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Q9ESK3

- CAN10_MOUSE

UniProt

Q9ESK3 - CAN10_MOUSE

Protein

Calpain-10

Gene

Capn10

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (12 Feb 2003)
      Previous versions | rss
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    Functioni

    Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake By similarity.By similarity

    Catalytic activityi

    Broad endopeptidase specificity.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei73 – 731By similarity
    Active sitei238 – 2381By similarity
    Active sitei263 – 2631By similarity

    GO - Molecular functioni

    1. calcium-dependent cysteine-type endopeptidase activity Source: RefGenome

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: BHF-UCL
    2. cellular response to insulin stimulus Source: BHF-UCL
    3. execution phase of apoptosis Source: Ensembl
    4. positive regulation of glucose import Source: BHF-UCL
    5. positive regulation of insulin secretion Source: Ensembl
    6. positive regulation of intracellular transport Source: BHF-UCL
    7. positive regulation of type B pancreatic cell apoptotic process Source: MGI
    8. proteolysis Source: RefGenome
    9. type B pancreatic cell apoptotic process Source: BHF-UCL

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Protein family/group databases

    MEROPSiC02.018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calpain-10 (EC:3.4.22.-)
    Alternative name(s):
    Calcium-activated neutral proteinase 10
    Short name:
    CANP 10
    Gene namesi
    Name:Capn10
    Synonyms:Capn8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:1344392. Capn10.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: RefGenome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 666666Calpain-10PRO_0000207727Add
    BLAST

    Proteomic databases

    PaxDbiQ9ESK3.
    PRIDEiQ9ESK3.

    PTM databases

    PhosphoSiteiQ9ESK3.

    Expressioni

    Gene expression databases

    BgeeiQ9ESK3.
    CleanExiMM_CAPN10.
    MM_CAPN8.
    GenevestigatoriQ9ESK3.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ESK3.
    SMRiQ9ESK3. Positions 10-484, 508-632.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 321309Calpain catalyticPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni322 – 488167Domain III 1Add
    BLAST
    Regioni507 – 648142Domain III 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C2 family.Curated
    Contains 1 calpain catalytic domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG313372.
    GeneTreeiENSGT00750000117383.
    HOGENOMiHOG000081807.
    HOVERGENiHBG050787.
    InParanoidiQ9ESK3.
    KOiK08579.
    OMAiVHLRCEL.
    OrthoDBiEOG7RV9FM.
    PhylomeDBiQ9ESK3.
    TreeFamiTF314748.

    Family and domain databases

    InterProiIPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR028791. CAPN10.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view]
    PANTHERiPTHR10183:SF30. PTHR10183:SF30. 1 hit.
    PfamiPF01067. Calpain_III. 2 hits.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view]
    PRINTSiPR00704. CALPAIN.
    SMARTiSM00720. calpain_III. 2 hits.
    SM00230. CysPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49758. SSF49758. 2 hits.
    PROSITEiPS50203. CALPAIN_CAT. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ESK3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRAVRAETPA RELFRDAAFP ASDSSLFYNL STPLAQFRED ITWRRPQEIC    50
    ATPQLFPDNP WEGQVKQGLL GDCWFLCACA ALQKSQHLLD QVFPPGQPGW 100
    SDQKYQGFFT CRIWQFGHWE EVTIDDRLPC LAGRLCFSRC QREDVFWLPL 150
    LEKAYAKVHG SYEHLWAGQV ADALVDLTGS LAERWSLKDV TKASGQQDRP 200
    SGGEHRTCRQ LLHLKDRCLI SCSVLSPRAG ARELGEFHAF IISDLQELRS 250
    QTGQGILLLR IHNPWGRRCW QGLWREGGEG WNQVEPAKES ELLAQLQEGE 300
    FWVEEEEFLR EFDEVTIGYP VTEAGHLQSL HTERVLCHTR TLPGAWVTGQ 350
    SAGGCRNNSC FPCNPKFWLR LLEPSEVCVA VLQRPRRRLV GQTRALAGAS 400
    PAPVNLPGKD YQAVGLHIWK VEKRKISLPR VLSAPPVAGT ACHAYDREIH 450
    LRCELSPGYY LAVPSTFLKD VPGQFLLRVF STGKISLSAV RLATKGASPG 500
    TALPAGEWET VQLQGCWRAG QTAGGSRNFA SYPCNPCLPF SVPEGAGPRY 550
    IRITLQQHCR LSDSQLHPIG FHVFQVPADG ENQDACSLLL QEPLLSCVPH 600
    RYAQEVSRLC LLSVGNYRIV PSTYLPDTEG TFTVTIATRI DRQSIHSQEM 650
    LGQLLQEVSF MAVMKA 666
    Length:666
    Mass (Da):74,596
    Last modified:February 12, 2003 - v2
    Checksum:iA0B1B37EE1DE2371
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti481 – 4811S → F(PubMed:11017071)Curated
    Sequence conflicti481 – 4811S → F1 PublicationCurated
    Sequence conflicti602 – 6054YAQE → TPRK1 PublicationCurated
    Sequence conflicti663 – 6631V → E in BAC40211. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089089 mRNA. Translation: AAG17967.1.
    AF203031 Genomic DNA. Translation: AAL54919.1.
    AF126867 mRNA. Translation: AAD41779.1.
    AK088207 mRNA. Translation: BAC40211.1.
    BC005681 mRNA. Translation: AAH05681.1.
    BC010969 mRNA. Translation: AAH10969.1.
    CCDSiCCDS15181.1.
    RefSeqiNP_035926.2. NM_011796.2.
    UniGeneiMm.294315.

    Genome annotation databases

    EnsembliENSMUST00000027488; ENSMUSP00000027488; ENSMUSG00000026270.
    GeneIDi23830.
    KEGGimmu:23830.
    UCSCiuc007cby.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF089089 mRNA. Translation: AAG17967.1 .
    AF203031 Genomic DNA. Translation: AAL54919.1 .
    AF126867 mRNA. Translation: AAD41779.1 .
    AK088207 mRNA. Translation: BAC40211.1 .
    BC005681 mRNA. Translation: AAH05681.1 .
    BC010969 mRNA. Translation: AAH10969.1 .
    CCDSi CCDS15181.1.
    RefSeqi NP_035926.2. NM_011796.2.
    UniGenei Mm.294315.

    3D structure databases

    ProteinModelPortali Q9ESK3.
    SMRi Q9ESK3. Positions 10-484, 508-632.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C02.018.

    PTM databases

    PhosphoSitei Q9ESK3.

    Proteomic databases

    PaxDbi Q9ESK3.
    PRIDEi Q9ESK3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000027488 ; ENSMUSP00000027488 ; ENSMUSG00000026270 .
    GeneIDi 23830.
    KEGGi mmu:23830.
    UCSCi uc007cby.1. mouse.

    Organism-specific databases

    CTDi 11132.
    MGIi MGI:1344392. Capn10.

    Phylogenomic databases

    eggNOGi NOG313372.
    GeneTreei ENSGT00750000117383.
    HOGENOMi HOG000081807.
    HOVERGENi HBG050787.
    InParanoidi Q9ESK3.
    KOi K08579.
    OMAi VHLRCEL.
    OrthoDBi EOG7RV9FM.
    PhylomeDBi Q9ESK3.
    TreeFami TF314748.

    Miscellaneous databases

    NextBioi 303493.
    PROi Q9ESK3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ESK3.
    CleanExi MM_CAPN10.
    MM_CAPN8.
    Genevestigatori Q9ESK3.

    Family and domain databases

    InterProi IPR022684. Calpain_cysteine_protease.
    IPR022682. Calpain_domain_III.
    IPR022683. Calpain_III.
    IPR028791. CAPN10.
    IPR000169. Pept_cys_AS.
    IPR001300. Peptidase_C2_calpain_cat.
    [Graphical view ]
    PANTHERi PTHR10183:SF30. PTHR10183:SF30. 1 hit.
    Pfami PF01067. Calpain_III. 2 hits.
    PF00648. Peptidase_C2. 1 hit.
    [Graphical view ]
    PRINTSi PR00704. CALPAIN.
    SMARTi SM00720. calpain_III. 2 hits.
    SM00230. CysPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49758. SSF49758. 2 hits.
    PROSITEi PS50203. CALPAIN_CAT. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning of mouse protease gene."
      Horikawa Y., Ye H., Bell G.I.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: 129/SvJ.
    3. "Identification of a new calpain-like cDNA in mouse lung."
      Braun C., Seifert M., Engel M., Welter C.
      Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Lung.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: NOD.
      Tissue: Thymus.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiCAN10_MOUSE
    AccessioniPrimary (citable) accession number: Q9ESK3
    Secondary accession number(s): Q99J13, Q9WVF0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2002
    Last sequence update: February 12, 2003
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3