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Q9ESS6

- BCAM_RAT

UniProt

Q9ESS6 - BCAM_RAT

Protein

Basal cell adhesion molecule

Gene

Bcam

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Laminin alpha-5 receptor. May mediate intracellular signaling By similarity.By similarity

    GO - Molecular functioni

    1. laminin receptor activity Source: Ensembl

    GO - Biological processi

    1. cell adhesion Source: RGD
    2. cell-matrix adhesion Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Basal cell adhesion molecule
    Alternative name(s):
    B-CAM cell surface glycoprotein
    Lutheran antigen
    CD_antigen: CD239
    Gene namesi
    Name:Bcam
    Synonyms:Lu
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi68378. Bcam.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 624599Basal cell adhesion moleculePRO_0000383339Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 119PROSITE-ProRule annotation
    Disulfide bondi166 ↔ 231PROSITE-ProRule annotation
    Disulfide bondi285 ↔ 331PROSITE-ProRule annotation
    Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi379 ↔ 419PROSITE-ProRule annotation
    Disulfide bondi468 ↔ 518PROSITE-ProRule annotation
    Modified residuei592 – 5921PhosphoserineBy similarity
    Modified residuei594 – 5941PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ9ESS6.
    PRIDEiQ9ESS6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ESS6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000047809.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ESS6.
    SMRiQ9ESS6. Positions 26-256.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 543518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini565 – 62460CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei544 – 56421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 136111Ig-like V-type 1Add
    BLAST
    Domaini141 – 251111Ig-like V-type 2Add
    BLAST
    Domaini268 – 34376Ig-like C2-type 1Add
    BLAST
    Domaini357 – 43680Ig-like C2-type 2Add
    BLAST
    Domaini443 – 53492Ig-like C2-type 3Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150030.
    GeneTreeiENSGT00530000063457.
    HOGENOMiHOG000113409.
    InParanoidiQ9ESS6.
    KOiK06578.
    OMAiHYPTEHV.
    OrthoDBiEOG7GBFWH.
    PhylomeDBiQ9ESS6.
    TreeFamiTF330534.

    Family and domain databases

    Gene3Di2.60.40.10. 5 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ESS6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPPDARAGL LWLTLLLSGY SGAQAELHVS VPPRVEVMRG EQIALDCTPR    50
    EHPENYVLEW LLVDASGARH RLASVEPQGS EFLGTIHNSR GRRPPYKIDS 100
    LGRLVIAEAQ VGDERDYVCV VKAGAAGTSE ATSSVRVFAT PEATEVAPNK 150
    GTLSVMEQFA QEIATCSSNN GNPVPRITWY QNGQRLDVPM ELNSKGYMTS 200
    RTVREASGLY SLTSTLYLRL HKEDRDASFH CAAHYDLPSG QHGRLDSHTF 250
    RLTLHYPTEH VEFWVGSPST TEGWVREGDA VQLLCQGDGS PSPEYSFFRE 300
    QGNQEEQLNV NLKGNLTLEG VHRSQSGIYG CRVEDYDADE EVQLVKKLKL 350
    HVAYLDPLEL SVPEEFSVFL NSSGTVVNCS ARGLPAPIVR WTKDSVTVAD 400
    GPILSLDSVT FDSAGTYTCE ASTPTVPLLS RTQSFQLVVQ GAPELKPNEI 450
    KPKSGTSWTE GDEVMLTCSA RGFPEPKLTW SQRGDTTPAE PPFEGRGWMS 500
    SSLTLKVTSA LSREGVSCEA SNIHGKNGHV FHFGSVAPQT AQAGVAVMAV 550
    AVSVGLLLLV VAAFYCMRRK GRPGCCQRAE KGAPPAREPE LSHSGSERPE 600
    HTGLLMGGPS GGGRGGNGGF GDEC 624
    Length:624
    Mass (Da):67,512
    Last modified:March 1, 2001 - v1
    Checksum:i129A40A015ECE119
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB035510 mRNA. Translation: BAB16052.1.
    CH473979 Genomic DNA. Translation: EDM08138.1.
    BC072479 mRNA. Translation: AAH72479.1.
    RefSeqiNP_113940.1. NM_031752.2.
    UniGeneiRn.7003.

    Genome annotation databases

    EnsembliENSRNOT00000045574; ENSRNOP00000047809; ENSRNOG00000029399.
    GeneIDi78958.
    KEGGirno:78958.
    UCSCiRGD:68378. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB035510 mRNA. Translation: BAB16052.1 .
    CH473979 Genomic DNA. Translation: EDM08138.1 .
    BC072479 mRNA. Translation: AAH72479.1 .
    RefSeqi NP_113940.1. NM_031752.2.
    UniGenei Rn.7003.

    3D structure databases

    ProteinModelPortali Q9ESS6.
    SMRi Q9ESS6. Positions 26-256.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000047809.

    Proteomic databases

    PaxDbi Q9ESS6.
    PRIDEi Q9ESS6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000045574 ; ENSRNOP00000047809 ; ENSRNOG00000029399 .
    GeneIDi 78958.
    KEGGi rno:78958.
    UCSCi RGD:68378. rat.

    Organism-specific databases

    CTDi 4059.
    RGDi 68378. Bcam.

    Phylogenomic databases

    eggNOGi NOG150030.
    GeneTreei ENSGT00530000063457.
    HOGENOMi HOG000113409.
    InParanoidi Q9ESS6.
    KOi K06578.
    OMAi HYPTEHV.
    OrthoDBi EOG7GBFWH.
    PhylomeDBi Q9ESS6.
    TreeFami TF330534.

    Miscellaneous databases

    NextBioi 614376.
    PROi Q9ESS6.

    Gene expression databases

    Genevestigatori Q9ESS6.

    Family and domain databases

    Gene3Di 2.60.40.10. 5 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat Lutheran antigen."
      Taira E., Okumura S., Miki N.
      Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Heart.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Heart.

    Entry informationi

    Entry nameiBCAM_RAT
    AccessioniPrimary (citable) accession number: Q9ESS6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 1, 2009
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3