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Q9ESF4

- LFG1_MOUSE

UniProt

Q9ESF4 - LFG1_MOUSE

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Protein

Protein lifeguard 1

Gene

Grina

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Potential apoptotic regulator.By similarity

GO - Molecular functioni

  1. ion channel binding Source: MGI

GO - Biological processi

  1. endoplasmic reticulum calcium ion homeostasis Source: MGI
  2. negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lifeguard 1
Alternative name(s):
Glutamate [NMDA] receptor-associated protein 1
NMDA receptor glutamate-binding subunit
Gene namesi
Name:Grina
Synonyms:Lag, Lfg1, Nmdara1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:1913418. Grina.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: MGI
  2. Golgi apparatus Source: MGI
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Protein lifeguard 1PRO_0000314440Add
BLAST

Proteomic databases

PRIDEiQ9ESF4.

PTM databases

PhosphoSiteiQ9ESF4.

Expressioni

Gene expression databases

BgeeiQ9ESF4.
GenevestigatoriQ9ESF4.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ9ESF4.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei139 – 15921HelicalSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei227 – 24721HelicalSequence AnalysisAdd
BLAST
Transmembranei257 – 27721HelicalSequence AnalysisAdd
BLAST
Transmembranei281 – 30121HelicalSequence AnalysisAdd
BLAST
Transmembranei320 – 34021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi15 – 114100Pro-richAdd
BLAST

Sequence similaritiesi

Belongs to the BI1 family. LFG subfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0670.
GeneTreeiENSGT00500000044791.
HOGENOMiHOG000060393.
HOVERGENiHBG012084.
InParanoidiQ9ESF4.
KOiK06890.
OMAiFQPSPYG.
OrthoDBiEOG7VB2G8.
PhylomeDBiQ9ESF4.
TreeFamiTF319996.

Family and domain databases

InterProiIPR006214. Bax_inhibitor_1-related.
[Graphical view]
PANTHERiPTHR23291. PTHR23291. 1 hit.
PfamiPF01027. Bax1-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESF4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSHEKSFLVS GDSYPPQNIV GPQAPMPPYV QAPYPGAPYP QAPFQPSPYG
60 70 80 90 100
QPGYPHGPSP YPQGGYPQGP YPQGGYPQGP YPQSPFPPNP YGQPPPFQDP
110 120 130 140 150
GSPQHGNYQE EGPPSYYDNQ DFPAVNWDKN IRQAFIRKVF LVLTLQLSVT
160 170 180 190 200
LSTVAIFTFV GEVKGFVREN VWTYYVSYAI FFISLIVLSC CGDFRRKHPW
210 220 230 240 250
NLVALSILTV SLSYMVGMIA SFYNTEAVIM AVGITTAVCF TVVIFSMQTR
260 270 280 290 300
YDFTSCMGVL LVSVVVLFIF AILCIFIRNR ILEIVYASLG ALLFTCFLAV
310 320 330 340
DTQLLLGNKQ LSLSPEEYVF AALNLYTDII NIFLYILTII GRAKE
Length:345
Mass (Da):38,408
Last modified:March 1, 2001 - v1
Checksum:iA76F722EB678A2F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF182040 mRNA. Translation: AAG16897.1.
BC010802 mRNA. Translation: AAH10802.1.
BC019157 mRNA. Translation: AAH19157.1.
BC037667 mRNA. Translation: AAH37667.2.
CCDSiCCDS27563.1.
RefSeqiNP_075657.1. NM_023168.3.
XP_006521312.1. XM_006521249.1.
XP_006521313.1. XM_006521250.1.
XP_006521314.1. XM_006521251.1.
UniGeneiMm.41665.

Genome annotation databases

EnsembliENSMUST00000023225; ENSMUSP00000023225; ENSMUSG00000022564.
GeneIDi66168.
KEGGimmu:66168.
UCSCiuc007wjl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF182040 mRNA. Translation: AAG16897.1 .
BC010802 mRNA. Translation: AAH10802.1 .
BC019157 mRNA. Translation: AAH19157.1 .
BC037667 mRNA. Translation: AAH37667.2 .
CCDSi CCDS27563.1.
RefSeqi NP_075657.1. NM_023168.3.
XP_006521312.1. XM_006521249.1.
XP_006521313.1. XM_006521250.1.
XP_006521314.1. XM_006521251.1.
UniGenei Mm.41665.

3D structure databases

ProteinModelPortali Q9ESF4.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q9ESF4.

PTM databases

PhosphoSitei Q9ESF4.

Proteomic databases

PRIDEi Q9ESF4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023225 ; ENSMUSP00000023225 ; ENSMUSG00000022564 .
GeneIDi 66168.
KEGGi mmu:66168.
UCSCi uc007wjl.1. mouse.

Organism-specific databases

CTDi 2907.
MGIi MGI:1913418. Grina.

Phylogenomic databases

eggNOGi COG0670.
GeneTreei ENSGT00500000044791.
HOGENOMi HOG000060393.
HOVERGENi HBG012084.
InParanoidi Q9ESF4.
KOi K06890.
OMAi FQPSPYG.
OrthoDBi EOG7VB2G8.
PhylomeDBi Q9ESF4.
TreeFami TF319996.

Miscellaneous databases

ChiTaRSi GRINA. mouse.
NextBioi 320838.
PROi Q9ESF4.
SOURCEi Search...

Gene expression databases

Bgeei Q9ESF4.
Genevestigatori Q9ESF4.

Family and domain databases

InterProi IPR006214. Bax_inhibitor_1-related.
[Graphical view ]
PANTHERi PTHR23291. PTHR23291. 1 hit.
Pfami PF01027. Bax1-I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and phylogeny of a novel family of eukaryotic membrane proteins related to a glutamate binding protein (GBP)."
    Goldberger O., Smith T., Minta J., Goldberger G.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N, FVB/N-3 and NMRI.
    Tissue: Kidney and Mammary tumor.
  3. "LFG: a candidate apoptosis regulatory gene family."
    Hu L., Smith T.F., Goldberger G.
    Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiLFG1_MOUSE
AccessioniPrimary (citable) accession number: Q9ESF4
Secondary accession number(s): Q8CI25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3