Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9ESJ0

- XPO4_MOUSE

UniProt

Q9ESJ0 - XPO4_MOUSE

Protein

Exportin-4

Gene

Xpo4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus By similarity.By similarity

    GO - Biological processi

    1. positive regulation of protein export from nucleus Source: Ensembl
    2. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exportin-4
    Short name:
    Exp4
    Gene namesi
    Name:Xpo4
    Synonyms:Kiaa1721
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1888526. Xpo4.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity
    Note: Shuttles between the nucleus and the cytoplasm.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 11511151Exportin-4PRO_0000204712Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei464 – 4641PhosphoserineBy similarity
    Modified residuei521 – 5211PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9ESJ0.
    PaxDbiQ9ESJ0.
    PRIDEiQ9ESJ0.

    PTM databases

    PhosphoSiteiQ9ESJ0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ESJ0.
    BgeeiQ9ESJ0.
    CleanExiMM_XPO4.
    GenevestigatoriQ9ESJ0.

    Interactioni

    Subunit structurei

    Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner By similarity.By similarity

    Protein-protein interaction databases

    BioGridi208228. 4 interactions.
    IntActiQ9ESJ0. 1 interaction.
    STRINGi10090.ENSMUSP00000086909.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the exportin family.Curated

    Phylogenomic databases

    eggNOGiNOG273883.
    GeneTreeiENSGT00730000111055.
    HOGENOMiHOG000154878.
    HOVERGENiHBG023214.
    InParanoidiQ9ESJ0.
    OrthoDBiEOG7FJGZW.
    TreeFamiTF312991.

    Family and domain databases

    InterProiIPR016024. ARM-type_fold.
    IPR014877. CRM1_C_dom.
    [Graphical view]
    PfamiPF08767. CRM1_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 5 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9ESJ0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMAAALGPPE VIAQLENAAK VLMAPPSMVS NEQRQHAEHI FLSFRKSKSP     50
    FAVCRHILET SKVDYVLFQA ATAIMEAVVR EWVLLEKGSI ESLRTFLLTY 100
    VLQRPNLQKY VREQILLAVA VIVKRGSLDK SIDCKSIFHE VSQLISSGNP 150
    TVQTLACSIL TALLSEFSSS SKTSNIGLSM EFHGNCKRVF QEEDLRQIFM 200
    LTVGVLQEFS RRENLSAQMS SVFQRYLALA NQVLSWNFLP PKLGRHYIAM 250
    FESSQNVLLK PTESWREALL DSRVMELFFT VHRKIREDSD MAQDSLQCLA 300
    QLASLHGPIF PDEGSQVDYL AHFIEGLLNT INGIEIEDSE AVGISSIISN 350
    LITVFPRNVL TAIPSELFSS FVNCLTHLTC SFGRSAALEE VLDKDDMVYM 400
    EAYDKLLESW LTLVRDDKHF HKGFFTQHAV QVFNSYIQCH LAAPDGTRNL 450
    TANGVASREE EEISELQEDD RDQFSDQLAS VGMLGRIAAE HCMPLLTSLL 500
    EERVTRLHGQ LQRHQQQFLA SPGSSTIDNK MLDDLYEDIH WLILVTGYLL 550
    ADDTQGETPL IPPEIMEYSI KHSSEVDINT TLQILGSPGE KASSIPGYSR 600
    TDSVIRLLSA VLRVSEVESR AIRADLTHLL SPQMGKDIVW FLKRWAKTYL 650
    LVDEKLYDQI SLPLSTAFGA DTEGSQWIIG YLLQKVISNL SVWSSEQDLA 700
    NDTVQLLVTL VERRERANLV IQCENWWNLA KQFASRSPPL NFLSSPVQRT 750
    LMKALVLGGF AHMDTETKQQ YWTEVLQPLQ QRFLRVINQE NFQQMCQQEE 800
    VKQEITATLE ALCGIAEATQ IDNVAILFNF LMDFLNNCIG LMEVYKNTPE 850
    TVNLIIEVFV EVAHKQICYL GESKAMHLYE ACLTLLQVYS KNNLGRQRID 900
    VTAEEEQYQD LLLIMELLTN LLSKEFIDFS DTDEVFRGHE PGQAAGRSVS 950
    AADVVLYGVN LILPLMSQDL LKFPTLCNQY YKLITFICEI FPEKIPQLPE 1000
    DLFKSLMYSL ELGMTSMSSE VCQLCLEALT PLAEQCAKAQ ETDSPLFLAT 1050
    RHFLKLVFDM LVLQKHNTEM TTAAGEAFYT LVCLHQAEYS ELVETLLSSQ 1100
    QDPVIYQRLA DAFNKLTASS TPPALDRKQK MAFLKSLEEF MANVGGLLCV 1150
    K 1151
    Length:1,151
    Mass (Da):129,979
    Last modified:July 27, 2011 - v2
    Checksum:i91428FC24FB54628
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti242 – 2421K → N in AAG09133. (PubMed:10944119)Curated
    Sequence conflicti242 – 2421K → N in BAC98240. (PubMed:14621295)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF145021 mRNA. Translation: AAG09133.1.
    AC154504 Genomic DNA. No translation available.
    AC154675 Genomic DNA. No translation available.
    AK129430 mRNA. Translation: BAC98240.1.
    CCDSiCCDS56961.1.
    RefSeqiNP_065252.1. NM_020506.1.
    UniGeneiMm.202747.

    Genome annotation databases

    EnsembliENSMUST00000089482; ENSMUSP00000086909; ENSMUSG00000021952.
    ENSMUST00000174545; ENSMUSP00000133280; ENSMUSG00000021952.
    GeneIDi57258.
    KEGGimmu:57258.
    UCSCiuc007udf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF145021 mRNA. Translation: AAG09133.1 .
    AC154504 Genomic DNA. No translation available.
    AC154675 Genomic DNA. No translation available.
    AK129430 mRNA. Translation: BAC98240.1 .
    CCDSi CCDS56961.1.
    RefSeqi NP_065252.1. NM_020506.1.
    UniGenei Mm.202747.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 208228. 4 interactions.
    IntActi Q9ESJ0. 1 interaction.
    STRINGi 10090.ENSMUSP00000086909.

    PTM databases

    PhosphoSitei Q9ESJ0.

    Proteomic databases

    MaxQBi Q9ESJ0.
    PaxDbi Q9ESJ0.
    PRIDEi Q9ESJ0.

    Protocols and materials databases

    DNASUi 57258.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000089482 ; ENSMUSP00000086909 ; ENSMUSG00000021952 .
    ENSMUST00000174545 ; ENSMUSP00000133280 ; ENSMUSG00000021952 .
    GeneIDi 57258.
    KEGGi mmu:57258.
    UCSCi uc007udf.1. mouse.

    Organism-specific databases

    CTDi 64328.
    MGIi MGI:1888526. Xpo4.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG273883.
    GeneTreei ENSGT00730000111055.
    HOGENOMi HOG000154878.
    HOVERGENi HBG023214.
    InParanoidi Q9ESJ0.
    OrthoDBi EOG7FJGZW.
    TreeFami TF312991.

    Miscellaneous databases

    NextBioi 313565.
    PROi Q9ESJ0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ESJ0.
    Bgeei Q9ESJ0.
    CleanExi MM_XPO4.
    Genevestigatori Q9ESJ0.

    Family and domain databases

    InterProi IPR016024. ARM-type_fold.
    IPR014877. CRM1_C_dom.
    [Graphical view ]
    Pfami PF08767. CRM1_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 5 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes."
      Lipowsky G., Bischoff F.R., Schwarzmaier P., Kraft R., Kostka S., Hartmann E., Kutay U., Goerlich D.
      EMBO J. 19:4362-4371(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
      DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1151.
      Tissue: Embryonic tail.

    Entry informationi

    Entry nameiXPO4_MOUSE
    AccessioniPrimary (citable) accession number: Q9ESJ0
    Secondary accession number(s): E9QLH3, Q6ZPJ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3