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Protein

Fibroblast growth factor 22

Gene

Fgf22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190370. FGFR1b ligand binding and activation.
R-MMU-190377. FGFR2b ligand binding and activation.
R-MMU-5654219. Phospholipase C-mediated cascade: FGFR1.
R-MMU-5654221. Phospholipase C-mediated cascade, FGFR2.
R-MMU-5654687. Downstream signaling of activated FGFR1.
R-MMU-5654688. SHC-mediated cascade:FGFR1.
R-MMU-5654689. PI-3K cascade:FGFR1.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654726. Negative regulation of FGFR1 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5658623. FGFRL1 modulation of FGFR1 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 22
Short name:
FGF-22
Gene namesi
Name:Fgf22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914362. Fgf22.

Subcellular locationi

GO - Cellular componenti

  • cell surface Source: MGI
  • Golgi apparatus Source: MGI
  • nucleolus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000899723 – 162Fibroblast growth factor 22Add BLAST140

Proteomic databases

PaxDbiQ9ESS2.
PRIDEiQ9ESS2.

PTM databases

PhosphoSitePlusiQ9ESS2.

Expressioni

Tissue specificityi

Preferentially expressed in skin; low expression in brain. Expressed in the inner root sheath of the hair follicle.

Gene expression databases

BgeeiENSMUSG00000020327.
CleanExiMM_FGF22.
GenevisibleiQ9ESS2. MM.

Interactioni

Subunit structurei

Interacts with FGFR1 and FGFR2. Interacts with FGFBP1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi211948. 1 interactor.
STRINGi10090.ENSMUSP00000020577.

Structurei

3D structure databases

ProteinModelPortaliQ9ESS2.
SMRiQ9ESS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiQ9ESS2.
KOiK04358.
OMAiGRTQRHH.
OrthoDBiEOG091G0NAY.
PhylomeDBiQ9ESS2.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028296. FGF22.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF41. PTHR11486:SF41. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ESS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSRLWLGLA WLLLARAPGA PGGYPHLEGD VRWRRLFSST HFFLRVDLGG
60 70 80 90 100
RVQGTRWRHG QDSIVEIRSV RVGTVVIKAV YSGFYVAMNR RGRLYGSRVY
110 120 130 140 150
SVDCRFRERI EENGYNTYAS RRWRHRGRPM FLALDSQGIP RQGRRTRRHQ
160
LSTHFLPVLV SS
Length:162
Mass (Da):18,927
Last modified:March 1, 2001 - v1
Checksum:i225EF512F4E1BE29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036765 mRNA. Translation: BAB16407.1.
CCDSiCCDS23988.1.
RefSeqiNP_075793.1. NM_023304.1.
UniGeneiMm.154211.

Genome annotation databases

EnsembliENSMUST00000020577; ENSMUSP00000020577; ENSMUSG00000020327.
GeneIDi67112.
KEGGimmu:67112.
UCSCiuc007fzp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB036765 mRNA. Translation: BAB16407.1.
CCDSiCCDS23988.1.
RefSeqiNP_075793.1. NM_023304.1.
UniGeneiMm.154211.

3D structure databases

ProteinModelPortaliQ9ESS2.
SMRiQ9ESS2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211948. 1 interactor.
STRINGi10090.ENSMUSP00000020577.

PTM databases

PhosphoSitePlusiQ9ESS2.

Proteomic databases

PaxDbiQ9ESS2.
PRIDEiQ9ESS2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020577; ENSMUSP00000020577; ENSMUSG00000020327.
GeneIDi67112.
KEGGimmu:67112.
UCSCiuc007fzp.1. mouse.

Organism-specific databases

CTDi27006.
MGIiMGI:1914362. Fgf22.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiQ9ESS2.
KOiK04358.
OMAiGRTQRHH.
OrthoDBiEOG091G0NAY.
PhylomeDBiQ9ESS2.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190370. FGFR1b ligand binding and activation.
R-MMU-190377. FGFR2b ligand binding and activation.
R-MMU-5654219. Phospholipase C-mediated cascade: FGFR1.
R-MMU-5654221. Phospholipase C-mediated cascade, FGFR2.
R-MMU-5654687. Downstream signaling of activated FGFR1.
R-MMU-5654688. SHC-mediated cascade:FGFR1.
R-MMU-5654689. PI-3K cascade:FGFR1.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654726. Negative regulation of FGFR1 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5658623. FGFRL1 modulation of FGFR1 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Miscellaneous databases

PROiQ9ESS2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020327.
CleanExiMM_FGF22.
GenevisibleiQ9ESS2. MM.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028296. FGF22.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF41. PTHR11486:SF41. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF22_MOUSE
AccessioniPrimary (citable) accession number: Q9ESS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.