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Q9ESJ0 (XPO4_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exportin-4

Short name=Exp4
Gene names
Name:Xpo4
Synonyms:Kiaa1721
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1151 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus By similarity.

Subunit structure

Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity. Note: Shuttles between the nucleus and the cytoplasm By similarity.

Sequence similarities

Belongs to the exportin family.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentCytoplasm
Nucleus
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpositive regulation of protein export from nucleus

Inferred from electronic annotation. Source: Ensembl

protein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 11511151Exportin-4
PRO_0000204712

Amino acid modifications

Modified residue4641Phosphoserine By similarity
Modified residue5211Phosphoserine By similarity

Experimental info

Sequence conflict2421K → N in AAG09133. Ref.1
Sequence conflict2421K → N in BAC98240. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9ESJ0 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 91428FC24FB54628

FASTA1,151129,979
        10         20         30         40         50         60 
MMAAALGPPE VIAQLENAAK VLMAPPSMVS NEQRQHAEHI FLSFRKSKSP FAVCRHILET 

        70         80         90        100        110        120 
SKVDYVLFQA ATAIMEAVVR EWVLLEKGSI ESLRTFLLTY VLQRPNLQKY VREQILLAVA 

       130        140        150        160        170        180 
VIVKRGSLDK SIDCKSIFHE VSQLISSGNP TVQTLACSIL TALLSEFSSS SKTSNIGLSM 

       190        200        210        220        230        240 
EFHGNCKRVF QEEDLRQIFM LTVGVLQEFS RRENLSAQMS SVFQRYLALA NQVLSWNFLP 

       250        260        270        280        290        300 
PKLGRHYIAM FESSQNVLLK PTESWREALL DSRVMELFFT VHRKIREDSD MAQDSLQCLA 

       310        320        330        340        350        360 
QLASLHGPIF PDEGSQVDYL AHFIEGLLNT INGIEIEDSE AVGISSIISN LITVFPRNVL 

       370        380        390        400        410        420 
TAIPSELFSS FVNCLTHLTC SFGRSAALEE VLDKDDMVYM EAYDKLLESW LTLVRDDKHF 

       430        440        450        460        470        480 
HKGFFTQHAV QVFNSYIQCH LAAPDGTRNL TANGVASREE EEISELQEDD RDQFSDQLAS 

       490        500        510        520        530        540 
VGMLGRIAAE HCMPLLTSLL EERVTRLHGQ LQRHQQQFLA SPGSSTIDNK MLDDLYEDIH 

       550        560        570        580        590        600 
WLILVTGYLL ADDTQGETPL IPPEIMEYSI KHSSEVDINT TLQILGSPGE KASSIPGYSR 

       610        620        630        640        650        660 
TDSVIRLLSA VLRVSEVESR AIRADLTHLL SPQMGKDIVW FLKRWAKTYL LVDEKLYDQI 

       670        680        690        700        710        720 
SLPLSTAFGA DTEGSQWIIG YLLQKVISNL SVWSSEQDLA NDTVQLLVTL VERRERANLV 

       730        740        750        760        770        780 
IQCENWWNLA KQFASRSPPL NFLSSPVQRT LMKALVLGGF AHMDTETKQQ YWTEVLQPLQ 

       790        800        810        820        830        840 
QRFLRVINQE NFQQMCQQEE VKQEITATLE ALCGIAEATQ IDNVAILFNF LMDFLNNCIG 

       850        860        870        880        890        900 
LMEVYKNTPE TVNLIIEVFV EVAHKQICYL GESKAMHLYE ACLTLLQVYS KNNLGRQRID 

       910        920        930        940        950        960 
VTAEEEQYQD LLLIMELLTN LLSKEFIDFS DTDEVFRGHE PGQAAGRSVS AADVVLYGVN 

       970        980        990       1000       1010       1020 
LILPLMSQDL LKFPTLCNQY YKLITFICEI FPEKIPQLPE DLFKSLMYSL ELGMTSMSSE 

      1030       1040       1050       1060       1070       1080 
VCQLCLEALT PLAEQCAKAQ ETDSPLFLAT RHFLKLVFDM LVLQKHNTEM TTAAGEAFYT 

      1090       1100       1110       1120       1130       1140 
LVCLHQAEYS ELVETLLSSQ QDPVIYQRLA DAFNKLTASS TPPALDRKQK MAFLKSLEEF 

      1150 
MANVGGLLCV K 

« Hide

References

« Hide 'large scale' references
[1]"Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes."
Lipowsky G., Bischoff F.R., Schwarzmaier P., Kraft R., Kostka S., Hartmann E., Kutay U., Goerlich D.
EMBO J. 19:4362-4371(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1151.
Tissue: Embryonic tail.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF145021 mRNA. Translation: AAG09133.1.
AC154504 Genomic DNA. No translation available.
AC154675 Genomic DNA. No translation available.
AK129430 mRNA. Translation: BAC98240.1.
RefSeqNP_065252.1. NM_020506.1.
UniGeneMm.202747.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid208228. 3 interactions.
IntActQ9ESJ0. 1 interaction.
STRING10090.ENSMUSP00000086909.

PTM databases

PhosphoSiteQ9ESJ0.

Proteomic databases

PaxDbQ9ESJ0.
PRIDEQ9ESJ0.

Protocols and materials databases

DNASU57258.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000089482; ENSMUSP00000086909; ENSMUSG00000021952.
ENSMUST00000174545; ENSMUSP00000133280; ENSMUSG00000021952.
GeneID57258.
KEGGmmu:57258.
UCSCuc007udf.1. mouse.

Organism-specific databases

CTD64328.
MGIMGI:1888526. Xpo4.
RougeSearch...

Phylogenomic databases

eggNOGNOG273883.
GeneTreeENSGT00730000111055.
HOGENOMHOG000154878.
HOVERGENHBG023214.
InParanoidQ9ESJ0.
OrthoDBEOG7FJGZW.
TreeFamTF312991.

Gene expression databases

ArrayExpressQ9ESJ0.
BgeeQ9ESJ0.
CleanExMM_XPO4.
GenevestigatorQ9ESJ0.

Family and domain databases

InterProIPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
[Graphical view]
PfamPF08767. CRM1_C. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 5 hits.
ProtoNetSearch...

Other

NextBio313565.
PROQ9ESJ0.
SOURCESearch...

Entry information

Entry nameXPO4_MOUSE
AccessionPrimary (citable) accession number: Q9ESJ0
Secondary accession number(s): E9QLH3, Q6ZPJ4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot