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Q9ESK3 (CAN10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calpain-10

EC=3.4.22.-
Alternative name(s):
Calcium-activated neutral proteinase 10
Short name=CANP 10
Gene names
Name:Capn10
Synonyms:Capn8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length666 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake By similarity.

Catalytic activity

Broad endopeptidase specificity.

Sequence similarities

Belongs to the peptidase C2 family.

Contains 1 calpain catalytic domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 666666Calpain-10
PRO_0000207727

Regions

Domain13 – 321309Calpain catalytic
Region322 – 488167Domain III 1
Region507 – 648142Domain III 2

Sites

Active site731 By similarity
Active site2381 By similarity
Active site2631 By similarity

Experimental info

Sequence conflict4811S → F Ref.1
Sequence conflict4811S → F Ref.2
Sequence conflict602 – 6054YAQE → TPRK Ref.3
Sequence conflict6631V → E in BAC40211. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q9ESK3 [UniParc].

Last modified February 12, 2003. Version 2.
Checksum: A0B1B37EE1DE2371

FASTA66674,596
        10         20         30         40         50         60 
MRAVRAETPA RELFRDAAFP ASDSSLFYNL STPLAQFRED ITWRRPQEIC ATPQLFPDNP 

        70         80         90        100        110        120 
WEGQVKQGLL GDCWFLCACA ALQKSQHLLD QVFPPGQPGW SDQKYQGFFT CRIWQFGHWE 

       130        140        150        160        170        180 
EVTIDDRLPC LAGRLCFSRC QREDVFWLPL LEKAYAKVHG SYEHLWAGQV ADALVDLTGS 

       190        200        210        220        230        240 
LAERWSLKDV TKASGQQDRP SGGEHRTCRQ LLHLKDRCLI SCSVLSPRAG ARELGEFHAF 

       250        260        270        280        290        300 
IISDLQELRS QTGQGILLLR IHNPWGRRCW QGLWREGGEG WNQVEPAKES ELLAQLQEGE 

       310        320        330        340        350        360 
FWVEEEEFLR EFDEVTIGYP VTEAGHLQSL HTERVLCHTR TLPGAWVTGQ SAGGCRNNSC 

       370        380        390        400        410        420 
FPCNPKFWLR LLEPSEVCVA VLQRPRRRLV GQTRALAGAS PAPVNLPGKD YQAVGLHIWK 

       430        440        450        460        470        480 
VEKRKISLPR VLSAPPVAGT ACHAYDREIH LRCELSPGYY LAVPSTFLKD VPGQFLLRVF 

       490        500        510        520        530        540 
STGKISLSAV RLATKGASPG TALPAGEWET VQLQGCWRAG QTAGGSRNFA SYPCNPCLPF 

       550        560        570        580        590        600 
SVPEGAGPRY IRITLQQHCR LSDSQLHPIG FHVFQVPADG ENQDACSLLL QEPLLSCVPH 

       610        620        630        640        650        660 
RYAQEVSRLC LLSVGNYRIV PSTYLPDTEG TFTVTIATRI DRQSIHSQEM LGQLLQEVSF 


MAVMKA 

« Hide

References

« Hide 'large scale' references
[1]"Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus."
Horikawa Y., Oda N., Cox N.J., Li X., Orho-Melander M., Hara M., Hinokio Y., Lindner T.H., Mashima H., Schwarz P.E.H., del Bosque-Plata L., Horikawa Y., Oda Y., Yoshiuchi I., Colilla S., Polonsky K.S., Wei S., Concannon P. expand/collapse author list , Iwasaki N., Schulze J., Baier L.J., Bogardus C., Groop L., Boerwinkle E., Hanis C.L., Bell G.I.
Nat. Genet. 26:163-175(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Cloning of mouse protease gene."
Horikawa Y., Ye H., Bell G.I.
Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 129/SvJ.
[3]"Identification of a new calpain-like cDNA in mouse lung."
Braun C., Seifert M., Engel M., Welter C.
Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Lung.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
Tissue: Thymus.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF089089 mRNA. Translation: AAG17967.1.
AF203031 Genomic DNA. Translation: AAL54919.1.
AF126867 mRNA. Translation: AAD41779.1.
AK088207 mRNA. Translation: BAC40211.1.
BC005681 mRNA. Translation: AAH05681.1.
BC010969 mRNA. Translation: AAH10969.1.
RefSeqNP_035926.2. NM_011796.2.
UniGeneMm.294315.

3D structure databases

ProteinModelPortalQ9ESK3.
SMRQ9ESK3. Positions 10-484, 508-632.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC02.018.

PTM databases

PhosphoSiteQ9ESK3.

Proteomic databases

PaxDbQ9ESK3.
PRIDEQ9ESK3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000027488; ENSMUSP00000027488; ENSMUSG00000026270.
GeneID23830.
KEGGmmu:23830.
UCSCuc007cby.1. mouse.

Organism-specific databases

CTD11132.
MGIMGI:1344392. Capn10.

Phylogenomic databases

eggNOGNOG313372.
GeneTreeENSGT00750000117383.
HOGENOMHOG000081807.
HOVERGENHBG050787.
InParanoidQ9ESK3.
KOK08579.
OMAVHLRCEL.
OrthoDBEOG7RV9FM.
PhylomeDBQ9ESK3.
TreeFamTF314748.

Gene expression databases

BgeeQ9ESK3.
CleanExMM_CAPN10.
MM_CAPN8.
GenevestigatorQ9ESK3.

Family and domain databases

InterProIPR022684. Calpain_cysteine_protease.
IPR022682. Calpain_domain_III.
IPR022683. Calpain_III.
IPR028791. CAPN10.
IPR000169. Pept_cys_AS.
IPR001300. Peptidase_C2_calpain_cat.
[Graphical view]
PANTHERPTHR10183:SF30. PTHR10183:SF30. 1 hit.
PfamPF01067. Calpain_III. 2 hits.
PF00648. Peptidase_C2. 1 hit.
[Graphical view]
PRINTSPR00704. CALPAIN.
SMARTSM00720. calpain_III. 2 hits.
SM00230. CysPc. 1 hit.
[Graphical view]
SUPFAMSSF49758. SSF49758. 2 hits.
PROSITEPS50203. CALPAIN_CAT. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio303493.
PROQ9ESK3.
SOURCESearch...

Entry information

Entry nameCAN10_MOUSE
AccessionPrimary (citable) accession number: Q9ESK3
Secondary accession number(s): Q99J13, Q9WVF0
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: February 12, 2003
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot