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Q9ESM0

- IP6K1_RAT

UniProt

Q9ESM0 - IP6K1_RAT

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Protein
Inositol hexakisphosphate kinase 1
Gene
Ip6k1, Ihpk1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 By similarity.

Catalytic activityi

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.
ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. inositol hexakisphosphate 1-kinase activity Source: UniProtKB-EC
  3. inositol hexakisphosphate 3-kinase activity Source: UniProtKB-EC
  4. inositol hexakisphosphate 5-kinase activity Source: UniProtKB-EC
  5. inositol-1,4,5-trisphosphate 3-kinase activity Source: InterPro
  6. protein binding Source: UniProtKB

GO - Biological processi

  1. phosphatidylinositol phosphorylation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_198650. Synthesis of IPs in the nucleus.
REACT_198653. Synthesis of pyrophosphates in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol hexakisphosphate kinase 1 (EC:2.7.4.21)
Short name:
InsP6 kinase 1
Alternative name(s):
Inositol hexaphosphate kinase 1
Gene namesi
Name:Ip6k1
Synonyms:Ihpk1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 8

Organism-specific databases

RGDi71025. Ip6k1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleolus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Inositol hexakisphosphate kinase 1
PRO_0000066876Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei151 – 1511Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9ESM0.

Expressioni

Gene expression databases

GenevestigatoriQ9ESM0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044935.

Structurei

3D structure databases

ProteinModelPortaliQ9ESM0.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni220 – 2289Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG274869.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000007418.
HOVERGENiHBG052140.
InParanoidiQ9ESM0.
KOiK07756.
OMAiQTMEVGK.
OrthoDBiEOG747PHX.
PhylomeDBiQ9ESM0.
TreeFamiTF314066.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 1 hit.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESM0-1 [UniParc]FASTAAdd to Basket

« Hide

MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP    50
LISREQRFYE SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE 100
TVEQDDTPER EQPRRKHSRR SLHRSGSGSD HKEEKASLSF ETSESSQETK 150
SPKVELHSHS DVPFQMLDSN SGLSSEKISY NPWSLRCHKQ QLSRMRSESK 200
DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK AARQMRKCEQ 250
STSASLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG 300
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRSELRL 350
KHVDMGLPEV PPLCGPSTSP SNTSLEAGPS SPPKVDVRMI DFAHSTFKGF 400
RDDPTVHDGP DRGYVFGLEN LISIMEQMRD ENQ 433
Length:433
Mass (Da):49,366
Last modified:March 1, 2001 - v1
Checksum:i31F6A9E4DA592943
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049151 mRNA. Translation: BAB13737.1.
BC078702 mRNA. Translation: AAH78702.1.
RefSeqiNP_445768.1. NM_053316.2.
XP_006243901.1. XM_006243839.1.
UniGeneiRn.16751.

Genome annotation databases

EnsembliENSRNOT00000041402; ENSRNOP00000044935; ENSRNOG00000019932.
GeneIDi50560.
KEGGirno:50560.
UCSCiRGD:71025. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB049151 mRNA. Translation: BAB13737.1 .
BC078702 mRNA. Translation: AAH78702.1 .
RefSeqi NP_445768.1. NM_053316.2.
XP_006243901.1. XM_006243839.1.
UniGenei Rn.16751.

3D structure databases

ProteinModelPortali Q9ESM0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000044935.

Proteomic databases

PRIDEi Q9ESM0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000041402 ; ENSRNOP00000044935 ; ENSRNOG00000019932 .
GeneIDi 50560.
KEGGi rno:50560.
UCSCi RGD:71025. rat.

Organism-specific databases

CTDi 9807.
RGDi 71025. Ip6k1.

Phylogenomic databases

eggNOGi NOG274869.
GeneTreei ENSGT00390000014381.
HOGENOMi HOG000007418.
HOVERGENi HBG052140.
InParanoidi Q9ESM0.
KOi K07756.
OMAi QTMEVGK.
OrthoDBi EOG747PHX.
PhylomeDBi Q9ESM0.
TreeFami TF314066.

Enzyme and pathway databases

Reactomei REACT_198650. Synthesis of IPs in the nucleus.
REACT_198653. Synthesis of pyrophosphates in the cytosol.

Miscellaneous databases

NextBioi 610382.
PROi Q9ESM0.

Gene expression databases

Genevestigatori Q9ESM0.

Family and domain databases

InterProi IPR005522. IPK.
[Graphical view ]
PANTHERi PTHR12400. PTHR12400. 1 hit.
Pfami PF03770. IPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of rat inositol hexakisphosphate kinase cDNA."
    Ohyama T., Matsuda K., Tachibana H., Horikawa Y., Sakata S.F., Tamaki N.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiIP6K1_RAT
AccessioniPrimary (citable) accession number: Q9ESM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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