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Protein

Probable G-protein coupled receptor 88

Gene

Gpr88

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 88
Alternative name(s):
Striatum-specific G-protein coupled receptor
Gene namesi
Name:Gpr88
Synonyms:Strg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi61921. Gpr88.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535ExtracellularSequence analysisAdd
BLAST
Transmembranei36 – 5621Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini57 – 7317CytoplasmicSequence analysisAdd
BLAST
Transmembranei74 – 9421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini95 – 11622ExtracellularSequence analysisAdd
BLAST
Transmembranei117 – 13620Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini137 – 15822CytoplasmicSequence analysisAdd
BLAST
Transmembranei159 – 17921Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini180 – 19516ExtracellularSequence analysisAdd
BLAST
Transmembranei196 – 21621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini217 – 28569CytoplasmicSequence analysisAdd
BLAST
Transmembranei286 – 30621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini307 – 3104ExtracellularSequence analysis
Transmembranei311 – 33121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini332 – 38453CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 384384Probable G-protein coupled receptor 88PRO_0000069599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ESP4.

PTM databases

PhosphoSiteiQ9ESP4.

Expressioni

Tissue specificityi

Expressed almost exclusively in striatum.1 Publication

Gene expression databases

GenevisibleiQ9ESP4. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038233.

Structurei

3D structure databases

ProteinModelPortaliQ9ESP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000009609.
HOGENOMiHOG000060315.
HOVERGENiHBG051821.
InParanoidiQ9ESP4.
KOiK08422.
OMAiEPPGDWD.
OrthoDBiEOG7ZD1WN.
PhylomeDBiQ9ESP4.
TreeFamiTF336499.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNSSSTSTS TTTGGSLLLL CEEEESWAGR RIPVSLLYSG LAIGGTLANG
60 70 80 90 100
MVIYLVSSFR KLQTTSNAFI VNGCAADLSV CALWMPQEAV LGLLPAGSAE
110 120 130 140 150
PPGDWDSGGG SYRLLRGGLL GLGLTVSLLS HCLVALNRYL LITRAPATYQ
160 170 180 190 200
VLYQRRHTAG MLALSWALAL GLVLLLPPWA PKPGAEPPQV HYPALLAAGA
210 220 230 240 250
LLAQTALLLH CYLGIVRRVR VSVKRVSVLN FHLLHQLPGC AAAAAAFPAA
260 270 280 290 300
PHAPGAGGAA HPAQPQPLPA ALQPRRAQRR LSGLSVLLLC CVFLLATQPL
310 320 330 340 350
VWVSLASGFS LPVPWGVQAA SWLLCCALSA LNPLLYTWRN EEFRRSVRSV
360 370 380
LPGVGDAAAA AAAATAVPAM SQAQLGTRAA GQHW
Length:384
Mass (Da):40,200
Last modified:March 1, 2001 - v1
Checksum:i0334B64D0F3FD669
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042407 mRNA. Translation: BAB18244.1.
RefSeqiNP_113884.1. NM_031696.1.
XP_006233282.1. XM_006233220.2.
XP_006233283.1. XM_006233221.2.
XP_006233284.1. XM_006233222.2.
XP_008759693.1. XM_008761471.1.
UniGeneiRn.59513.

Genome annotation databases

EnsembliENSRNOT00000037068; ENSRNOP00000038233; ENSRNOG00000026953.
GeneIDi64443.
KEGGirno:64443.
UCSCiRGD:61921. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042407 mRNA. Translation: BAB18244.1.
RefSeqiNP_113884.1. NM_031696.1.
XP_006233282.1. XM_006233220.2.
XP_006233283.1. XM_006233221.2.
XP_006233284.1. XM_006233222.2.
XP_008759693.1. XM_008761471.1.
UniGeneiRn.59513.

3D structure databases

ProteinModelPortaliQ9ESP4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000038233.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9ESP4.

Proteomic databases

PaxDbiQ9ESP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000037068; ENSRNOP00000038233; ENSRNOG00000026953.
GeneIDi64443.
KEGGirno:64443.
UCSCiRGD:61921. rat.

Organism-specific databases

CTDi54112.
RGDi61921. Gpr88.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000009609.
HOGENOMiHOG000060315.
HOVERGENiHBG051821.
InParanoidiQ9ESP4.
KOiK08422.
OMAiEPPGDWD.
OrthoDBiEOG7ZD1WN.
PhylomeDBiQ9ESP4.
TreeFamiTF336499.

Miscellaneous databases

PROiQ9ESP4.

Gene expression databases

GenevisibleiQ9ESP4. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel G-protein-coupled receptor gene expressed in striatum."
    Mizushima K., Miyamoto Y., Tsukahara F., Hirai M., Sakaki Y., Ito T.
    Genomics 69:314-321(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR88_RAT
AccessioniPrimary (citable) accession number: Q9ESP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.