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Q9ESK8

- KCMB4_RAT

UniProt

Q9ESK8 - KCMB4_RAT

Protein

Calcium-activated potassium channel subunit beta-4

Gene

Kcnmb4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations By similarity.By similarity

    GO - Molecular functioni

    1. calcium-activated potassium channel activity Source: UniProtKB

    GO - Biological processi

    1. action potential Source: UniProtKB
    2. detection of calcium ion Source: UniProtKB
    3. neuronal action potential Source: UniProtKB
    4. potassium ion transmembrane transport Source: GOC
    5. potassium ion transport Source: UniProtKB

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-activated potassium channel subunit beta-4
    Alternative name(s):
    BK channel subunit beta-4
    Short name:
    BKbeta4
    Calcium-activated potassium channel, subfamily M subunit beta-4
    Charybdotoxin receptor subunit beta-4
    K(VCA)beta-4
    Maxi K channel subunit beta-4
    Slo-beta-4
    Gene namesi
    Name:Kcnmb4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620728. Kcnmb4.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. voltage-gated potassium channel complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210Calcium-activated potassium channel subunit beta-4PRO_0000187057Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)By similarity
    Glycosylationi90 – 901N-linked (GlcNAc...)By similarity

    Post-translational modificationi

    Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics By similarity.By similarity
    N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin By similarity.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ESK8.

    Interactioni

    Subunit structurei

    Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer By similarity.By similarity

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 167127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini189 – 21022CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821Helical; Name=2Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG83271.
    HOGENOMiHOG000113205.
    HOVERGENiHBG052224.
    InParanoidiQ9ESK8.
    KOiK04941.
    PhylomeDBiQ9ESK8.

    Family and domain databases

    InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
    [Graphical view]
    PANTHERiPTHR10258. PTHR10258. 1 hit.
    PfamiPF03185. CaKB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ESK8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKLRVSYEY TEAEDKSIRL GLFLIVSGIL SLFIFGFCWL SPALQDLQAT    50
    AANCTVLSVQ QIGEVFECTF TCGTDCRGTS QYPCVQVYVN NSESNSRALL 100
    HSDQHQLLTN PKCSYIPPCK RENQKNSESV MNWQQYWKDE IGSQPFTCYF 150
    NQHQRPEDVL LQRTHDEIVL LHCFLWPVVA FVVGVLIVVL TICAKSLAVK 200
    AEAMKKRKFS 210
    Length:210
    Mass (Da):23,885
    Last modified:March 1, 2001 - v1
    Checksum:i11D49F58F9C6F1D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050637 mRNA. Translation: BAB17595.1.
    AY028605 mRNA. Translation: AAK21964.1.
    RefSeqiNP_076450.1. NM_023960.2.
    UniGeneiRn.162953.

    Genome annotation databases

    GeneIDi66016.
    KEGGirno:66016.
    UCSCiRGD:620728. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB050637 mRNA. Translation: BAB17595.1 .
    AY028605 mRNA. Translation: AAK21964.1 .
    RefSeqi NP_076450.1. NM_023960.2.
    UniGenei Rn.162953.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 66016.
    KEGGi rno:66016.
    UCSCi RGD:620728. rat.

    Organism-specific databases

    CTDi 27345.
    RGDi 620728. Kcnmb4.

    Phylogenomic databases

    eggNOGi NOG83271.
    HOGENOMi HOG000113205.
    HOVERGENi HBG052224.
    InParanoidi Q9ESK8.
    KOi K04941.
    PhylomeDBi Q9ESK8.

    Miscellaneous databases

    NextBioi 614292.
    PROi Q9ESK8.

    Gene expression databases

    Genevestigatori Q9ESK8.

    Family and domain databases

    InterProi IPR003930. K_chnl_Ca-activ_BK_bsu.
    [Graphical view ]
    PANTHERi PTHR10258. PTHR10258. 1 hit.
    Pfami PF03185. CaKB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rat calcium activated potassium channel beta 4 subunit (KCNMB4)."
      Ohya S., Ohi Y., Imaizumi Y.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Molecular cloning of large-conductance calcium-activated potassium channel beta 4 subunit from rat brain."
      Ha T.S., Park C.-S.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiKCMB4_RAT
    AccessioniPrimary (citable) accession number: Q9ESK8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3