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Q9ESP1

- SDF2L_MOUSE

UniProt

Q9ESP1 - SDF2L_MOUSE

Protein

Stromal cell-derived factor 2-like protein 1

Gene

Sdf2l1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 2 (20 Jun 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATPase binding Source: MGI
    2. chaperone binding Source: MGI
    3. misfolded protein binding Source: MGI

    GO - Biological processi

    1. cellular response to misfolded protein Source: MGI
    2. ER-associated misfolded protein catabolic process Source: MGI
    3. regulation of apoptotic process Source: MGI
    4. response to endoplasmic reticulum stress Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Stromal cell-derived factor 2-like protein 1
    Short name:
    SDF2-like protein 1
    Gene namesi
    Name:Sdf2l1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2149842. Sdf2l1.

    Subcellular locationi

    Endoplasmic reticulum lumen PROSITE-ProRule annotation

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. endoplasmic reticulum lumen Source: UniProtKB-SubCell
    3. membrane Source: MGI

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 221193Stromal cell-derived factor 2-like protein 1PRO_0000031958Add
    BLAST

    Proteomic databases

    MaxQBiQ9ESP1.
    PaxDbiQ9ESP1.
    PRIDEiQ9ESP1.

    2D gel databases

    REPRODUCTION-2DPAGEQ9ESP1.

    Expressioni

    Tissue specificityi

    Ubiquitously expressed with high expression in the testis, ovary, uterus, and low expression in heart and skeletal muscle.

    Inductioni

    By tunicamycin and a calcium ionophore, A23187.

    Gene expression databases

    BgeeiQ9ESP1.
    CleanExiMM_SDF2L1.
    GenevestigatoriQ9ESP1.

    Interactioni

    Protein-protein interaction databases

    BioGridi211030. 1 interaction.
    IntActiQ9ESP1. 5 interactions.
    MINTiMINT-1851587.
    STRINGi10090.ENSMUSP00000023453.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ESP1.
    SMRiQ9ESP1. Positions 35-206.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini33 – 8755MIR 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini95 – 15056MIR 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini151 – 20555MIR 3PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi218 – 2214Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Contains 3 MIR domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG136457.
    GeneTreeiENSGT00510000046663.
    HOGENOMiHOG000236354.
    HOVERGENiHBG024385.
    InParanoidiQ9ESP1.
    OMAiSGQHWER.
    OrthoDBiEOG71VSV4.
    PhylomeDBiQ9ESP1.
    TreeFamiTF314557.

    Family and domain databases

    InterProiIPR027005. GlyclTrfase_39_like.
    IPR016093. MIR_motif.
    [Graphical view]
    PANTHERiPTHR10050. PTHR10050. 1 hit.
    PfamiPF02815. MIR. 1 hit.
    [Graphical view]
    SMARTiSM00472. MIR. 3 hits.
    [Graphical view]
    SUPFAMiSSF82109. SSF82109. 1 hit.
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS50919. MIR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ESP1-1 [UniParc]FASTAAdd to Basket

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    MWGASRGRVA GPTLLGLLLA LSVRSGGASK ASAGLVTCGS VLKLLNTHHK    50
    VRLHSHDIKY GSGSGQQSVT GVEESDDANS YWRIRGGSEG GCPRGLPVRC 100
    GQAVRLTHVL TGKNLHTHHF PSPLSNNQEV SAFGEDGEGD DLDLWTVRCS 150
    GQHWEREASV RFQHVGTSVF LSVTGEQYGN PIRGQHEVHG MPSANAHNTW 200
    KAMEGIFIKP GADLSTGHDE L 221
    Length:221
    Mass (Da):23,648
    Last modified:June 20, 2002 - v2
    Checksum:iD2A7C15D360EB25D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB043006 mRNA. Translation: BAB18276.1.
    AB043008 Genomic DNA. Translation: BAB18278.1.
    BC053425 mRNA. Translation: AAH53425.1.
    CCDSiCCDS37270.1.
    RefSeqiNP_071719.1. NM_022324.3.
    UniGeneiMm.30222.

    Genome annotation databases

    EnsembliENSMUST00000023453; ENSMUSP00000023453; ENSMUSG00000022769.
    GeneIDi64136.
    KEGGimmu:64136.
    UCSCiuc007ykc.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB043006 mRNA. Translation: BAB18276.1 .
    AB043008 Genomic DNA. Translation: BAB18278.1 .
    BC053425 mRNA. Translation: AAH53425.1 .
    CCDSi CCDS37270.1.
    RefSeqi NP_071719.1. NM_022324.3.
    UniGenei Mm.30222.

    3D structure databases

    ProteinModelPortali Q9ESP1.
    SMRi Q9ESP1. Positions 35-206.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 211030. 1 interaction.
    IntActi Q9ESP1. 5 interactions.
    MINTi MINT-1851587.
    STRINGi 10090.ENSMUSP00000023453.

    2D gel databases

    REPRODUCTION-2DPAGE Q9ESP1.

    Proteomic databases

    MaxQBi Q9ESP1.
    PaxDbi Q9ESP1.
    PRIDEi Q9ESP1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023453 ; ENSMUSP00000023453 ; ENSMUSG00000022769 .
    GeneIDi 64136.
    KEGGi mmu:64136.
    UCSCi uc007ykc.2. mouse.

    Organism-specific databases

    CTDi 23753.
    MGIi MGI:2149842. Sdf2l1.

    Phylogenomic databases

    eggNOGi NOG136457.
    GeneTreei ENSGT00510000046663.
    HOGENOMi HOG000236354.
    HOVERGENi HBG024385.
    InParanoidi Q9ESP1.
    OMAi SGQHWER.
    OrthoDBi EOG71VSV4.
    PhylomeDBi Q9ESP1.
    TreeFami TF314557.

    Miscellaneous databases

    ChiTaRSi SDF2L1. mouse.
    NextBioi 319923.
    PROi Q9ESP1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ESP1.
    CleanExi MM_SDF2L1.
    Genevestigatori Q9ESP1.

    Family and domain databases

    InterProi IPR027005. GlyclTrfase_39_like.
    IPR016093. MIR_motif.
    [Graphical view ]
    PANTHERi PTHR10050. PTHR10050. 1 hit.
    Pfami PF02815. MIR. 1 hit.
    [Graphical view ]
    SMARTi SM00472. MIR. 3 hits.
    [Graphical view ]
    SUPFAMi SSF82109. SSF82109. 1 hit.
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS50919. MIR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine and human SDF2L1 is an endoplasmic reticulum stress-inducible gene and encodes a new member of the Pmt/rt protein family."
      Fukuda S., Sumii M., Masuda Y., Takahashi M., Koike N., Teishima J., Yasumoto H., Itamoto T., Asahara T., Dohi K., Kamiya K.
      Biochem. Biophys. Res. Commun. 280:407-414(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Limb.

    Entry informationi

    Entry nameiSDF2L_MOUSE
    AccessioniPrimary (citable) accession number: Q9ESP1
    Secondary accession number(s): Q9ESP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2002
    Last sequence update: June 20, 2002
    Last modified: October 1, 2014
    This is version 97 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3