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Q9ESK8

- KCMB4_RAT

UniProt

Q9ESK8 - KCMB4_RAT

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Protein

Calcium-activated potassium channel subunit beta-4

Gene

Kcnmb4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations (By similarity).By similarity

GO - Molecular functioni

  1. calcium-activated potassium channel activity Source: UniProtKB

GO - Biological processi

  1. action potential Source: UniProtKB
  2. detection of calcium ion Source: UniProtKB
  3. neuronal action potential Source: UniProtKB
  4. potassium ion transmembrane transport Source: GOC
  5. potassium ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-4
Alternative name(s):
BK channel subunit beta-4
Short name:
BKbeta4
Calcium-activated potassium channel, subfamily M subunit beta-4
Charybdotoxin receptor subunit beta-4
K(VCA)beta-4
Maxi K channel subunit beta-4
Slo-beta-4
Gene namesi
Name:Kcnmb4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi620728. Kcnmb4.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Calcium-activated potassium channel subunit beta-4PRO_0000187057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)By similarity
Glycosylationi90 – 901N-linked (GlcNAc...)By similarity

Post-translational modificationi

Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics (By similarity).By similarity
N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Expressioni

Gene expression databases

GenevestigatoriQ9ESK8.

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer (By similarity).By similarity

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini41 – 167127ExtracellularSequence AnalysisAdd
BLAST
Topological domaini189 – 21022CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=2Sequence AnalysisAdd
BLAST

Family & Domainsi

Domaini

Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG83271.
HOGENOMiHOG000113205.
HOVERGENiHBG052224.
InParanoidiQ9ESK8.
KOiK04941.
PhylomeDBiQ9ESK8.

Family and domain databases

InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESK8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKLRVSYEY TEAEDKSIRL GLFLIVSGIL SLFIFGFCWL SPALQDLQAT
60 70 80 90 100
AANCTVLSVQ QIGEVFECTF TCGTDCRGTS QYPCVQVYVN NSESNSRALL
110 120 130 140 150
HSDQHQLLTN PKCSYIPPCK RENQKNSESV MNWQQYWKDE IGSQPFTCYF
160 170 180 190 200
NQHQRPEDVL LQRTHDEIVL LHCFLWPVVA FVVGVLIVVL TICAKSLAVK
210
AEAMKKRKFS
Length:210
Mass (Da):23,885
Last modified:March 1, 2001 - v1
Checksum:i11D49F58F9C6F1D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB050637 mRNA. Translation: BAB17595.1.
AY028605 mRNA. Translation: AAK21964.1.
RefSeqiNP_076450.1. NM_023960.2.
UniGeneiRn.162953.

Genome annotation databases

GeneIDi66016.
KEGGirno:66016.
UCSCiRGD:620728. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB050637 mRNA. Translation: BAB17595.1 .
AY028605 mRNA. Translation: AAK21964.1 .
RefSeqi NP_076450.1. NM_023960.2.
UniGenei Rn.162953.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 66016.
KEGGi rno:66016.
UCSCi RGD:620728. rat.

Organism-specific databases

CTDi 27345.
RGDi 620728. Kcnmb4.

Phylogenomic databases

eggNOGi NOG83271.
HOGENOMi HOG000113205.
HOVERGENi HBG052224.
InParanoidi Q9ESK8.
KOi K04941.
PhylomeDBi Q9ESK8.

Miscellaneous databases

NextBioi 614292.
PROi Q9ESK8.

Gene expression databases

Genevestigatori Q9ESK8.

Family and domain databases

InterProi IPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view ]
PANTHERi PTHR10258. PTHR10258. 1 hit.
Pfami PF03185. CaKB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Rat calcium activated potassium channel beta 4 subunit (KCNMB4)."
    Ohya S., Ohi Y., Imaizumi Y.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "Molecular cloning of large-conductance calcium-activated potassium channel beta 4 subunit from rat brain."
    Ha T.S., Park C.-S.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiKCMB4_RAT
AccessioniPrimary (citable) accession number: Q9ESK8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3