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Q9ESJ1

- CABL1_MOUSE

UniProt

Q9ESJ1 - CABL1_MOUSE

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Protein

CDK5 and ABL1 enzyme substrate 1

Gene

Cables1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity).By similarity

GO - Molecular functioni

  1. cyclin-dependent protein serine/threonine kinase regulator activity Source: InterPro

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. G1/S transition of mitotic cell cycle Source: MGI
  3. nervous system development Source: MGI
  4. regulation of cell cycle Source: MGI
  5. regulation of cell division Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division

Enzyme and pathway databases

ReactomeiREACT_198649. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
CDK5 and ABL1 enzyme substrate 1
Alternative name(s):
Interactor with CDK3 1
Short name:
Ik3-1
Gene namesi
Name:Cables1
Synonyms:Cables
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1927065. Cables1.

Subcellular locationi

Nucleus. Cytoplasm. Cell projectiongrowth cone
Note: Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons.

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytosol Source: Reactome
  3. nucleoplasm Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi274 – 2741S → A: Less efficiently phosphorylated in vitro. 1 Publication
Mutagenesisi274 – 2741S → T: Efficiently phosphorylated in vitro. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568CDK5 and ABL1 enzyme substrate 1PRO_0000080511Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei248 – 2481PhosphoserineBy similarity
Modified residuei274 – 2741Phosphoserine; by CDK2 and CDK31 Publication
Modified residuei350 – 3501PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated on Ser-274 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ESJ1.
PRIDEiQ9ESJ1.

PTM databases

PhosphoSiteiQ9ESJ1.

Expressioni

Tissue specificityi

Ubiquitous. Expressed in postnatal day 1 (P1), in postmitotic neurons of the subplate, cortex (V/VI) and marginal zone; in postnatal day 7 (P7), in all layers of the cerebral cortex and in the CA1 and CA2 regions of the hippocampus (at protein level). Highly expressed in brain, kidney, liver and lung.2 Publications

Developmental stagei

Expressed in embryo at 15 dpc and strongly expressed in postmitotic neurons of the subplate, cortical plate, subventrical and marginal zones at 18 dpc (at protein level). Expressed in embryo at 7 dpc onwards.1 Publication

Gene expression databases

BgeeiQ9ESJ1.
CleanExiMM_CABLES1.
ExpressionAtlasiQ9ESJ1. baseline and differential.
GenevestigatoriQ9ESJ1.

Interactioni

Subunit structurei

Found in a complex with p53/TP53 (By similarity). Found in a number of complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, CDK17, CCNA1, CCNE1 and TP73. Interacts with CDK2, CDK3, CDK5, ABL1 and TDRD7.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TP53P046373EBI-604411,EBI-366083From a different organism.
Tp63O888982EBI-604411,EBI-2338025
TP73O153503EBI-604411,EBI-389606From a different organism.

Protein-protein interaction databases

IntActiQ9ESJ1. 3 interactions.
MINTiMINT-6615591.

Structurei

3D structure databases

ProteinModelPortaliQ9ESJ1.
SMRiQ9ESJ1. Positions 437-564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9898Interacts with TDRD7Add
BLAST
Regioni140 – 427288Interacts with CDK3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 5421Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the cyclin family.Curated

Phylogenomic databases

eggNOGiNOG256533.
GeneTreeiENSGT00400000022086.
HOGENOMiHOG000231236.
HOVERGENiHBG050759.
InParanoidiQ9ESJ1.

Family and domain databases

Gene3Di1.10.472.10. 1 hit.
InterProiIPR012388. Cdk5/c-Abl_linker_Cables.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PfamiPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFiPIRSF025798. Cables. 1 hit.
SMARTiSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ESJ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAATATAGT AACSSSSSSR GGSTDAAATS GVQPPPPPPA TAPPEPLRKP
60 70 80 90 100
RMDPRRRQAA LSFLTNISLD GRPPLQDHEW GGGEEGGGTK PGARARLSLL
110 120 130 140 150
AAGCNAFSAP GTAAAPWTAG SGSSPCPLPP SLVPRVLGEP SQPPRSAPAV
160 170 180 190 200
TGAQLQLPDG PGGAGQEELE EDDAFTNVQV PSASFLGSGT PGSTSGSRGR
210 220 230 240 250
LNSFTQGILP IAFSRQNSQN YCALEQSGQG GSTSALEQLQ RSRRRLISQR
260 270 280 290 300
SSLETLEDIE ENAPLRRCRT LSGSPRPKNF KKIHFIKNMR QHDTKNGRDL
310 320 330 340 350
KLDGGRQSAG AMSLKEIIGL EGVELGADGK TVSYTQFLLP TNAFGNRRNT
360 370 380 390 400
IDSTASFSQF RSLSHRSLSM GRAGSTQGSL DAGSDLGDFM DYDPNLLDDP
410 420 430 440 450
QWPCGKHKRV LTFPSYMTTV IDYVKPSDLK KDMNETFKEK FPHIKLTLSK
460 470 480 490 500
IRSLKREMRK LAQEDCGFEE PTVAMAFVYF EKLALRGKLN KQNRKLCAGA
510 520 530 540 550
CVLLAAKVGS DLRKHEVKHL IDKLEEKFRL NRRELIAFEF PVLVALEFAL
560
HLPEHEVMPH YRRLIQSS
Length:568
Mass (Da):61,429
Last modified:July 27, 2011 - v2
Checksum:iA5B8131FCDAD1B7D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti84 – 852EE → DQ in AAG33933. (PubMed:10896159)Curated
Sequence conflicti242 – 2421S → A in AAG33933. (PubMed:10896159)Curated
Sequence conflicti384 – 3841S → C in AAG33933. (PubMed:10896159)Curated
Sequence conflicti390 – 3901M → V in AAG33933. (PubMed:10896159)Curated
Sequence conflicti390 – 3901M → V in AAG42916. (PubMed:10873625)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133208 mRNA. Translation: AAG33933.1.
AF328140 mRNA. Translation: AAG42916.1.
AC100751 Genomic DNA. No translation available.
AC132941 Genomic DNA. No translation available.
CCDSiCCDS29061.1.
PIRiJC7317.
RefSeqiNP_071304.2. NM_022021.2.
UniGeneiMm.40717.

Genome annotation databases

EnsembliENSMUST00000046948; ENSMUSP00000040639; ENSMUSG00000040957.
GeneIDi63955.
KEGGimmu:63955.
UCSCiuc012azi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133208 mRNA. Translation: AAG33933.1 .
AF328140 mRNA. Translation: AAG42916.1 .
AC100751 Genomic DNA. No translation available.
AC132941 Genomic DNA. No translation available.
CCDSi CCDS29061.1.
PIRi JC7317.
RefSeqi NP_071304.2. NM_022021.2.
UniGenei Mm.40717.

3D structure databases

ProteinModelPortali Q9ESJ1.
SMRi Q9ESJ1. Positions 437-564.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9ESJ1. 3 interactions.
MINTi MINT-6615591.

PTM databases

PhosphoSitei Q9ESJ1.

Proteomic databases

MaxQBi Q9ESJ1.
PRIDEi Q9ESJ1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046948 ; ENSMUSP00000040639 ; ENSMUSG00000040957 .
GeneIDi 63955.
KEGGi mmu:63955.
UCSCi uc012azi.1. mouse.

Organism-specific databases

CTDi 91768.
MGIi MGI:1927065. Cables1.

Phylogenomic databases

eggNOGi NOG256533.
GeneTreei ENSGT00400000022086.
HOGENOMi HOG000231236.
HOVERGENi HBG050759.
InParanoidi Q9ESJ1.

Enzyme and pathway databases

Reactomei REACT_198649. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

NextBioi 319819.
PROi Q9ESJ1.
SOURCEi Search...

Gene expression databases

Bgeei Q9ESJ1.
CleanExi MM_CABLES1.
ExpressionAtlasi Q9ESJ1. baseline and differential.
Genevestigatori Q9ESJ1.

Family and domain databases

Gene3Di 1.10.472.10. 1 hit.
InterProi IPR012388. Cdk5/c-Abl_linker_Cables.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view ]
Pfami PF00134. Cyclin_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF025798. Cables. 1 hit.
SMARTi SM00385. CYCLIN. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth."
    Zukerberg L.R., Patrick G.N., Nikolic M., Humbert S., Wu C.-L., Lanier L.M., Gertler F.B., Vidal M., Van Etten R.A., Tsai L.-H.
    Neuron 26:633-646(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, PHOSPHORYLATION BY CDK5 AND ABL1, IDENTIFICATION IN A TRIMOLECULAR COMPLEX WITH CDK5 AND ABL1, INTERACTION WITH CDK5 AND ABL1.
    Tissue: Brain.
  2. "Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo."
    Matsuoka M., Matsuura Y., Semba K., Nishimoto I.
    Biochem. Biophys. Res. Commun. 273:442-447(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROBABLE FUNCTION IN G1-S CELL CYCLE TRANSITION, TISSUE SPECIFICITY, INTERACTION WITH CDK3.
    Strain: BALB/c.
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Cited for: PHOSPHORYLATION BY CCNA1/CDK2; CCNE1/CDK2; CCNA1/CDK3 AND CCNE1/CDK3, PHOSPHORYLATION AT SER-274, MUTAGENESIS OF SER-274.
  5. Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TDRD7, IDENTIFICATION IN A COMPLEX WITH TDRD7 AND CDK17.
  6. "Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers."
    Wu C.-L., Kirley S.D., Xiao H., Chuang Y., Chung D.C., Zukerberg L.R.
    Cancer Res. 61:7325-7332(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH CDK2; CCNA1 AND CCNE1, INTERACTION WITH CDK2.
  7. "Differential effect of ik3-1/cables on p53- and p73-induced cell death."
    Tsuji K., Mizumoto K., Yamochi T., Nishimoto I., Matsuoka M.
    J. Biol. Chem. 277:2951-2957(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN CELL DEATH, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH TP53 AND TP73.

Entry informationi

Entry nameiCABL1_MOUSE
AccessioniPrimary (citable) accession number: Q9ESJ1
Secondary accession number(s): E9QNI6, Q9EPR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

PubMed:10896159 demonstrated that CABLES1 is not associated with CDK3.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3