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Q9ESS0

- DUS10_MOUSE

UniProt

Q9ESS0 - DUS10_MOUSE

Protein

Dual specificity protein phosphatase 10

Gene

Dusp10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Protein phosphatase involved in the inactivation of MAP kinases. Has a specificity for the MAPK11/MAPK12/MAPK13/MAPK14 subfamily By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei409 – 4091Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. MAP kinase phosphatase activity Source: UniProtKB
    2. MAP kinase tyrosine/serine/threonine phosphatase activity Source: InterPro
    3. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    4. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. inactivation of MAPK activity Source: UniProtKB
    2. negative regulation of JNK cascade Source: MGI
    3. negative regulation of JUN kinase activity Source: MGI
    4. negative regulation of respiratory burst involved in inflammatory response Source: MGI
    5. negative regulation of stress-activated MAPK cascade Source: MGI
    6. oligodendrocyte differentiation Source: MGI
    7. protein dephosphorylation Source: UniProtKB
    8. regulation of adaptive immune response Source: MGI
    9. regulation of innate immune response Source: MGI
    10. response to lipopolysaccharide Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 10 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Mitogen-activated protein kinase phosphatase 5
    Short name:
    MAP kinase phosphatase 5
    Short name:
    MKP-5
    Gene namesi
    Name:Dusp10
    Synonyms:Mkp5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1927070. Dusp10.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. Golgi apparatus Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Dual specificity protein phosphatase 10PRO_0000094814Add
    BLAST

    Proteomic databases

    PaxDbiQ9ESS0.
    PRIDEiQ9ESS0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ESS0.
    BgeeiQ9ESS0.
    CleanExiMM_DUSP10.
    GenevestigatoriQ9ESS0.

    Interactioni

    Subunit structurei

    Monomer. Interacts with MAPK14 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi211005. 1 interaction.
    IntActiQ9ESS0. 1 interaction.
    STRINGi10090.ENSMUSP00000045838.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ESS0.
    SMRiQ9ESS0. Positions 149-288, 322-468.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini169 – 286118RhodanesePROSITE-ProRule annotationAdd
    BLAST
    Domaini386 – 45671Tyrosine-protein phosphataseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni200 – 21617Interaction with MAP kinasesBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 rhodanese domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00750000117567.
    HOGENOMiHOG000069871.
    HOVERGENiHBG102158.
    InParanoidiQ8R3L3.
    KOiK04459.
    OMAiTCPANQM.
    TreeFamiTF105122.

    Family and domain databases

    Gene3Di3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    PR01764. MAPKPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEiPS50206. RHODANESE_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ESS0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPSPLDDRV VVALSRPVRP QDLNLCLDSS YLGSASPGSG SHAPVLATAV    50
    VTLKAANLTY MPSSSGSARS LNCGCSSTSC CTVATYDKDH QAQTQAIAAG 100
    TATTAIGTST TCPANQMVNN NENTGSVLSP SGGVGSPVSG TPKQLASIKI 150
    IYPNDLAKKM TKCSKSHLPS QGPVIIDCRP FMEYNKSHIQ GAVHINCADK 200
    ISRRRLQQGK ITVLDLISCR EGKDSFKRIF SKEIIVYDEN TNEPSRVTPS 250
    QPLHIVLESL KREGKEPLVL KGGLSSFKQN HGNLCDNSLQ LQECREVGGG 300
    ASAASSMLPQ SVPTTPDIEN AELTPILPFL FLGNEQDAQD LDTMQRLNIG 350
    YVINVTTHLP LYHYEKGLFN YKRLPATDSN KQNLRQYFEE AFEFIEEAHQ 400
    CGKGLLIHCQ AGVSRSATIV IAYLMKHTRM TMTDAYKFVK GKRPIISPNL 450
    NFMGQLLEFE EDLNNGVTPR ILTPKLMGME TVV 483
    Length:483
    Mass (Da):52,532
    Last modified:July 27, 2011 - v2
    Checksum:i7797A1877D986AA8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti48 – 481T → A in BAB17680. (PubMed:11060451)Curated
    Sequence conflicti113 – 1131P → S in BAB27966. (PubMed:16141072)Curated
    Sequence conflicti386 – 3861Q → R in BAB17680. (PubMed:11060451)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037908 mRNA. Translation: BAB17680.1.
    AK011995 mRNA. Translation: BAB27966.1.
    AK035293 mRNA. Translation: BAC29019.1.
    AK050528 mRNA. Translation: BAC34308.1.
    AK088024 mRNA. Translation: BAC40102.1.
    AK088186 mRNA. Translation: BAC40196.1.
    AK088357 mRNA. Translation: BAC40300.1.
    AK142568 mRNA. Translation: BAE25109.1.
    BC025066 mRNA. Translation: AAH25066.1.
    CCDSiCCDS15591.1.
    RefSeqiNP_071302.2. NM_022019.5.
    XP_006497251.1. XM_006497188.1.
    XP_006497252.1. XM_006497189.1.
    UniGeneiMm.404024.

    Genome annotation databases

    EnsembliENSMUST00000048655; ENSMUSP00000045838; ENSMUSG00000039384.
    GeneIDi63953.
    KEGGimmu:63953.
    UCSCiuc007dym.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB037908 mRNA. Translation: BAB17680.1 .
    AK011995 mRNA. Translation: BAB27966.1 .
    AK035293 mRNA. Translation: BAC29019.1 .
    AK050528 mRNA. Translation: BAC34308.1 .
    AK088024 mRNA. Translation: BAC40102.1 .
    AK088186 mRNA. Translation: BAC40196.1 .
    AK088357 mRNA. Translation: BAC40300.1 .
    AK142568 mRNA. Translation: BAE25109.1 .
    BC025066 mRNA. Translation: AAH25066.1 .
    CCDSi CCDS15591.1.
    RefSeqi NP_071302.2. NM_022019.5.
    XP_006497251.1. XM_006497188.1.
    XP_006497252.1. XM_006497189.1.
    UniGenei Mm.404024.

    3D structure databases

    ProteinModelPortali Q9ESS0.
    SMRi Q9ESS0. Positions 149-288, 322-468.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211005. 1 interaction.
    IntActi Q9ESS0. 1 interaction.
    STRINGi 10090.ENSMUSP00000045838.

    Proteomic databases

    PaxDbi Q9ESS0.
    PRIDEi Q9ESS0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000048655 ; ENSMUSP00000045838 ; ENSMUSG00000039384 .
    GeneIDi 63953.
    KEGGi mmu:63953.
    UCSCi uc007dym.1. mouse.

    Organism-specific databases

    CTDi 11221.
    MGIi MGI:1927070. Dusp10.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00750000117567.
    HOGENOMi HOG000069871.
    HOVERGENi HBG102158.
    InParanoidi Q8R3L3.
    KOi K04459.
    OMAi TCPANQM.
    TreeFami TF105122.

    Miscellaneous databases

    NextBioi 319811.
    PROi Q9ESS0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ESS0.
    Bgeei Q9ESS0.
    CleanExi MM_DUSP10.
    Genevestigatori Q9ESS0.

    Family and domain databases

    Gene3Di 3.40.250.10. 1 hit.
    3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR008343. MKP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    PR01764. MAPKPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 1 hit.
    PROSITEi PS50206. RHODANESE_3. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression and comparative chromosomal mapping of MKP-5 genes DUSP10/Dusp10."
      Masuda K., Shima H., Kikuchi K., Watanabe Y., Matsuda Y.
      Cytogenet. Cell Genet. 90:71-74(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J and NOD.
      Tissue: Embryo, Kidney, Pancreas, Thymus and Urinary bladder.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Czech II.
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiDUS10_MOUSE
    AccessioniPrimary (citable) accession number: Q9ESS0
    Secondary accession number(s): Q8R3L3, Q9CZY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 9, 2003
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 107 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3