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Q9ESP1

- SDF2L_MOUSE

UniProt

Q9ESP1 - SDF2L_MOUSE

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Protein

Stromal cell-derived factor 2-like protein 1

Gene

Sdf2l1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. ATPase binding Source: MGI
  2. chaperone binding Source: MGI
  3. misfolded protein binding Source: MGI

GO - Biological processi

  1. cellular response to misfolded protein Source: MGI
  2. ER-associated misfolded protein catabolic process Source: MGI
  3. regulation of apoptotic process Source: MGI
  4. response to endoplasmic reticulum stress Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Stromal cell-derived factor 2-like protein 1
Short name:
SDF2-like protein 1
Gene namesi
Name:Sdf2l1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2149842. Sdf2l1.

Subcellular locationi

Endoplasmic reticulum lumen PROSITE-ProRule annotation

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 221193Stromal cell-derived factor 2-like protein 1PRO_0000031958Add
BLAST

Proteomic databases

MaxQBiQ9ESP1.
PaxDbiQ9ESP1.
PRIDEiQ9ESP1.

2D gel databases

REPRODUCTION-2DPAGEQ9ESP1.

Expressioni

Tissue specificityi

Ubiquitously expressed with high expression in the testis, ovary, uterus, and low expression in heart and skeletal muscle.

Inductioni

By tunicamycin and a calcium ionophore, A23187.

Gene expression databases

BgeeiQ9ESP1.
CleanExiMM_SDF2L1.
GenevestigatoriQ9ESP1.

Interactioni

Protein-protein interaction databases

BioGridi211030. 1 interaction.
IntActiQ9ESP1. 5 interactions.
MINTiMINT-1851587.
STRINGi10090.ENSMUSP00000023453.

Structurei

3D structure databases

ProteinModelPortaliQ9ESP1.
SMRiQ9ESP1. Positions 35-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 8755MIR 1PROSITE-ProRule annotationAdd
BLAST
Domaini95 – 15056MIR 2PROSITE-ProRule annotationAdd
BLAST
Domaini151 – 20555MIR 3PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi218 – 2214Prevents secretion from ERPROSITE-ProRule annotation

Sequence similaritiesi

Contains 3 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG136457.
GeneTreeiENSGT00510000046663.
HOGENOMiHOG000236354.
HOVERGENiHBG024385.
InParanoidiQ9ESP1.
OMAiSGQHWER.
OrthoDBiEOG71VSV4.
PhylomeDBiQ9ESP1.
TreeFamiTF314557.

Family and domain databases

InterProiIPR027005. GlyclTrfase_39_like.
IPR016093. MIR_motif.
[Graphical view]
PANTHERiPTHR10050. PTHR10050. 1 hit.
PfamiPF02815. MIR. 1 hit.
[Graphical view]
SMARTiSM00472. MIR. 3 hits.
[Graphical view]
SUPFAMiSSF82109. SSF82109. 1 hit.
PROSITEiPS00014. ER_TARGET. 1 hit.
PS50919. MIR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ESP1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MWGASRGRVA GPTLLGLLLA LSVRSGGASK ASAGLVTCGS VLKLLNTHHK
60 70 80 90 100
VRLHSHDIKY GSGSGQQSVT GVEESDDANS YWRIRGGSEG GCPRGLPVRC
110 120 130 140 150
GQAVRLTHVL TGKNLHTHHF PSPLSNNQEV SAFGEDGEGD DLDLWTVRCS
160 170 180 190 200
GQHWEREASV RFQHVGTSVF LSVTGEQYGN PIRGQHEVHG MPSANAHNTW
210 220
KAMEGIFIKP GADLSTGHDE L
Length:221
Mass (Da):23,648
Last modified:June 20, 2002 - v2
Checksum:iD2A7C15D360EB25D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB043006 mRNA. Translation: BAB18276.1.
AB043008 Genomic DNA. Translation: BAB18278.1.
BC053425 mRNA. Translation: AAH53425.1.
CCDSiCCDS37270.1.
RefSeqiNP_071719.1. NM_022324.3.
UniGeneiMm.30222.

Genome annotation databases

EnsembliENSMUST00000023453; ENSMUSP00000023453; ENSMUSG00000022769.
GeneIDi64136.
KEGGimmu:64136.
UCSCiuc007ykc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB043006 mRNA. Translation: BAB18276.1 .
AB043008 Genomic DNA. Translation: BAB18278.1 .
BC053425 mRNA. Translation: AAH53425.1 .
CCDSi CCDS37270.1.
RefSeqi NP_071719.1. NM_022324.3.
UniGenei Mm.30222.

3D structure databases

ProteinModelPortali Q9ESP1.
SMRi Q9ESP1. Positions 35-206.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 211030. 1 interaction.
IntActi Q9ESP1. 5 interactions.
MINTi MINT-1851587.
STRINGi 10090.ENSMUSP00000023453.

2D gel databases

REPRODUCTION-2DPAGE Q9ESP1.

Proteomic databases

MaxQBi Q9ESP1.
PaxDbi Q9ESP1.
PRIDEi Q9ESP1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023453 ; ENSMUSP00000023453 ; ENSMUSG00000022769 .
GeneIDi 64136.
KEGGi mmu:64136.
UCSCi uc007ykc.2. mouse.

Organism-specific databases

CTDi 23753.
MGIi MGI:2149842. Sdf2l1.

Phylogenomic databases

eggNOGi NOG136457.
GeneTreei ENSGT00510000046663.
HOGENOMi HOG000236354.
HOVERGENi HBG024385.
InParanoidi Q9ESP1.
OMAi SGQHWER.
OrthoDBi EOG71VSV4.
PhylomeDBi Q9ESP1.
TreeFami TF314557.

Miscellaneous databases

ChiTaRSi SDF2L1. mouse.
NextBioi 319923.
PROi Q9ESP1.
SOURCEi Search...

Gene expression databases

Bgeei Q9ESP1.
CleanExi MM_SDF2L1.
Genevestigatori Q9ESP1.

Family and domain databases

InterProi IPR027005. GlyclTrfase_39_like.
IPR016093. MIR_motif.
[Graphical view ]
PANTHERi PTHR10050. PTHR10050. 1 hit.
Pfami PF02815. MIR. 1 hit.
[Graphical view ]
SMARTi SM00472. MIR. 3 hits.
[Graphical view ]
SUPFAMi SSF82109. SSF82109. 1 hit.
PROSITEi PS00014. ER_TARGET. 1 hit.
PS50919. MIR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family."
    Fukuda S., Sumii M., Masuda Y., Takahashi M., Koike N., Teishima J., Yasumoto H., Itamoto T., Asahara T., Dohi K., Kamiya K.
    Biochem. Biophys. Res. Commun. 280:407-414(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.

Entry informationi

Entry nameiSDF2L_MOUSE
AccessioniPrimary (citable) accession number: Q9ESP1
Secondary accession number(s): Q9ESP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 20, 2002
Last modified: October 29, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3