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Protein

Probable palmitoyltransferase ZDHHC16

Gene

Zdhhc16

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in apoptosis regulation.1 Publication

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 20551DHHC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Probable palmitoyltransferase ZDHHC16 (EC:2.3.1.225)
Alternative name(s):
Abl-philin 2
Zinc finger DHHC domain-containing protein 16
Short name:
DHHC-16
Gene namesi
Name:Zdhhc16
Synonyms:Aph2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1921418. Zdhhc16.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7777CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 9821HelicalSequence analysisAdd
BLAST
Topological domaini99 – 11618LumenalSequence analysisAdd
BLAST
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Topological domaini138 – 19861CytoplasmicSequence analysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence analysisAdd
BLAST
Topological domaini220 – 25031LumenalSequence analysisAdd
BLAST
Transmembranei251 – 27121HelicalSequence analysisAdd
BLAST
Topological domaini272 – 36190CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Probable palmitoyltransferase ZDHHC16PRO_0000212899Add
BLAST

Proteomic databases

MaxQBiQ9ESG8.
PaxDbiQ9ESG8.
PRIDEiQ9ESG8.

PTM databases

PhosphoSiteiQ9ESG8.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiQ9ESG8.
CleanExiMM_ZDHHC16.
GenevisibleiQ9ESG8. MM.

Interactioni

Subunit structurei

Interacts with ABL1 (PubMed:12021275). Interacts with COPS5 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi216543. 1 interaction.
STRINGi10090.ENSMUSP00000026154.

Family & Domainsi

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated
Contains 1 DHHC-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri155 – 20551DHHC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG1313. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129737.
HOGENOMiHOG000234766.
HOVERGENiHBG054667.
InParanoidiQ9ESG8.
KOiK18932.
OMAiKNWKLFL.
OrthoDBiEOG75QR41.
PhylomeDBiQ9ESG8.
TreeFamiTF320809.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRGQRSLLLG PARLCLRLLL LLGYRRRCPP LLRGLVQRWR YGKVCLRSLL
60 70 80 90 100
YNSFGGSDTA VDAAFEPVYW LVDNVIRWFG VVFVVLVIVL TGSIVAIAYL
110 120 130 140 150
CVLPLILRTY SVPRLCWHFF YSHWNLILIV FHYYQAITTP PGYPPQGRND
160 170 180 190 200
IATVSICKKC IYPKPARTHH CSICNRCVLK MDHHCPWLNN CVGHYNHRYF
210 220 230 240 250
FSFCFFMTLG CVYCSYGSWD LFREAYAAIE TYHQTPPPTF SFRERITHKS
260 270 280 290 300
LVYLWFLCSS VALALGALTM WHAVLISRGE TSIERHINKK ERRRLQAKGR
310 320 330 340 350
VFRNPYNYGC LDNWKVFLGV DTGRHWLTRV LLPSSHLPHG NGMSWDPPPW
360
VTAHSASVMA V
Length:361
Mass (Da):41,794
Last modified:November 22, 2005 - v2
Checksum:iB9A4D4B4C4170FE9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331R → Q in BAE40024 (PubMed:16141072).Curated
Sequence conflicti63 – 631A → S in AAG09269 (PubMed:12021275).Curated
Sequence conflicti171 – 1711C → R in AAH10835 (PubMed:15489334).Curated
Sequence conflicti335 – 3351S → N in AAG09269 (PubMed:12021275).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176814 mRNA. Translation: AAG09269.1.
AK151505 mRNA. Translation: BAE30456.1.
AK168042 mRNA. Translation: BAE40024.1.
BC010835 mRNA. Translation: AAH10835.1.
CCDSiCCDS29817.1.
RefSeqiNP_076229.2. NM_023740.2.
UniGeneiMm.20387.

Genome annotation databases

EnsembliENSMUST00000026154; ENSMUSP00000026154; ENSMUSG00000025157.
GeneIDi74168.
KEGGimmu:74168.
UCSCiuc008hmq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF176814 mRNA. Translation: AAG09269.1.
AK151505 mRNA. Translation: BAE30456.1.
AK168042 mRNA. Translation: BAE40024.1.
BC010835 mRNA. Translation: AAH10835.1.
CCDSiCCDS29817.1.
RefSeqiNP_076229.2. NM_023740.2.
UniGeneiMm.20387.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216543. 1 interaction.
STRINGi10090.ENSMUSP00000026154.

PTM databases

PhosphoSiteiQ9ESG8.

Proteomic databases

MaxQBiQ9ESG8.
PaxDbiQ9ESG8.
PRIDEiQ9ESG8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026154; ENSMUSP00000026154; ENSMUSG00000025157.
GeneIDi74168.
KEGGimmu:74168.
UCSCiuc008hmq.2. mouse.

Organism-specific databases

CTDi84287.
MGIiMGI:1921418. Zdhhc16.

Phylogenomic databases

eggNOGiKOG1313. Eukaryota.
COG5273. LUCA.
GeneTreeiENSGT00840000129737.
HOGENOMiHOG000234766.
HOVERGENiHBG054667.
InParanoidiQ9ESG8.
KOiK18932.
OMAiKNWKLFL.
OrthoDBiEOG75QR41.
PhylomeDBiQ9ESG8.
TreeFamiTF320809.

Miscellaneous databases

NextBioi339976.
PROiQ9ESG8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ESG8.
CleanExiMM_ZDHHC16.
GenevisibleiQ9ESG8. MM.

Family and domain databases

InterProiIPR001594. Znf_DHHC_palmitoyltrfase.
[Graphical view]
PfamiPF01529. zf-DHHC. 1 hit.
[Graphical view]
PROSITEiPS50216. ZF_DHHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Aph2, a protein with a zf-DHHC motif, interacts with c-Abl and has pro-apoptotic activity."
    Li B., Cong F., Tan C.P., Wang S.X., Goff S.P.
    J. Biol. Chem. 277:28870-28876(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INTERACTION WITH ABL1, SUBCELLULAR LOCATION, FUNCTION.
    Strain: BALB/cJ.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
    Tissue: Bone marrow.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiZDH16_MOUSE
AccessioniPrimary (citable) accession number: Q9ESG8
Secondary accession number(s): Q3TI22, Q3UA59, Q91XC5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 22, 2005
Last modified: May 11, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.