ID   LFG1_MOUSE              Reviewed;         345 AA.
AC   Q9ESF4; Q8CI25;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 129.
DE   RecName: Full=Protein lifeguard 1;
DE   AltName: Full=Glutamate [NMDA] receptor-associated protein 1;
DE   AltName: Full=NMDA receptor glutamate-binding subunit;
GN   Name=Grina; Synonyms=Lag, Lfg1, Nmdara1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Goldberger O., Smith T., Minta J., Goldberger G.;
RT   "Identification and phylogeny of a novel family of eukaryotic membrane
RT   proteins related to a glutamate binding protein (GBP).";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N, FVB/N-3, and NMRI; TISSUE=Kidney, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19784873; DOI=10.1007/s10495-009-0402-2;
RA   Hu L., Smith T.F., Goldberger G.;
RT   "LFG: a candidate apoptosis regulatory gene family.";
RL   Apoptosis 14:1255-1265(2009).
CC   -!- FUNCTION: Potential apoptotic regulator. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BI1 family. LFG subfamily. {ECO:0000305}.
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DR   EMBL; AF182040; AAG16897.1; -; mRNA.
DR   EMBL; BC010802; AAH10802.1; -; mRNA.
DR   EMBL; BC019157; AAH19157.1; -; mRNA.
DR   EMBL; BC037667; AAH37667.2; -; mRNA.
DR   CCDS; CCDS27563.1; -.
DR   RefSeq; NP_075657.1; NM_023168.3.
DR   RefSeq; XP_006521312.1; XM_006521249.3.
DR   RefSeq; XP_006521313.1; XM_006521250.3.
DR   RefSeq; XP_006521314.1; XM_006521251.3.
DR   RefSeq; XP_011244011.1; XM_011245709.2.
DR   AlphaFoldDB; Q9ESF4; -.
DR   SMR; Q9ESF4; -.
DR   STRING; 10090.ENSMUSP00000023225; -.
DR   PhosphoSitePlus; Q9ESF4; -.
DR   PaxDb; 10090-ENSMUSP00000023225; -.
DR   Antibodypedia; 48337; 243 antibodies from 25 providers.
DR   DNASU; 66168; -.
DR   Ensembl; ENSMUST00000023225.8; ENSMUSP00000023225.7; ENSMUSG00000022564.8.
DR   GeneID; 66168; -.
DR   KEGG; mmu:66168; -.
DR   UCSC; uc007wjl.1; mouse.
DR   AGR; MGI:1913418; -.
DR   CTD; 2907; -.
DR   MGI; MGI:1913418; Grina.
DR   VEuPathDB; HostDB:ENSMUSG00000022564; -.
DR   eggNOG; KOG2322; Eukaryota.
DR   GeneTree; ENSGT01050000244890; -.
DR   HOGENOM; CLU_058671_3_0_1; -.
DR   InParanoid; Q9ESF4; -.
DR   OMA; YYVSYAF; -.
DR   OrthoDB; 377780at2759; -.
DR   PhylomeDB; Q9ESF4; -.
DR   TreeFam; TF319996; -.
DR   BioGRID-ORCS; 66168; 2 hits in 80 CRISPR screens.
DR   ChiTaRS; Grina; mouse.
DR   PRO; PR:Q9ESF4; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q9ESF4; Protein.
DR   Bgee; ENSMUSG00000022564; Expressed in granulocyte and 72 other cell types or tissues.
DR   ExpressionAtlas; Q9ESF4; baseline and differential.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0044325; F:transmembrane transporter binding; IDA:MGI.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IDA:MGI.
DR   GO; GO:2001234; P:negative regulation of apoptotic signaling pathway; IBA:GO_Central.
DR   GO; GO:1902236; P:negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; IDA:MGI.
DR   CDD; cd10428; LFG_like; 1.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; BAX INHIBITOR-RELATED; 1.
DR   PANTHER; PTHR23291:SF16; PROTEIN LIFEGUARD 1; 1.
DR   Pfam; PF01027; Bax1-I; 1.
DR   Genevisible; Q9ESF4; MM.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..345
FT                   /note="Protein lifeguard 1"
FT                   /id="PRO_0000314440"
FT   TRANSMEM        139..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        281..301
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..101
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   345 AA;  38408 MW;  A76F722EB678A2F7 CRC64;
     MSHEKSFLVS GDSYPPQNIV GPQAPMPPYV QAPYPGAPYP QAPFQPSPYG QPGYPHGPSP
     YPQGGYPQGP YPQGGYPQGP YPQSPFPPNP YGQPPPFQDP GSPQHGNYQE EGPPSYYDNQ
     DFPAVNWDKN IRQAFIRKVF LVLTLQLSVT LSTVAIFTFV GEVKGFVREN VWTYYVSYAI
     FFISLIVLSC CGDFRRKHPW NLVALSILTV SLSYMVGMIA SFYNTEAVIM AVGITTAVCF
     TVVIFSMQTR YDFTSCMGVL LVSVVVLFIF AILCIFIRNR ILEIVYASLG ALLFTCFLAV
     DTQLLLGNKQ LSLSPEEYVF AALNLYTDII NIFLYILTII GRAKE
//