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Q9ESN9

- JIP3_MOUSE

UniProt

Q9ESN9 - JIP3_MOUSE

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Protein

C-Jun-amino-terminal kinase-interacting protein 3

Gene

Mapk8ip3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins.2 Publications

GO - Molecular functioni

  1. JUN kinase binding Source: BHF-UCL
  2. kinesin binding Source: UniProtKB
  3. MAP-kinase scaffold activity Source: UniProtKB
  4. mitogen-activated protein kinase kinase binding Source: BHF-UCL
  5. mitogen-activated protein kinase kinase kinase binding Source: BHF-UCL

GO - Biological processi

  1. activation of JUN kinase activity Source: MGI
  2. axon guidance Source: MGI
  3. forebrain development Source: MGI
  4. in utero embryonic development Source: MGI
  5. JNK cascade Source: MGI
  6. lung alveolus development Source: MGI
  7. lung morphogenesis Source: MGI
  8. positive regulation of JUN kinase activity Source: BHF-UCL
  9. positive regulation of neuron differentiation Source: Ensembl
  10. post-embryonic development Source: MGI
  11. protein localization Source: MGI
  12. regulation of gene expression Source: MGI
  13. regulation of JNK cascade Source: UniProtKB
  14. respiratory gaseous exchange Source: MGI
  15. vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
C-Jun-amino-terminal kinase-interacting protein 3
Short name:
JIP-3
Short name:
JNK-interacting protein 3
Alternative name(s):
JNK MAP kinase scaffold protein 3
JNK/SAPK-associated protein 1
Short name:
JSAP1
Mitogen-activated protein kinase 8-interacting protein 3
Sunday driver 2
Gene namesi
Name:Mapk8ip3
Synonyms:Jip3, Jsap1, Syd2
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1353598. Mapk8ip3.

Subcellular locationi

Cytoplasm. Golgi apparatus. Cytoplasmic vesicle. Cell projectiongrowth cone
Note: Localized in the soma and growth cones of differentiated neurites and the Golgi and vesicles of the early secretory compartment of epithelial cells.

GO - Cellular componenti

  1. axolemma Source: MGI
  2. cytoplasm Source: BHF-UCL
  3. cytoplasmic vesicle Source: UniProtKB-KW
  4. dendrite Source: MGI
  5. Golgi membrane Source: UniProtKB
  6. plasma membrane Source: MGI
  7. smooth endoplasmic reticulum Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Golgi apparatus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi205 – 2051R → G: Results in inhibition of JNK binding. 1 Publication
Mutagenesisi206 – 2061P → G: Results in inhibition of JNK binding. 1 Publication
Mutagenesisi207 – 2071T → G: Results in inhibition of JNK binding. 1 Publication
Mutagenesisi208 – 2081S → G: Results in inhibition of JNK binding. 1 Publication
Mutagenesisi209 – 2091L → G: Results in inhibition of JNK binding. 1 Publication
Mutagenesisi266 – 2661T → A: Results in loss of phosphorylation of MAPK8IP3; when associated with A-276 and A-287. Does not effect binding of components of the JNK pathway. 1 Publication
Mutagenesisi276 – 2761T → A: Results in loss of phosphorylation of MAPK8IP3; when associated with A-266 and A-287. Does not effect binding of components of the JNK pathway. 1 Publication
Mutagenesisi287 – 2871T → A: Results in loss of phosphorylation of MAPK8IP3; when associated with A-266 and A-287. Does not effect binding of components of the JNK pathway. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13371337C-Jun-amino-terminal kinase-interacting protein 3PRO_0000220634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei266 – 2661Phosphothreonine; by MAPK1 Publication
Modified residuei276 – 2761Phosphothreonine; by MAPK1 Publication
Modified residuei287 – 2871Phosphothreonine; by MAPK1 Publication
Modified residuei315 – 3151Phosphoserine; by ROCK1By similarity
Modified residuei365 – 3651Phosphoserine; by ROCK1By similarity
Modified residuei366 – 3661Phosphoserine; by ROCK1By similarity
Modified residuei677 – 6771Phosphoserine1 Publication

Post-translational modificationi

Phosphorylation by ROCK1 is crucial for the recruitment of JNK.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ESN9.
PaxDbiQ9ESN9.
PRIDEiQ9ESN9.

PTM databases

PhosphoSiteiQ9ESN9.

Expressioni

Tissue specificityi

Highly expressed throughout many regions of the brain and at lower levels in the heart, liver, lung, testes and kidney. All isoforms have been identified in the brain, isoform 1a is also expressed in the spleen and lung.2 Publications

Inductioni

Expressed in neurites 5 days following initiation of nerve growth factor induced differentiation. NGF withdrawal results in the down-regulation of MAPK8IP3 protein by caspase-mediated cleavage.1 Publication

Gene expression databases

BgeeiQ9ESN9.
ExpressionAtlasiQ9ESN9. baseline and differential.
GenevestigatoriQ9ESN9.

Interactioni

Subunit structurei

Forms homo- or heterooligomeric complexes. The central region of MAPK8IP3 interacts with the C-terminal of MAPK8IP2 but not MAPK8IP1. Binds specific components of the JNK signaling pathway namely MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3 to the N-terminal region, MAP2K4/MKK4 and MAP2K7/MKK7 to the central region and MAP3K11 to the C-terminal region. Binds the TPR motif-containing C-terminal of kinesin light chain, pre-assembled MAPK8IP1 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Interacts with ROCK1 and this interaction is enhanced by ultraviolet-B (UVB) radiation (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Arf6P623318EBI-301496,EBI-988682
Kif5cP287388EBI-301496,EBI-2506834
Klc1O884479EBI-301496,EBI-301550
Klc2O884486EBI-301496,EBI-301558
Map2k1P319383EBI-9549291,EBI-298860
Map2k4P478093EBI-9549291,EBI-447934
Map3k1P533493EBI-9549291,EBI-447913
Mapk10Q618314EBI-9549291,EBI-400741
RAF1P040492EBI-9549291,EBI-365996From a different organism.

Protein-protein interaction databases

BioGridi206033. 6 interactions.
IntActiQ9ESN9. 15 interactions.
MINTiMINT-7892366.

Structurei

3D structure databases

ProteinModelPortaliQ9ESN9.
SMRiQ9ESN9. Positions 417-476, 1067-1119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili58 – 177120Sequence AnalysisAdd
BLAST
Coiled coili437 – 555119Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the JIP scaffold family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG270333.
GeneTreeiENSGT00670000097546.
HOVERGENiHBG024110.
InParanoidiQ9ESN9.
KOiK04436.
OrthoDBiEOG7GXP9P.
PhylomeDBiQ9ESN9.
TreeFamiTF313096.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR019143. JNK/Rab-associated_protein-1_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF09744. Jnk-SapK_ap_N. 1 hit.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1c (identifier: Q9ESN9-1) [UniParc]FASTAAdd to Basket

Also known as: 3b

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMEIQMDEGG GVVVYQDDYC SGSVMSERVS GLAGSIYREF ERLIHCYDEE
60 70 80 90 100
VVKELMPLVV NVLENLDSVL SENQEHEVEL ELLREDNEQL LTQYEREKAL
110 120 130 140 150
RKQAEEKFIE FEDALEQEKK ELQIQVEHYE FQTRQLELKA KNYADQISRL
160 170 180 190 200
EERESEMKKE YNALHQRHTE MIQTYVEHIE RSKMQQVGGS GQTESSLPGR
210 220 230 240 250
SRKERPTSLN VFPLADGMVR AQMGGKLVPA GDHWHLSDLG QLQSSSSYQC
260 270 280 290 300
PNDEMSESGQ SSAAATPSTT GTKSNTPTSS VPSAAVTPLN ESLQPLGDYV
310 320 330 340 350
SVTKNNKQAR EKRNSRNMEV QVTQEMRNVS IGMGSSDEWS DVQDIIDSTP
360 370 380 390 400
ELDVCPETRL ERTGSSPTQG IVNKAFGINT DSLYHELSTA GSEVIGDVDE
410 420 430 440 450
GADLLGEFSV RDDFFGMGKE VGNLLLENSQ LLETKNALNV VKNDLIAKVD
460 470 480 490 500
QLSGEQEVLK GELEAAKQAK VKLENRIKEL EEELKRVKSE AVTARREPRE
510 520 530 540 550
EVEDVSSYLC TELDKIPMAQ RRRFTRVEMA RVLMERNQYK ERLMELQEAV
560 570 580 590 600
RWTEMIRASR EHPSVQEKKK STIWQFFSRL FSSSSSPPPA KRSYPSVNIH
610 620 630 640 650
YKSPTAAGFS QRRSHALCQI SAGSRPLEFF PDDDCTSSAR REQKREQYRQ
660 670 680 690 700
VREHVRNDDG RLQACGWSLP AKYKQLSPNG GQEDTRMKNV PVPVYCRPLV
710 720 730 740 750
EKDPSTKLWC AAGVNLSGWK PHEEDSSNGP KPVPGRDPLT CDREGEGEPK
760 770 780 790 800
STHPSPEKKK AKETPEADAT SSRVWILTST LTTSKVVIID ANQPGTIVDQ
810 820 830 840 850
FTVCNAHVLC ISSIPAASDS DYPPGEMFLD SDVNPEDSGA DGVLAGITLV
860 870 880 890 900
GCATRCNVPR SNCSSRGDTP VLDKGQGDVA TTANGKVNPS QSTEEATEAT
910 920 930 940 950
EVPDPGPSES EATTVRPGPL TEHVFTDPAP TPSSSTQPAS ENGSESNGTI
960 970 980 990 1000
VQPQVEPSGE LSTTTSSAAP TMWLGAQNGW LYVHSAVANW KKCLHSIKLK
1010 1020 1030 1040 1050
DSVLSLVHVK GRVLVALADG TLAIFHRGED GQWDLSNYHL MDLGHPHHSI
1060 1070 1080 1090 1100
RCMAVVNDRV WCGYKNKVHV IQPKTMQIEK SFDAHPRRES QVRQLAWIGD
1110 1120 1130 1140 1150
GVWVSIRLDS TLRLYHAHTH QHLQDVDIEP YVSKMLGTGK LGFSFVRITA
1160 1170 1180 1190 1200
LLIAGNRLWV GTGNGVVISI PLTETVVLHR GQLLGLRANK TSPTSGEGTR
1210 1220 1230 1240 1250
PGGIIHVYGD DSSDKAASSF IPYCSMAQAQ LCFHGHRDAV KFFVSVPGNV
1260 1270 1280 1290 1300
LATLNGSVLD SPSEGPGPAA PAADAEGQKL KNALVLSGGE GYIDFRIGDG
1310 1320 1330
EDDETEECAG DVNQTKPSLS KAERSHIIVW QVSYTPE
Length:1,337
Mass (Da):147,561
Last modified:March 1, 2001 - v1
Checksum:iD7DEE54C17B74106
GO
Isoform 1a (identifier: Q9ESN9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: Missing.
     219-249: Missing.

Show »
Length:1,305
Mass (Da):144,138
Checksum:i0BF7257DCFF6D236
GO
Isoform 1b (identifier: Q9ESN9-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: S → SPRQSWRKS
     219-249: Missing.

Show »
Length:1,314
Mass (Da):145,251
Checksum:i1EAD24AC1DAD9AB7
GO
Isoform 1d (identifier: Q9ESN9-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: Missing.

Show »
Length:1,336
Mass (Da):147,474
Checksum:i362061FA2B2AA3C1
GO
Isoform 3a (identifier: Q9ESN9-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-415: Missing.
     505-513: Missing.

Show »
Length:1,322
Mass (Da):145,785
Checksum:i8C71A02B7FF3FBB4
GO
Isoform 1e (identifier: Q9ESN9-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     201-201: S → SPRQSWRKS

Show »
Length:1,345
Mass (Da):148,587
Checksum:iAA7157299921450A
GO

Sequence cautioni

The sequence AAG36931.1 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti312 – 3121K → R in AAG36931. (PubMed:11106729)Curated
Sequence conflicti376 – 3761F → L in AAF26843. (PubMed:10629060)Curated
Sequence conflicti561 – 5611E → K in AAG36931. (PubMed:11106729)Curated
Sequence conflicti1272 – 12721A → V in AAG36931. (PubMed:11106729)Curated
Sequence conflicti1322 – 13221A → D in AAG36931. (PubMed:11106729)Curated
Sequence conflicti1325 – 13251S → T in AAG36931. (PubMed:11106729)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei201 – 2011Missing in isoform 1a and isoform 1d. 1 PublicationVSP_002775
Alternative sequencei201 – 2011S → SPRQSWRKS in isoform 1b and isoform 1e. 1 PublicationVSP_002776
Alternative sequencei219 – 24931Missing in isoform 1a and isoform 1b. 2 PublicationsVSP_002777Add
BLAST
Alternative sequencei410 – 4156Missing in isoform 3a. CuratedVSP_002778
Alternative sequencei505 – 5139Missing in isoform 3a. CuratedVSP_002779

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB005662 mRNA. Translation: BAA85874.1.
AB043124 mRNA. Translation: BAB16675.1.
AB043125 mRNA. Translation: BAB16676.1.
AB043123 mRNA. Translation: BAB16674.1.
AB043129 Genomic DNA. Translation: BAB16685.1.
AF178637 mRNA. Translation: AAF26843.1.
AF178636 mRNA. Translation: AAF26842.1.
AF262046 mRNA. Translation: AAG36931.1. Different initiation.
BC004003 mRNA. Translation: AAH04003.1.
BC060603 mRNA. Translation: AAH60603.1.
CCDSiCCDS37498.1. [Q9ESN9-1]
CCDS50024.1. [Q9ESN9-4]
CCDS50025.1. [Q9ESN9-5]
CCDS50026.1. [Q9ESN9-2]
CCDS50029.1. [Q9ESN9-3]
RefSeqiNP_001156919.1. NM_001163447.1. [Q9ESN9-4]
NP_001156920.1. NM_001163448.1. [Q9ESN9-5]
NP_001156921.1. NM_001163449.1. [Q9ESN9-3]
NP_001156923.1. NM_001163451.1. [Q9ESN9-2]
NP_038959.2. NM_013931.4. [Q9ESN9-1]
UniGeneiMm.43081.

Genome annotation databases

EnsembliENSMUST00000088345; ENSMUSP00000085683; ENSMUSG00000024163. [Q9ESN9-1]
ENSMUST00000115228; ENSMUSP00000110883; ENSMUSG00000024163. [Q9ESN9-5]
ENSMUST00000117509; ENSMUSP00000112712; ENSMUSG00000024163. [Q9ESN9-3]
ENSMUST00000119115; ENSMUSP00000112955; ENSMUSG00000024163. [Q9ESN9-2]
ENSMUST00000120035; ENSMUSP00000114084; ENSMUSG00000024163. [Q9ESN9-4]
ENSMUST00000146923; ENSMUSP00000114802; ENSMUSG00000024163. [Q9ESN9-1]
GeneIDi30957.
KEGGimmu:30957.
UCSCiuc008aza.2. mouse. [Q9ESN9-5]
uc008azb.2. mouse. [Q9ESN9-1]
uc008azc.2. mouse. [Q9ESN9-3]
uc008aze.2. mouse. [Q9ESN9-2]
uc008azf.2. mouse. [Q9ESN9-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB005662 mRNA. Translation: BAA85874.1 .
AB043124 mRNA. Translation: BAB16675.1 .
AB043125 mRNA. Translation: BAB16676.1 .
AB043123 mRNA. Translation: BAB16674.1 .
AB043129 Genomic DNA. Translation: BAB16685.1 .
AF178637 mRNA. Translation: AAF26843.1 .
AF178636 mRNA. Translation: AAF26842.1 .
AF262046 mRNA. Translation: AAG36931.1 . Different initiation.
BC004003 mRNA. Translation: AAH04003.1 .
BC060603 mRNA. Translation: AAH60603.1 .
CCDSi CCDS37498.1. [Q9ESN9-1 ]
CCDS50024.1. [Q9ESN9-4 ]
CCDS50025.1. [Q9ESN9-5 ]
CCDS50026.1. [Q9ESN9-2 ]
CCDS50029.1. [Q9ESN9-3 ]
RefSeqi NP_001156919.1. NM_001163447.1. [Q9ESN9-4 ]
NP_001156920.1. NM_001163448.1. [Q9ESN9-5 ]
NP_001156921.1. NM_001163449.1. [Q9ESN9-3 ]
NP_001156923.1. NM_001163451.1. [Q9ESN9-2 ]
NP_038959.2. NM_013931.4. [Q9ESN9-1 ]
UniGenei Mm.43081.

3D structure databases

ProteinModelPortali Q9ESN9.
SMRi Q9ESN9. Positions 417-476, 1067-1119.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206033. 6 interactions.
IntActi Q9ESN9. 15 interactions.
MINTi MINT-7892366.

PTM databases

PhosphoSitei Q9ESN9.

Proteomic databases

MaxQBi Q9ESN9.
PaxDbi Q9ESN9.
PRIDEi Q9ESN9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000088345 ; ENSMUSP00000085683 ; ENSMUSG00000024163 . [Q9ESN9-1 ]
ENSMUST00000115228 ; ENSMUSP00000110883 ; ENSMUSG00000024163 . [Q9ESN9-5 ]
ENSMUST00000117509 ; ENSMUSP00000112712 ; ENSMUSG00000024163 . [Q9ESN9-3 ]
ENSMUST00000119115 ; ENSMUSP00000112955 ; ENSMUSG00000024163 . [Q9ESN9-2 ]
ENSMUST00000120035 ; ENSMUSP00000114084 ; ENSMUSG00000024163 . [Q9ESN9-4 ]
ENSMUST00000146923 ; ENSMUSP00000114802 ; ENSMUSG00000024163 . [Q9ESN9-1 ]
GeneIDi 30957.
KEGGi mmu:30957.
UCSCi uc008aza.2. mouse. [Q9ESN9-5 ]
uc008azb.2. mouse. [Q9ESN9-1 ]
uc008azc.2. mouse. [Q9ESN9-3 ]
uc008aze.2. mouse. [Q9ESN9-2 ]
uc008azf.2. mouse. [Q9ESN9-4 ]

Organism-specific databases

CTDi 23162.
MGIi MGI:1353598. Mapk8ip3.

Phylogenomic databases

eggNOGi NOG270333.
GeneTreei ENSGT00670000097546.
HOVERGENi HBG024110.
InParanoidi Q9ESN9.
KOi K04436.
OrthoDBi EOG7GXP9P.
PhylomeDBi Q9ESN9.
TreeFami TF313096.

Miscellaneous databases

NextBioi 307444.
PROi Q9ESN9.
SOURCEi Search...

Gene expression databases

Bgeei Q9ESN9.
ExpressionAtlasi Q9ESN9. baseline and differential.
Genevestigatori Q9ESN9.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR019143. JNK/Rab-associated_protein-1_N.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF09744. Jnk-SapK_ap_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a scaffold factor in the JNK signaling pathway."
    Ito M., Yoshioka K., Akechi M., Yamashita S., Takamatsu N., Sugiyama K., Hibi M., Nakabeppu Y., Shiba T., Yamamoto K.
    Mol. Cell. Biol. 19:7539-7548(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A), FUNCTION, PHOSPHORYLATION, INTERACTION WITH MAPK8; MAPK9; MAPK10; MAP2K4 AND MAP3K1.
    Tissue: Brain.
  2. "Isoforms of JSAP1 scaffold protein generated through alternative splicing."
    Ito M., Akechi M., Hirose R., Ichimura M., Takamatsu N., Xu P., Nakabeppu Y., Tadayoshi S., Yamamoto K., Yoshioka K.
    Gene 255:229-234(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1A; 1B; 1C; 1D AND 1E), TISSUE SPECIFICITY.
    Tissue: Brain.
  3. "Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3."
    Kelkar N., Gupta S., Dickens M., Davis R.J.
    Mol. Cell. Biol. 20:1030-1043(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORMS 1C AND 3A), FUNCTION, INDUCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION, PHOSPHORYLATION AT THR-266; THR-276 AND THR-287, MUTAGENESIS OF ARG-205; PRO-206; THR-207; SER-208; LEU-209; THR-266; THR-276 AND THR-287, INTERACTION WITH MAPK8IP2; MAPK8; MAPK9; MAPK10; MAP2K7 AND MAP3K11.
    Strain: C57BL/6.
    Tissue: Brain and Heart.
  4. "Kinesin-dependent axonal transport is mediated by the Sunday Driver (SYD) protein."
    Bowman A.B., Kamal A., Ritchings B.W., Philp A.V., McGrail M., Gindhart J.G., Goldstein L.S.B.
    Cell 103:583-594(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1C), SUBCELLULAR LOCATION, INTERACTION WITH KLC1.
    Strain: C57BL/6.
    Tissue: Brain.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1B), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1240-1337 (ISOFORM 1C).
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules."
    Verhey K.J., Meyer D., Deehan R., Blenis J., Schnapp B.J., Rapoport T.A., Margolis B.
    J. Cell Biol. 152:959-970(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH KLC.
    Tissue: Brain.
  7. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-677, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiJIP3_MOUSE
AccessioniPrimary (citable) accession number: Q9ESN9
Secondary accession number(s): Q5D062
, Q99KU7, Q9EQD8, Q9ESN7, Q9ESN8, Q9ESP0, Q9JLH2, Q9JLH3, Q9R0U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3