Q9ESP1 (SDF2L_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Stromal cell-derived factor 2-like protein 1
Short name=SDF2-like protein 1

Gene names

Name:

Sdf2l1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	221 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Endoplasmic reticulum lumen Potential.
Tissue specificity	Ubiquitously expressed with high expression in the testis, ovary, uterus, and low expression in heart and skeletal muscle.
Induction	By tunicamycin and a calcium ionophore, A23187.
Sequence similarities	Contains 3 MIR domains.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum
Domain	Repeat Signal
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	endoplasmic reticulum Inferred from sequence alignment PubMed 11278416. Source: MGI endoplasmic reticulum lumen Inferred from electronic annotation. Source: UniProtKB-SubCell membrane Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 28	28	Potential
	Chain	29 – 221	193	Stromal cell-derived factor 2-like protein 1		PRO_0000031958
Regions
	Domain	33 – 87	55	MIR 1
	Domain	95 – 150	56	MIR 2
	Domain	151 – 205	55	MIR 3
	Motif	218 – 221	4	Prevents secretion from ER Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ESP1 [UniParc]. Last modified June 20, 2002. Version 2. Checksum: D2A7C15D360EB25D	FASTA	221	23,648
	10 20 30 40 50 60 MWGASRGRVA GPTLLGLLLA LSVRSGGASK ASAGLVTCGS VLKLLNTHHK VRLHSHDIKY 70 80 90 100 110 120 GSGSGQQSVT GVEESDDANS YWRIRGGSEG GCPRGLPVRC GQAVRLTHVL TGKNLHTHHF 130 140 150 160 170 180 PSPLSNNQEV SAFGEDGEGD DLDLWTVRCS GQHWEREASV RFQHVGTSVF LSVTGEQYGN 190 200 210 220 PIRGQHEVHG MPSANAHNTW KAMEGIFIKP GADLSTGHDE L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family." Fukuda S., Sumii M., Masuda Y., Takahashi M., Koike N., Teishima J., Yasumoto H., Itamoto T., Asahara T., Dohi K., Kamiya K. Biochem. Biophys. Res. Commun. 280:407-414(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Limb.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB043006 mRNA. Translation: BAB18276.1. AB043008 Genomic DNA. Translation: BAB18278.1. BC053425 mRNA. Translation: AAH53425.1.
IPI	IPI00227657.
RefSeq	NP_071719.1. NM_022324.3.
UniGene	Mm.30222.
3D structure databases
ProteinModelPortal	Q9ESP1.
SMR	Q9ESP1. Positions 35-206.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000023453.
2D gel databases
REPRODUCTION-2DPAGE	Q9ESP1.
Proteomic databases
PaxDb	Q9ESP1.
PRIDE	Q9ESP1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023453; ENSMUSP00000023453; ENSMUSG00000022769.
GeneID	64136.
KEGG	mmu:64136.
UCSC	uc007ykc.2. mouse.
Organism-specific databases
CTD	23753.
MGI	MGI:2149842. Sdf2l1.
Phylogenomic databases
eggNOG	NOG136457.
GeneTree	ENSGT00510000046663.
HOGENOM	HOG000236354.
HOVERGEN	HBG024385.
InParanoid	Q9ESP1.
OMA	CGQAIRI.
OrthoDB	EOG4NVZMD.
Gene expression databases
Bgee	Q9ESP1.
CleanEx	MM_SDF2L1.
Genevestigator	Q9ESP1.
GermOnline	ENSMUSG00000022769. Mus musculus.
Family and domain databases
InterPro	IPR027005. GlyclTrfase_39_like. IPR016093. MIR_motif. [Graphical view]
PANTHER	PTHR10050. PTHR10050. 1 hit.
Pfam	PF02815. MIR. 1 hit. [Graphical view]
SMART	SM00472. MIR. 3 hits. [Graphical view]
SUPFAM	SSF82109. MIR. 1 hit.
PROSITE	PS00014. ER_TARGET. 1 hit. PS50919. MIR. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SDF2L1. mouse.
NextBio	319923.
SOURCE	Search...

Entry information

Entry name

SDF2L_MOUSE

Accession

Primary (citable) accession number: Q9ESP1
Secondary accession number(s): Q9ESP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2002
Last sequence update:	June 20, 2002
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program