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Q9ESS6

- BCAM_RAT

UniProt

Q9ESS6 - BCAM_RAT

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Protein

Basal cell adhesion molecule

Gene

Bcam

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity).By similarity

GO - Molecular functioni

  1. laminin receptor activity Source: Ensembl

GO - Biological processi

  1. cell adhesion Source: RGD
  2. cell-matrix adhesion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Basal cell adhesion molecule
Alternative name(s):
B-CAM cell surface glycoprotein
Lutheran antigen
CD_antigen: CD239
Gene namesi
Name:Bcam
Synonyms:Lu
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi68378. Bcam.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 624599Basal cell adhesion moleculePRO_0000383339Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi47 ↔ 119PROSITE-ProRule annotation
Disulfide bondi166 ↔ 231PROSITE-ProRule annotation
Disulfide bondi285 ↔ 331PROSITE-ProRule annotation
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi371 – 3711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi378 – 3781N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi379 ↔ 419PROSITE-ProRule annotation
Disulfide bondi468 ↔ 518PROSITE-ProRule annotation
Modified residuei592 – 5921PhosphoserineBy similarity
Modified residuei594 – 5941PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ESS6.
PRIDEiQ9ESS6.

Expressioni

Gene expression databases

GenevestigatoriQ9ESS6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047809.

Structurei

3D structure databases

ProteinModelPortaliQ9ESS6.
SMRiQ9ESS6. Positions 26-256.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 543518ExtracellularSequence AnalysisAdd
BLAST
Topological domaini565 – 62460CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei544 – 56421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 136111Ig-like V-type 1Add
BLAST
Domaini141 – 251111Ig-like V-type 2Add
BLAST
Domaini268 – 34376Ig-like C2-type 1Add
BLAST
Domaini357 – 43680Ig-like C2-type 2Add
BLAST
Domaini443 – 53492Ig-like C2-type 3Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150030.
GeneTreeiENSGT00530000063457.
HOGENOMiHOG000113409.
InParanoidiQ9ESS6.
KOiK06578.
OMAiHYPTEHV.
OrthoDBiEOG7GBFWH.
PhylomeDBiQ9ESS6.
TreeFamiTF330534.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ESS6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEPPDARAGL LWLTLLLSGY SGAQAELHVS VPPRVEVMRG EQIALDCTPR
60 70 80 90 100
EHPENYVLEW LLVDASGARH RLASVEPQGS EFLGTIHNSR GRRPPYKIDS
110 120 130 140 150
LGRLVIAEAQ VGDERDYVCV VKAGAAGTSE ATSSVRVFAT PEATEVAPNK
160 170 180 190 200
GTLSVMEQFA QEIATCSSNN GNPVPRITWY QNGQRLDVPM ELNSKGYMTS
210 220 230 240 250
RTVREASGLY SLTSTLYLRL HKEDRDASFH CAAHYDLPSG QHGRLDSHTF
260 270 280 290 300
RLTLHYPTEH VEFWVGSPST TEGWVREGDA VQLLCQGDGS PSPEYSFFRE
310 320 330 340 350
QGNQEEQLNV NLKGNLTLEG VHRSQSGIYG CRVEDYDADE EVQLVKKLKL
360 370 380 390 400
HVAYLDPLEL SVPEEFSVFL NSSGTVVNCS ARGLPAPIVR WTKDSVTVAD
410 420 430 440 450
GPILSLDSVT FDSAGTYTCE ASTPTVPLLS RTQSFQLVVQ GAPELKPNEI
460 470 480 490 500
KPKSGTSWTE GDEVMLTCSA RGFPEPKLTW SQRGDTTPAE PPFEGRGWMS
510 520 530 540 550
SSLTLKVTSA LSREGVSCEA SNIHGKNGHV FHFGSVAPQT AQAGVAVMAV
560 570 580 590 600
AVSVGLLLLV VAAFYCMRRK GRPGCCQRAE KGAPPAREPE LSHSGSERPE
610 620
HTGLLMGGPS GGGRGGNGGF GDEC
Length:624
Mass (Da):67,512
Last modified:March 1, 2001 - v1
Checksum:i129A40A015ECE119
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB035510 mRNA. Translation: BAB16052.1.
CH473979 Genomic DNA. Translation: EDM08138.1.
BC072479 mRNA. Translation: AAH72479.1.
RefSeqiNP_113940.1. NM_031752.2.
UniGeneiRn.7003.

Genome annotation databases

EnsembliENSRNOT00000045574; ENSRNOP00000047809; ENSRNOG00000029399.
GeneIDi78958.
KEGGirno:78958.
UCSCiRGD:68378. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB035510 mRNA. Translation: BAB16052.1 .
CH473979 Genomic DNA. Translation: EDM08138.1 .
BC072479 mRNA. Translation: AAH72479.1 .
RefSeqi NP_113940.1. NM_031752.2.
UniGenei Rn.7003.

3D structure databases

ProteinModelPortali Q9ESS6.
SMRi Q9ESS6. Positions 26-256.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000047809.

Proteomic databases

PaxDbi Q9ESS6.
PRIDEi Q9ESS6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000045574 ; ENSRNOP00000047809 ; ENSRNOG00000029399 .
GeneIDi 78958.
KEGGi rno:78958.
UCSCi RGD:68378. rat.

Organism-specific databases

CTDi 4059.
RGDi 68378. Bcam.

Phylogenomic databases

eggNOGi NOG150030.
GeneTreei ENSGT00530000063457.
HOGENOMi HOG000113409.
InParanoidi Q9ESS6.
KOi K06578.
OMAi HYPTEHV.
OrthoDBi EOG7GBFWH.
PhylomeDBi Q9ESS6.
TreeFami TF330534.

Miscellaneous databases

NextBioi 614376.
PROi Q9ESS6.

Gene expression databases

Genevestigatori Q9ESS6.

Family and domain databases

Gene3Di 2.60.40.10. 5 hits.
InterProi IPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view ]
Pfami PF08205. C2-set_2. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 5 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Rat Lutheran antigen."
    Taira E., Okumura S., Miki N.
    Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Heart.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.

Entry informationi

Entry nameiBCAM_RAT
AccessioniPrimary (citable) accession number: Q9ESS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3