Q9ESH6 (GLRX1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutaredoxin-1

Alternative name(s):
Thioltransferase-1
Short name=TTase-1

Gene names

Name:	Glrx
Synonyms:	Glrx1, Grx

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Cytoplasm
Domain	Redox-active center
PTM	Acetylation Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 107	106	Glutaredoxin-1		PRO_0000141604
Regions
	Domain	3 – 106	104	Glutaredoxin
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Disulfide bond	23 ↔ 26		Redox-active By similarity
	Disulfide bond	79 ↔ 83		By similarity
Experimental info
	Sequence conflict	9	1	K → R in AAK07419. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9ESH6 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: C46C67042138E9E8	FASTA	107	11,879
	10 20 30 40 50 60 MAQEFVNCKI QSGKVVVFIK PTCPYCRKTQ EILSQLPFKR GLLEFVDITA TNNTNAIQDY 70 80 90 100 LQQLTGARTV PRVFIGKDCI GGCSDLLSMQ QNGELTARLK QIGALQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of rat glutaredoxin." Miranda-Vizuete A. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and expression of glutaredoxin cDNA gene from PC12 cell line in E.coli." Liu C.Z., Xie Z.H., He Y.H., Wang A.M., Ma C. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF167981 mRNA. Translation: AAF89637.3. AF319950 mRNA. Translation: AAK07419.1. BC061555 mRNA. Translation: AAH61555.1.
IPI	IPI00231191.
RefSeq	NP_071614.1. NM_022278.1.
UniGene	Rn.1484.
3D structure databases
ProteinModelPortal	Q9ESH6.
SMR	Q9ESH6. Positions 2-106.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9ESH6.
Proteomic databases
PRIDE	Q9ESH6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000016372; ENSRNOP00000016372; ENSRNOG00000012183.
GeneID	64045.
KEGG	rno:64045.
UCSC	NM_022278. rat.
Organism-specific databases
CTD	64045.
RGD	70951. Glrx1.
Phylogenomic databases
eggNOG	roNOG16576.
GeneTree	ENSGT00390000003677.
HOVERGEN	HBG000283.
InParanoid	Q9ESH6.
OMA	TNAIQDY.
OrthoDB	EOG4N8R6D.
PhylomeDB	Q9ESH6.
Gene expression databases
ArrayExpress	Q9ESH6.
Genevestigator	Q9ESH6.
GermOnline	ENSRNOG00000012183. Rattus norvegicus.
Family and domain databases
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR011899. Glutaredoxin_euk/vir. IPR014025. Glutaredoxin_subgr. IPR012336. Thioredoxin-like_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
KO	K03676.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
SUPFAM	SSF52833. Thiordxn-like_fd. 1 hit.
TIGRFAMs	TIGR02180. GRX_euk. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	612705.

Entry information

Entry name

GLRX1_RAT

Accession

Primary (citable) accession number: Q9ESH6
Secondary accession number(s): Q99PB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	January 23, 2007
Last modified:	November 16, 2011
This is version 78 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program