) accession number: Q9ESS9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3