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Protein

Basal cell adhesion molecule

Gene

Bcam

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Laminin alpha-5 receptor. May mediate intracellular signaling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: RGD
  • cell-matrix adhesion Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Names & Taxonomyi

Protein namesi
Recommended name:
Basal cell adhesion molecule
Alternative name(s):
B-CAM cell surface glycoprotein
Lutheran antigen
CD_antigen: CD239
Gene namesi
Name:Bcam
Synonyms:Lu
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi68378. Bcam.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 543ExtracellularSequence analysisAdd BLAST518
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Topological domaini565 – 624CytoplasmicSequence analysisAdd BLAST60

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000038333926 – 624Basal cell adhesion moleculeAdd BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi47 ↔ 119PROSITE-ProRule annotation
Disulfide bondi166 ↔ 231PROSITE-ProRule annotation
Disulfide bondi285 ↔ 331PROSITE-ProRule annotation
Glycosylationi315N-linked (GlcNAc...)Sequence analysis1
Glycosylationi371N-linked (GlcNAc...)Sequence analysis1
Glycosylationi378N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi379 ↔ 419PROSITE-ProRule annotation
Disulfide bondi468 ↔ 518PROSITE-ProRule annotation
Modified residuei592PhosphoserineBy similarity1
Modified residuei594PhosphoserineBy similarity1
Modified residuei596PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ESS6.
PRIDEiQ9ESS6.

PTM databases

iPTMnetiQ9ESS6.
PhosphoSitePlusiQ9ESS6.

Expressioni

Gene expression databases

BgeeiENSRNOG00000029399.
GenevisibleiQ9ESS6. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047809.

Structurei

3D structure databases

ProteinModelPortaliQ9ESS6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 136Ig-like V-type 1Add BLAST111
Domaini141 – 251Ig-like V-type 2Add BLAST111
Domaini268 – 343Ig-like C2-type 1Add BLAST76
Domaini357 – 436Ig-like C2-type 2Add BLAST80
Domaini443 – 534Ig-like C2-type 3Add BLAST92

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJIS. Eukaryota.
ENOG4111XZT. LUCA.
GeneTreeiENSGT00530000063457.
HOGENOMiHOG000113409.
InParanoidiQ9ESS6.
KOiK06578.
OMAiWFLTDRS.
OrthoDBiEOG091G05IA.
PhylomeDBiQ9ESS6.
TreeFamiTF330534.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ESS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPDARAGL LWLTLLLSGY SGAQAELHVS VPPRVEVMRG EQIALDCTPR
60 70 80 90 100
EHPENYVLEW LLVDASGARH RLASVEPQGS EFLGTIHNSR GRRPPYKIDS
110 120 130 140 150
LGRLVIAEAQ VGDERDYVCV VKAGAAGTSE ATSSVRVFAT PEATEVAPNK
160 170 180 190 200
GTLSVMEQFA QEIATCSSNN GNPVPRITWY QNGQRLDVPM ELNSKGYMTS
210 220 230 240 250
RTVREASGLY SLTSTLYLRL HKEDRDASFH CAAHYDLPSG QHGRLDSHTF
260 270 280 290 300
RLTLHYPTEH VEFWVGSPST TEGWVREGDA VQLLCQGDGS PSPEYSFFRE
310 320 330 340 350
QGNQEEQLNV NLKGNLTLEG VHRSQSGIYG CRVEDYDADE EVQLVKKLKL
360 370 380 390 400
HVAYLDPLEL SVPEEFSVFL NSSGTVVNCS ARGLPAPIVR WTKDSVTVAD
410 420 430 440 450
GPILSLDSVT FDSAGTYTCE ASTPTVPLLS RTQSFQLVVQ GAPELKPNEI
460 470 480 490 500
KPKSGTSWTE GDEVMLTCSA RGFPEPKLTW SQRGDTTPAE PPFEGRGWMS
510 520 530 540 550
SSLTLKVTSA LSREGVSCEA SNIHGKNGHV FHFGSVAPQT AQAGVAVMAV
560 570 580 590 600
AVSVGLLLLV VAAFYCMRRK GRPGCCQRAE KGAPPAREPE LSHSGSERPE
610 620
HTGLLMGGPS GGGRGGNGGF GDEC
Length:624
Mass (Da):67,512
Last modified:March 1, 2001 - v1
Checksum:i129A40A015ECE119
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035510 mRNA. Translation: BAB16052.1.
CH473979 Genomic DNA. Translation: EDM08138.1.
BC072479 mRNA. Translation: AAH72479.1.
RefSeqiNP_113940.1. NM_031752.2.
UniGeneiRn.7003.

Genome annotation databases

EnsembliENSRNOT00000045574; ENSRNOP00000047809; ENSRNOG00000029399.
GeneIDi78958.
KEGGirno:78958.
UCSCiRGD:68378. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB035510 mRNA. Translation: BAB16052.1.
CH473979 Genomic DNA. Translation: EDM08138.1.
BC072479 mRNA. Translation: AAH72479.1.
RefSeqiNP_113940.1. NM_031752.2.
UniGeneiRn.7003.

3D structure databases

ProteinModelPortaliQ9ESS6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000047809.

PTM databases

iPTMnetiQ9ESS6.
PhosphoSitePlusiQ9ESS6.

Proteomic databases

PaxDbiQ9ESS6.
PRIDEiQ9ESS6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000045574; ENSRNOP00000047809; ENSRNOG00000029399.
GeneIDi78958.
KEGGirno:78958.
UCSCiRGD:68378. rat.

Organism-specific databases

CTDi4059.
RGDi68378. Bcam.

Phylogenomic databases

eggNOGiENOG410IJIS. Eukaryota.
ENOG4111XZT. LUCA.
GeneTreeiENSGT00530000063457.
HOGENOMiHOG000113409.
InParanoidiQ9ESS6.
KOiK06578.
OMAiWFLTDRS.
OrthoDBiEOG091G05IA.
PhylomeDBiQ9ESS6.
TreeFamiTF330534.

Miscellaneous databases

PROiQ9ESS6.

Gene expression databases

BgeeiENSRNOG00000029399.
GenevisibleiQ9ESS6. RN.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF13895. Ig_2. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 5 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 5 hits.
PROSITEiPS50835. IG_LIKE. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBCAM_RAT
AccessioniPrimary (citable) accession number: Q9ESS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: March 1, 2001
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.