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Q9ESF4 (LFG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein lifeguard 1
Alternative name(s):
Glutamate [NMDA] receptor-associated protein 1
NMDA receptor glutamate-binding subunit
Gene names
Name:Grina
Synonyms:Lag, Lfg1, Nmdara1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length345 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential apoptotic regulator By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the BI1 family. LFG subfamily.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 345345Protein lifeguard 1
PRO_0000314440

Regions

Transmembrane139 – 15921Helical; Potential
Transmembrane171 – 19121Helical; Potential
Transmembrane202 – 22221Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane281 – 30121Helical; Potential
Transmembrane320 – 34021Helical; Potential
Compositional bias15 – 114100Pro-rich

Sequences

Sequence LengthMass (Da)Tools
Q9ESF4 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: A76F722EB678A2F7

FASTA34538,408
        10         20         30         40         50         60 
MSHEKSFLVS GDSYPPQNIV GPQAPMPPYV QAPYPGAPYP QAPFQPSPYG QPGYPHGPSP 

        70         80         90        100        110        120 
YPQGGYPQGP YPQGGYPQGP YPQSPFPPNP YGQPPPFQDP GSPQHGNYQE EGPPSYYDNQ 

       130        140        150        160        170        180 
DFPAVNWDKN IRQAFIRKVF LVLTLQLSVT LSTVAIFTFV GEVKGFVREN VWTYYVSYAI 

       190        200        210        220        230        240 
FFISLIVLSC CGDFRRKHPW NLVALSILTV SLSYMVGMIA SFYNTEAVIM AVGITTAVCF 

       250        260        270        280        290        300 
TVVIFSMQTR YDFTSCMGVL LVSVVVLFIF AILCIFIRNR ILEIVYASLG ALLFTCFLAV 

       310        320        330        340 
DTQLLLGNKQ LSLSPEEYVF AALNLYTDII NIFLYILTII GRAKE 

« Hide

References

« Hide 'large scale' references
[1]"Identification and phylogeny of a novel family of eukaryotic membrane proteins related to a glutamate binding protein (GBP)."
Goldberger O., Smith T., Minta J., Goldberger G.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N, FVB/N-3 and NMRI.
Tissue: Kidney and Mammary tumor.
[3]"LFG: a candidate apoptosis regulatory gene family."
Hu L., Smith T.F., Goldberger G.
Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF182040 mRNA. Translation: AAG16897.1.
BC010802 mRNA. Translation: AAH10802.1.
BC019157 mRNA. Translation: AAH19157.1.
BC037667 mRNA. Translation: AAH37667.2.
CCDSCCDS27563.1.
RefSeqNP_075657.1. NM_023168.3.
XP_006521312.1. XM_006521249.1.
XP_006521313.1. XM_006521250.1.
XP_006521314.1. XM_006521251.1.
UniGeneMm.41665.

3D structure databases

ProteinModelPortalQ9ESF4.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ9ESF4.

PTM databases

PhosphoSiteQ9ESF4.

Proteomic databases

PRIDEQ9ESF4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023225; ENSMUSP00000023225; ENSMUSG00000022564.
GeneID66168.
KEGGmmu:66168.
UCSCuc007wjl.1. mouse.

Organism-specific databases

CTD2907.
MGIMGI:1913418. Grina.

Phylogenomic databases

eggNOGCOG0670.
GeneTreeENSGT00500000044791.
HOGENOMHOG000060393.
HOVERGENHBG012084.
InParanoidQ9ESF4.
KOK06890.
OMAFQPSPYG.
OrthoDBEOG7VB2G8.
PhylomeDBQ9ESF4.
TreeFamTF319996.

Gene expression databases

BgeeQ9ESF4.
GenevestigatorQ9ESF4.

Family and domain databases

InterProIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERPTHR23291. PTHR23291. 1 hit.
PfamPF01027. Bax1-I. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGRINA. mouse.
NextBio320838.
PROQ9ESF4.
SOURCESearch...

Entry information

Entry nameLFG1_MOUSE
AccessionPrimary (citable) accession number: Q9ESF4
Secondary accession number(s): Q8CI25
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot