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Q9ESM0

- IP6K1_RAT

UniProt

Q9ESM0 - IP6K1_RAT

Protein

Inositol hexakisphosphate kinase 1

Gene

Ip6k1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 By similarity.By similarity

    Catalytic activityi

    ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
    ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
    3. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
    4. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
    5. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC
    6. protein binding Source: UniProtKB

    GO - Biological processi

    1. phosphatidylinositol phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_198650. Synthesis of IPs in the nucleus.
    REACT_198653. Synthesis of pyrophosphates in the cytosol.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol hexakisphosphate kinase 1 (EC:2.7.4.21)
    Short name:
    InsP6 kinase 1
    Alternative name(s):
    Inositol hexaphosphate kinase 1
    Gene namesi
    Name:Ip6k1
    Synonyms:Ihpk1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 8

    Organism-specific databases

    RGDi71025. Ip6k1.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleolus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 433433Inositol hexakisphosphate kinase 1PRO_0000066876Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei151 – 1511PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9ESM0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ESM0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000044935.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ESM0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni220 – 2289Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG274869.
    GeneTreeiENSGT00390000014381.
    HOGENOMiHOG000007418.
    HOVERGENiHBG052140.
    InParanoidiQ9ESM0.
    KOiK07756.
    OMAiQTMEVGK.
    OrthoDBiEOG747PHX.
    PhylomeDBiQ9ESM0.
    TreeFamiTF314066.

    Family and domain databases

    InterProiIPR005522. IPK.
    [Graphical view]
    PANTHERiPTHR12400. PTHR12400. 1 hit.
    PfamiPF03770. IPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ESM0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP    50
    LISREQRFYE SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE 100
    TVEQDDTPER EQPRRKHSRR SLHRSGSGSD HKEEKASLSF ETSESSQETK 150
    SPKVELHSHS DVPFQMLDSN SGLSSEKISY NPWSLRCHKQ QLSRMRSESK 200
    DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK AARQMRKCEQ 250
    STSASLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG 300
    LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRSELRL 350
    KHVDMGLPEV PPLCGPSTSP SNTSLEAGPS SPPKVDVRMI DFAHSTFKGF 400
    RDDPTVHDGP DRGYVFGLEN LISIMEQMRD ENQ 433
    Length:433
    Mass (Da):49,366
    Last modified:March 1, 2001 - v1
    Checksum:i31F6A9E4DA592943
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049151 mRNA. Translation: BAB13737.1.
    BC078702 mRNA. Translation: AAH78702.1.
    RefSeqiNP_445768.1. NM_053316.2.
    XP_006243901.1. XM_006243839.1.
    UniGeneiRn.16751.

    Genome annotation databases

    EnsembliENSRNOT00000041402; ENSRNOP00000044935; ENSRNOG00000019932.
    GeneIDi50560.
    KEGGirno:50560.
    UCSCiRGD:71025. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB049151 mRNA. Translation: BAB13737.1 .
    BC078702 mRNA. Translation: AAH78702.1 .
    RefSeqi NP_445768.1. NM_053316.2.
    XP_006243901.1. XM_006243839.1.
    UniGenei Rn.16751.

    3D structure databases

    ProteinModelPortali Q9ESM0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000044935.

    Proteomic databases

    PRIDEi Q9ESM0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000041402 ; ENSRNOP00000044935 ; ENSRNOG00000019932 .
    GeneIDi 50560.
    KEGGi rno:50560.
    UCSCi RGD:71025. rat.

    Organism-specific databases

    CTDi 9807.
    RGDi 71025. Ip6k1.

    Phylogenomic databases

    eggNOGi NOG274869.
    GeneTreei ENSGT00390000014381.
    HOGENOMi HOG000007418.
    HOVERGENi HBG052140.
    InParanoidi Q9ESM0.
    KOi K07756.
    OMAi QTMEVGK.
    OrthoDBi EOG747PHX.
    PhylomeDBi Q9ESM0.
    TreeFami TF314066.

    Enzyme and pathway databases

    Reactomei REACT_198650. Synthesis of IPs in the nucleus.
    REACT_198653. Synthesis of pyrophosphates in the cytosol.

    Miscellaneous databases

    NextBioi 610382.
    PROi Q9ESM0.

    Gene expression databases

    Genevestigatori Q9ESM0.

    Family and domain databases

    InterProi IPR005522. IPK.
    [Graphical view ]
    PANTHERi PTHR12400. PTHR12400. 1 hit.
    Pfami PF03770. IPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing of rat inositol hexakisphosphate kinase cDNA."
      Ohyama T., Matsuda K., Tachibana H., Horikawa Y., Sakata S.F., Tamaki N.
      Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiIP6K1_RAT
    AccessioniPrimary (citable) accession number: Q9ESM0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3