Q9ESK4 (ING2_MOUSE) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 99.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Inhibitor of growth protein 2 Alternative name(s): Inhibitor of growth 1-like protein p33ING2 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus |
Protein attributes
| Sequence length | 281 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) By similarity. |
| Subunit structure | Interacts with H3K4me3 and to a lesser extent with H3K4me2 By similarity. Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2 By similarity. |
| Subcellular location | Nucleus By similarity. Note: Predominantly cytoplasmic. Localized to chromatin and nuclear matrix. Upon reduced PtdIns5P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm By similarity. |
| Domain | The PHD-type zinc finger mediates the binding to H3K4me3 By similarity. The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns5P) By similarity. |
| Sequence similarities | Belongs to the ING family. Contains 1 PHD-type zinc finger. |
| Sequence caution | The sequence AAH50003.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||
Molecule processing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 281 | 281 | Inhibitor of growth protein 2 | PRO_0000212664 | |||||||||||||||
Regions | |||||||||||||||||||
| Zinc finger | 213 – 262 | 50 | PHD-type | ||||||||||||||||
| Region | 265 – 281 | 17 | PBR By similarity | ||||||||||||||||
| Coiled coil | 49 – 101 | 53 | Potential | ||||||||||||||||
Sites | |||||||||||||||||||
| Binding site | 215 | 1 | Histone H3K4me3 By similarity | ||||||||||||||||
| Binding site | 226 | 1 | Histone H3K4me3 By similarity | ||||||||||||||||
| Binding site | 230 | 1 | Histone H3K4me3 By similarity | ||||||||||||||||
| Binding site | 238 | 1 | Histone H3K4me3 By similarity | ||||||||||||||||
Experimental info | |||||||||||||||||||
| Sequence conflict | 26 | 1 | T → S in BAC33461. Ref.2 | ||||||||||||||||
| Sequence conflict | 26 | 1 | T → S in BAC38783. Ref.2 | ||||||||||||||||
| Sequence conflict | 72 | 1 | K → E in AAG12173. Ref.1 | ||||||||||||||||
| Sequence conflict | 104 | 1 | I → N in AAG12173. Ref.1 | ||||||||||||||||
| Sequence conflict | 110 | 1 | E → G in AAG12173. Ref.1 | ||||||||||||||||
| Sequence conflict | 116 | 1 | A → S in AAG12173. Ref.1 | ||||||||||||||||
| Sequence conflict | 203 | 1 | P → S in AAG12173. Ref.1 | ||||||||||||||||
| Sequence conflict | 250 | 1 | P → H in AAG12173. Ref.1 | ||||||||||||||||
Secondary structure | |||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||
| Turn | 216 – 219 | 4 | |||||||||||||||||
| Beta strand | 224 – 228 | 5 | |||||||||||||||||
| Beta strand | 238 – 240 | 3 | |||||||||||||||||
| Helix | 242 – 244 | 3 | |||||||||||||||||
| Helix | 257 – 260 | 4 | |||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Nagashima M., Hagiwara K., Hancock A.R., Harris C.C. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y.Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Cerebellum and Hippocampus. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N-3. Tissue: Mammary gland. |
| [4] | "Solution structure of PHD domain of inhibitor of growth family, member 1-like." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2004) to the PDB data bank Cited for: STRUCTURE BY NMR OF 205-262. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | AF078834 mRNA. Translation: AAG12173.1. AK048800 mRNA. Translation: BAC33461.1. AK083144 mRNA. Translation: BAC38783.1. BC050003 mRNA. Translation: AAH50003.1. Sequence problems. | ||||||||||||||||||
| IPI | IPI00308151. | ||||||||||||||||||
| RefSeq | NP_075992.2. NM_023503.3. | ||||||||||||||||||
| UniGene | Mm.430733. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
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| ProteinModelPortal | Q9ESK4. | ||||||||||||||||||
| SMR | Q9ESK4. Positions 212-263. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| MINT | MINT-1340342. | ||||||||||||||||||
| STRING | Q9ESK4. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PRIDE | Q9ESK4. | ||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| GeneID | 69260. | ||||||||||||||||||
| KEGG | mmu:69260. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 3622. | ||||||||||||||||||
| MGI | MGI:1916510. Ing2. | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| GeneTree | ENSGT00550000074538. | ||||||||||||||||||
| HOGENOM | HBG716496. | ||||||||||||||||||
| HOVERGEN | HBG006607. | ||||||||||||||||||
| InParanoid | Q9ESK4. | ||||||||||||||||||
| OrthoDB | EOG42RD87. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | Q9ESK4. | ||||||||||||||||||
| Bgee | Q9ESK4. | ||||||||||||||||||
| CleanEx | MM_ING2. | ||||||||||||||||||
| Genevestigator | Q9ESK4. | ||||||||||||||||||
| GermOnline | ENSMUSG00000063049. Mus musculus. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR024610. ING_N. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR013083. Znf_RING/FYVE/PHD. [Graphical view] | ||||||||||||||||||
| Gene3D | G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit. | ||||||||||||||||||
| Pfam | PF12998. ING. 1 hit. PF00628. PHD. 1 hit. [Graphical view] | ||||||||||||||||||
| SMART | SM00249. PHD. 1 hit. [Graphical view] | ||||||||||||||||||
| SUPFAM | SSF57903. FYVE_PHD_ZnF. 1 hit. | ||||||||||||||||||
| PROSITE | PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other | |||||||||||||||||||
| NextBio | 328987. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | ING2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q9ESK4 Secondary accession number(s): Q80VI5, Q8BGU8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with