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Protein

Tumor necrosis factor ligand superfamily member 11

Gene

Tnfsf11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei140 – 1412CleavageBy similarity

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. immune response Source: InterPro
  3. multicellular organismal development Source: UniProtKB-KW
  4. positive regulation of bone resorption Source: RGD
  5. positive regulation of osteoclast differentiation Source: RGD
  6. response to immobilization stress Source: RGD
  7. response to radiation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Receptor

Keywords - Biological processi

Differentiation

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 11
Alternative name(s):
Osteoclast differentiation factor
Short name:
ODF
Osteoprotegerin ligand
Short name:
OPGL
Receptor activator of nuclear factor kappa-B ligand
Short name:
RANKL
TNF-related activation-induced cytokine
Short name:
TRANCE
CD_antigen: CD254
Cleaved into the following 2 chains:
Gene namesi
Name:Tnfsf11
Synonyms:Opgl, Rankl, Trance
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620784. Tnfsf11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4747CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei48 – 6821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini69 – 318250ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Tumor necrosis factor ligand superfamily member 11, membrane formPRO_0000034518Add
BLAST
Chaini141 – 318178Tumor necrosis factor ligand superfamily member 11, soluble formPRO_0000034519Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ESE2.

Expressioni

Tissue specificityi

Highly expressed in thymus and bone tissues.

Gene expression databases

GenevestigatoriQ9ESE2.

Interactioni

Subunit structurei

Homotrimer. Interacts with TNFRSF11A and TNFRSF11B (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9ESE2.
SMRiQ9ESE2. Positions 163-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40842.
HOGENOMiHOG000132981.
HOVERGENiHBG054257.
InParanoidiQ9ESE2.
KOiK05473.
PhylomeDBiQ9ESE2.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006052. TNF_dom.
IPR017355. TNF_ligand_10/11.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF038013. TNF10_TNF11. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ESE2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRANRDYGK YLRGSEEMGS CPGVPHEGPL HPAPSAPAPA PPPAASRFMF
60 70 80 90 100
LALLGLGLGQ VVCSIALFLY FRAQMDPNRI SEDSTRCFYR ILRLRENTGL
110 120 130 140 150
QDSTLESEDT EALPDSCRRM KQAFQGAVQR ELQHIVGPQR FSGVPAMMEG
160 170 180 190 200
SWLDVARRGK PEAQPFAHLT INAADIPSGS HKVSLSSWYH DRGWAKISNM
210 220 230 240 250
TLSNGKLRVN QDGFYYLYAN ICFRHHETSG SVPADYLQLM VYVVKTSIKI
260 270 280 290 300
PSSHNLMKGG STKNWSGNSE FHFYSINVGG FFKLRAGEEI SVQVSNPSLL
310
DPDQDATYFG AFKVQDID
Length:318
Mass (Da):35,370
Last modified:February 28, 2001 - v1
Checksum:i4B87A4D706AD098F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti317 – 3171I → M in AAL23963 (PubMed:11804028).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187319 mRNA. Translation: AAG17031.1.
AF425669 mRNA. Translation: AAL23963.1.
RefSeqiNP_476490.1. NM_057149.1.
UniGeneiRn.217570.
Rn.64517.

Genome annotation databases

GeneIDi117516.
KEGGirno:117516.
UCSCiRGD:620784. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187319 mRNA. Translation: AAG17031.1.
AF425669 mRNA. Translation: AAL23963.1.
RefSeqiNP_476490.1. NM_057149.1.
UniGeneiRn.217570.
Rn.64517.

3D structure databases

ProteinModelPortaliQ9ESE2.
SMRiQ9ESE2. Positions 163-318.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9ESE2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi117516.
KEGGirno:117516.
UCSCiRGD:620784. rat.

Organism-specific databases

CTDi8600.
RGDi620784. Tnfsf11.

Phylogenomic databases

eggNOGiNOG40842.
HOGENOMiHOG000132981.
HOVERGENiHBG054257.
InParanoidiQ9ESE2.
KOiK05473.
PhylomeDBiQ9ESE2.

Miscellaneous databases

NextBioi620273.
PROiQ9ESE2.

Gene expression databases

GenevestigatoriQ9ESE2.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006052. TNF_dom.
IPR017355. TNF_ligand_10/11.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
PIRSFiPIRSF038013. TNF10_TNF11. 1 hit.
SMARTiSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
PROSITEiPS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning, sequence and functional characterization of the rat homologue of receptor activator of NF-kB ligand."
    Xu J.K., Tan J.K., Huang L., Gao X.H., Laird R., Liu D., Wysocki S., Zheng M.H.
    J. Bone Miner. Res. 15:2178-2186(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Tibial bone.
  2. "Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene."
    Odgren P.R., Kim N., van Wesenbeeck L., MacKay C., Mason-Savas A., Safadi F.F., Popoff S.N., Lengner C., van-Hul W., Choi Y., Marks S.C. Jr.
    Int. J. Dev. Biol. 45:853-859(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 266-318.
    Strain: Fischer 344.

Entry informationi

Entry nameiTNF11_RAT
AccessioniPrimary (citable) accession number: Q9ESE2
Secondary accession number(s): Q91ZI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 5, 2002
Last sequence update: February 28, 2001
Last modified: January 6, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.