Reviewed, UniProtKB/Swiss-Prot Q9ESH6 (GLRX1_RAT)

Names and origin

Protein names

Recommended name:
    Glutaredoxin-1
Alternative name(s):
    Thioltransferase-1
      Short name=TTase-1

Gene names

Name:	Glrx
Synonyms:	Glrx1, Grx

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	107 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain.

Ontologies

Keywords
Biological process	Electron transport Transport
Cellular component	Cytoplasm
Domain	Redox-active center
PTM	Acetylation Disulfide bond
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	electron carrier activity Inferred from electronic annotation. Source: InterPro protein disulfide oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 107	106	Glutaredoxin-1		PRO_0000141604
Regions
	Domain	3 – 106	104	Glutaredoxin
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity
	Disulfide bond	23 ↔ 26		Redox-active By similarity
	Disulfide bond	79 ↔ 83		By similarity
Experimental info
	Sequence conflict	9	1	K → R in AAK07419. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9ESH6-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: C46C67042138E9E8	FASTA	107	11,879
	10 20 30 40 50 60 MAQEFVNCKI QSGKVVVFIK PTCPYCRKTQ EILSQLPFKR GLLEFVDITA TNNTNAIQDY 70 80 90 100 LQQLTGARTV PRVFIGKDCI GGCSDLLSMQ QNGELTARLK QIGALQL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of rat glutaredoxin." Miranda-Vizuete A. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Cloning and expression of glutaredoxin cDNA gene from PC12 cell line in E.coli." Liu C.Z., Xie Z.H., He Y.H., Wang A.M., Ma C. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pituitary.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF167981 mRNA. Translation: AAF89637.3. AF319950 mRNA. Translation: AAK07419.1. BC061555 mRNA. Translation: AAH61555.1.
IPI	IPI00231191.
RefSeq	NP_071614.1.
UniGene	Rn.1484
3D structure databases
HSSP	HSSP built from PDB template 1JHB based on UniProtKB P35754.
SMR	Q9ESH6. Positions 2-106.
ModBase	Search...
Proteomic databases
PRIDE	Q9ESH6.
Genome annotation databases
Ensembl	ENSRNOG00000012183. Rattus norvegicus. [Contig view]
GeneID	64045.
KEGG	rno:64045.
Organism-specific databases
RGD	70951. Glrx1.
Phylogenomic databases
HOVERGEN	Q9ESH6.
OMA	Q9ESH6. GGCSDLI.
Gene expression databases
ArrayExpress	Q9ESH6.
GermOnline	ENSRNOG00000012183. Rattus norvegicus.
Family and domain databases
InterPro	IPR011767. GLR_AS. IPR002109. Glutaredoxin. IPR014025. Glutaredoxin_sub. IPR011899. GRX_euk. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
Pfam	PF00462. Glutaredoxin. 1 hit. [Graphical view]
PRINTS	PR00160. GLUTAREDOXIN.
TIGRFAMs	TIGR02180. GRX_euk. 1 hit.
PROSITE	PS00195. GLUTAREDOXIN_1. 1 hit. PS51354. GLUTAREDOXIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	612705.

Entry information

Entry name

GLRX1_RAT

Accession

Primary (citable) accession number: Q9ESH6
Secondary accession number(s): Q99PB7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 57 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)