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Q9ESM0 (IP6K1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inositol hexakisphosphate kinase 1

Short name=InsP6 kinase 1
EC=2.7.4.21
Alternative name(s):
Inositol hexaphosphate kinase 1
Gene names
Name:Ip6k1
Synonyms:Ihpk1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length433 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). Converts 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 By similarity.

Catalytic activity

ATP + 1D-myo-inositol hexakisphosphate = ADP + 1D-myo-inositol 5-diphosphate 1,2,3,4,6-pentakisphosphate.

ATP + 1D-myo-inositol 1-diphosphate 2,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol 1,5-bis(diphosphate) 2,3,4,6-tetrakisphosphate.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Sequence similarities

Belongs to the inositol phosphokinase (IPK) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 433433Inositol hexakisphosphate kinase 1
PRO_0000066876

Regions

Region220 – 2289Substrate binding By similarity

Amino acid modifications

Modified residue1511Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ESM0 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 31F6A9E4DA592943

FASTA43349,366
        10         20         30         40         50         60 
MCVCQTMEVG QYGKNASRAG DRGVLLEPFI HQVGGHSSMM RYDDHTVCKP LISREQRFYE 

        70         80         90        100        110        120 
SLPPEMKEFT PEYKGVVSVC FEGDSDGYIN LVAYPYVESE TVEQDDTPER EQPRRKHSRR 

       130        140        150        160        170        180 
SLHRSGSGSD HKEEKASLSF ETSESSQETK SPKVELHSHS DVPFQMLDSN SGLSSEKISY 

       190        200        210        220        230        240 
NPWSLRCHKQ QLSRMRSESK DRKLYKFLLL ENVVHHFKYP CVLDLKMGTR QHGDDASAEK 

       250        260        270        280        290        300 
AARQMRKCEQ STSASLGVRV CGMQVYQLDT GHYLCRNKYY GRGLSIEGFR NALYQYLHNG 

       310        320        330        340        350        360 
LDLRRDLFEP ILSKLRGLKA VLERQASYRF YSSSLLVIYD GKECRSELRL KHVDMGLPEV 

       370        380        390        400        410        420 
PPLCGPSTSP SNTSLEAGPS SPPKVDVRMI DFAHSTFKGF RDDPTVHDGP DRGYVFGLEN 

       430 
LISIMEQMRD ENQ 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and sequencing of rat inositol hexakisphosphate kinase cDNA."
Ohyama T., Matsuda K., Tachibana H., Horikawa Y., Sakata S.F., Tamaki N.
Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB049151 mRNA. Translation: BAB13737.1.
BC078702 mRNA. Translation: AAH78702.1.
RefSeqNP_445768.1. NM_053316.2.
XP_006243901.1. XM_006243839.1.
UniGeneRn.16751.

3D structure databases

ProteinModelPortalQ9ESM0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000044935.

Proteomic databases

PRIDEQ9ESM0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000041402; ENSRNOP00000044935; ENSRNOG00000019932.
GeneID50560.
KEGGrno:50560.
UCSCRGD:71025. rat.

Organism-specific databases

CTD9807.
RGD71025. Ip6k1.

Phylogenomic databases

eggNOGNOG274869.
GeneTreeENSGT00390000014381.
HOGENOMHOG000007418.
HOVERGENHBG052140.
InParanoidQ9ESM0.
KOK07756.
OMAQTMEVGK.
OrthoDBEOG747PHX.
PhylomeDBQ9ESM0.
TreeFamTF314066.

Gene expression databases

GenevestigatorQ9ESM0.

Family and domain databases

InterProIPR005522. IPK.
[Graphical view]
PANTHERPTHR12400. PTHR12400. 1 hit.
PfamPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610382.
PROQ9ESM0.

Entry information

Entry nameIP6K1_RAT
AccessionPrimary (citable) accession number: Q9ESM0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 1, 2001
Last modified: June 11, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families