Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuromedin-U receptor 2

Gene

Nmur2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the neuromedin-U and neuromedin-S neuropeptides.3 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-375276 Peptide ligand-binding receptors
R-RNO-416476 G alpha (q) signalling events
R-RNO-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuromedin-U receptor 2
Short name:
NMU-R2
Alternative name(s):
G-protein coupled receptor TGR-1
G-protein-coupled receptor FM-4
Gene namesi
Name:Nmur2
Synonyms:Tgr1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi621155 Nmur2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41ExtracellularSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 74CytoplasmicSequence analysisAdd BLAST12
Transmembranei75 – 95Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini96 – 115ExtracellularSequence analysisAdd BLAST20
Transmembranei116 – 138Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini139 – 157CytoplasmicSequence analysisAdd BLAST19
Transmembranei158 – 178Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini179 – 212ExtracellularSequence analysisAdd BLAST34
Transmembranei213 – 233Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini234 – 257CytoplasmicSequence analysisAdd BLAST24
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 293ExtracellularSequence analysisAdd BLAST15
Transmembranei294 – 314Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini315 – 395CytoplasmicSequence analysisAdd BLAST81

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000699121 – 395Neuromedin-U receptor 2Add BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi19N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi111 ↔ 196PROSITE-ProRule annotation
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ESQ4
PRIDEiQ9ESQ4

PTM databases

PhosphoSitePlusiQ9ESQ4

Expressioni

Tissue specificityi

The highest level is detected in the uterus. In the central nervous system, high expression levels were found in the hypothalamus and moderate levels in both the medulla oblongata and spinal cord. Expressed in the hypothalamic paraventricular nucleus (PVN) and suprachiasmatic nuclei (SCN) of the hypothalamus. Expression is low in the gastrointestinal tract. In other peripheral tissues, moderate expression was observed in the lung and ovary.3 Publications

Gene expression databases

BgeeiENSRNOG00000014081
GenevisibleiQ9ESQ4 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018967

Structurei

3D structure databases

ProteinModelPortaliQ9ESQ4
SMRiQ9ESQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00700000104070
HOGENOMiHOG000113804
HOVERGENiHBG103506
InParanoidiQ9ESQ4
KOiK05053
OMAiSQYAMIN
OrthoDBiEOG091G0ZDG
PhylomeDBiQ9ESQ4
TreeFamiTF318522

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR005390 NeuromedU_rcpt
IPR005392 NeuromedU_rcpt_2
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01565 NEUROMEDINUR
PR01567 NEUROMEDNU2R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ESQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKLENASWI HDPLMKYLNS TEEYLAHLCG PKRSDLSLPV SVAYALIFLV
60 70 80 90 100
GVMGNLLVCM VIVRHQTLKT PTNYYLFSLA VSDLLVLLLG MPLEIYEMWH
110 120 130 140 150
NYPFLFGPVG CYFKTALFET VCFASILSVT TVSVERYVAI VHPFRAKLES
160 170 180 190 200
TRRRALRILS LVWSFSVVFS LPNTSIHGIK FQHFPNGSSV PGSATCTVTK
210 220 230 240 250
PMWVYNLIIQ ATSFLFYILP MTLISVLYYL MGLRLKRDES LEANKVAVNI
260 270 280 290 300
HRPSRKSVTK MLFVLVLVFA ICWTPFHVDR LFFSFVEEWT ESLAAVFNLI
310 320 330 340 350
HVVSGVFFYL SSAVNPIIYN LLSRRFRAAF RNVVSPTCKW CHPRHRPQGP
360 370 380 390
PAQKIIFLTE CHLVELTEDA GPQFPGQSSI HNTNLTTAPC AGEVP
Length:395
Mass (Da):44,723
Last modified:December 6, 2005 - v2
Checksum:i01D3765B5D5355C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti346R → Q in BAB13722 (PubMed:10887190).Curated1
Sequence conflicti364V → M in BAB13722 (PubMed:10887190).Curated1
Sequence conflicti387T → M in BAB13722 (PubMed:10887190).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041229 mRNA Translation: BAB13722.1
AF242875 mRNA Translation: AAF82756.1
RefSeqiNP_071611.3, NM_022275.3
UniGeneiRn.160579

Genome annotation databases

EnsembliENSRNOT00000018967; ENSRNOP00000018967; ENSRNOG00000014081
GeneIDi64042
KEGGirno:64042
UCSCiRGD:621155 rat

Similar proteinsi

Entry informationi

Entry nameiNMUR2_RAT
AccessioniPrimary (citable) accession number: Q9ESQ4
Secondary accession number(s): Q9JIB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 23, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health