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Protein

Protein lifeguard 1

Gene

Grina

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Potential apoptotic regulator.By similarity

GO - Molecular functioni

  1. ion channel binding Source: MGI

GO - Biological processi

  1. endoplasmic reticulum calcium ion homeostasis Source: MGI
  2. negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 1
Alternative name(s):
Glutamate [NMDA] receptor-associated protein 1
NMDA receptor glutamate-binding subunit
Gene namesi
Name:Grina
Synonyms:Lag, Lfg1, Nmdara1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913418. Grina.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence AnalysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. Golgi apparatus Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Protein lifeguard 1PRO_0000314440Add
BLAST

Proteomic databases

PRIDEiQ9ESF4.

PTM databases

PhosphoSiteiQ9ESF4.

Expressioni

Gene expression databases

BgeeiQ9ESF4.
GenevestigatoriQ9ESF4.

Structurei

3D structure databases

ProteinModelPortaliQ9ESF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 114100Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0670.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ9ESF4.
KOiK06890.
OMAiFQPSPYG.
OrthoDBiEOG7VB2G8.
PhylomeDBiQ9ESF4.
TreeFamiTF319996.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHEKSFLVS GDSYPPQNIV GPQAPMPPYV QAPYPGAPYP QAPFQPSPYG
60 70 80 90 100
QPGYPHGPSP YPQGGYPQGP YPQGGYPQGP YPQSPFPPNP YGQPPPFQDP
110 120 130 140 150
GSPQHGNYQE EGPPSYYDNQ DFPAVNWDKN IRQAFIRKVF LVLTLQLSVT
160 170 180 190 200
LSTVAIFTFV GEVKGFVREN VWTYYVSYAI FFISLIVLSC CGDFRRKHPW
210 220 230 240 250
NLVALSILTV SLSYMVGMIA SFYNTEAVIM AVGITTAVCF TVVIFSMQTR
260 270 280 290 300
YDFTSCMGVL LVSVVVLFIF AILCIFIRNR ILEIVYASLG ALLFTCFLAV
310 320 330 340
DTQLLLGNKQ LSLSPEEYVF AALNLYTDII NIFLYILTII GRAKE
Length:345
Mass (Da):38,408
Last modified:March 1, 2001 - v1
Checksum:iA76F722EB678A2F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182040 mRNA. Translation: AAG16897.1.
BC010802 mRNA. Translation: AAH10802.1.
BC019157 mRNA. Translation: AAH19157.1.
BC037667 mRNA. Translation: AAH37667.2.
CCDSiCCDS27563.1.
RefSeqiNP_075657.1. NM_023168.3.
XP_006521312.1. XM_006521249.2.
XP_006521313.1. XM_006521250.2.
XP_006521314.1. XM_006521251.2.
UniGeneiMm.41665.

Genome annotation databases

EnsembliENSMUST00000023225; ENSMUSP00000023225; ENSMUSG00000022564.
GeneIDi66168.
KEGGimmu:66168.
UCSCiuc007wjl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182040 mRNA. Translation: AAG16897.1.
BC010802 mRNA. Translation: AAH10802.1.
BC019157 mRNA. Translation: AAH19157.1.
BC037667 mRNA. Translation: AAH37667.2.
CCDSiCCDS27563.1.
RefSeqiNP_075657.1. NM_023168.3.
XP_006521312.1. XM_006521249.2.
XP_006521313.1. XM_006521250.2.
XP_006521314.1. XM_006521251.2.
UniGeneiMm.41665.

3D structure databases

ProteinModelPortaliQ9ESF4.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9ESF4.

Proteomic databases

PRIDEiQ9ESF4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023225; ENSMUSP00000023225; ENSMUSG00000022564.
GeneIDi66168.
KEGGimmu:66168.
UCSCiuc007wjl.1. mouse.

Organism-specific databases

CTDi2907.
MGIiMGI:1913418. Grina.

Phylogenomic databases

eggNOGiCOG0670.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ9ESF4.
KOiK06890.
OMAiFQPSPYG.
OrthoDBiEOG7VB2G8.
PhylomeDBiQ9ESF4.
TreeFamiTF319996.

Miscellaneous databases

ChiTaRSiGrina. mouse.
NextBioi320838.
PROiQ9ESF4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ESF4.
GenevestigatoriQ9ESF4.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and phylogeny of a novel family of eukaryotic membrane proteins related to a glutamate binding protein (GBP)."
    Goldberger O., Smith T., Minta J., Goldberger G.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N, FVB/N-3 and NMRI.
    Tissue: Kidney and Mammary tumor.
  3. "LFG: a candidate apoptosis regulatory gene family."
    Hu L., Smith T.F., Goldberger G.
    Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiLFG1_MOUSE
AccessioniPrimary (citable) accession number: Q9ESF4
Secondary accession number(s): Q8CI25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: April 1, 2015
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.