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Protein

Probable G-protein coupled receptor 88

Gene

Gpr88

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable G-protein coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 88
Alternative name(s):
Striatum-specific G-protein coupled receptor
Gene namesi
Name:Gpr88
Synonyms:Strg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi61921 Gpr88

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini57 – 73CytoplasmicSequence analysisAdd BLAST17
Transmembranei74 – 94Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini95 – 116ExtracellularSequence analysisAdd BLAST22
Transmembranei117 – 136Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini137 – 158CytoplasmicSequence analysisAdd BLAST22
Transmembranei159 – 179Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini180 – 195ExtracellularSequence analysisAdd BLAST16
Transmembranei196 – 216Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini217 – 285CytoplasmicSequence analysisAdd BLAST69
Transmembranei286 – 306Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini307 – 310ExtracellularSequence analysis4
Transmembranei311 – 331Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini332 – 384CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695991 – 384Probable G-protein coupled receptor 88Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ESP4
PRIDEiQ9ESP4

PTM databases

PhosphoSitePlusiQ9ESP4

Expressioni

Tissue specificityi

Expressed predominantly in the striatum (PubMed:11056049). Expressed also in olfactory tubercle, nucleus accumbens, amygdala, and neocortex. Spinal cord, pons, and medulla expression remains discrete (PubMed:26918661). Also expressed in peripheral tissues, including adrenal cortex (E16-E21) and cochlear ganglia (E19-postnatal day 3(P3)) and also at moderate levels in retina (E18-E19) and spleen (E21-P7) (PubMed:26918661).2 Publications

Developmental stagei

Detected at embryonic day 16 (E16) in the striatum. From E16-E20 to adulthood, the highest expression levels of protein is observed in the striatum, olfactory tubercle, nucleus accumbens, amygdala, and neocortex.1 Publication

Gene expression databases

BgeeiENSRNOG00000026953
GenevisibleiQ9ESP4 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038233

Structurei

3D structure databases

ProteinModelPortaliQ9ESP4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00390000009609
HOGENOMiHOG000060315
HOVERGENiHBG051821
InParanoidiQ9ESP4
KOiK08422
OMAiTYQVLYQ
OrthoDBiEOG091G0JWW
PhylomeDBiQ9ESP4
TreeFamiTF336499

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ESP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSSSTSTS TTTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG
60 70 80 90 100
MVIYLVSSFR KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPAGSAE
110 120 130 140 150
PPGDWDSGGG SYRLLRGGLL GLGLTVSLLS HCLVALNRYL LITRAPATYQ
160 170 180 190 200
VLYQRRHTAG MLALSWALAL GLVLLLPPWA PKPGAEPPQV HYPALLAAGA
210 220 230 240 250
LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC AAAAAAFPAA
260 270 280 290 300
PHAPGAGGAA HPAQPQPLPA ALQPRRAQRR LSGLSVLLLC CVFLLATQPL
310 320 330 340 350
VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV
360 370 380
LPGVGDAAAA AAAATAVPAM SQAQLGTRAA GQHW
Length:384
Mass (Da):40,200
Last modified:March 1, 2001 - v1
Checksum:i0334B64D0F3FD669
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042407 mRNA Translation: BAB18244.1
RefSeqiNP_113884.1, NM_031696.1
XP_006233282.1, XM_006233220.3
XP_006233283.1, XM_006233221.3
XP_006233284.1, XM_006233222.3
UniGeneiRn.59513

Genome annotation databases

EnsembliENSRNOT00000037068; ENSRNOP00000038233; ENSRNOG00000026953
GeneIDi64443
KEGGirno:64443
UCSCiRGD:61921 rat

Similar proteinsi

Entry informationi

Entry nameiGPR88_RAT
AccessioniPrimary (citable) accession number: Q9ESP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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