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Q9ESN9

- JIP3_MOUSE

UniProt

Q9ESN9 - JIP3_MOUSE

Protein

C-Jun-amino-terminal kinase-interacting protein 3

Gene

Mapk8ip3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins.2 Publications

    GO - Molecular functioni

    1. JUN kinase binding Source: BHF-UCL
    2. kinesin binding Source: UniProtKB
    3. MAP-kinase scaffold activity Source: UniProtKB
    4. mitogen-activated protein kinase kinase binding Source: BHF-UCL
    5. mitogen-activated protein kinase kinase kinase binding Source: BHF-UCL
    6. protein binding Source: IntAct

    GO - Biological processi

    1. activation of JUN kinase activity Source: MGI
    2. axon guidance Source: MGI
    3. forebrain development Source: MGI
    4. in utero embryonic development Source: MGI
    5. JNK cascade Source: MGI
    6. lung alveolus development Source: MGI
    7. lung morphogenesis Source: MGI
    8. positive regulation of JUN kinase activity Source: BHF-UCL
    9. positive regulation of neuron differentiation Source: Ensembl
    10. post-embryonic development Source: MGI
    11. protein localization Source: MGI
    12. regulation of gene expression Source: MGI
    13. regulation of JNK cascade Source: UniProtKB
    14. respiratory gaseous exchange Source: MGI
    15. vesicle-mediated transport Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-Jun-amino-terminal kinase-interacting protein 3
    Short name:
    JIP-3
    Short name:
    JNK-interacting protein 3
    Alternative name(s):
    JNK MAP kinase scaffold protein 3
    JNK/SAPK-associated protein 1
    Short name:
    JSAP1
    Mitogen-activated protein kinase 8-interacting protein 3
    Sunday driver 2
    Gene namesi
    Name:Mapk8ip3
    Synonyms:Jip3, Jsap1, Syd2
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1353598. Mapk8ip3.

    Subcellular locationi

    Cytoplasm. Golgi apparatus. Cytoplasmic vesicle. Cell projectiongrowth cone
    Note: Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells.

    GO - Cellular componenti

    1. axolemma Source: MGI
    2. cytoplasm Source: BHF-UCL
    3. cytoplasmic membrane-bounded vesicle Source: UniProtKB-SubCell
    4. dendrite Source: MGI
    5. Golgi membrane Source: UniProtKB
    6. growth cone Source: UniProtKB-SubCell
    7. plasma membrane Source: MGI
    8. smooth endoplasmic reticulum Source: MGI

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi205 – 2051R → G: Results in inhibition of JNK binding. 1 Publication
    Mutagenesisi206 – 2061P → G: Results in inhibition of JNK binding. 1 Publication
    Mutagenesisi207 – 2071T → G: Results in inhibition of JNK binding. 1 Publication
    Mutagenesisi208 – 2081S → G: Results in inhibition of JNK binding. 1 Publication
    Mutagenesisi209 – 2091L → G: Results in inhibition of JNK binding. 1 Publication
    Mutagenesisi266 – 2661T → A: Results in loss of phosphorylation of MAPK8IP3; when associated with A-276 and A-287. Does not effect binding of components of the JNK pathway. 1 Publication
    Mutagenesisi276 – 2761T → A: Results in loss of phosphorylation of MAPK8IP3; when associated with A-266 and A-287. Does not effect binding of components of the JNK pathway. 1 Publication
    Mutagenesisi287 – 2871T → A: Results in loss of phosphorylation of MAPK8IP3; when associated with A-266 and A-287. Does not effect binding of components of the JNK pathway. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13371337C-Jun-amino-terminal kinase-interacting protein 3PRO_0000220634Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei266 – 2661Phosphothreonine; by MAPK2 Publications
    Modified residuei276 – 2761Phosphothreonine; by MAPK2 Publications
    Modified residuei287 – 2871Phosphothreonine; by MAPK2 Publications
    Modified residuei315 – 3151Phosphoserine; by ROCK1By similarity
    Modified residuei365 – 3651Phosphoserine; by ROCK1By similarity
    Modified residuei366 – 3661Phosphoserine; by ROCK1By similarity
    Modified residuei677 – 6771Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylation by ROCK1 is crucial for the recruitment of JNK.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9ESN9.
    PaxDbiQ9ESN9.
    PRIDEiQ9ESN9.

    PTM databases

    PhosphoSiteiQ9ESN9.

    Expressioni

    Tissue specificityi

    Highly expressed throughout many regions of the brain and at lower levels in the heart, liver, lung, testes and kidney. All isoforms have been identified in the brain, isoform 1a is also expressed in the spleen and lung.2 Publications

    Inductioni

    Expressed in neurites 5 days following initiation of nerve growth factor induced differentiation. NGF withdrawal results in the down-regulation of MAPK8IP3 protein by caspase-mediated cleavage.1 Publication

    Gene expression databases

    ArrayExpressiQ9ESN9.
    BgeeiQ9ESN9.
    GenevestigatoriQ9ESN9.

    Interactioni

    Subunit structurei

    Forms homo- or heterooligomeric complexes. The central region of MAPK8IP3 interacts with the C-terminal of MAPK8IP2 but not MAPK8IP1. Binds specific components of the JNK signaling pathway namely MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 to the N-terminal region, MAP2K4/MKK4 and MAP2K7/MKK7 to the central region and MAP3K11 to the C-terminal region. Binds the TPR motif-containing C-terminal of kinesin light chain, pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Interacts with ROCK1 and this interaction is enhanced by ultraviolet-B (UVB) radiation By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Arf6P623318EBI-301496,EBI-988682
    Kif5cP287388EBI-301496,EBI-2506834
    Klc1O884479EBI-301496,EBI-301550
    Klc2O884486EBI-301496,EBI-301558
    Map2k1P319383EBI-9549291,EBI-298860
    Map2k4P478093EBI-9549291,EBI-447934
    Map3k1P533493EBI-9549291,EBI-447913
    Mapk10Q618314EBI-9549291,EBI-400741
    RAF1P040492EBI-9549291,EBI-365996From a different organism.

    Protein-protein interaction databases

    BioGridi206033. 6 interactions.
    IntActiQ9ESN9. 15 interactions.
    MINTiMINT-7892366.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ESN9.
    SMRiQ9ESN9. Positions 417-476.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili58 – 177120Sequence AnalysisAdd
    BLAST
    Coiled coili437 – 555119Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the JIP scaffold family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG270333.
    GeneTreeiENSGT00670000097546.
    HOVERGENiHBG024110.
    KOiK04436.
    OrthoDBiEOG7GXP9P.
    PhylomeDBiQ9ESN9.
    TreeFamiTF313096.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    InterProiIPR019143. JNK/Rab-associated_protein-1_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF09744. Jnk-SapK_ap_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50978. SSF50978. 1 hit.

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1c (identifier: Q9ESN9-1) [UniParc]FASTAAdd to Basket

    Also known as: 3b

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMEIQMDEGG GVVVYQDDYC SGSVMSERVS GLAGSIYREF ERLIHCYDEE     50
    VVKELMPLVV NVLENLDSVL SENQEHEVEL ELLREDNEQL LTQYEREKAL 100
    RKQAEEKFIE FEDALEQEKK ELQIQVEHYE FQTRQLELKA KNYADQISRL 150
    EERESEMKKE YNALHQRHTE MIQTYVEHIE RSKMQQVGGS GQTESSLPGR 200
    SRKERPTSLN VFPLADGMVR AQMGGKLVPA GDHWHLSDLG QLQSSSSYQC 250
    PNDEMSESGQ SSAAATPSTT GTKSNTPTSS VPSAAVTPLN ESLQPLGDYV 300
    SVTKNNKQAR EKRNSRNMEV QVTQEMRNVS IGMGSSDEWS DVQDIIDSTP 350
    ELDVCPETRL ERTGSSPTQG IVNKAFGINT DSLYHELSTA GSEVIGDVDE 400
    GADLLGEFSV RDDFFGMGKE VGNLLLENSQ LLETKNALNV VKNDLIAKVD 450
    QLSGEQEVLK GELEAAKQAK VKLENRIKEL EEELKRVKSE AVTARREPRE 500
    EVEDVSSYLC TELDKIPMAQ RRRFTRVEMA RVLMERNQYK ERLMELQEAV 550
    RWTEMIRASR EHPSVQEKKK STIWQFFSRL FSSSSSPPPA KRSYPSVNIH 600
    YKSPTAAGFS QRRSHALCQI SAGSRPLEFF PDDDCTSSAR REQKREQYRQ 650
    VREHVRNDDG RLQACGWSLP AKYKQLSPNG GQEDTRMKNV PVPVYCRPLV 700
    EKDPSTKLWC AAGVNLSGWK PHEEDSSNGP KPVPGRDPLT CDREGEGEPK 750
    STHPSPEKKK AKETPEADAT SSRVWILTST LTTSKVVIID ANQPGTIVDQ 800
    FTVCNAHVLC ISSIPAASDS DYPPGEMFLD SDVNPEDSGA DGVLAGITLV 850
    GCATRCNVPR SNCSSRGDTP VLDKGQGDVA TTANGKVNPS QSTEEATEAT 900
    EVPDPGPSES EATTVRPGPL TEHVFTDPAP TPSSSTQPAS ENGSESNGTI 950
    VQPQVEPSGE LSTTTSSAAP TMWLGAQNGW LYVHSAVANW KKCLHSIKLK 1000
    DSVLSLVHVK GRVLVALADG TLAIFHRGED GQWDLSNYHL MDLGHPHHSI 1050
    RCMAVVNDRV WCGYKNKVHV IQPKTMQIEK SFDAHPRRES QVRQLAWIGD 1100
    GVWVSIRLDS TLRLYHAHTH QHLQDVDIEP YVSKMLGTGK LGFSFVRITA 1150
    LLIAGNRLWV GTGNGVVISI PLTETVVLHR GQLLGLRANK TSPTSGEGTR 1200
    PGGIIHVYGD DSSDKAASSF IPYCSMAQAQ LCFHGHRDAV KFFVSVPGNV 1250
    LATLNGSVLD SPSEGPGPAA PAADAEGQKL KNALVLSGGE GYIDFRIGDG 1300
    EDDETEECAG DVNQTKPSLS KAERSHIIVW QVSYTPE 1337
    Length:1,337
    Mass (Da):147,561
    Last modified:March 1, 2001 - v1
    Checksum:iD7DEE54C17B74106
    GO
    Isoform 1a (identifier: Q9ESN9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         201-201: Missing.
         219-249: Missing.

    Show »
    Length:1,305
    Mass (Da):144,138
    Checksum:i0BF7257DCFF6D236
    GO
    Isoform 1b (identifier: Q9ESN9-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         201-201: S → SPRQSWRKS
         219-249: Missing.

    Show »
    Length:1,314
    Mass (Da):145,251
    Checksum:i1EAD24AC1DAD9AB7
    GO
    Isoform 1d (identifier: Q9ESN9-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         201-201: Missing.

    Show »
    Length:1,336
    Mass (Da):147,474
    Checksum:i362061FA2B2AA3C1
    GO
    Isoform 3a (identifier: Q9ESN9-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         410-415: Missing.
         505-513: Missing.

    Show »
    Length:1,322
    Mass (Da):145,785
    Checksum:i8C71A02B7FF3FBB4
    GO
    Isoform 1e (identifier: Q9ESN9-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         201-201: S → SPRQSWRKS

    Show »
    Length:1,345
    Mass (Da):148,587
    Checksum:iAA7157299921450A
    GO

    Sequence cautioni

    The sequence AAG36931.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti312 – 3121K → R in AAG36931. (PubMed:11106729)Curated
    Sequence conflicti376 – 3761F → L in AAF26843. (PubMed:10629060)Curated
    Sequence conflicti561 – 5611E → K in AAG36931. (PubMed:11106729)Curated
    Sequence conflicti1272 – 12721A → V in AAG36931. (PubMed:11106729)Curated
    Sequence conflicti1322 – 13221A → D in AAG36931. (PubMed:11106729)Curated
    Sequence conflicti1325 – 13251S → T in AAG36931. (PubMed:11106729)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei201 – 2011Missing in isoform 1a and isoform 1d. 1 PublicationVSP_002775
    Alternative sequencei201 – 2011S → SPRQSWRKS in isoform 1b and isoform 1e. 1 PublicationVSP_002776
    Alternative sequencei219 – 24931Missing in isoform 1a and isoform 1b. 2 PublicationsVSP_002777Add
    BLAST
    Alternative sequencei410 – 4156Missing in isoform 3a. CuratedVSP_002778
    Alternative sequencei505 – 5139Missing in isoform 3a. CuratedVSP_002779

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005662 mRNA. Translation: BAA85874.1.
    AB043124 mRNA. Translation: BAB16675.1.
    AB043125 mRNA. Translation: BAB16676.1.
    AB043123 mRNA. Translation: BAB16674.1.
    AB043129 Genomic DNA. Translation: BAB16685.1.
    AF178637 mRNA. Translation: AAF26843.1.
    AF178636 mRNA. Translation: AAF26842.1.
    AF262046 mRNA. Translation: AAG36931.1. Different initiation.
    BC004003 mRNA. Translation: AAH04003.1.
    BC060603 mRNA. Translation: AAH60603.1.
    CCDSiCCDS37498.1. [Q9ESN9-1]
    CCDS50024.1. [Q9ESN9-4]
    CCDS50025.1. [Q9ESN9-5]
    CCDS50026.1. [Q9ESN9-2]
    CCDS50029.1. [Q9ESN9-3]
    RefSeqiNP_001156919.1. NM_001163447.1. [Q9ESN9-4]
    NP_001156920.1. NM_001163448.1. [Q9ESN9-5]
    NP_001156921.1. NM_001163449.1. [Q9ESN9-3]
    NP_001156923.1. NM_001163451.1. [Q9ESN9-2]
    NP_038959.2. NM_013931.4. [Q9ESN9-1]
    UniGeneiMm.43081.

    Genome annotation databases

    EnsembliENSMUST00000088345; ENSMUSP00000085683; ENSMUSG00000024163. [Q9ESN9-1]
    ENSMUST00000115228; ENSMUSP00000110883; ENSMUSG00000024163. [Q9ESN9-5]
    ENSMUST00000117509; ENSMUSP00000112712; ENSMUSG00000024163. [Q9ESN9-3]
    ENSMUST00000119115; ENSMUSP00000112955; ENSMUSG00000024163. [Q9ESN9-2]
    ENSMUST00000120035; ENSMUSP00000114084; ENSMUSG00000024163. [Q9ESN9-4]
    ENSMUST00000146923; ENSMUSP00000114802; ENSMUSG00000024163. [Q9ESN9-1]
    GeneIDi30957.
    KEGGimmu:30957.
    UCSCiuc008aza.2. mouse. [Q9ESN9-5]
    uc008azb.2. mouse. [Q9ESN9-1]
    uc008azc.2. mouse. [Q9ESN9-3]
    uc008aze.2. mouse. [Q9ESN9-2]
    uc008azf.2. mouse. [Q9ESN9-4]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB005662 mRNA. Translation: BAA85874.1 .
    AB043124 mRNA. Translation: BAB16675.1 .
    AB043125 mRNA. Translation: BAB16676.1 .
    AB043123 mRNA. Translation: BAB16674.1 .
    AB043129 Genomic DNA. Translation: BAB16685.1 .
    AF178637 mRNA. Translation: AAF26843.1 .
    AF178636 mRNA. Translation: AAF26842.1 .
    AF262046 mRNA. Translation: AAG36931.1 . Different initiation.
    BC004003 mRNA. Translation: AAH04003.1 .
    BC060603 mRNA. Translation: AAH60603.1 .
    CCDSi CCDS37498.1. [Q9ESN9-1 ]
    CCDS50024.1. [Q9ESN9-4 ]
    CCDS50025.1. [Q9ESN9-5 ]
    CCDS50026.1. [Q9ESN9-2 ]
    CCDS50029.1. [Q9ESN9-3 ]
    RefSeqi NP_001156919.1. NM_001163447.1. [Q9ESN9-4 ]
    NP_001156920.1. NM_001163448.1. [Q9ESN9-5 ]
    NP_001156921.1. NM_001163449.1. [Q9ESN9-3 ]
    NP_001156923.1. NM_001163451.1. [Q9ESN9-2 ]
    NP_038959.2. NM_013931.4. [Q9ESN9-1 ]
    UniGenei Mm.43081.

    3D structure databases

    ProteinModelPortali Q9ESN9.
    SMRi Q9ESN9. Positions 417-476.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 206033. 6 interactions.
    IntActi Q9ESN9. 15 interactions.
    MINTi MINT-7892366.

    PTM databases

    PhosphoSitei Q9ESN9.

    Proteomic databases

    MaxQBi Q9ESN9.
    PaxDbi Q9ESN9.
    PRIDEi Q9ESN9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000088345 ; ENSMUSP00000085683 ; ENSMUSG00000024163 . [Q9ESN9-1 ]
    ENSMUST00000115228 ; ENSMUSP00000110883 ; ENSMUSG00000024163 . [Q9ESN9-5 ]
    ENSMUST00000117509 ; ENSMUSP00000112712 ; ENSMUSG00000024163 . [Q9ESN9-3 ]
    ENSMUST00000119115 ; ENSMUSP00000112955 ; ENSMUSG00000024163 . [Q9ESN9-2 ]
    ENSMUST00000120035 ; ENSMUSP00000114084 ; ENSMUSG00000024163 . [Q9ESN9-4 ]
    ENSMUST00000146923 ; ENSMUSP00000114802 ; ENSMUSG00000024163 . [Q9ESN9-1 ]
    GeneIDi 30957.
    KEGGi mmu:30957.
    UCSCi uc008aza.2. mouse. [Q9ESN9-5 ]
    uc008azb.2. mouse. [Q9ESN9-1 ]
    uc008azc.2. mouse. [Q9ESN9-3 ]
    uc008aze.2. mouse. [Q9ESN9-2 ]
    uc008azf.2. mouse. [Q9ESN9-4 ]

    Organism-specific databases

    CTDi 23162.
    MGIi MGI:1353598. Mapk8ip3.

    Phylogenomic databases

    eggNOGi NOG270333.
    GeneTreei ENSGT00670000097546.
    HOVERGENi HBG024110.
    KOi K04436.
    OrthoDBi EOG7GXP9P.
    PhylomeDBi Q9ESN9.
    TreeFami TF313096.

    Miscellaneous databases

    NextBioi 307444.
    PROi Q9ESN9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ESN9.
    Bgeei Q9ESN9.
    Genevestigatori Q9ESN9.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    InterProi IPR019143. JNK/Rab-associated_protein-1_N.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF09744. Jnk-SapK_ap_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50978. SSF50978. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a scaffold factor in the JNK signaling pathway."
      Ito M., Yoshioka K., Akechi M., Yamashita S., Takamatsu N., Sugiyama K., Hibi M., Nakabeppu Y., Shiba T., Yamamoto K.
      Mol. Cell. Biol. 19:7539-7548(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A), FUNCTION, PHOSPHORYLATION, INTERACTION WITH MAPK8; MAPK9; MAPK10; MAP2K4 AND MAP3K1.
      Tissue: Brain.
    2. "Isoforms of JSAP1 scaffold protein generated through alternative splicing."
      Ito M., Akechi M., Hirose R., Ichimura M., Takamatsu N., Xu P., Nakabeppu Y., Tadayoshi S., Yamamoto K., Yoshioka K.
      Gene 255:229-234(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1A; 1B; 1C; 1D AND 1E), TISSUE SPECIFICITY.
      Tissue: Brain.
    3. "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3."
      Kelkar N., Gupta S., Dickens M., Davis R.J.
      Mol. Cell. Biol. 20:1030-1043(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1C AND 3A), FUNCTION, INDUCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-266; THR-276 AND THR-287, MUTAGENESIS OF ARG-205; PRO-206; THR-207; SER-208; LEU-209; THR-266; THR-276 AND THR-287, INTERACTION WITH MAPK8IP2; MAPK8; MAPK9; MAPK10; MAP2K7 AND MAP3K11.
      Strain: C57BL/6.
      Tissue: Brain and Heart.
    4. "Kinesin-dependent axonal transport is mediated by the Sunday Driver (SYD) protein."
      Bowman A.B., Kamal A., Ritchings B.W., Philp A.V., McGrail M., Gindhart J.G., Goldstein L.S.B.
      Cell 103:583-594(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1C), SUBCELLULAR LOCATION, INTERACTION WITH KLC1.
      Strain: C57BL/6.
      Tissue: Brain.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1B), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1240-1337 (ISOFORM 1C).
      Strain: C57BL/6.
      Tissue: Brain.
    6. "Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules."
      Verhey K.J., Meyer D., Deehan R., Blenis J., Schnapp B.J., Rapoport T.A., Margolis B.
      J. Cell Biol. 152:959-970(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH KLC.
      Tissue: Brain.
    7. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-677, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.

    Entry informationi

    Entry nameiJIP3_MOUSE
    AccessioniPrimary (citable) accession number: Q9ESN9
    Secondary accession number(s): Q5D062
    , Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3