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Protein

Neuromedin-U receptor 2

Gene

Nmur2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.3 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 2
Short name:
NMU-R2
Alternative name(s):
G-protein coupled receptor TGR-1
G-protein-coupled receptor FM-4
Gene namesi
Name:Nmur2
Synonyms:Tgr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621155. Nmur2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 74CytoplasmicSequence analysisAdd BLAST12
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 115ExtracellularSequence analysisAdd BLAST20
Transmembranei116 – 138Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini139 – 157CytoplasmicSequence analysisAdd BLAST19
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 212ExtracellularSequence analysisAdd BLAST34
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini234 – 257CytoplasmicSequence analysisAdd BLAST24
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 293ExtracellularSequence analysisAdd BLAST15
Transmembranei294 – 314Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini315 – 395CytoplasmicSequence analysisAdd BLAST81

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699121 – 395Neuromedin-U receptor 2Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi111 ↔ 196PROSITE-ProRule annotation
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ESQ4.
PRIDEiQ9ESQ4.

PTM databases

PhosphoSitePlusiQ9ESQ4.

Expressioni

Tissue specificityi

The highest level is detected in the uterus. In the central nervous system, high expression levels were found in the hypothalamus and moderate levels in both the medulla oblongata and spinal cord. Expressed in the hypothalamic paraventricular nucleus (PVN) and suprachiasmatic nuclei (SCN) of the hypothalamus. Expression is low in the gastrointestinal tract. In other peripheral tissues, moderate expression was observed in the lung and ovary.3 Publications

Gene expression databases

GenevisibleiQ9ESQ4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018967.

Structurei

3D structure databases

ProteinModelPortaliQ9ESQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ9ESQ4.
KOiK05053.
OMAiHYFPNGS.
OrthoDBiEOG091G0ZDG.
PhylomeDBiQ9ESQ4.
TreeFamiTF318522.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005392. NeuromedU_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01567. NEUROMEDNU2R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLENASWI HDPLMKYLNS TEEYLAHLCG PKRSDLSLPV SVAYALIFLV
60 70 80 90 100
GVMGNLLVCM VIVRHQTLKT PTNYYLFSLA VSDLLVLLLG MPLEIYEMWH
110 120 130 140 150
NYPFLFGPVG CYFKTALFET VCFASILSVT TVSVERYVAI VHPFRAKLES
160 170 180 190 200
TRRRALRILS LVWSFSVVFS LPNTSIHGIK FQHFPNGSSV PGSATCTVTK
210 220 230 240 250
PMWVYNLIIQ ATSFLFYILP MTLISVLYYL MGLRLKRDES LEANKVAVNI
260 270 280 290 300
HRPSRKSVTK MLFVLVLVFA ICWTPFHVDR LFFSFVEEWT ESLAAVFNLI
310 320 330 340 350
HVVSGVFFYL SSAVNPIIYN LLSRRFRAAF RNVVSPTCKW CHPRHRPQGP
360 370 380 390
PAQKIIFLTE CHLVELTEDA GPQFPGQSSI HNTNLTTAPC AGEVP
Length:395
Mass (Da):44,723
Last modified:December 6, 2005 - v2
Checksum:i01D3765B5D5355C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti346R → Q in BAB13722 (PubMed:10887190).Curated1
Sequence conflicti364V → M in BAB13722 (PubMed:10887190).Curated1
Sequence conflicti387T → M in BAB13722 (PubMed:10887190).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041229 mRNA. Translation: BAB13722.1.
AF242875 mRNA. Translation: AAF82756.1.
RefSeqiNP_071611.3. NM_022275.3.
UniGeneiRn.160579.

Genome annotation databases

EnsembliENSRNOT00000018967; ENSRNOP00000018967; ENSRNOG00000014081.
GeneIDi64042.
KEGGirno:64042.
UCSCiRGD:621155. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041229 mRNA. Translation: BAB13722.1.
AF242875 mRNA. Translation: AAF82756.1.
RefSeqiNP_071611.3. NM_022275.3.
UniGeneiRn.160579.

3D structure databases

ProteinModelPortaliQ9ESQ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018967.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9ESQ4.

Proteomic databases

PaxDbiQ9ESQ4.
PRIDEiQ9ESQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018967; ENSRNOP00000018967; ENSRNOG00000014081.
GeneIDi64042.
KEGGirno:64042.
UCSCiRGD:621155. rat.

Organism-specific databases

CTDi56923.
RGDi621155. Nmur2.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000113804.
HOVERGENiHBG103506.
InParanoidiQ9ESQ4.
KOiK05053.
OMAiHYFPNGS.
OrthoDBiEOG091G0ZDG.
PhylomeDBiQ9ESQ4.
TreeFamiTF318522.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-416476. G alpha (q) signalling events.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ9ESQ4.

Gene expression databases

GenevisibleiQ9ESQ4. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005390. NeuromedU_rcpt.
IPR005392. NeuromedU_rcpt_2.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01565. NEUROMEDINUR.
PR01567. NEUROMEDNU2R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNMUR2_RAT
AccessioniPrimary (citable) accession number: Q9ESQ4
Secondary accession number(s): Q9JIB1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.