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Protein

Inositol hexakisphosphate kinase 1

Gene

Ip6k1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 (By similarity).By similarity

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-RNO-1855167 Synthesis of pyrophosphates in the cytosol
R-RNO-1855191 Synthesis of IPs in the nucleus

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 1 (EC:2.7.4.21)
Short name:
InsP6 kinase 1
Alternative name(s):
Inositol hexaphosphate kinase 1
Gene namesi
Name:Ip6k1
Synonyms:Ihpk1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi71025 Ip6k1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000668761 – 433Inositol hexakisphosphate kinase 1Add BLAST433

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9ESM0
PRIDEiQ9ESM0

Expressioni

Gene expression databases

BgeeiENSRNOG00000019932

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044935

Structurei

3D structure databases

ProteinModelPortaliQ9ESM0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni220 – 228Substrate bindingBy similarity9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1620 Eukaryota
ENOG410YB60 LUCA
GeneTreeiENSGT00390000014381
HOGENOMiHOG000007418
HOVERGENiHBG052140
InParanoidiQ9ESM0
KOiK07756
OMAiIHSDVPF
OrthoDBiEOG091G0JK2
PhylomeDBiQ9ESM0
TreeFamiTF314066

Family and domain databases

Gene3Di1.10.510.50, 1 hit
InterProiView protein in InterPro
IPR005522 IPK
IPR038286 IPK_sf
PANTHERiPTHR12400 PTHR12400, 1 hit
PfamiView protein in Pfam
PF03770 IPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ESM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP
60 70 80 90 100
LISREQRFYE SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE
110 120 130 140 150
TVEQDDTPER EQPRRKHSRR SLHRSGSGSD HKEEKASLSF ETSESSQETK
160 170 180 190 200
SPKVELHSHS DVPFQMLDSN SGLSSEKISY NPWSLRCHKQ QLSRMRSESK
210 220 230 240 250
DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK AARQMRKCEQ
260 270 280 290 300
STSASLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG
310 320 330 340 350
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRSELRL
360 370 380 390 400
KHVDMGLPEV PPLCGPSTSP SNTSLEAGPS SPPKVDVRMI DFAHSTFKGF
410 420 430
RDDPTVHDGP DRGYVFGLEN LISIMEQMRD ENQ
Length:433
Mass (Da):49,366
Last modified:March 1, 2001 - v1
Checksum:i31F6A9E4DA592943
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049151 mRNA Translation: BAB13737.1
BC078702 mRNA Translation: AAH78702.1
RefSeqiNP_445768.1, NM_053316.2
XP_006243901.1, XM_006243839.1
UniGeneiRn.16751

Genome annotation databases

EnsembliENSRNOT00000041402; ENSRNOP00000044935; ENSRNOG00000019932
GeneIDi50560
KEGGirno:50560
UCSCiRGD:71025 rat

Similar proteinsi

Entry informationi

Entry nameiIP6K1_RAT
AccessioniPrimary (citable) accession number: Q9ESM0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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