ID   Q9ESJ3_RAT              Unreviewed;       326 AA.
AC   Q9ESJ3;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=Melatonin receptor type 1A {ECO:0000256|ARBA:ARBA00040985};
DE   Flags: Fragment;
GN   Name=Mtnr1a {ECO:0000313|RGD:620797};
GN   Synonyms=MT1 {ECO:0000313|EMBL:AAG18471.1};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAG18471.1};
RN   [1] {ECO:0000313|EMBL:AAG18471.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Wistar {ECO:0000313|EMBL:AAG18471.1};
RX   PubMed=12133595; DOI=10.1016/S0006-8993(02)02824-X;
RA   Poirel V.J., Masson-Pevet M., Pevet P., Gauer F.;
RT   "MT1 melatonin receptor mRNA expression exhibits a circadian variation in
RT   the rat suprachiasmatic nuclei.";
RL   Brain Res. 946:64-71(2002).
CC   -!- FUNCTION: High affinity receptor for melatonin. Likely to mediate the
CC       reproductive and circadian actions of melatonin. The activity of this
CC       receptor is mediated by pertussis toxin sensitive G proteins that
CC       inhibit adenylate cyclase activity. {ECO:0000256|ARBA:ARBA00025159}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
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DR   EMBL; AF130341; AAG18471.1; -; mRNA.
DR   AlphaFoldDB; Q9ESJ3; -.
DR   SMR; Q9ESJ3; -.
DR   RGD; 620797; Mtnr1a.
DR   PhylomeDB; Q9ESJ3; -.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008502; F:melatonin receptor activity; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002278; Mel_1A/1B_rcpt.
DR   InterPro; IPR000025; Melatonin_rcpt.
DR   PANTHER; PTHR24228; B2 BRADYKININ RECEPTOR/ANGIOTENSIN II RECEPTOR; 1.
DR   PANTHER; PTHR24228:SF53; MELATONIN RECEPTOR TYPE 1A; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01149; MELATONIN1AR.
DR   PRINTS; PR00857; MELATONINR.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU000688};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        26..48
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        60..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        98..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        185..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        232..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        271..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          40..291
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAG18471.1"
FT   NON_TER         326
FT                   /evidence="ECO:0000313|EMBL:AAG18471.1"
SQ   SEQUENCE   326 AA;  36911 MW;  1D69D8CF39A2E59F CRC64;
     LLNASQQAPG GGVEIRSRPS WLASTLAFIL IFTIVVDILG NLLVILSVYR NKKLRNAGNI
     FVASLAVADL VVAIYPFPWA LTSILNNGWN LGYLHCQVSA FLMGLSVIGS VFNITGIAMN
     RYCYICHSLK YDRIYSNKNS LCYVFLIWTL TLIAIMPNLQ TGTLQYDPRI YSCTFTQSVS
     SAYTIALVVF HFVVPMIIVT FCYLRIWILV LQVRRRVKPD SKPKLKPQDF RNFVTMFVVF
     VLFALCWAPL NFIGLIVASD PATMAPRIPE WLFVASYYLA YFNSCLNAII YGLLNQNFRK
     EYKRIIISLC TAKMFFVDSS NDAADK
//