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Q9ESJ1 (CABL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CDK5 and ABL1 enzyme substrate 1
Alternative name(s):
Interactor with CDK3 1
Short name=Ik3-1
Gene names
Name:Cables1
Synonyms:Cables
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death By similarity. Ref.2 Ref.7

Subunit structure

Found in a complex with p53/TP53 By similarity. Found in a number of complexes with CDK2, CDK3, CDK5, ABL1, TDRD7, CDK17, CCNA1, CCNE1 and TP73. Interacts with CDK2, CDK3, CDK5, ABL1 and TDRD7. Ref.1 Ref.2 Ref.5 Ref.6 Ref.7

Subcellular location

Nucleus. Cytoplasm. Cell projectiongrowth cone. Note: Located in the cell body and proximal region of the developing axonal shaft of immature neurons. Located in axonal growth cone, but not in the distal part of the axon shaft or in dendritic growth cone of mature neurons. Ref.1 Ref.5 Ref.6 Ref.7

Tissue specificity

Ubiquitous. Expressed in postnatal day 1 (P1), in postmitotic neurons of the subplate, cortex (V/VI) and marginal zone; in postnatal day 7 (P7), in all layers of the cerebral cortex and in the CA1 and CA2 regions of the hippocampus (at protein level). Highly expressed in brain, kidney, liver and lung. Ref.1 Ref.2

Developmental stage

Expressed in embryo at 15 dpc and strongly expressed in postmitotic neurons of the subplate, cortical plate, subventrical and marginal zones at 18 dpc (at protein level). Expressed in embryo at 7 dpc onwards. Ref.1

Post-translational modification

Phosphorylated on Ser-274 by CCNE1/CDK3. Phosphorylated on serine/threonine residues by CDK5 and on tyrosine residues by ABL1. Also phosphorylated in vitro by CCNA1/CDK2, CCNE1/CDK2, CCNA1/CDK3 and CCNE1/CDK3. Ref.1 Ref.4

Sequence similarities

Belongs to the cyclin family.

Caution

Ref.1 demonstrated that CABLES1 is not associated with CDK3.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TP53P046373EBI-604411,EBI-366083From a different organism.
Tp63O888982EBI-604411,EBI-2338025
TP73O153503EBI-604411,EBI-389606From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 568568CDK5 and ABL1 enzyme substrate 1
PRO_0000080511

Regions

Region1 – 9898Interacts with TDRD7
Region140 – 427288Interacts with CDK3
Compositional bias34 – 5421Pro-rich

Amino acid modifications

Modified residue2481Phosphoserine By similarity
Modified residue2741Phosphoserine; by CDK2 and CDK3 Ref.4
Modified residue3501Phosphothreonine By similarity

Experimental info

Mutagenesis2741S → A: Less efficiently phosphorylated in vitro. Ref.4
Mutagenesis2741S → T: Efficiently phosphorylated in vitro. Ref.4
Sequence conflict84 – 852EE → DQ in AAG33933. Ref.1
Sequence conflict2421S → A in AAG33933. Ref.1
Sequence conflict3841S → C in AAG33933. Ref.1
Sequence conflict3901M → V in AAG33933. Ref.1
Sequence conflict3901M → V in AAG42916. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9ESJ1 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: A5B8131FCDAD1B7D

FASTA56861,429
        10         20         30         40         50         60 
MAAATATAGT AACSSSSSSR GGSTDAAATS GVQPPPPPPA TAPPEPLRKP RMDPRRRQAA 

        70         80         90        100        110        120 
LSFLTNISLD GRPPLQDHEW GGGEEGGGTK PGARARLSLL AAGCNAFSAP GTAAAPWTAG 

       130        140        150        160        170        180 
SGSSPCPLPP SLVPRVLGEP SQPPRSAPAV TGAQLQLPDG PGGAGQEELE EDDAFTNVQV 

       190        200        210        220        230        240 
PSASFLGSGT PGSTSGSRGR LNSFTQGILP IAFSRQNSQN YCALEQSGQG GSTSALEQLQ 

       250        260        270        280        290        300 
RSRRRLISQR SSLETLEDIE ENAPLRRCRT LSGSPRPKNF KKIHFIKNMR QHDTKNGRDL 

       310        320        330        340        350        360 
KLDGGRQSAG AMSLKEIIGL EGVELGADGK TVSYTQFLLP TNAFGNRRNT IDSTASFSQF 

       370        380        390        400        410        420 
RSLSHRSLSM GRAGSTQGSL DAGSDLGDFM DYDPNLLDDP QWPCGKHKRV LTFPSYMTTV 

       430        440        450        460        470        480 
IDYVKPSDLK KDMNETFKEK FPHIKLTLSK IRSLKREMRK LAQEDCGFEE PTVAMAFVYF 

       490        500        510        520        530        540 
EKLALRGKLN KQNRKLCAGA CVLLAAKVGS DLRKHEVKHL IDKLEEKFRL NRRELIAFEF 

       550        560 
PVLVALEFAL HLPEHEVMPH YRRLIQSS 

« Hide

References

« Hide 'large scale' references
[1]"Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth."
Zukerberg L.R., Patrick G.N., Nikolic M., Humbert S., Wu C.-L., Lanier L.M., Gertler F.B., Vidal M., Van Etten R.A., Tsai L.-H.
Neuron 26:633-646(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, PHOSPHORYLATION BY CDK5 AND ABL1, IDENTIFICATION IN A TRIMOLECULAR COMPLEX WITH CDK5 AND ABL1, INTERACTION WITH CDK5 AND ABL1.
Tissue: Brain.
[2]"Molecular cloning of a cyclin-like protein associated with cyclin-dependent kinase 3 (cdk 3) in vivo."
Matsuoka M., Matsuura Y., Semba K., Nishimoto I.
Biochem. Biophys. Res. Commun. 273:442-447(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROBABLE FUNCTION IN G1-S CELL CYCLE TRANSITION, TISSUE SPECIFICITY, INTERACTION WITH CDK3.
Strain: BALB/c.
Tissue: Brain.
[3]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[4]"ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)."
Yamochi T., Semba K., Tsuji K., Mizumoto K., Sato H., Matsuura Y., Nishimoto I., Matsuoka M.
Eur. J. Biochem. 268:6076-6082(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION BY CCNA1/CDK2; CCNE1/CDK2; CCNA1/CDK3 AND CCNE1/CDK3, PHOSPHORYLATION AT SER-274, MUTAGENESIS OF SER-274.
[5]"ik3-1/Cables is associated with Trap and Pctaire2."
Yamochi T., Nishimoto I., Okuda T., Matsuoka M.
Biochem. Biophys. Res. Commun. 286:1045-1050(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, INTERACTION WITH TDRD7, IDENTIFICATION IN A COMPLEX WITH TDRD7 AND CDK17.
[6]"Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers."
Wu C.-L., Kirley S.D., Xiao H., Chuang Y., Chung D.C., Zukerberg L.R.
Cancer Res. 61:7325-7332(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH CDK2; CCNA1 AND CCNE1, INTERACTION WITH CDK2.
[7]"Differential effect of ik3-1/cables on p53- and p73-induced cell death."
Tsuji K., Mizumoto K., Yamochi T., Nishimoto I., Matsuoka M.
J. Biol. Chem. 277:2951-2957(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION IN CELL DEATH, SUBCELLULAR LOCATION, IDENTIFICATION IN A COMPLEX WITH TP53 AND TP73.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF133208 mRNA. Translation: AAG33933.1.
AF328140 mRNA. Translation: AAG42916.1.
AC100751 Genomic DNA. No translation available.
AC132941 Genomic DNA. No translation available.
CCDSCCDS29061.1.
PIRJC7317.
RefSeqNP_071304.2. NM_022021.2.
UniGeneMm.40717.

3D structure databases

ProteinModelPortalQ9ESJ1.
SMRQ9ESJ1. Positions 437-564.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9ESJ1. 3 interactions.
MINTMINT-6615591.

PTM databases

PhosphoSiteQ9ESJ1.

Proteomic databases

PRIDEQ9ESJ1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046948; ENSMUSP00000040639; ENSMUSG00000040957.
GeneID63955.
KEGGmmu:63955.
UCSCuc012azi.1. mouse.

Organism-specific databases

CTD91768.
MGIMGI:1927065. Cables1.

Phylogenomic databases

eggNOGNOG256533.
GeneTreeENSGT00400000022086.
HOGENOMHOG000231236.
HOVERGENHBG050759.
InParanoidQ9ESJ1.

Enzyme and pathway databases

ReactomeREACT_224553. Hemostasis.

Gene expression databases

ArrayExpressQ9ESJ1.
BgeeQ9ESJ1.
CleanExMM_CABLES1.
GenevestigatorQ9ESJ1.

Family and domain databases

Gene3D1.10.472.10. 1 hit.
InterProIPR012388. Cdk5/c-Abl_linker_Cables.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
[Graphical view]
PfamPF00134. Cyclin_N. 1 hit.
[Graphical view]
PIRSFPIRSF025798. Cables. 1 hit.
SMARTSM00385. CYCLIN. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 1 hit.
ProtoNetSearch...

Other

NextBio319819.
PROQ9ESJ1.
SOURCESearch...

Entry information

Entry nameCABL1_MOUSE
AccessionPrimary (citable) accession number: Q9ESJ1
Secondary accession number(s): E9QNI6, Q9EPR8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot