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Protein

P2Y purinoceptor 14

Gene

P2ry14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for UDP-glucose coupled to G-proteins.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-417957. P2Y receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 14
Short name:
P2Y14
Alternative name(s):
G-protein coupled receptor 105
UDP-glucose receptor
Gene namesi
Name:P2ry14
Synonyms:Gpr105
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2155705. P2ry14.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence analysisAdd
BLAST
Transmembranei30 – 5021Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini51 – 555CytoplasmicSequence analysis
Transmembranei56 – 7621Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini77 – 9620ExtracellularSequence analysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini118 – 13922CytoplasmicSequence analysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini161 – 18828ExtracellularSequence analysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini210 – 23425CytoplasmicSequence analysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini256 – 27823ExtracellularSequence analysisAdd
BLAST
Transmembranei279 – 29921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini300 – 33839CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1770046.
GuidetoPHARMACOLOGYi330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338P2Y purinoceptor 14PRO_0000070045Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence analysis
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9ESG6.
PaxDbiQ9ESG6.
PRIDEiQ9ESG6.

PTM databases

iPTMnetiQ9ESG6.
PhosphoSiteiQ9ESG6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000036381.
CleanExiMM_P2RY14.
ExpressionAtlasiQ9ESG6. baseline and differential.
GenevisibleiQ9ESG6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066669.

Chemistry

BindingDBiQ9ESG6.

Structurei

3D structure databases

ProteinModelPortaliQ9ESG6.
SMRiQ9ESG6. Positions 14-306.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK1E. Eukaryota.
ENOG4111GWF. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ9ESG6.
KOiK04299.
PhylomeDBiQ9ESG6.
TreeFamiTF330969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005466. P2Y14_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01655. UDPGLUCOSER.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESG6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNSTTTDPP NQPCSWNTLI TKQIIPVLYG MVFITGLLLN GISGWIFFYV
60 70 80 90 100
PSSKSFIIYL KNIVVADFLM GLTFPFKVLG DSGLGPWQVN VFVCRVSAVI
110 120 130 140 150
FYVNMYVSIV FFGLISFDRY YKIVKPLLTS IVQSVNYSKL LSVLVWMLML
160 170 180 190 200
LLAVPNIILT NQGVKEVTKI QCMELKNELG RKWHKASNYI FVSIFWVVFL
210 220 230 240 250
LLIVFYTAIT RKIFKSHLKS RKNSTSVKRK SSRNIFSIVL VFVVCFVPYH
260 270 280 290 300
IARIPYTKSQ TEGHYSCRTK ETLLYAKEFT LLLSAANVCL DPIIYFFLCQ
310 320 330
PFREVLNKKL HMSLKVQNDL EVSKTKRENA IHESTDTL
Length:338
Mass (Da):38,861
Last modified:March 1, 2001 - v1
Checksum:i4376B50622A68A4E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177211 mRNA. Translation: AAG09275.1.
BC028995 mRNA. Translation: AAH28995.1.
BC058558 mRNA. Translation: AAH58558.1.
CCDSiCCDS17371.1.
RefSeqiNP_001008497.1. NM_001008497.2.
NP_001274048.1. NM_001287119.1.
NP_001274049.1. NM_001287120.1.
NP_001274050.1. NM_001287121.1.
NP_001274051.1. NM_001287122.1.
NP_001274052.1. NM_001287123.1.
NP_573463.1. NM_133200.4.
UniGeneiMm.439021.

Genome annotation databases

EnsembliENSMUST00000065220; ENSMUSP00000066669; ENSMUSG00000036381.
ENSMUST00000091112; ENSMUSP00000088642; ENSMUSG00000036381.
ENSMUST00000196081; ENSMUSP00000142601; ENSMUSG00000036381.
ENSMUST00000197220; ENSMUSP00000143070; ENSMUSG00000036381.
GeneIDi140795.
KEGGimmu:140795.
UCSCiuc008pik.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF177211 mRNA. Translation: AAG09275.1.
BC028995 mRNA. Translation: AAH28995.1.
BC058558 mRNA. Translation: AAH58558.1.
CCDSiCCDS17371.1.
RefSeqiNP_001008497.1. NM_001008497.2.
NP_001274048.1. NM_001287119.1.
NP_001274049.1. NM_001287120.1.
NP_001274050.1. NM_001287121.1.
NP_001274051.1. NM_001287122.1.
NP_001274052.1. NM_001287123.1.
NP_573463.1. NM_133200.4.
UniGeneiMm.439021.

3D structure databases

ProteinModelPortaliQ9ESG6.
SMRiQ9ESG6. Positions 14-306.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000066669.

Chemistry

BindingDBiQ9ESG6.
ChEMBLiCHEMBL1770046.
GuidetoPHARMACOLOGYi330.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ9ESG6.
PhosphoSiteiQ9ESG6.

Proteomic databases

EPDiQ9ESG6.
PaxDbiQ9ESG6.
PRIDEiQ9ESG6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065220; ENSMUSP00000066669; ENSMUSG00000036381.
ENSMUST00000091112; ENSMUSP00000088642; ENSMUSG00000036381.
ENSMUST00000196081; ENSMUSP00000142601; ENSMUSG00000036381.
ENSMUST00000197220; ENSMUSP00000143070; ENSMUSG00000036381.
GeneIDi140795.
KEGGimmu:140795.
UCSCiuc008pik.2. mouse.

Organism-specific databases

CTDi9934.
MGIiMGI:2155705. P2ry14.

Phylogenomic databases

eggNOGiENOG410IK1E. Eukaryota.
ENOG4111GWF. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ9ESG6.
KOiK04299.
PhylomeDBiQ9ESG6.
TreeFamiTF330969.

Enzyme and pathway databases

ReactomeiR-MMU-417957. P2Y receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ9ESG6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036381.
CleanExiMM_P2RY14.
ExpressionAtlasiQ9ESG6. baseline and differential.
GenevisibleiQ9ESG6. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005466. P2Y14_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01655. UDPGLUCOSER.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2Y14_MOUSE
AccessioniPrimary (citable) accession number: Q9ESG6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.