Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tumor necrosis factor ligand superfamily member 11

Gene

Tnfsf11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Receptor
Biological processDifferentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 11
Alternative name(s):
Osteoclast differentiation factor
Short name:
ODF
Osteoprotegerin ligand
Short name:
OPGL
Receptor activator of nuclear factor kappa-B ligand
Short name:
RANKL
TNF-related activation-induced cytokine
Short name:
TRANCE
CD_antigen: CD254
Cleaved into the following 2 chains:
Gene namesi
Name:Tnfsf11
Synonyms:Opgl, Rankl, Trance
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620784 Tnfsf11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 47CytoplasmicSequence analysisAdd BLAST47
Transmembranei48 – 68Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini69 – 318ExtracellularSequence analysisAdd BLAST250

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000345181 – 318Tumor necrosis factor ligand superfamily member 11, membrane formAdd BLAST318
ChainiPRO_0000034519141 – 318Tumor necrosis factor ligand superfamily member 11, soluble formAdd BLAST178

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei140 – 141CleavageBy similarity2

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ESE2

Expressioni

Tissue specificityi

Highly expressed in thymus and bone tissues.

Interactioni

Subunit structurei

Homotrimer. Interacts with TNFRSF11A and TNFRSF11B. Interacts with FBN1 (via N-terminal domain) in a Ca(+2)-dependent manner.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000013210

Structurei

3D structure databases

ProteinModelPortaliQ9ESE2
SMRiQ9ESE2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEIS Eukaryota
ENOG410YGCE LUCA
HOGENOMiHOG000132981
HOVERGENiHBG054257
InParanoidiQ9ESE2
KOiK05473
PhylomeDBiQ9ESE2

Family and domain databases

Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR006052 TNF_dom
IPR017355 TNF_ligand_10/11
IPR008983 Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229 TNF, 1 hit
PIRSFiPIRSF038013 TNF10_TNF11, 1 hit
SMARTiView protein in SMART
SM00207 TNF, 1 hit
SUPFAMiSSF49842 SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS50049 TNF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ESE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRANRDYGK YLRGSEEMGS CPGVPHEGPL HPAPSAPAPA PPPAASRFMF
60 70 80 90 100
LALLGLGLGQ VVCSIALFLY FRAQMDPNRI SEDSTRCFYR ILRLRENTGL
110 120 130 140 150
QDSTLESEDT EALPDSCRRM KQAFQGAVQR ELQHIVGPQR FSGVPAMMEG
160 170 180 190 200
SWLDVARRGK PEAQPFAHLT INAADIPSGS HKVSLSSWYH DRGWAKISNM
210 220 230 240 250
TLSNGKLRVN QDGFYYLYAN ICFRHHETSG SVPADYLQLM VYVVKTSIKI
260 270 280 290 300
PSSHNLMKGG STKNWSGNSE FHFYSINVGG FFKLRAGEEI SVQVSNPSLL
310
DPDQDATYFG AFKVQDID
Length:318
Mass (Da):35,370
Last modified:March 1, 2001 - v1
Checksum:i4B87A4D706AD098F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti317I → M in AAL23963 (PubMed:11804028).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187319 mRNA Translation: AAG17031.1
AF425669 mRNA Translation: AAL23963.1
RefSeqiNP_476490.1, NM_057149.1
UniGeneiRn.217570
Rn.64517

Genome annotation databases

GeneIDi117516
KEGGirno:117516
UCSCiRGD:620784 rat

Similar proteinsi

Entry informationi

Entry nameiTNF11_RAT
AccessioniPrimary (citable) accession number: Q9ESE2
Secondary accession number(s): Q91ZI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health