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Q9ESJ1

- CABL1_MOUSE

UniProt

Q9ESJ1 - CABL1_MOUSE

Protein

CDK5 and ABL1 enzyme substrate 1

Gene

Cables1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death By similarity.By similarity

    GO - Molecular functioni

    1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro
    2. protein binding Source: IntAct

    GO - Biological processi

    1. cell division Source: UniProtKB-KW
    2. G1/S transition of mitotic cell cycle Source: MGI
    3. nervous system development Source: MGI
    4. regulation of cell cycle Source: MGI
    5. regulation of cell division Source: InterPro

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division

    Enzyme and pathway databases

    ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CDK5 and ABL1 enzyme substrate 1
    Alternative name(s):
    Interactor with CDK3 1
    Short name:
    Ik3-1
    Gene namesi
    Name:Cables1
    Synonyms:Cables
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1927065. Cables1.

    Subcellular locationi

    Nucleus. Cytoplasm. Cell projectiongrowth cone
    Note: Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons.

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. growth cone Source: UniProtKB-SubCell
    3. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi274 – 2741S → A: Less efficiently phosphorylated in vitro. 1 Publication
    Mutagenesisi274 – 2741S → T: Efficiently phosphorylated in vitro. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 568568CDK5 and ABL1 enzyme substrate 1PRO_0000080511Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei248 – 2481PhosphoserineBy similarity
    Modified residuei274 – 2741Phosphoserine; by CDK2 and CDK31 Publication
    Modified residuei350 – 3501PhosphothreonineBy similarity

    Post-translational modificationi

    Phosphorylated on Ser-274 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3.2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9ESJ1.

    PTM databases

    PhosphoSiteiQ9ESJ1.

    Expressioni

    Tissue specificityi

    Ubiquitous. Expressed in postnatal day 1 (P1), in postmitotic neurons of the subplate, cortex (V/VI) and marginal zone; in postnatal day 7 (P7), in all layers of the cerebral cortex and in the CA1 and CA2 regions of the hippocampus (at protein level). Highly expressed in brain, kidney, liver and lung.2 Publications

    Developmental stagei

    Expressed in embryo at 15 dpc and strongly expressed in postmitotic neurons of the subplate, cortical plate, subventrical and marginal zones at 18 dpc (at protein level). Expressed in embryo at 7 dpc onwards.1 Publication

    Gene expression databases

    ArrayExpressiQ9ESJ1.
    BgeeiQ9ESJ1.
    CleanExiMM_CABLES1.
    GenevestigatoriQ9ESJ1.

    Interactioni

    Subunit structurei

    Found in a complex with p53/TP53 By similarity. Found in a number of complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, CDK17, CCNA1, CCNE1 and TP73. Interacts with CDK2, CDK3, CDK5, ABL1 and TDRD7.By similarity5 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TP53P046373EBI-604411,EBI-366083From a different organism.
    Tp63O888982EBI-604411,EBI-2338025
    TP73O153503EBI-604411,EBI-389606From a different organism.

    Protein-protein interaction databases

    IntActiQ9ESJ1. 3 interactions.
    MINTiMINT-6615591.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ESJ1.
    SMRiQ9ESJ1. Positions 437-564.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9898Interacts with TDRD7Add
    BLAST
    Regioni140 – 427288Interacts with CDK3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi34 – 5421Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the cyclin family.Curated

    Phylogenomic databases

    eggNOGiNOG256533.
    GeneTreeiENSGT00400000022086.
    HOGENOMiHOG000231236.
    HOVERGENiHBG050759.
    InParanoidiQ9ESJ1.

    Family and domain databases

    Gene3Di1.10.472.10. 1 hit.
    InterProiIPR012388. Cdk5/c-Abl_linker_Cables.
    IPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    [Graphical view]
    PfamiPF00134. Cyclin_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF025798. Cables. 1 hit.
    SMARTiSM00385. CYCLIN. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9ESJ1-1 [UniParc]FASTAAdd to Basket

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    MAAATATAGT AACSSSSSSR GGSTDAAATS GVQPPPPPPA TAPPEPLRKP    50
    RMDPRRRQAA LSFLTNISLD GRPPLQDHEW GGGEEGGGTK PGARARLSLL 100
    AAGCNAFSAP GTAAAPWTAG SGSSPCPLPP SLVPRVLGEP SQPPRSAPAV 150
    TGAQLQLPDG PGGAGQEELE EDDAFTNVQV PSASFLGSGT PGSTSGSRGR 200
    LNSFTQGILP IAFSRQNSQN YCALEQSGQG GSTSALEQLQ RSRRRLISQR 250
    SSLETLEDIE ENAPLRRCRT LSGSPRPKNF KKIHFIKNMR QHDTKNGRDL 300
    KLDGGRQSAG AMSLKEIIGL EGVELGADGK TVSYTQFLLP TNAFGNRRNT 350
    IDSTASFSQF RSLSHRSLSM GRAGSTQGSL DAGSDLGDFM DYDPNLLDDP 400
    QWPCGKHKRV LTFPSYMTTV IDYVKPSDLK KDMNETFKEK FPHIKLTLSK 450
    IRSLKREMRK LAQEDCGFEE PTVAMAFVYF EKLALRGKLN KQNRKLCAGA 500
    CVLLAAKVGS DLRKHEVKHL IDKLEEKFRL NRRELIAFEF PVLVALEFAL 550
    HLPEHEVMPH YRRLIQSS 568
    Length:568
    Mass (Da):61,429
    Last modified:July 27, 2011 - v2
    Checksum:iA5B8131FCDAD1B7D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti84 – 852EE → DQ in AAG33933. (PubMed:10896159)Curated
    Sequence conflicti242 – 2421S → A in AAG33933. (PubMed:10896159)Curated
    Sequence conflicti384 – 3841S → C in AAG33933. (PubMed:10896159)Curated
    Sequence conflicti390 – 3901M → V in AAG33933. (PubMed:10896159)Curated
    Sequence conflicti390 – 3901M → V in AAG42916. (PubMed:10873625)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133208 mRNA. Translation: AAG33933.1.
    AF328140 mRNA. Translation: AAG42916.1.
    AC100751 Genomic DNA. No translation available.
    AC132941 Genomic DNA. No translation available.
    CCDSiCCDS29061.1.
    PIRiJC7317.
    RefSeqiNP_071304.2. NM_022021.2.
    UniGeneiMm.40717.

    Genome annotation databases

    EnsembliENSMUST00000046948; ENSMUSP00000040639; ENSMUSG00000040957.
    GeneIDi63955.
    KEGGimmu:63955.
    UCSCiuc012azi.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF133208 mRNA. Translation: AAG33933.1 .
    AF328140 mRNA. Translation: AAG42916.1 .
    AC100751 Genomic DNA. No translation available.
    AC132941 Genomic DNA. No translation available.
    CCDSi CCDS29061.1.
    PIRi JC7317.
    RefSeqi NP_071304.2. NM_022021.2.
    UniGenei Mm.40717.

    3D structure databases

    ProteinModelPortali Q9ESJ1.
    SMRi Q9ESJ1. Positions 437-564.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9ESJ1. 3 interactions.
    MINTi MINT-6615591.

    PTM databases

    PhosphoSitei Q9ESJ1.

    Proteomic databases

    PRIDEi Q9ESJ1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046948 ; ENSMUSP00000040639 ; ENSMUSG00000040957 .
    GeneIDi 63955.
    KEGGi mmu:63955.
    UCSCi uc012azi.1. mouse.

    Organism-specific databases

    CTDi 91768.
    MGIi MGI:1927065. Cables1.

    Phylogenomic databases

    eggNOGi NOG256533.
    GeneTreei ENSGT00400000022086.
    HOGENOMi HOG000231236.
    HOVERGENi HBG050759.
    InParanoidi Q9ESJ1.

    Enzyme and pathway databases

    Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

    Miscellaneous databases

    NextBioi 319819.
    PROi Q9ESJ1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ESJ1.
    Bgeei Q9ESJ1.
    CleanExi MM_CABLES1.
    Genevestigatori Q9ESJ1.

    Family and domain databases

    Gene3Di 1.10.472.10. 1 hit.
    InterProi IPR012388. Cdk5/c-Abl_linker_Cables.
    IPR013763. Cyclin-like.
    IPR006671. Cyclin_N.
    [Graphical view ]
    Pfami PF00134. Cyclin_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF025798. Cables. 1 hit.
    SMARTi SM00385. CYCLIN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth."
      Zukerberg L.R., Patrick G.N., Nikolic M., Humbert S., Wu C.-L., Lanier L.M., Gertler F.B., Vidal M., Van Etten R.A., Tsai L.-H.
      Neuron 26:633-646(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, PHOSPHORYLATION BY CDK5 AND ABL1, IDENTIFICATION IN A TRIMOLECULAR COMPLEX WITH CDK5 AND ABL1, INTERACTION WITH CDK5 AND ABL1.
      Tissue: Brain.
    2. "Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo."
      Matsuoka M., Matsuura Y., Semba K., Nishimoto I.
      Biochem. Biophys. Res. Commun. 273:442-447(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROBABLE FUNCTION IN G1-S CELL CYCLE TRANSITION, TISSUE SPECIFICITY, INTERACTION WITH CDK3.
      Strain: BALB/c.
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Cited for: PHOSPHORYLATION BY CCNA1/CDK2; CCNE1/CDK2; CCNA1/CDK3 AND CCNE1/CDK3, PHOSPHORYLATION AT SER-274, MUTAGENESIS OF SER-274.
    5. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TDRD7, IDENTIFICATION IN A COMPLEX WITH TDRD7 AND CDK17.
    6. "Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers."
      Wu C.-L., Kirley S.D., Xiao H., Chuang Y., Chung D.C., Zukerberg L.R.
      Cancer Res. 61:7325-7332(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH CDK2; CCNA1 AND CCNE1, INTERACTION WITH CDK2.
    7. "Differential effect of ik3-1/cables on p53- and p73-induced cell death."
      Tsuji K., Mizumoto K., Yamochi T., Nishimoto I., Matsuoka M.
      J. Biol. Chem. 277:2951-2957(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN CELL DEATH, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH TP53 AND TP73.

    Entry informationi

    Entry nameiCABL1_MOUSE
    AccessioniPrimary (citable) accession number: Q9ESJ1
    Secondary accession number(s): E9QNI6, Q9EPR8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 1, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    PubMed:10896159 demonstrated that CABLES1 is not associated with CDK3.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3