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Protein

Exportin-4

Gene

Xpo4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity).By similarity

GO - Biological processi

  1. positive regulation of protein export from nucleus Source: MGI
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-4
Short name:
Exp4
Gene namesi
Name:Xpo4
Synonyms:Kiaa1721
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1888526. Xpo4.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Shuttles between the nucleus and the cytoplasm.By similarity

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11511151Exportin-4PRO_0000204712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei464 – 4641PhosphoserineBy similarity
Modified residuei521 – 5211PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ESJ0.
PaxDbiQ9ESJ0.
PRIDEiQ9ESJ0.

PTM databases

PhosphoSiteiQ9ESJ0.

Expressioni

Gene expression databases

BgeeiQ9ESJ0.
CleanExiMM_XPO4.
ExpressionAtlasiQ9ESJ0. baseline and differential.
GenevestigatoriQ9ESJ0.

Interactioni

Subunit structurei

Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner (By similarity).By similarity

Protein-protein interaction databases

BioGridi208228. 4 interactions.
IntActiQ9ESJ0. 1 interaction.
STRINGi10090.ENSMUSP00000086909.

Family & Domainsi

Sequence similaritiesi

Belongs to the exportin family.Curated

Phylogenomic databases

eggNOGiNOG273883.
GeneTreeiENSGT00730000111055.
HOGENOMiHOG000154878.
HOVERGENiHBG023214.
InParanoidiQ9ESJ0.
OrthoDBiEOG7FJGZW.
TreeFamiTF312991.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
[Graphical view]
PfamiPF08767. CRM1_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequencei

Sequence statusi: Complete.

Q9ESJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMAAALGPPE VIAQLENAAK VLMAPPSMVS NEQRQHAEHI FLSFRKSKSP
60 70 80 90 100
FAVCRHILET SKVDYVLFQA ATAIMEAVVR EWVLLEKGSI ESLRTFLLTY
110 120 130 140 150
VLQRPNLQKY VREQILLAVA VIVKRGSLDK SIDCKSIFHE VSQLISSGNP
160 170 180 190 200
TVQTLACSIL TALLSEFSSS SKTSNIGLSM EFHGNCKRVF QEEDLRQIFM
210 220 230 240 250
LTVGVLQEFS RRENLSAQMS SVFQRYLALA NQVLSWNFLP PKLGRHYIAM
260 270 280 290 300
FESSQNVLLK PTESWREALL DSRVMELFFT VHRKIREDSD MAQDSLQCLA
310 320 330 340 350
QLASLHGPIF PDEGSQVDYL AHFIEGLLNT INGIEIEDSE AVGISSIISN
360 370 380 390 400
LITVFPRNVL TAIPSELFSS FVNCLTHLTC SFGRSAALEE VLDKDDMVYM
410 420 430 440 450
EAYDKLLESW LTLVRDDKHF HKGFFTQHAV QVFNSYIQCH LAAPDGTRNL
460 470 480 490 500
TANGVASREE EEISELQEDD RDQFSDQLAS VGMLGRIAAE HCMPLLTSLL
510 520 530 540 550
EERVTRLHGQ LQRHQQQFLA SPGSSTIDNK MLDDLYEDIH WLILVTGYLL
560 570 580 590 600
ADDTQGETPL IPPEIMEYSI KHSSEVDINT TLQILGSPGE KASSIPGYSR
610 620 630 640 650
TDSVIRLLSA VLRVSEVESR AIRADLTHLL SPQMGKDIVW FLKRWAKTYL
660 670 680 690 700
LVDEKLYDQI SLPLSTAFGA DTEGSQWIIG YLLQKVISNL SVWSSEQDLA
710 720 730 740 750
NDTVQLLVTL VERRERANLV IQCENWWNLA KQFASRSPPL NFLSSPVQRT
760 770 780 790 800
LMKALVLGGF AHMDTETKQQ YWTEVLQPLQ QRFLRVINQE NFQQMCQQEE
810 820 830 840 850
VKQEITATLE ALCGIAEATQ IDNVAILFNF LMDFLNNCIG LMEVYKNTPE
860 870 880 890 900
TVNLIIEVFV EVAHKQICYL GESKAMHLYE ACLTLLQVYS KNNLGRQRID
910 920 930 940 950
VTAEEEQYQD LLLIMELLTN LLSKEFIDFS DTDEVFRGHE PGQAAGRSVS
960 970 980 990 1000
AADVVLYGVN LILPLMSQDL LKFPTLCNQY YKLITFICEI FPEKIPQLPE
1010 1020 1030 1040 1050
DLFKSLMYSL ELGMTSMSSE VCQLCLEALT PLAEQCAKAQ ETDSPLFLAT
1060 1070 1080 1090 1100
RHFLKLVFDM LVLQKHNTEM TTAAGEAFYT LVCLHQAEYS ELVETLLSSQ
1110 1120 1130 1140 1150
QDPVIYQRLA DAFNKLTASS TPPALDRKQK MAFLKSLEEF MANVGGLLCV

K
Length:1,151
Mass (Da):129,979
Last modified:July 26, 2011 - v2
Checksum:i91428FC24FB54628
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti242 – 2421K → N in AAG09133 (PubMed:10944119).Curated
Sequence conflicti242 – 2421K → N in BAC98240 (PubMed:14621295).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145021 mRNA. Translation: AAG09133.1.
AC154504 Genomic DNA. No translation available.
AC154675 Genomic DNA. No translation available.
AK129430 mRNA. Translation: BAC98240.1.
CCDSiCCDS56961.1.
RefSeqiNP_065252.1. NM_020506.1.
UniGeneiMm.202747.

Genome annotation databases

EnsembliENSMUST00000089482; ENSMUSP00000086909; ENSMUSG00000021952.
GeneIDi57258.
KEGGimmu:57258.
UCSCiuc007udf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF145021 mRNA. Translation: AAG09133.1.
AC154504 Genomic DNA. No translation available.
AC154675 Genomic DNA. No translation available.
AK129430 mRNA. Translation: BAC98240.1.
CCDSiCCDS56961.1.
RefSeqiNP_065252.1. NM_020506.1.
UniGeneiMm.202747.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208228. 4 interactions.
IntActiQ9ESJ0. 1 interaction.
STRINGi10090.ENSMUSP00000086909.

PTM databases

PhosphoSiteiQ9ESJ0.

Proteomic databases

MaxQBiQ9ESJ0.
PaxDbiQ9ESJ0.
PRIDEiQ9ESJ0.

Protocols and materials databases

DNASUi57258.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089482; ENSMUSP00000086909; ENSMUSG00000021952.
GeneIDi57258.
KEGGimmu:57258.
UCSCiuc007udf.1. mouse.

Organism-specific databases

CTDi64328.
MGIiMGI:1888526. Xpo4.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG273883.
GeneTreeiENSGT00730000111055.
HOGENOMiHOG000154878.
HOVERGENiHBG023214.
InParanoidiQ9ESJ0.
OrthoDBiEOG7FJGZW.
TreeFamiTF312991.

Miscellaneous databases

NextBioi313565.
PROiQ9ESJ0.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ESJ0.
CleanExiMM_XPO4.
ExpressionAtlasiQ9ESJ0. baseline and differential.
GenevestigatoriQ9ESJ0.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
[Graphical view]
PfamiPF08767. CRM1_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes."
    Lipowsky G., Bischoff F.R., Schwarzmaier P., Kraft R., Kostka S., Hartmann E., Kutay U., Goerlich D.
    EMBO J. 19:4362-4371(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1151.
    Tissue: Embryonic tail.

Entry informationi

Entry nameiXPO4_MOUSE
AccessioniPrimary (citable) accession number: Q9ESJ0
Secondary accession number(s): E9QLH3, Q6ZPJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2001
Last sequence update: July 26, 2011
Last modified: March 3, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.