Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 20

Gene

Fgf20

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Neurotrophic factor that regulates central nervous development and function.

GO - Molecular functioni

GO - Biological processi

  • cell differentiation Source: MGI
  • fibroblast growth factor receptor signaling pathway Source: MGI
  • inner ear receptor cell differentiation Source: MGI
  • negative regulation of neuron apoptotic process Source: MGI
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of ERK1 and ERK2 cascade Source: MGI
  • regulation of cardiac muscle cell proliferation Source: MGI
  • regulation of neuron differentiation Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190322. FGFR4 ligand binding and activation.
R-MMU-190371. FGFR3b ligand binding and activation.
R-MMU-190372. FGFR3c ligand binding and activation.
R-MMU-190373. FGFR1c ligand binding and activation.
R-MMU-190375. FGFR2c ligand binding and activation.
R-MMU-5654219. Phospholipase C-mediated cascade: FGFR1.
R-MMU-5654221. Phospholipase C-mediated cascade, FGFR2.
R-MMU-5654227. Phospholipase C-mediated cascade, FGFR3.
R-MMU-5654228. Phospholipase C-mediated cascade, FGFR4.
R-MMU-5654687. Downstream signaling of activated FGFR1.
R-MMU-5654688. SHC-mediated cascade:FGFR1.
R-MMU-5654689. PI-3K cascade:FGFR1.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654704. SHC-mediated cascade:FGFR3.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654710. PI-3K cascade:FGFR3.
R-MMU-5654712. FRS-mediated FGFR4 signaling.
R-MMU-5654719. SHC-mediated cascade:FGFR4.
R-MMU-5654720. PI-3K cascade:FGFR4.
R-MMU-5654726. Negative regulation of FGFR1 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5654732. Negative regulation of FGFR3 signaling.
R-MMU-5654733. Negative regulation of FGFR4 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 20
Short name:
FGF-20
Gene namesi
Name:Fgf20
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1891346. Fgf20.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476171 – 211Fibroblast growth factor 20Add BLAST211

Proteomic databases

PaxDbiQ9ESL9.
PRIDEiQ9ESL9.

PTM databases

PhosphoSitePlusiQ9ESL9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000031603.
CleanExiMM_FGF20.
ExpressionAtlasiQ9ESL9. baseline and differential.
GenevisibleiQ9ESL9. MM.

Interactioni

Subunit structurei

Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034014.

Structurei

3D structure databases

ProteinModelPortaliQ9ESL9.
SMRiQ9ESL9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiQ9ESL9.
KOiK04358.
OMAiYKDILMY.
OrthoDBiEOG091G0NAY.
PhylomeDBiQ9ESL9.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028291. FGF20.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF72. PTHR11486:SF72. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLTEVGAF LGGLEGLSQQ VGSHFLLPPA GERPPLLGER RGALERGARG
60 70 80 90 100
GPGSVELAHL HGILRRRQLY CRTGFHLQIL PDGTVQGTRQ DHSLFGILEF
110 120 130 140 150
ISVAVGLVSI RGVDSGLYLG MNDKGELYGS EKLTSECIFR EQFEENWYNT
160 170 180 190 200
YSSNIYKHGD TGRRYFVALN KDGTPRDGAR SKRHQKFTHF LPRPVDPERV
210
PELYKDLLMY T
Length:211
Mass (Da):23,614
Last modified:April 26, 2005 - v2
Checksum:i6CF4714BD4F6CDFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti18S → G in BAB16406 (Ref. 1) Curated1
Sequence conflicti160D → N in BAB16406 (Ref. 1) Curated1
Sequence conflicti184H → R in BAB16406 (Ref. 1) Curated1
Sequence conflicti211T → TG in BAB16406 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049218 mRNA. Translation: BAB16406.1.
AK052233 mRNA. Translation: BAC34892.1.
CCDSiCCDS52544.1.
RefSeqiNP_085113.2. NM_030610.2.
UniGeneiMm.425526.

Genome annotation databases

EnsembliENSMUST00000034014; ENSMUSP00000034014; ENSMUSG00000031603.
GeneIDi80857.
KEGGimmu:80857.
UCSCiuc009lml.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049218 mRNA. Translation: BAB16406.1.
AK052233 mRNA. Translation: BAC34892.1.
CCDSiCCDS52544.1.
RefSeqiNP_085113.2. NM_030610.2.
UniGeneiMm.425526.

3D structure databases

ProteinModelPortaliQ9ESL9.
SMRiQ9ESL9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034014.

PTM databases

PhosphoSitePlusiQ9ESL9.

Proteomic databases

PaxDbiQ9ESL9.
PRIDEiQ9ESL9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034014; ENSMUSP00000034014; ENSMUSG00000031603.
GeneIDi80857.
KEGGimmu:80857.
UCSCiuc009lml.2. mouse.

Organism-specific databases

CTDi26281.
MGIiMGI:1891346. Fgf20.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiQ9ESL9.
KOiK04358.
OMAiYKDILMY.
OrthoDBiEOG091G0NAY.
PhylomeDBiQ9ESL9.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190322. FGFR4 ligand binding and activation.
R-MMU-190371. FGFR3b ligand binding and activation.
R-MMU-190372. FGFR3c ligand binding and activation.
R-MMU-190373. FGFR1c ligand binding and activation.
R-MMU-190375. FGFR2c ligand binding and activation.
R-MMU-5654219. Phospholipase C-mediated cascade: FGFR1.
R-MMU-5654221. Phospholipase C-mediated cascade, FGFR2.
R-MMU-5654227. Phospholipase C-mediated cascade, FGFR3.
R-MMU-5654228. Phospholipase C-mediated cascade, FGFR4.
R-MMU-5654687. Downstream signaling of activated FGFR1.
R-MMU-5654688. SHC-mediated cascade:FGFR1.
R-MMU-5654689. PI-3K cascade:FGFR1.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654695. PI-3K cascade:FGFR2.
R-MMU-5654699. SHC-mediated cascade:FGFR2.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654704. SHC-mediated cascade:FGFR3.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654710. PI-3K cascade:FGFR3.
R-MMU-5654712. FRS-mediated FGFR4 signaling.
R-MMU-5654719. SHC-mediated cascade:FGFR4.
R-MMU-5654720. PI-3K cascade:FGFR4.
R-MMU-5654726. Negative regulation of FGFR1 signaling.
R-MMU-5654727. Negative regulation of FGFR2 signaling.
R-MMU-5654732. Negative regulation of FGFR3 signaling.
R-MMU-5654733. Negative regulation of FGFR4 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Miscellaneous databases

PROiQ9ESL9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031603.
CleanExiMM_FGF20.
ExpressionAtlasiQ9ESL9. baseline and differential.
GenevisibleiQ9ESL9. MM.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028291. FGF20.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF72. PTHR11486:SF72. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF20_MOUSE
AccessioniPrimary (citable) accession number: Q9ESL9
Secondary accession number(s): Q8C7A8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: April 26, 2005
Last modified: November 30, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.