Reviewed,
UniProtKB/Swiss-Prot Q9ESK4 (ING2_MOUSE)
Last modified
March 2, 2010.
Version 82.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Inhibitor of growth protein 2 Alternative name(s): p33ING2 Inhibitor of growth 1-like protein | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 281 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) By similarity. |
| Subunit structure | Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2 By similarity. |
| Subcellular location | Nucleus By similarity. Note: Predominantly cytoplasmic. Localized to chromatin and nuclear matrix. Upon reduced PtdIns5P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm By similarity. |
| Domain | The PHD-type zinc finger domain binds to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns5P) By similarity. |
| Sequence similarities | Belongs to the ING family. Contains 1 PHD-type zinc finger. |
| Sequence caution | The sequence AAH50003.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. Potential poly-A sequence. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Growth regulation Transcription Transcription regulation |
| Cellular component | Nucleus |
| Domain | Coiled coil Zinc-finger |
| Ligand | Metal-binding Zinc |
| Molecular function | Chromatin regulator |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Biological process | cellular transcription Inferred from electronic annotation. Source: UniProtKB-KW chromatin modificationInferred from electronic annotation. Source: UniProtKB-KW positive regulation of cellular transcriptionInferred from direct assay. Source: MGI regulation of growthInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | Sin3 complex Inferred from sequence or structural similarity. Source: UniProtKB |
| Molecular function | protein binding Inferred from electronic annotation. Source: InterPro transcription activator activityInferred from direct assay. Source: MGI zinc ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||
Molecule processing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 281 | 281 | Inhibitor of growth protein 2 | PRO_0000212664 | |||||||||||||||
Regions | |||||||||||||||||||
| Zinc finger | 213 – 262 | 50 | PHD-type | ||||||||||||||||
| Coiled coil | 49 – 101 | 53 | Potential | ||||||||||||||||
Experimental info | |||||||||||||||||||
| Sequence conflict | 26 | 1 | T → S in BAC33461. Ref.2 | ||||||||||||||||
| Sequence conflict | 26 | 1 | T → S in BAC38783. Ref.2 | ||||||||||||||||
| Sequence conflict | 72 | 1 | K → E in AAG12173. Ref.1 | ||||||||||||||||
| Sequence conflict | 104 | 1 | I → N in AAG12173. Ref.1 | ||||||||||||||||
| Sequence conflict | 110 | 1 | E → G in AAG12173. Ref.1 | ||||||||||||||||
| Sequence conflict | 116 | 1 | A → S in AAG12173. Ref.1 | ||||||||||||||||
| Sequence conflict | 203 | 1 | P → S in AAG12173. Ref.1 | ||||||||||||||||
| Sequence conflict | 250 | 1 | P → H in AAG12173. Ref.1 | ||||||||||||||||
Secondary structure | |||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||
| Turn | 216 – 219 | 4 | |||||||||||||||||
| Beta strand | 224 – 228 | 5 | |||||||||||||||||
| Beta strand | 238 – 240 | 3 | |||||||||||||||||
| Helix | 242 – 244 | 3 | |||||||||||||||||
| Helix | 257 – 260 | 4 | |||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Nagashima M., Hagiwara K., Hancock A.R., Harris C.C. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cerebellum and Hippocampus. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N-3. Tissue: Mammary gland. |
| [4] | "Solution structure of PHD domain of inhibitor of growth family, member 1-like." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 205-262. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AF078834 mRNA. Translation: AAG12173.1. AK048800 mRNA. Translation: BAC33461.1. AK083144 mRNA. Translation: BAC38783.1. BC050003 mRNA. Translation: AAH50003.1. Sequence problems. | ||||||||||||||||||
| IPI | IPI00308151. | ||||||||||||||||||
| RefSeq | NP_075992.2. | ||||||||||||||||||
| UniGene | Mm.430733 | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
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| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| STRING | Q9ESK4. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | Q9ESK4. | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENSMUST00000080353; ENSMUSP00000079226; ENSMUSG00000063049; Mus musculus. [Genome view] | ||||||||||||||||||
| GeneID | 69260. | ||||||||||||||||||
| KEGG | mmu:69260. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 69260. | ||||||||||||||||||
| MGI | MGI:1916510. Ing2. | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| HOGENOM | HBG716496. | ||||||||||||||||||
| HOVERGEN | HBG006607. | ||||||||||||||||||
| InParanoid | Q9ESK4. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q9ESK4. | ||||||||||||||||||
| Bgee | Q9ESK4. | ||||||||||||||||||
| CleanEx | MM_ING2. | ||||||||||||||||||
| Genevestigator | Q9ESK4. | ||||||||||||||||||
| GermOnline | ENSMUSG00000063049. Mus musculus. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. [Graphical view] | ||||||||||||||||||
| Pfam | PF00628. PHD. 1 hit. [Graphical view] | ||||||||||||||||||
| SMART | SM00249. PHD. 1 hit. [Graphical view] | ||||||||||||||||||
| SUPFAM | SSF57903. FYVE_PHD_ZnF. 1 hit. | ||||||||||||||||||
| PROSITE | PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other Resources | |||||||||||||||||||
| NextBio | 328987. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | ING2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9ESK4 Secondary accession number(s): Q80VI5, Q8BGU8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


