Q9ESG6 (P2Y14_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
P2Y purinoceptor 14
Short name=P2Y14

Alternative name(s):
G-protein coupled receptor 105
UDP-glucose receptor

Gene names

Name:	P2ry14
Synonyms:	Gpr105

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for UDP-glucose coupled to G-proteins By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled purinergic nucleotide receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 338	338	P2Y purinoceptor 14		PRO_0000070045
Regions
	Topological domain	1 – 29	29	Extracellular Potential
	Transmembrane	30 – 50	21	Helical; Name=1; Potential
	Topological domain	51 – 55	5	Cytoplasmic Potential
	Transmembrane	56 – 76	21	Helical; Name=2; Potential
	Topological domain	77 – 96	20	Extracellular Potential
	Transmembrane	97 – 117	21	Helical; Name=3; Potential
	Topological domain	118 – 139	22	Cytoplasmic Potential
	Transmembrane	140 – 160	21	Helical; Name=4; Potential
	Topological domain	161 – 188	28	Extracellular Potential
	Transmembrane	189 – 209	21	Helical; Name=5; Potential
	Topological domain	210 – 234	25	Cytoplasmic Potential
	Transmembrane	235 – 255	21	Helical; Name=6; Potential
	Topological domain	256 – 278	23	Extracellular Potential
	Transmembrane	279 – 299	21	Helical; Name=7; Potential
	Topological domain	300 – 338	39	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	2	1	N-linked (GlcNAc...) Potential
	Glycosylation	3	1	N-linked (GlcNAc...) Potential
	Disulfide bond	94 ↔ 172		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9ESG6 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: 4376B50622A68A4E	FASTA	338	38,861
	10 20 30 40 50 60 MNNSTTTDPP NQPCSWNTLI TKQIIPVLYG MVFITGLLLN GISGWIFFYV PSSKSFIIYL 70 80 90 100 110 120 KNIVVADFLM GLTFPFKVLG DSGLGPWQVN VFVCRVSAVI FYVNMYVSIV FFGLISFDRY 130 140 150 160 170 180 YKIVKPLLTS IVQSVNYSKL LSVLVWMLML LLAVPNIILT NQGVKEVTKI QCMELKNELG 190 200 210 220 230 240 RKWHKASNYI FVSIFWVVFL LLIVFYTAIT RKIFKSHLKS RKNSTSVKRK SSRNIFSIVL 250 260 270 280 290 300 VFVVCFVPYH IARIPYTKSQ TEGHYSCRTK ETLLYAKEFT LLLSAANVCL DPIIYFFLCQ 310 320 330 PFREVLNKKL HMSLKVQNDL EVSKTKRENA IHESTDTL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"7 transmembrane G protein coupled receptor from hematopoietic progenitors." Lee B.C., Scadden D.T. Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Olfactory epithelium and Retina.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF177211 mRNA. Translation: AAG09275.1. BC028995 mRNA. Translation: AAH28995.1. BC058558 mRNA. Translation: AAH58558.1.
IPI	IPI00113311.
RefSeq	NP_001008497.1. NM_001008497.1. NP_573463.1. NM_133200.3.
UniGene	Mm.439021.
3D structure databases
ProteinModelPortal	Q9ESG6.
SMR	Q9ESG6. Positions 13-303.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9ESG6.
Proteomic databases
PRIDE	Q9ESG6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000065220; ENSMUSP00000066669; ENSMUSG00000036381. ENSMUST00000091112; ENSMUSP00000088642; ENSMUSG00000036381.
GeneID	140795.
KEGG	mmu:140795.
Organism-specific databases
CTD	9934.
MGI	MGI:2155705. P2ry14.
Phylogenomic databases
eggNOG	NOG149084.
GeneTree	ENSGT00640000091213.
HOGENOM	HOG000273884.
HOVERGEN	HBG108228.
InParanoid	Q9ESG6.
KO	K04299.
OMA	MSLTFPF.
OrthoDB	EOG4FXR8H.
Gene expression databases
ArrayExpress	Q9ESG6.
Bgee	Q9ESG6.
CleanEx	MM_P2RY14.
Genevestigator	Q9ESG6.
GermOnline	ENSMUSG00000036381. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002286. P2_purnocptor. IPR005466. UDPG_rcpt. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR01157. P2YPURNOCPTR. PR01655. UDPGLUCOSER.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9ESG6.
ChEMBL	CHEMBL1770046.
NextBio	369991.
SOURCE	Search...

Entry information

Entry name

P2Y14_MOUSE

Accession

Primary (citable) accession number: Q9ESG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	March 1, 2001
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program