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Protein

Basal cell adhesion molecule

Gene

Bcam

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: RGD
  • cell-matrix adhesion Source: Ensembl

Keywordsi

Molecular functionReceptor
Biological processCell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Basal cell adhesion molecule
Alternative name(s):
B-CAM cell surface glycoprotein
Lutheran antigen
CD_antigen: CD239
Gene namesi
Name:Bcam
Synonyms:Lu
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi68378 Bcam

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 543ExtracellularSequence analysisAdd BLAST518
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Topological domaini565 – 624CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000038333926 – 624Basal cell adhesion moleculeAdd BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 119PROSITE-ProRule annotation
Disulfide bondi166 ↔ 231PROSITE-ProRule annotation
Disulfide bondi285 ↔ 331PROSITE-ProRule annotation
Glycosylationi315N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi378N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi379 ↔ 419PROSITE-ProRule annotation
Disulfide bondi468 ↔ 518PROSITE-ProRule annotation
Modified residuei592PhosphoserineBy similarity1
Modified residuei594PhosphoserineBy similarity1
Modified residuei596PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ESS6
PRIDEiQ9ESS6

PTM databases

iPTMnetiQ9ESS6
PhosphoSitePlusiQ9ESS6

Expressioni

Gene expression databases

BgeeiENSRNOG00000029399
GenevisibleiQ9ESS6 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047809

Structurei

3D structure databases

ProteinModelPortaliQ9ESS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 136Ig-like V-type 1Add BLAST111
Domaini141 – 251Ig-like V-type 2Add BLAST111
Domaini268 – 343Ig-like C2-type 1Add BLAST76
Domaini357 – 436Ig-like C2-type 2Add BLAST80
Domaini443 – 534Ig-like C2-type 3Add BLAST92

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJIS Eukaryota
ENOG4111XZT LUCA
GeneTreeiENSGT00530000063457
HOGENOMiHOG000113409
InParanoidiQ9ESS6
KOiK06578
OMAiRDASFHC
OrthoDBiEOG091G05IA
PhylomeDBiQ9ESS6
TreeFamiTF330534

Family and domain databases

Gene3Di2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF13895 Ig_2, 1 hit
SMARTiView protein in SMART
SM00409 IG, 5 hits
SM00408 IGc2, 3 hits
SUPFAMiSSF48726 SSF48726, 5 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 5 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ESS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPDARAGL LWLTLLLSGY SGAQAELHVS VPPRVEVMRG EQIALDCTPR
60 70 80 90 100
EHPENYVLEW LLVDASGARH RLASVEPQGS EFLGTIHNSR GRRPPYKIDS
110 120 130 140 150
LGRLVIAEAQ VGDERDYVCV VKAGAAGTSE ATSSVRVFAT PEATEVAPNK
160 170 180 190 200
GTLSVMEQFA QEIATCSSNN GNPVPRITWY QNGQRLDVPM ELNSKGYMTS
210 220 230 240 250
RTVREASGLY SLTSTLYLRL HKEDRDASFH CAAHYDLPSG QHGRLDSHTF
260 270 280 290 300
RLTLHYPTEH VEFWVGSPST TEGWVREGDA VQLLCQGDGS PSPEYSFFRE
310 320 330 340 350
QGNQEEQLNV NLKGNLTLEG VHRSQSGIYG CRVEDYDADE EVQLVKKLKL
360 370 380 390 400
HVAYLDPLEL SVPEEFSVFL NSSGTVVNCS ARGLPAPIVR WTKDSVTVAD
410 420 430 440 450
GPILSLDSVT FDSAGTYTCE ASTPTVPLLS RTQSFQLVVQ GAPELKPNEI
460 470 480 490 500
KPKSGTSWTE GDEVMLTCSA RGFPEPKLTW SQRGDTTPAE PPFEGRGWMS
510 520 530 540 550
SSLTLKVTSA LSREGVSCEA SNIHGKNGHV FHFGSVAPQT AQAGVAVMAV
560 570 580 590 600
AVSVGLLLLV VAAFYCMRRK GRPGCCQRAE KGAPPAREPE LSHSGSERPE
610 620
HTGLLMGGPS GGGRGGNGGF GDEC
Length:624
Mass (Da):67,512
Last modified:March 1, 2001 - v1
Checksum:i129A40A015ECE119
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035510 mRNA Translation: BAB16052.1
CH473979 Genomic DNA Translation: EDM08138.1
BC072479 mRNA Translation: AAH72479.1
RefSeqiNP_113940.1, NM_031752.2
UniGeneiRn.7003

Genome annotation databases

EnsembliENSRNOT00000045574; ENSRNOP00000047809; ENSRNOG00000029399
GeneIDi78958
KEGGirno:78958
UCSCiRGD:68378 rat

Similar proteinsi

Entry informationi

Entry nameiBCAM_RAT
AccessioniPrimary (citable) accession number: Q9ESS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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