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Protein

Glutaredoxin-1

Gene

Glrx

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins.

GO - Molecular functioni

GO - Biological processi

  • aging Source: RGD
  • cell redox homeostasis Source: InterPro
  • cellular response to estradiol stimulus Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • negative regulation of hydrogen peroxide-mediated programmed cell death Source: RGD
  • negative regulation of platelet-derived growth factor receptor-beta signaling pathway Source: RGD
  • ovulation cycle process Source: RGD
  • positive regulation of cell adhesion molecule production Source: RGD
  • positive regulation of exocytosis Source: RGD
  • positive regulation of insulin secretion Source: RGD
  • positive regulation of NIK/NF-kappaB signaling Source: RGD
  • response to ischemia Source: RGD

Keywordsi

Biological processElectron transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-499943 Interconversion of nucleotide di- and triphosphates

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin-1
Alternative name(s):
Thioltransferase-1
Short name:
TTase-1
Gene namesi
Name:Glrx
Synonyms:Glrx1, Grx
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi70951 Glrx

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001416042 – 107Glutaredoxin-1Add BLAST106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei9N6-succinyllysineBy similarity1
Disulfide bondi23 ↔ 26Redox-activeBy similarity
Disulfide bondi79 ↔ 83By similarity

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiQ9ESH6
PRIDEiQ9ESH6

PTM databases

iPTMnetiQ9ESH6
PhosphoSitePlusiQ9ESH6
SwissPalmiQ9ESH6

Expressioni

Gene expression databases

BgeeiENSRNOG00000012183
GenevisibleiQ9ESH6 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016372

Structurei

3D structure databases

ProteinModelPortaliQ9ESH6
SMRiQ9ESH6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 106GlutaredoxinPROSITE-ProRule annotationAdd BLAST104

Sequence similaritiesi

Belongs to the glutaredoxin family.Curated

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiKOG1752 Eukaryota
COG0695 LUCA
GeneTreeiENSGT00900000141068
HOGENOMiHOG000095204
HOVERGENiHBG000283
InParanoidiQ9ESH6
KOiK03676
OMAiKPGHLEC
OrthoDBiEOG091G0WLY
PhylomeDBiQ9ESH6
TreeFamiTF326994

Family and domain databases

InterProiView protein in InterPro
IPR011767 GLR_AS
IPR002109 Glutaredoxin
IPR011899 Glutaredoxin_euk/vir
IPR014025 Glutaredoxin_subgr
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
PRINTSiPR00160 GLUTAREDOXIN
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR02180 GRX_euk, 1 hit
PROSITEiView protein in PROSITE
PS00195 GLUTAREDOXIN_1, 1 hit
PS51354 GLUTAREDOXIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ESH6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQEFVNCKI QSGKVVVFIK PTCPYCRKTQ EILSQLPFKR GLLEFVDITA
60 70 80 90 100
TNNTNAIQDY LQQLTGARTV PRVFIGKDCI GGCSDLLSMQ QNGELTARLK

QIGALQL
Length:107
Mass (Da):11,879
Last modified:January 23, 2007 - v3
Checksum:iC46C67042138E9E8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9K → R in AAK07419 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF167981 mRNA Translation: AAF89637.3
AF319950 mRNA Translation: AAK07419.1
BC061555 mRNA Translation: AAH61555.1
RefSeqiNP_071614.1, NM_022278.1
UniGeneiRn.1484

Genome annotation databases

EnsembliENSRNOT00000016372; ENSRNOP00000016372; ENSRNOG00000012183
GeneIDi64045
KEGGirno:64045
UCSCiRGD:70951 rat

Entry informationi

Entry nameiGLRX1_RAT
AccessioniPrimary (citable) accession number: Q9ESH6
Secondary accession number(s): Q99PB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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