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Protein

CDK5 and ABL1 enzyme substrate 1

Gene

Cables1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).By similarity1 Publication

GO - Biological processi

  • blood coagulation Source: Reactome
  • cell division Source: UniProtKB-KW
  • G1/S transition of mitotic cell cycle Source: MGI
  • nervous system development Source: MGI
  • regulation of cell cycle Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiR-MMU-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
CDK5 and ABL1 enzyme substrate 1
Alternative name(s):
Interactor with CDK3 1
Short name:
Ik3-1
Gene namesi
Name:Cables1
Synonyms:Cables
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1927065. Cables1.

Subcellular locationi

  • Nucleus
  • Cytoplasm
  • Cell projectiongrowth cone

  • Note: Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi274S → A: Less efficiently phosphorylated in vitro. 1 Publication1
Mutagenesisi274S → T: Efficiently phosphorylated in vitro. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805111 – 568CDK5 and ABL1 enzyme substrate 1Add BLAST568

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei248PhosphoserineBy similarity1
Modified residuei274Phosphoserine; by CDK2 and CDK31 Publication1
Modified residuei350PhosphothreonineCombined sources1

Post-translational modificationi

Phosphorylated on Ser-274 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ESJ1.
PaxDbiQ9ESJ1.
PRIDEiQ9ESJ1.

PTM databases

iPTMnetiQ9ESJ1.
PhosphoSitePlusiQ9ESJ1.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in postnatal day 1 (P1), in postmitotic neurons of the subplate, cortex (V/VI) and marginal zone; in postnatal day 7 (P7), in all layers of the cerebral cortex and in the CA1 and CA2 regions of the hippocampus (at protein level). Highly expressed in brain, kidney, liver and lung.2 Publications

Developmental stagei

Expressed in embryo at 15 dpc and strongly expressed in postmitotic neurons of the subplate, cortical plate, subventrical and marginal zones at 18 dpc (at protein level). Expressed in embryo at 7 dpc onwards.1 Publication

Gene expression databases

BgeeiENSMUSG00000040957.
CleanExiMM_CABLES1.
ExpressionAtlasiQ9ESJ1. baseline and differential.
GenevisibleiQ9ESJ1. MM.

Interactioni

Subunit structurei

Found in a complex with p53/TP53 (By similarity). Found in a number of complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, CDK17, CCNA1, CCNE1 and TP73. Interacts with CDK2, CDK3, CDK5, ABL1 and TDRD7.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046373EBI-604411,EBI-366083From a different organism.
Tp63O888982EBI-604411,EBI-2338025
TP73O153503EBI-604411,EBI-389606From a different organism.

Protein-protein interaction databases

IntActiQ9ESJ1. 3 interactors.
MINTiMINT-6615591.
STRINGi10090.ENSMUSP00000129463.

Structurei

3D structure databases

ProteinModelPortaliQ9ESJ1.
SMRiQ9ESJ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 98Interaction with TDRD71 PublicationAdd BLAST98
Regioni140 – 427Interaction with CDK31 PublicationAdd BLAST288

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 54Pro-richAdd BLAST21

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiKOG4164. Eukaryota.
ENOG4110WYV. LUCA.
GeneTreeiENSGT00400000022086.
HOGENOMiHOG000231236.
HOVERGENiHBG050759.
InParanoidiQ9ESJ1.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR012388. CABLES1/2.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR22896. PTHR22896. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ESJ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAATATAGT AACSSSSSSR GGSTDAAATS GVQPPPPPPA TAPPEPLRKP
60 70 80 90 100
RMDPRRRQAA LSFLTNISLD GRPPLQDHEW GGGEEGGGTK PGARARLSLL
110 120 130 140 150
AAGCNAFSAP GTAAAPWTAG SGSSPCPLPP SLVPRVLGEP SQPPRSAPAV
160 170 180 190 200
TGAQLQLPDG PGGAGQEELE EDDAFTNVQV PSASFLGSGT PGSTSGSRGR
210 220 230 240 250
LNSFTQGILP IAFSRQNSQN YCALEQSGQG GSTSALEQLQ RSRRRLISQR
260 270 280 290 300
SSLETLEDIE ENAPLRRCRT LSGSPRPKNF KKIHFIKNMR QHDTKNGRDL
310 320 330 340 350
KLDGGRQSAG AMSLKEIIGL EGVELGADGK TVSYTQFLLP TNAFGNRRNT
360 370 380 390 400
IDSTASFSQF RSLSHRSLSM GRAGSTQGSL DAGSDLGDFM DYDPNLLDDP
410 420 430 440 450
QWPCGKHKRV LTFPSYMTTV IDYVKPSDLK KDMNETFKEK FPHIKLTLSK
460 470 480 490 500
IRSLKREMRK LAQEDCGFEE PTVAMAFVYF EKLALRGKLN KQNRKLCAGA
510 520 530 540 550
CVLLAAKVGS DLRKHEVKHL IDKLEEKFRL NRRELIAFEF PVLVALEFAL
560
HLPEHEVMPH YRRLIQSS
Length:568
Mass (Da):61,429
Last modified:July 27, 2011 - v2
Checksum:iA5B8131FCDAD1B7D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti84 – 85EE → DQ in AAG33933 (PubMed:10896159).Curated2
Sequence conflicti242S → A in AAG33933 (PubMed:10896159).Curated1
Sequence conflicti384S → C in AAG33933 (PubMed:10896159).Curated1
Sequence conflicti390M → V in AAG33933 (PubMed:10896159).Curated1
Sequence conflicti390M → V in AAG42916 (PubMed:10873625).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133208 mRNA. Translation: AAG33933.1.
AF328140 mRNA. Translation: AAG42916.1.
AC100751 Genomic DNA. No translation available.
AC132941 Genomic DNA. No translation available.
CCDSiCCDS29061.1.
PIRiJC7317.
RefSeqiNP_071304.2. NM_022021.2.
UniGeneiMm.40717.

Genome annotation databases

EnsembliENSMUST00000046948; ENSMUSP00000040639; ENSMUSG00000040957.
GeneIDi63955.
KEGGimmu:63955.
UCSCiuc012azi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133208 mRNA. Translation: AAG33933.1.
AF328140 mRNA. Translation: AAG42916.1.
AC100751 Genomic DNA. No translation available.
AC132941 Genomic DNA. No translation available.
CCDSiCCDS29061.1.
PIRiJC7317.
RefSeqiNP_071304.2. NM_022021.2.
UniGeneiMm.40717.

3D structure databases

ProteinModelPortaliQ9ESJ1.
SMRiQ9ESJ1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ESJ1. 3 interactors.
MINTiMINT-6615591.
STRINGi10090.ENSMUSP00000129463.

PTM databases

iPTMnetiQ9ESJ1.
PhosphoSitePlusiQ9ESJ1.

Proteomic databases

MaxQBiQ9ESJ1.
PaxDbiQ9ESJ1.
PRIDEiQ9ESJ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046948; ENSMUSP00000040639; ENSMUSG00000040957.
GeneIDi63955.
KEGGimmu:63955.
UCSCiuc012azi.1. mouse.

Organism-specific databases

CTDi91768.
MGIiMGI:1927065. Cables1.

Phylogenomic databases

eggNOGiKOG4164. Eukaryota.
ENOG4110WYV. LUCA.
GeneTreeiENSGT00400000022086.
HOGENOMiHOG000231236.
HOVERGENiHBG050759.
InParanoidiQ9ESJ1.

Enzyme and pathway databases

ReactomeiR-MMU-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

PROiQ9ESJ1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000040957.
CleanExiMM_CABLES1.
ExpressionAtlasiQ9ESJ1. baseline and differential.
GenevisibleiQ9ESJ1. MM.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR012388. CABLES1/2.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PANTHERiPTHR22896. PTHR22896. 1 hit.
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCABL1_MOUSE
AccessioniPrimary (citable) accession number: Q9ESJ1
Secondary accession number(s): E9QNI6, Q9EPR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

PubMed:10896159 demonstrated that CABLES1 is not associated with CDK3.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.