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Protein

ATP-binding cassette sub-family A member 2

Gene

Abca2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable transporter, its natural substrate has not been found yet. May have a role in macrophage lipid metabolism and neural development.Curated

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi1024 – 10318ATP 1PROSITE-ProRule annotation
Nucleotide bindingi2088 – 20958ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • ATP binding Source: UniProtKB
  • transporter activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 2
Alternative name(s):
ATP-binding cassette transporter 2
Short name:
ATP-binding cassette 2
Gene namesi
Name:Abca2Imported
Synonyms:Abc2Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620238. Abca2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence analysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence analysisAdd
BLAST
Transmembranei699 – 71921HelicalSequence analysisAdd
BLAST
Transmembranei750 – 77021HelicalSequence analysisAdd
BLAST
Transmembranei782 – 80221HelicalSequence analysisAdd
BLAST
Transmembranei813 – 83321HelicalSequence analysisAdd
BLAST
Transmembranei857 – 87721HelicalSequence analysisAdd
BLAST
Transmembranei893 – 91321HelicalSequence analysisAdd
BLAST
Transmembranei1461 – 148121HelicalSequence analysisAdd
BLAST
Transmembranei1793 – 181321HelicalSequence analysisAdd
BLAST
Transmembranei1842 – 186221HelicalSequence analysisAdd
BLAST
Transmembranei1873 – 189321HelicalSequence analysisAdd
BLAST
Transmembranei1906 – 192621HelicalSequence analysisAdd
BLAST
Transmembranei1992 – 201221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: UniProtKB
  • endosome Source: UniProtKB
  • endosome membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB
  • lysosomal membrane Source: UniProtKB
  • lysosome Source: UniProtKB
  • microtubule organizing center Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24342434ATP-binding cassette sub-family A member 2PRO_0000093292Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence analysis
Glycosylationi168 – 1681N-linked (GlcNAc...)Sequence analysis
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis
Glycosylationi305 – 3051N-linked (GlcNAc...)Sequence analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence analysis
Glycosylationi379 – 3791N-linked (GlcNAc...)Sequence analysis
Glycosylationi420 – 4201N-linked (GlcNAc...)Sequence analysis
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence analysis
Glycosylationi476 – 4761N-linked (GlcNAc...)Sequence analysis
Glycosylationi484 – 4841N-linked (GlcNAc...)Sequence analysis
Glycosylationi494 – 4941N-linked (GlcNAc...)Sequence analysis
Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence analysis
Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence analysis
Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence analysis
Glycosylationi600 – 6001N-linked (GlcNAc...)Sequence analysis
Glycosylationi628 – 6281N-linked (GlcNAc...)Sequence analysis
Glycosylationi1247 – 12471N-linked (GlcNAc...)Sequence analysis
Modified residuei1327 – 13271PhosphoserineCombined sources
Modified residuei1331 – 13311PhosphoserineCombined sources
Glycosylationi1496 – 14961N-linked (GlcNAc...)Sequence analysis
Glycosylationi1549 – 15491N-linked (GlcNAc...)Sequence analysis
Glycosylationi1557 – 15571N-linked (GlcNAc...)Sequence analysis
Glycosylationi1613 – 16131N-linked (GlcNAc...)Sequence analysis
Glycosylationi1678 – 16781N-linked (GlcNAc...)Sequence analysis
Glycosylationi1776 – 17761N-linked (GlcNAc...)Sequence analysis
Glycosylationi2055 – 20551N-linked (GlcNAc...)Sequence analysis
Modified residuei2411 – 24111PhosphothreonineCombined sources

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ESR9.
PRIDEiQ9ESR9.

PTM databases

PhosphoSiteiQ9ESR9.
UniCarbKBiQ9ESR9.

Expressioni

Tissue specificityi

Expressed at high levels in brain, at moderate levels in heart, kidney and lung, and at low levels in skeletal muscle, stomach, spleen, colon and pancreas. Not detected in the liver or small intestine. In brain, highly expressed in white matter and detected in oligodendrocytes.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi249446. 1 interaction.
STRINGi10116.ENSRNOP00000020339.

Structurei

3D structure databases

ProteinModelPortaliQ9ESR9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini990 – 1221232ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini2051 – 2286236ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
HOGENOMiHOG000231547.
HOVERGENiHBG050436.
InParanoidiQ9ESR9.
KOiK05642.
PhylomeDBiQ9ESR9.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030366. ABCA2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 5 hits.
PTHR19229:SF116. PTHR19229:SF116. 5 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESR9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFLHQLQLL LWKNVTLKRR SPWVLAFEIF IPLVLFFILL GLRQKKPTIS
60 70 80 90 100
VKEAFYTAAP LTSAGILPVM QSLCPDGQRD EFGFLQYANS TVTQLLERLN
110 120 130 140 150
RVVEESNLFD PERPSLGSEL EALHQRLEAL SSGPGTWESH SARPAVSSFS
160 170 180 190 200
LDSVARDKRE LWRFLMQNLS LPNSTAQALL AARVDPSEVY RLLFGPLPDL
210 220 230 240 250
DGKLGFLRKQ EPWSHLGSNP LFQMEELLLA PALLEQLTCA PGSGELGRIL
260 270 280 290 300
TMPEGHQVDL QGYRDAVCSG QATARAQHFS DLATELRNQL DIAKIAQQLG
310 320 330 340 350
FNVPNGSDPQ PQAPSPQSLQ ALLGDLLDVQ KVLQDVDVLS ALALLLPQGA
360 370 380 390 400
CAGRAPAPQA GSPSGPANST GVGANTGPNT TVEEGTQSPV TPASPDTLQG
410 420 430 440 450
QCSAFVQLWA GLQPILCGNN RTIEPEALRR GNMSSLGFTS KEQRNLGLLV
460 470 480 490 500
HLMTSNPKIL YAPAGSEADH VILKANETFA FVGNVTHYAQ VWLNISAEIR
510 520 530 540 550
SFLEQGRLQQ HLHWLQQYVA DLRLHPEAMN LSLDELPPAL RLDYFSLPNG
560 570 580 590 600
TALLQQLDTI DNAACGWIQF MSKVSVDIFK GFPDEESIVN YTLNQAYQDN
610 620 630 640 650
VTVFASVIFQ TRKDGSLPPH VHYKIRQNSS FTEKTNEIRR AYWRPGPNTG
660 670 680 690 700
GRFYFLYGFV WIQDMIERAI INTFVGHDVV EPGNYVQMFP YPCYTRDDFL
710 720 730 740 750
FVIEHMMPLC MVISWVYSVA MTIQHIVAEK EHRLKEVMKT MGLNNAVHWV
760 770 780 790 800
AWFITGFVQL SISVTALTAI LKYGQVLMHS HVLIIWLFLA VYAVATIMFC
810 820 830 840 850
FLVSVLYSKA KLASACGGII YFLSYVPYMY VAIREEVAHD KITAFEKCIA
860 870 880 890 900
SLMSTTAFGL GSKYFALYEV AGVGIQWHTF SQSPVEGDDF NLLLAVTMLM
910 920 930 940 950
VDTVVYGVLT WYIEAVHPGM YGLPRPWYFP LQKSYWLGSG RTETWEWSWP
960 970 980 990 1000
WAHAPRLSVM EEDQACAMES RHFEETRGME EEPTHLPLVV CVDKLTKVYK
1010 1020 1030 1040 1050
NDKKLALNKL SLNLYENQVV SFLGHNGAGK TTTMSILTGL FPPTSGSATI
1060 1070 1080 1090 1100
YGHDIRTEMD EIRKNLGMCP QHNVLFDQLT VEEHLWFYSR LKSMAQEEIR
1110 1120 1130 1140 1150
KEMDKMIEDL ELSNKRHSLV QTLSGGMKRK LSVAIAFVGG SRAIILDEPT
1160 1170 1180 1190 1200
AGVDPYARRA IWDLILKYKP GRTILLSTHH MDEADLLGDR IAIISHGKLK
1210 1220 1230 1240 1250
CCGSPLFLKG AYGDGYRLTL VKRPAEPGTS QEPGMASSPS GRPQLSNCSE
1260 1270 1280 1290 1300
MQVSQFIRKH VASSLLVSDT STELSYILPS EAVKKGAFER LFQQLEHSLD
1310 1320 1330 1340 1350
ALHLSSFGLM DTTLEEVFLK VSEEDQSLEN SEADVKESRK DALPGAEGLT
1360 1370 1380 1390 1400
AVESQAGNLA RCSELAQSQA SLQSASSVGS ARGDEGAGYT DGYGDYRPLF
1410 1420 1430 1440 1450
DNLQDPDSVS LQEAEMEALA RVGQGSRKLE GWWLKMRQFH GLLVKRFHCA
1460 1470 1480 1490 1500
RRNSKALCSQ ILLPAFFVCV AMTVALSVPE IGDLPPLVLS PSQYHNYTQP
1510 1520 1530 1540 1550
RGNFIPYANE ERREYRLRLS PDASPQQLVS TFRLPSGVGA TCVLKSPANG
1560 1570 1580 1590 1600
SLGPMLNLSS GESRLLAARF FDSMCLESFT QGLPLSNFVP PPPSPAPSDS
1610 1620 1630 1640 1650
PLSPDEDSLL AWNTSLPPTA GPETWTWAPS LPRLVHEPVR CTCSAQGTGF
1660 1670 1680 1690 1700
SCPSSVGGHP PQMRVVTGDI LTDITGHNVS EYLLFTSDRF RLHRYGAITF
1710 1720 1730 1740 1750
GNIQKSIPAP IGTRTPLMVR KIAVRRVAQV LYNNKGYHSM PTYLNSLNNA
1760 1770 1780 1790 1800
ILRANLPKSK GNPAAYGITV TNHPMNKTSA SLSLDYLLQG TDVVIAIFII
1810 1820 1830 1840 1850
VAMSFVPASF VVFLVAEKST KAKHLQFVSG CNPVIYWLAN YVWDMLNYLV
1860 1870 1880 1890 1900
PATCCIIILF VFDLPAYTSP TNFPAVLSLF LLYGWSITPI MYPASFWFEV
1910 1920 1930 1940 1950
PSSAYVFLIV INLFIGITAT VATFLLQLFE HDKDLKVVNS YLKSCFLIFP
1960 1970 1980 1990 2000
NYNLGHGLME IAYNEYINEY YAKIGQFDKM KSPFEWDIVT RGLVAMTVEG
2010 2020 2030 2040 2050
FVGFFLTIMC QYNFLRQPQR LPVSTKPVED DVDVASERQR VLRGDADNDM
2060 2070 2080 2090 2100
VKIENLTKVY KSRKIGRILA VDRLCLGVRP GECFGLLGVN GAGKTSTFKM
2110 2120 2130 2140 2150
LTGDESTTGG EAFVNGHSVL KDLLQVQQSL GYCPQFDALF DELTAREHLQ
2160 2170 2180 2190 2200
LYTRLRGIPW KDEAQVVRWA LEKLELTKCA DKPAGSYSGG NKRKLSTAIA
2210 2220 2230 2240 2250
LIGYPAFIFL DEPTTGMDPK ARRFLWNLIL DLIKTGRSVV LTSHSMEECE
2260 2270 2280 2290 2300
AVCTRLAIMV NGRLRCLGSI QHLKNRFGDG YMITVRTKSS QNVKDVVRFF
2310 2320 2330 2340 2350
NRNFPEAMLK ERHHTKVQYQ LKSEHISLAQ VFSKMEHVVG VLGIEDYSVS
2360 2370 2380 2390 2400
QTTLDNVFVN FAKKQSDNVE QQEAEPSTLP SPLGLLSLLR PRPAPTELRA
2410 2420 2430
LVADEPEDLD TEDEGLISFE EERAQLSFNT DTLC
Length:2,434
Mass (Da):270,928
Last modified:March 1, 2001 - v1
Checksum:iCD424A9C4F63513F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037937 mRNA. Translation: BAB16596.1.
RefSeqiNP_077372.1. NM_024396.1.
UniGeneiRn.13115.

Genome annotation databases

GeneIDi79248.
KEGGirno:79248.
UCSCiRGD:620238. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037937 mRNA. Translation: BAB16596.1.
RefSeqiNP_077372.1. NM_024396.1.
UniGeneiRn.13115.

3D structure databases

ProteinModelPortaliQ9ESR9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249446. 1 interaction.
STRINGi10116.ENSRNOP00000020339.

PTM databases

PhosphoSiteiQ9ESR9.
UniCarbKBiQ9ESR9.

Proteomic databases

PaxDbiQ9ESR9.
PRIDEiQ9ESR9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi79248.
KEGGirno:79248.
UCSCiRGD:620238. rat.

Organism-specific databases

CTDi20.
RGDi620238. Abca2.

Phylogenomic databases

eggNOGiKOG0059. Eukaryota.
COG1131. LUCA.
HOGENOMiHOG000231547.
HOVERGENiHBG050436.
InParanoidiQ9ESR9.
KOiK05642.
PhylomeDBiQ9ESR9.

Miscellaneous databases

NextBioi614716.
PROiQ9ESR9.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR026082. ABC_A.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030366. ABCA2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR19229. PTHR19229. 5 hits.
PTHR19229:SF116. PTHR19229:SF116. 5 hits.
PfamiPF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2."
    Zhao L.-X., Zhou C.-J., Tanaka A., Nakata M., Hirabayashi T., Amachi T., Shioda S., Ueda K., Inagaki N.
    Biochem. J. 350:865-872(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, GLYCOSYLATION.
    Tissue: BrainImported.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1327; SER-1331 AND THR-2411, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiABCA2_RAT
AccessioniPrimary (citable) accession number: Q9ESR9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.