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Protein

Hyaluronan and proteoglycan link protein 2

Gene

Hapln2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates a firm binding of versican V2 to hyaluronic acid. May play a pivotal role in the formation of the hyaluronan-associated matrix in the central nervous system (CNS) which facilitates neuronal conduction and general structural stabilization. Binds to hyaluronic acid.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: InterPro
  • central nervous system development Source: GO_Central
  • establishment of blood-nerve barrier Source: MGI
  • extracellular matrix assembly Source: MGI
  • skeletal system development Source: GO_Central

Keywordsi

LigandHyaluronic acid

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan and proteoglycan link protein 2
Alternative name(s):
Brain link protein 1
Gene namesi
Name:Hapln2
Synonyms:Bral1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2137300 Hapln2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001318828 – 341Hyaluronan and proteoglycan link protein 2Add BLAST314

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi58 ↔ 129By similarity
Disulfide bondi171 ↔ 241By similarity
Disulfide bondi195 ↔ 216By similarity
Disulfide bondi266 ↔ 337By similarity
Disulfide bondi291 ↔ 312By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9ESM3
PRIDEiQ9ESM3

PTM databases

iPTMnetiQ9ESM3

Expressioni

Tissue specificityi

Brain. Predominantly expressed by neurons. Colocalizes with versican V2 in developing and adult cerebellar white matter and at the nodes of Ranvier.1 Publication

Developmental stagei

Expression starts at postnatal day 20 and increases thereafter.

Gene expression databases

BgeeiENSMUSG00000004894
CleanExiMM_HAPLN2
ExpressionAtlasiQ9ESM3 baseline and differential
GenevisibleiQ9ESM3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000005014

Structurei

3D structure databases

ProteinModelPortaliQ9ESM3
SMRiQ9ESM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 143Ig-like V-typeAdd BLAST109
Domaini149 – 243Link 1PROSITE-ProRule annotationAdd BLAST95
Domaini246 – 339Link 2PROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Belongs to the HAPLN family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIS5 Eukaryota
ENOG410XVBZ LUCA
GeneTreeiENSGT00760000119025
HOGENOMiHOG000234353
HOVERGENiHBG051922
InParanoidiQ9ESM3
KOiK06851
OMAiRDRYDAF
OrthoDBiEOG091G09EL
PhylomeDBiQ9ESM3
TreeFamiTF332134

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.10.100.10, 2 hits
InterProiView protein in InterPro
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR000538 Link_dom
PfamiView protein in Pfam
PF07686 V-set, 1 hit
PF00193 Xlink, 2 hits
PRINTSiPR01265 LINKMODULE
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00406 IGv, 1 hit
SM00445 LINK, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF56436 SSF56436, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS01241 LINK_1, 2 hits
PS50963 LINK_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ESM3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSRIPLPAF CCFLLPWAFT SFHKALGNPA PHPGPHYLLP PIHEVIHSRR
60 70 80 90 100
GATATLPCVL GTSPPSYKVR WSKVEPGELR ETLILITNGL HARDYGLLGG
110 120 130 140 150
RASLRRGHRL DASLIIKNVR LEDEGRYRCE LINGIEDESV ALTLRLEGVV
160 170 180 190 200
FPYQPSRGRY QFNYFEAKRA CEEQDGRLAT YGQLYQAWTE GLDWCNAGWL
210 220 230 240 250
LEGSVRYPVL TARAPCGGHG RPGIRSYGPR DRSRDRYDAF CFTSALAGQV
260 270 280 290 300
FFVPGRLTLS EAHAACRRRG AVVAKVGHLY AAWKFSGLDQ CDGGWLADGS
310 320 330 340
VRFPITTPRP RCGGLPDPGV RSFGFPRPQQ ASYGTYCYAE K
Length:341
Mass (Da):37,925
Last modified:March 1, 2001 - v1
Checksum:i1F65DCD07B5CFF02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049055 mRNA Translation: BAB17663.1
CCDSiCCDS17463.1
RefSeqiNP_071314.1, NM_022031.2
XP_006502211.1, XM_006502148.2
UniGeneiMm.294467

Genome annotation databases

EnsembliENSMUST00000005014; ENSMUSP00000005014; ENSMUSG00000004894
GeneIDi73940
KEGGimmu:73940
UCSCiuc008ptq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiHPLN2_MOUSE
AccessioniPrimary (citable) accession number: Q9ESM3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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