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Protein

Fez family zinc finger protein 2

Gene

Fezf2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation.4 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri272 – 29423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43524C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • axonal fasciculation Source: MGI
  • axon guidance Source: MGI
  • cerebral cortex GABAergic interneuron migration Source: MGI
  • cerebral cortex neuron differentiation Source: MGI
  • commitment of neuronal cell to specific neuron type in forebrain Source: MGI
  • dendrite development Source: MGI
  • dentate gyrus development Source: MGI
  • forebrain anterior/posterior pattern specification Source: MGI
  • forebrain development Source: MGI
  • locomotory behavior Source: MGI
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of neuron differentiation Source: MGI
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • neuron fate determination Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: GOC
  • regulation of axon guidance Source: MGI
  • telencephalon development Source: UniProtKB
  • transcription from RNA polymerase II promoter Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Fez family zinc finger protein 2
Alternative name(s):
Forebrain embryonic zinc finger-like protein 2
Zinc finger protein 312
Zinc finger protein Fez-like
Gene namesi
Name:Fezf2
Synonyms:Fez, Fezl, Zfp312
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1859823. Fezf2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

In null mutant mice, no subcerebral projection neurons are born and no cortical projections to the brainstem or the spinal cord ever develop. In contrast, other populations of neurons are unaffected. There seems to be a redundant role for FEZF1 and FEZF2 in diencephalon development.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Fez family zinc finger protein 2PRO_0000295121Add
BLAST

Proteomic databases

PaxDbiQ9ESP5.
PRIDEiQ9ESP5.

PTM databases

PhosphoSiteiQ9ESP5.

Expressioni

Tissue specificityi

Highly expressed in neocortical layer V, moderately expressed in layer VI. Expressed in subcortically projecting neurons.2 Publications

Developmental stagei

Expressed in the olfactory epithelium, hypothalamus, ventrolateral pallium and prethalamus at mid-gestation. At E12.5, highly enriched in the postmigratory pyramidal neurons forming the cortical plate situated beneath the pial surface. At E13.5, expressed in the ventricular zone and subventricular zone at low levels, expression is much higher in the developing cortical plate, where postmitotic neurons are positioned. During late embryonic and early postnatal development, expression disappears from cortical progenitors and becomes restricted to the subplate and the prospective layer V and VI pyramidal neurons.3 Publications

Gene expression databases

BgeeiQ9ESP5.
CleanExiMM_FEZF2.
GenevisibleiQ9ESP5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022262.

Structurei

3D structure databases

ProteinModelPortaliQ9ESP5.
SMRiQ9ESP5. Positions 105-138, 184-215, 234-435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi27 – 4216Engrailed homology 1 repressorAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi102 – 11211Poly-GlyAdd
BLAST

Sequence similaritiesi

Contains 6 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri272 – 29423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri300 – 32223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri328 – 35023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri356 – 37823C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri384 – 40623C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri412 – 43524C2H2-type 6PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ9ESP5.
OMAiNYSELWK.
OrthoDBiEOG7Z0JW5.
PhylomeDBiQ9ESP5.
TreeFamiTF316780.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSASLETM VPPACPRAGA SPATSKTLAF SIERIMAKTS EPRAPFEPRP
60 70 80 90 100
AALEADSSQS KKLLNLCSPL PCMIPLQPLG YEVPSKTLLS YSEFWKSSLR
110 120 130 140 150
AGGGGGGGSG GGAPVCGASG LCKTNCGVCC KAELGLAPSA LPAGRVIKPQ
160 170 180 190 200
VINQAVGLPA SGSLYYFNYL DSTAYPPSEL LGGHLFPSGL LNAQAPTSLA
210 220 230 240 250
AHPKLFLLEN AKLASLAADK FPHPASYPHK ERLHAPLEQV LKENSALTAE
260 270 280 290 300
RGGVKSHSKL PGGSTDSKPK NFTCEVCGKV FNAHYNLTRH MPVHTGARPF
310 320 330 340 350
VCKVCGKGFR QASTLCRHKI IHTQEKPHKC NQCGKAFNRS STLNTHIRIH
360 370 380 390 400
AGYKPFVCEF CGKGFHQKGN YKNHKLTHSG EKQYKCTICN KAFHQVYNLT
410 420 430 440 450
FHMHTHNDKK PFTCATCGKG FCRNFDLKKH VRKLHDSVGP TATPSAKDLA

RTVQS
Length:455
Mass (Da):48,931
Last modified:March 1, 2001 - v1
Checksum:i506C648982A0345B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti429 – 4291K → R in BAB31958 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042399 mRNA. Translation: BAB17670.1.
AK019996 mRNA. Translation: BAB31958.1.
BC055718 mRNA. Translation: AAH55718.1.
CCDSiCCDS26818.1.
RefSeqiNP_536681.2. NM_080433.3.
UniGeneiMm.34644.

Genome annotation databases

EnsembliENSMUST00000022262; ENSMUSP00000022262; ENSMUSG00000021743.
GeneIDi54713.
KEGGimmu:54713.
UCSCiuc007sfs.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042399 mRNA. Translation: BAB17670.1.
AK019996 mRNA. Translation: BAB31958.1.
BC055718 mRNA. Translation: AAH55718.1.
CCDSiCCDS26818.1.
RefSeqiNP_536681.2. NM_080433.3.
UniGeneiMm.34644.

3D structure databases

ProteinModelPortaliQ9ESP5.
SMRiQ9ESP5. Positions 105-138, 184-215, 234-435.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022262.

PTM databases

PhosphoSiteiQ9ESP5.

Proteomic databases

PaxDbiQ9ESP5.
PRIDEiQ9ESP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022262; ENSMUSP00000022262; ENSMUSG00000021743.
GeneIDi54713.
KEGGimmu:54713.
UCSCiuc007sfs.2. mouse.

Organism-specific databases

CTDi55079.
MGIiMGI:1859823. Fezf2.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00740000115096.
HOGENOMiHOG000013052.
HOVERGENiHBG098441.
InParanoidiQ9ESP5.
OMAiNYSELWK.
OrthoDBiEOG7Z0JW5.
PhylomeDBiQ9ESP5.
TreeFamiTF316780.

Miscellaneous databases

PROiQ9ESP5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ESP5.
CleanExiMM_FEZF2.
GenevisibleiQ9ESP5. MM.

Family and domain databases

Gene3Di3.30.160.60. 6 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 6 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the zinc finger gene fez-like in zebrafish forebrain."
    Hashimoto H., Yabe T., Hirata T., Shimizu T., Bae Y.-K., Yamanaka Y., Hirano T., Hibi M.
    Mech. Dev. 97:191-195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. "Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex."
    Chen J.-G., Rasin M.-R., Kwan K.Y., Sestan N.
    Proc. Natl. Acad. Sci. U.S.A. 102:17792-17797(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  5. "Fezl is required for the birth and specification of corticospinal motor neurons."
    Molyneaux B.J., Arlotta P., Hirata T., Hibi M., Macklis J.D.
    Neuron 47:817-831(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  6. "Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously."
    Hirata T., Nakazawa M., Yoshihara S., Miyachi H., Kitamura K., Yoshihara Y., Hibi M.
    Development 133:1433-1443(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
  7. "Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions."
    Hirata T., Nakazawa M., Muraoka O., Nakayama R., Suda Y., Hibi M.
    Development 133:3993-4004(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Pancreas.

Entry informationi

Entry nameiFEZF2_MOUSE
AccessioniPrimary (citable) accession number: Q9ESP5
Secondary accession number(s): Q9D298
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.