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Q9ESS0

- DUS10_MOUSE

UniProt

Q9ESS0 - DUS10_MOUSE

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Protein

Dual specificity protein phosphatase 10

Gene

Dusp10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily By similarity.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei409 – 4091Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. MAP kinase phosphatase activity Source: UniProtKB
  2. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
  3. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  4. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. inactivation of MAPK activity Source: UniProtKB
  2. negative regulation of JNK cascade Source: MGI
  3. negative regulation of JUN kinase activity Source: MGI
  4. negative regulation of respiratory burst involved in inflammatory response Source: MGI
  5. negative regulation of stress-activated MAPK cascade Source: MGI
  6. oligodendrocyte differentiation Source: MGI
  7. protein dephosphorylation Source: UniProtKB
  8. regulation of adaptive immune response Source: MGI
  9. regulation of innate immune response Source: MGI
  10. response to lipopolysaccharide Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 10 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Mitogen-activated protein kinase phosphatase 5
Short name:
MAP kinase phosphatase 5
Short name:
MKP-5
Gene namesi
Name:Dusp10
Synonyms:Mkp5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1927070. Dusp10.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Dual specificity protein phosphatase 10PRO_0000094814Add
BLAST

Proteomic databases

PaxDbiQ9ESS0.
PRIDEiQ9ESS0.

Expressioni

Gene expression databases

BgeeiQ9ESS0.
CleanExiMM_DUSP10.
ExpressionAtlasiQ9ESS0. baseline and differential.
GenevestigatoriQ9ESS0.

Interactioni

Subunit structurei

Monomer. Interacts with MAPK14 By similarity.By similarity

Protein-protein interaction databases

BioGridi211005. 1 interaction.
IntActiQ9ESS0. 1 interaction.
STRINGi10090.ENSMUSP00000045838.

Structurei

3D structure databases

ProteinModelPortaliQ9ESS0.
SMRiQ9ESS0. Positions 149-468.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini169 – 286118RhodanesePROSITE-ProRule annotationAdd
BLAST
Domaini386 – 45671Tyrosine-protein phosphataseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni200 – 21617Interaction with MAP kinasesBy similarityAdd
BLAST

Sequence similaritiesi

Contains 1 rhodanese domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00760000118902.
HOGENOMiHOG000069871.
HOVERGENiHBG102158.
InParanoidiQ9ESS0.
KOiK04459.
OMAiTCPANQM.
TreeFamiTF105122.

Family and domain databases

Gene3Di3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
PR01764. MAPKPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEiPS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESS0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPSPLDDRV VVALSRPVRP QDLNLCLDSS YLGSASPGSG SHAPVLATAV
60 70 80 90 100
VTLKAANLTY MPSSSGSARS LNCGCSSTSC CTVATYDKDH QAQTQAIAAG
110 120 130 140 150
TATTAIGTST TCPANQMVNN NENTGSVLSP SGGVGSPVSG TPKQLASIKI
160 170 180 190 200
IYPNDLAKKM TKCSKSHLPS QGPVIIDCRP FMEYNKSHIQ GAVHINCADK
210 220 230 240 250
ISRRRLQQGK ITVLDLISCR EGKDSFKRIF SKEIIVYDEN TNEPSRVTPS
260 270 280 290 300
QPLHIVLESL KREGKEPLVL KGGLSSFKQN HGNLCDNSLQ LQECREVGGG
310 320 330 340 350
ASAASSMLPQ SVPTTPDIEN AELTPILPFL FLGNEQDAQD LDTMQRLNIG
360 370 380 390 400
YVINVTTHLP LYHYEKGLFN YKRLPATDSN KQNLRQYFEE AFEFIEEAHQ
410 420 430 440 450
CGKGLLIHCQ AGVSRSATIV IAYLMKHTRM TMTDAYKFVK GKRPIISPNL
460 470 480
NFMGQLLEFE EDLNNGVTPR ILTPKLMGME TVV
Length:483
Mass (Da):52,532
Last modified:July 27, 2011 - v2
Checksum:i7797A1877D986AA8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481T → A in BAB17680. (PubMed:11060451)Curated
Sequence conflicti113 – 1131P → S in BAB27966. (PubMed:16141072)Curated
Sequence conflicti386 – 3861Q → R in BAB17680. (PubMed:11060451)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037908 mRNA. Translation: BAB17680.1.
AK011995 mRNA. Translation: BAB27966.1.
AK035293 mRNA. Translation: BAC29019.1.
AK050528 mRNA. Translation: BAC34308.1.
AK088024 mRNA. Translation: BAC40102.1.
AK088186 mRNA. Translation: BAC40196.1.
AK088357 mRNA. Translation: BAC40300.1.
AK142568 mRNA. Translation: BAE25109.1.
BC025066 mRNA. Translation: AAH25066.1.
CCDSiCCDS15591.1.
RefSeqiNP_071302.2. NM_022019.5.
XP_006497251.1. XM_006497188.1.
XP_006497252.1. XM_006497189.1.
UniGeneiMm.404024.

Genome annotation databases

EnsembliENSMUST00000048655; ENSMUSP00000045838; ENSMUSG00000039384.
GeneIDi63953.
KEGGimmu:63953.
UCSCiuc007dym.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB037908 mRNA. Translation: BAB17680.1 .
AK011995 mRNA. Translation: BAB27966.1 .
AK035293 mRNA. Translation: BAC29019.1 .
AK050528 mRNA. Translation: BAC34308.1 .
AK088024 mRNA. Translation: BAC40102.1 .
AK088186 mRNA. Translation: BAC40196.1 .
AK088357 mRNA. Translation: BAC40300.1 .
AK142568 mRNA. Translation: BAE25109.1 .
BC025066 mRNA. Translation: AAH25066.1 .
CCDSi CCDS15591.1.
RefSeqi NP_071302.2. NM_022019.5.
XP_006497251.1. XM_006497188.1.
XP_006497252.1. XM_006497189.1.
UniGenei Mm.404024.

3D structure databases

ProteinModelPortali Q9ESS0.
SMRi Q9ESS0. Positions 149-468.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211005. 1 interaction.
IntActi Q9ESS0. 1 interaction.
STRINGi 10090.ENSMUSP00000045838.

Proteomic databases

PaxDbi Q9ESS0.
PRIDEi Q9ESS0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000048655 ; ENSMUSP00000045838 ; ENSMUSG00000039384 .
GeneIDi 63953.
KEGGi mmu:63953.
UCSCi uc007dym.1. mouse.

Organism-specific databases

CTDi 11221.
MGIi MGI:1927070. Dusp10.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00760000118902.
HOGENOMi HOG000069871.
HOVERGENi HBG102158.
InParanoidi Q9ESS0.
KOi K04459.
OMAi TCPANQM.
TreeFami TF105122.

Miscellaneous databases

NextBioi 319811.
PROi Q9ESS0.
SOURCEi Search...

Gene expression databases

Bgeei Q9ESS0.
CleanExi MM_DUSP10.
ExpressionAtlasi Q9ESS0. baseline and differential.
Genevestigatori Q9ESS0.

Family and domain databases

Gene3Di 3.40.250.10. 1 hit.
3.90.190.10. 1 hit.
InterProi IPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR008343. MKP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view ]
PRINTSi PR01908. ADSPHPHTASE.
PR01764. MAPKPHPHTASE.
SMARTi SM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 1 hit.
PROSITEi PS50206. RHODANESE_3. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10."
    Masuda K., Shima H., Kikuchi K., Watanabe Y., Matsuda Y.
    Cytogenet. Cell Genet. 90:71-74(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and NOD.
    Tissue: Embryo, Kidney, Pancreas, Thymus and Urinary bladder.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II.
    Tissue: Mammary tumor.

Entry informationi

Entry nameiDUS10_MOUSE
AccessioniPrimary (citable) accession number: Q9ESS0
Secondary accession number(s): Q8R3L3, Q9CZY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3