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Q9ESF4

- LFG1_MOUSE

UniProt

Q9ESF4 - LFG1_MOUSE

Protein

Protein lifeguard 1

Gene

Grina

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Potential apoptotic regulator.By similarity

    GO - Molecular functioni

    1. ion channel binding Source: MGI

    GO - Biological processi

    1. endoplasmic reticulum calcium ion homeostasis Source: MGI
    2. negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein lifeguard 1
    Alternative name(s):
    Glutamate [NMDA] receptor-associated protein 1
    NMDA receptor glutamate-binding subunit
    Gene namesi
    Name:Grina
    Synonyms:Lag, Lfg1, Nmdara1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:1913418. Grina.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: MGI
    2. Golgi apparatus Source: MGI
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 345345Protein lifeguard 1PRO_0000314440Add
    BLAST

    Proteomic databases

    PRIDEiQ9ESF4.

    PTM databases

    PhosphoSiteiQ9ESF4.

    Expressioni

    Gene expression databases

    BgeeiQ9ESF4.
    GenevestigatoriQ9ESF4.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ESF4.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei139 – 15921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei257 – 27721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei281 – 30121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei320 – 34021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi15 – 114100Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the BI1 family. LFG subfamily.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0670.
    GeneTreeiENSGT00500000044791.
    HOGENOMiHOG000060393.
    HOVERGENiHBG012084.
    InParanoidiQ9ESF4.
    KOiK06890.
    OMAiFQPSPYG.
    OrthoDBiEOG7VB2G8.
    PhylomeDBiQ9ESF4.
    TreeFamiTF319996.

    Family and domain databases

    InterProiIPR006214. Bax_inhibitor_1-related.
    [Graphical view]
    PANTHERiPTHR23291. PTHR23291. 1 hit.
    PfamiPF01027. Bax1-I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ESF4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSHEKSFLVS GDSYPPQNIV GPQAPMPPYV QAPYPGAPYP QAPFQPSPYG    50
    QPGYPHGPSP YPQGGYPQGP YPQGGYPQGP YPQSPFPPNP YGQPPPFQDP 100
    GSPQHGNYQE EGPPSYYDNQ DFPAVNWDKN IRQAFIRKVF LVLTLQLSVT 150
    LSTVAIFTFV GEVKGFVREN VWTYYVSYAI FFISLIVLSC CGDFRRKHPW 200
    NLVALSILTV SLSYMVGMIA SFYNTEAVIM AVGITTAVCF TVVIFSMQTR 250
    YDFTSCMGVL LVSVVVLFIF AILCIFIRNR ILEIVYASLG ALLFTCFLAV 300
    DTQLLLGNKQ LSLSPEEYVF AALNLYTDII NIFLYILTII GRAKE 345
    Length:345
    Mass (Da):38,408
    Last modified:March 1, 2001 - v1
    Checksum:iA76F722EB678A2F7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182040 mRNA. Translation: AAG16897.1.
    BC010802 mRNA. Translation: AAH10802.1.
    BC019157 mRNA. Translation: AAH19157.1.
    BC037667 mRNA. Translation: AAH37667.2.
    CCDSiCCDS27563.1.
    RefSeqiNP_075657.1. NM_023168.3.
    XP_006521312.1. XM_006521249.1.
    XP_006521313.1. XM_006521250.1.
    XP_006521314.1. XM_006521251.1.
    UniGeneiMm.41665.

    Genome annotation databases

    EnsembliENSMUST00000023225; ENSMUSP00000023225; ENSMUSG00000022564.
    GeneIDi66168.
    KEGGimmu:66168.
    UCSCiuc007wjl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF182040 mRNA. Translation: AAG16897.1 .
    BC010802 mRNA. Translation: AAH10802.1 .
    BC019157 mRNA. Translation: AAH19157.1 .
    BC037667 mRNA. Translation: AAH37667.2 .
    CCDSi CCDS27563.1.
    RefSeqi NP_075657.1. NM_023168.3.
    XP_006521312.1. XM_006521249.1.
    XP_006521313.1. XM_006521250.1.
    XP_006521314.1. XM_006521251.1.
    UniGenei Mm.41665.

    3D structure databases

    ProteinModelPortali Q9ESF4.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q9ESF4.

    PTM databases

    PhosphoSitei Q9ESF4.

    Proteomic databases

    PRIDEi Q9ESF4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023225 ; ENSMUSP00000023225 ; ENSMUSG00000022564 .
    GeneIDi 66168.
    KEGGi mmu:66168.
    UCSCi uc007wjl.1. mouse.

    Organism-specific databases

    CTDi 2907.
    MGIi MGI:1913418. Grina.

    Phylogenomic databases

    eggNOGi COG0670.
    GeneTreei ENSGT00500000044791.
    HOGENOMi HOG000060393.
    HOVERGENi HBG012084.
    InParanoidi Q9ESF4.
    KOi K06890.
    OMAi FQPSPYG.
    OrthoDBi EOG7VB2G8.
    PhylomeDBi Q9ESF4.
    TreeFami TF319996.

    Miscellaneous databases

    ChiTaRSi GRINA. mouse.
    NextBioi 320838.
    PROi Q9ESF4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ESF4.
    Genevestigatori Q9ESF4.

    Family and domain databases

    InterProi IPR006214. Bax_inhibitor_1-related.
    [Graphical view ]
    PANTHERi PTHR23291. PTHR23291. 1 hit.
    Pfami PF01027. Bax1-I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and phylogeny of a novel family of eukaryotic membrane proteins related to a glutamate binding protein (GBP)."
      Goldberger O., Smith T., Minta J., Goldberger G.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N, FVB/N-3 and NMRI.
      Tissue: Kidney and Mammary tumor.
    3. "LFG: a candidate apoptosis regulatory gene family."
      Hu L., Smith T.F., Goldberger G.
      Apoptosis 14:1255-1265(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiLFG1_MOUSE
    AccessioniPrimary (citable) accession number: Q9ESF4
    Secondary accession number(s): Q8CI25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3