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Q9ESJ0

- XPO4_MOUSE

UniProt

Q9ESJ0 - XPO4_MOUSE

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Protein

Exportin-4

Gene
Xpo4, Kiaa1721
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus By similarity.

GO - Biological processi

  1. positive regulation of protein export from nucleus Source: Ensembl
  2. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Exportin-4
Short name:
Exp4
Gene namesi
Name:Xpo4
Synonyms:Kiaa1721
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1888526. Xpo4.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: Shuttles between the nucleus and the cytoplasm By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11511151Exportin-4PRO_0000204712Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei464 – 4641Phosphoserine By similarity
Modified residuei521 – 5211Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ESJ0.
PaxDbiQ9ESJ0.
PRIDEiQ9ESJ0.

PTM databases

PhosphoSiteiQ9ESJ0.

Expressioni

Gene expression databases

ArrayExpressiQ9ESJ0.
BgeeiQ9ESJ0.
CleanExiMM_XPO4.
GenevestigatoriQ9ESJ0.

Interactioni

Subunit structurei

Found in a complex with XPO4, Ran and EIF5A. Found in a complex with XPO4, Ran and SMAD3. Interacts with SMAD3. Interacts with Ran and cargo proteins in a GTP-dependent manner By similarity.

Protein-protein interaction databases

BioGridi208228. 4 interactions.
IntActiQ9ESJ0. 1 interaction.
STRINGi10090.ENSMUSP00000086909.

Family & Domainsi

Sequence similaritiesi

Belongs to the exportin family.

Phylogenomic databases

eggNOGiNOG273883.
GeneTreeiENSGT00730000111055.
HOGENOMiHOG000154878.
HOVERGENiHBG023214.
InParanoidiQ9ESJ0.
OrthoDBiEOG7FJGZW.
TreeFamiTF312991.

Family and domain databases

InterProiIPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
[Graphical view]
PfamiPF08767. CRM1_C. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequencei

Sequence statusi: Complete.

Q9ESJ0-1 [UniParc]FASTAAdd to Basket

« Hide

MMAAALGPPE VIAQLENAAK VLMAPPSMVS NEQRQHAEHI FLSFRKSKSP     50
FAVCRHILET SKVDYVLFQA ATAIMEAVVR EWVLLEKGSI ESLRTFLLTY 100
VLQRPNLQKY VREQILLAVA VIVKRGSLDK SIDCKSIFHE VSQLISSGNP 150
TVQTLACSIL TALLSEFSSS SKTSNIGLSM EFHGNCKRVF QEEDLRQIFM 200
LTVGVLQEFS RRENLSAQMS SVFQRYLALA NQVLSWNFLP PKLGRHYIAM 250
FESSQNVLLK PTESWREALL DSRVMELFFT VHRKIREDSD MAQDSLQCLA 300
QLASLHGPIF PDEGSQVDYL AHFIEGLLNT INGIEIEDSE AVGISSIISN 350
LITVFPRNVL TAIPSELFSS FVNCLTHLTC SFGRSAALEE VLDKDDMVYM 400
EAYDKLLESW LTLVRDDKHF HKGFFTQHAV QVFNSYIQCH LAAPDGTRNL 450
TANGVASREE EEISELQEDD RDQFSDQLAS VGMLGRIAAE HCMPLLTSLL 500
EERVTRLHGQ LQRHQQQFLA SPGSSTIDNK MLDDLYEDIH WLILVTGYLL 550
ADDTQGETPL IPPEIMEYSI KHSSEVDINT TLQILGSPGE KASSIPGYSR 600
TDSVIRLLSA VLRVSEVESR AIRADLTHLL SPQMGKDIVW FLKRWAKTYL 650
LVDEKLYDQI SLPLSTAFGA DTEGSQWIIG YLLQKVISNL SVWSSEQDLA 700
NDTVQLLVTL VERRERANLV IQCENWWNLA KQFASRSPPL NFLSSPVQRT 750
LMKALVLGGF AHMDTETKQQ YWTEVLQPLQ QRFLRVINQE NFQQMCQQEE 800
VKQEITATLE ALCGIAEATQ IDNVAILFNF LMDFLNNCIG LMEVYKNTPE 850
TVNLIIEVFV EVAHKQICYL GESKAMHLYE ACLTLLQVYS KNNLGRQRID 900
VTAEEEQYQD LLLIMELLTN LLSKEFIDFS DTDEVFRGHE PGQAAGRSVS 950
AADVVLYGVN LILPLMSQDL LKFPTLCNQY YKLITFICEI FPEKIPQLPE 1000
DLFKSLMYSL ELGMTSMSSE VCQLCLEALT PLAEQCAKAQ ETDSPLFLAT 1050
RHFLKLVFDM LVLQKHNTEM TTAAGEAFYT LVCLHQAEYS ELVETLLSSQ 1100
QDPVIYQRLA DAFNKLTASS TPPALDRKQK MAFLKSLEEF MANVGGLLCV 1150
K 1151
Length:1,151
Mass (Da):129,979
Last modified:July 27, 2011 - v2
Checksum:i91428FC24FB54628
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti242 – 2421K → N in AAG09133. 1 Publication
Sequence conflicti242 – 2421K → N in BAC98240. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF145021 mRNA. Translation: AAG09133.1.
AC154504 Genomic DNA. No translation available.
AC154675 Genomic DNA. No translation available.
AK129430 mRNA. Translation: BAC98240.1.
CCDSiCCDS56961.1.
RefSeqiNP_065252.1. NM_020506.1.
UniGeneiMm.202747.

Genome annotation databases

EnsembliENSMUST00000089482; ENSMUSP00000086909; ENSMUSG00000021952.
ENSMUST00000174545; ENSMUSP00000133280; ENSMUSG00000021952.
GeneIDi57258.
KEGGimmu:57258.
UCSCiuc007udf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF145021 mRNA. Translation: AAG09133.1 .
AC154504 Genomic DNA. No translation available.
AC154675 Genomic DNA. No translation available.
AK129430 mRNA. Translation: BAC98240.1 .
CCDSi CCDS56961.1.
RefSeqi NP_065252.1. NM_020506.1.
UniGenei Mm.202747.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 208228. 4 interactions.
IntActi Q9ESJ0. 1 interaction.
STRINGi 10090.ENSMUSP00000086909.

PTM databases

PhosphoSitei Q9ESJ0.

Proteomic databases

MaxQBi Q9ESJ0.
PaxDbi Q9ESJ0.
PRIDEi Q9ESJ0.

Protocols and materials databases

DNASUi 57258.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000089482 ; ENSMUSP00000086909 ; ENSMUSG00000021952 .
ENSMUST00000174545 ; ENSMUSP00000133280 ; ENSMUSG00000021952 .
GeneIDi 57258.
KEGGi mmu:57258.
UCSCi uc007udf.1. mouse.

Organism-specific databases

CTDi 64328.
MGIi MGI:1888526. Xpo4.
Rougei Search...

Phylogenomic databases

eggNOGi NOG273883.
GeneTreei ENSGT00730000111055.
HOGENOMi HOG000154878.
HOVERGENi HBG023214.
InParanoidi Q9ESJ0.
OrthoDBi EOG7FJGZW.
TreeFami TF312991.

Miscellaneous databases

NextBioi 313565.
PROi Q9ESJ0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9ESJ0.
Bgeei Q9ESJ0.
CleanExi MM_XPO4.
Genevestigatori Q9ESJ0.

Family and domain databases

InterProi IPR016024. ARM-type_fold.
IPR014877. CRM1_C_dom.
[Graphical view ]
Pfami PF08767. CRM1_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 5 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Exportin 4: a mediator of a novel nuclear export pathway in higher eukaryotes."
    Lipowsky G., Bischoff F.R., Schwarzmaier P., Kraft R., Kostka S., Hartmann E., Kutay U., Goerlich D.
    EMBO J. 19:4362-4371(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1151.
    Tissue: Embryonic tail.

Entry informationi

Entry nameiXPO4_MOUSE
AccessioniPrimary (citable) accession number: Q9ESJ0
Secondary accession number(s): E9QLH3, Q6ZPJ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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