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Protein

Pro-FMRFamide-related neuropeptide VF

Gene

Npvf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Neuropeptide RFRP-1 acts as a potent negative regulator of gonadotropin synthesis and secretion. Neuropeptides NPSF and NPVF efficiently inhibit forskolin-induced production of cAMP (By similarity). Neuropeptide NPVF blocks morphine-induced analgesia.By similarity1 Publication

GO - Molecular functioni

  • signaling receptor binding Source: RGD

GO - Biological processi

  • neuropeptide signaling pathway Source: RGD
  • sensory perception of pain Source: RGD

Keywordsi

Molecular functionNeuropeptide

Names & Taxonomyi

Protein namesi
Recommended name:
Pro-FMRFamide-related neuropeptide VF
Alternative name(s):
FMRFamide-related peptides
Cleaved into the following 3 chains:
Alternative name(s):
Neuropeptide RFRP-2
Gene namesi
Name:Npvf
Synonyms:Rfrp
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi61815 Npvf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000000993227 – 57Add BLAST31
PeptideiPRO_000000993358 – 94Neuropeptide NPSFAdd BLAST37
PeptideiPRO_000040117283 – 94Neuropeptide RFRP-1Sequence analysisAdd BLAST12
PropeptideiPRO_000000993497 – 10610
PeptideiPRO_0000009935108 – 125Neuropeptide NPVFAdd BLAST18
PropeptideiPRO_0000009936128 – 203Add BLAST76

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei94Phenylalanine amideBy similarity1
Modified residuei125Phenylalanine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ9ESQ9

Expressioni

Tissue specificityi

Isoform 1 is expressed at high levels in the hypothalamus and eye. Isoform 2 is specifically expressed in a region between the dorsomedial hypothalamic and ventromedial hypothalamic nuclei.2 Publications

Interactioni

GO - Molecular functioni

  • signaling receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000014437

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWCW Eukaryota
ENOG410Z21X LUCA
HOGENOMiHOG000133054
HOVERGENiHBG031581
InParanoidiQ9ESQ9
PhylomeDBiQ9ESQ9

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ESQ9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIISSKRFI LLTLATSSFL TSNTLCSDEL MMPHFHSKEG YGKYYQLRGI
60 70 80 90 100
PKGVKERSVT FQELKDWGAK KDIKMSPAPA NKVPHSAANL PLRFGRNIED
110 120 130 140 150
RRSPRARANM EAGTMSHFPS LPQRFGRTTA RRITKTLAGL PQKSLHSLAS
160 170 180 190 200
SELLYAMTRQ HQEIQSPGQE QPRKRVFTET DDAERKQEKI GNLQPVLQGA

MKL
Length:203
Mass (Da):22,979
Last modified:March 1, 2001 - v1
Checksum:iB5F0F26E852BE214
GO
Isoform 2 (identifier: Q9ESQ9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     174-203: Missing.

Show »
Length:173
Mass (Da):19,553
Checksum:i95A9AC1E20BA9772
GO

Mass spectrometryi

Molecular mass is 1010.54 Da from positions 108 - 125. Determined by ESI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039964174 – 203Missing in isoform 2. 1 PublicationAdd BLAST30

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB040288 mRNA Translation: BAB17672.1
AF330059 mRNA Translation: AAK94203.2
RefSeqiNP_076442.1, NM_023952.1 [Q9ESQ9-1]
UniGeneiRn.62354

Genome annotation databases

GeneIDi60570
KEGGirno:60570
UCSCiRGD:61815 rat [Q9ESQ9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNPVF_RAT
AccessioniPrimary (citable) accession number: Q9ESQ9
Secondary accession number(s): Q920A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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