Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9ESS6 (BCAM_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Basal cell adhesion molecule
Alternative name(s):
B-CAM cell surface glycoprotein
Lutheran antigen
CD_antigen=CD239
Gene names
Name:Bcam
Synonyms:Lu
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length624 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Laminin alpha-5 receptor. May mediate intracellular signaling By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 2 Ig-like V-type (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 624599Basal cell adhesion molecule
PRO_0000383339

Regions

Topological domain26 – 543518Extracellular Potential
Transmembrane544 – 56421Helical; Potential
Topological domain565 – 62460Cytoplasmic Potential
Domain26 – 136111Ig-like V-type 1
Domain141 – 251111Ig-like V-type 2
Domain268 – 34376Ig-like C2-type 1
Domain357 – 43680Ig-like C2-type 2
Domain443 – 53492Ig-like C2-type 3

Amino acid modifications

Modified residue5921Phosphoserine By similarity
Modified residue5941Phosphoserine By similarity
Glycosylation3151N-linked (GlcNAc...) Potential
Glycosylation3711N-linked (GlcNAc...) Potential
Glycosylation3781N-linked (GlcNAc...) Potential
Disulfide bond47 ↔ 119 By similarity
Disulfide bond166 ↔ 231 By similarity
Disulfide bond285 ↔ 331 By similarity
Disulfide bond379 ↔ 419 By similarity
Disulfide bond468 ↔ 518 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ESS6 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 129A40A015ECE119

FASTA62467,512
        10         20         30         40         50         60 
MEPPDARAGL LWLTLLLSGY SGAQAELHVS VPPRVEVMRG EQIALDCTPR EHPENYVLEW 

        70         80         90        100        110        120 
LLVDASGARH RLASVEPQGS EFLGTIHNSR GRRPPYKIDS LGRLVIAEAQ VGDERDYVCV 

       130        140        150        160        170        180 
VKAGAAGTSE ATSSVRVFAT PEATEVAPNK GTLSVMEQFA QEIATCSSNN GNPVPRITWY 

       190        200        210        220        230        240 
QNGQRLDVPM ELNSKGYMTS RTVREASGLY SLTSTLYLRL HKEDRDASFH CAAHYDLPSG 

       250        260        270        280        290        300 
QHGRLDSHTF RLTLHYPTEH VEFWVGSPST TEGWVREGDA VQLLCQGDGS PSPEYSFFRE 

       310        320        330        340        350        360 
QGNQEEQLNV NLKGNLTLEG VHRSQSGIYG CRVEDYDADE EVQLVKKLKL HVAYLDPLEL 

       370        380        390        400        410        420 
SVPEEFSVFL NSSGTVVNCS ARGLPAPIVR WTKDSVTVAD GPILSLDSVT FDSAGTYTCE 

       430        440        450        460        470        480 
ASTPTVPLLS RTQSFQLVVQ GAPELKPNEI KPKSGTSWTE GDEVMLTCSA RGFPEPKLTW 

       490        500        510        520        530        540 
SQRGDTTPAE PPFEGRGWMS SSLTLKVTSA LSREGVSCEA SNIHGKNGHV FHFGSVAPQT 

       550        560        570        580        590        600 
AQAGVAVMAV AVSVGLLLLV VAAFYCMRRK GRPGCCQRAE KGAPPAREPE LSHSGSERPE 

       610        620 
HTGLLMGGPS GGGRGGNGGF GDEC 

« Hide

References

« Hide 'large scale' references
[1]"Rat Lutheran antigen."
Taira E., Okumura S., Miki N.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Heart.
[2]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Heart.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB035510 mRNA. Translation: BAB16052.1.
CH473979 Genomic DNA. Translation: EDM08138.1.
BC072479 mRNA. Translation: AAH72479.1.
RefSeqNP_113940.1. NM_031752.2.
UniGeneRn.7003.

3D structure databases

ProteinModelPortalQ9ESS6.
SMRQ9ESS6. Positions 26-256.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000047809.

Proteomic databases

PaxDbQ9ESS6.
PRIDEQ9ESS6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000045574; ENSRNOP00000047809; ENSRNOG00000029399.
GeneID78958.
KEGGrno:78958.
UCSCRGD:68378. rat.

Organism-specific databases

CTD4059.
RGD68378. Bcam.

Phylogenomic databases

eggNOGNOG150030.
GeneTreeENSGT00530000063457.
HOGENOMHOG000113409.
InParanoidQ9ESS6.
KOK06578.
OMAHYPTEHV.
OrthoDBEOG7GBFWH.
PhylomeDBQ9ESS6.
TreeFamTF330534.

Gene expression databases

GenevestigatorQ9ESS6.

Family and domain databases

Gene3D2.60.40.10. 5 hits.
InterProIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio614376.
PROQ9ESS6.

Entry information

Entry nameBCAM_RAT
AccessionPrimary (citable) accession number: Q9ESS6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families