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Q9ESE2

- TNF11_RAT

UniProt

Q9ESE2 - TNF11_RAT

Protein

Tumor necrosis factor ligand superfamily member 11

Gene

Tnfsf11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei140 – 1412CleavageBy similarity

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. immune response Source: InterPro
    3. multicellular organismal development Source: UniProtKB-KW
    4. positive regulation of bone resorption Source: RGD
    5. positive regulation of osteoclast differentiation Source: RGD
    6. response to immobilization stress Source: RGD
    7. response to radiation Source: RGD

    Keywords - Molecular functioni

    Cytokine, Developmental protein, Receptor

    Keywords - Biological processi

    Differentiation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tumor necrosis factor ligand superfamily member 11
    Alternative name(s):
    Osteoclast differentiation factor
    Short name:
    ODF
    Osteoprotegerin ligand
    Short name:
    OPGL
    Receptor activator of nuclear factor kappa-B ligand
    Short name:
    RANKL
    TNF-related activation-induced cytokine
    Short name:
    TRANCE
    CD_antigen: CD254
    Cleaved into the following 2 chains:
    Gene namesi
    Name:Tnfsf11
    Synonyms:Opgl, Rankl, Trance
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620784. Tnfsf11.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Tumor necrosis factor ligand superfamily member 11, membrane formPRO_0000034518Add
    BLAST
    Chaini141 – 318178Tumor necrosis factor ligand superfamily member 11, soluble formPRO_0000034519Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The soluble form derives from the membrane form by proteolytic processing.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9ESE2.

    Expressioni

    Tissue specificityi

    Highly expressed in thymus and bone tissues.

    Gene expression databases

    GenevestigatoriQ9ESE2.

    Interactioni

    Subunit structurei

    Homotrimer. Interacts with TNFRSF11A and TNFRSF11B By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ESE2.
    SMRiQ9ESE2. Positions 163-318.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4747CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini69 – 318250ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei48 – 6821Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the tumor necrosis factor family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40842.
    HOGENOMiHOG000132981.
    HOVERGENiHBG054257.
    InParanoidiQ9ESE2.
    KOiK05473.
    PhylomeDBiQ9ESE2.

    Family and domain databases

    Gene3Di2.60.120.40. 1 hit.
    InterProiIPR006052. TNF_dom.
    IPR017355. TNF_ligand_10/11.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view]
    PfamiPF00229. TNF. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038013. TNF10_TNF11. 1 hit.
    SMARTiSM00207. TNF. 1 hit.
    [Graphical view]
    SUPFAMiSSF49842. SSF49842. 1 hit.
    PROSITEiPS50049. TNF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ESE2-1 [UniParc]FASTAAdd to Basket

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    MRRANRDYGK YLRGSEEMGS CPGVPHEGPL HPAPSAPAPA PPPAASRFMF    50
    LALLGLGLGQ VVCSIALFLY FRAQMDPNRI SEDSTRCFYR ILRLRENTGL 100
    QDSTLESEDT EALPDSCRRM KQAFQGAVQR ELQHIVGPQR FSGVPAMMEG 150
    SWLDVARRGK PEAQPFAHLT INAADIPSGS HKVSLSSWYH DRGWAKISNM 200
    TLSNGKLRVN QDGFYYLYAN ICFRHHETSG SVPADYLQLM VYVVKTSIKI 250
    PSSHNLMKGG STKNWSGNSE FHFYSINVGG FFKLRAGEEI SVQVSNPSLL 300
    DPDQDATYFG AFKVQDID 318
    Length:318
    Mass (Da):35,370
    Last modified:March 1, 2001 - v1
    Checksum:i4B87A4D706AD098F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti317 – 3171I → M in AAL23963. (PubMed:11804028)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF187319 mRNA. Translation: AAG17031.1.
    AF425669 mRNA. Translation: AAL23963.1.
    RefSeqiNP_476490.1. NM_057149.1.
    UniGeneiRn.217570.
    Rn.64517.

    Genome annotation databases

    GeneIDi117516.
    KEGGirno:117516.
    UCSCiRGD:620784. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF187319 mRNA. Translation: AAG17031.1 .
    AF425669 mRNA. Translation: AAL23963.1 .
    RefSeqi NP_476490.1. NM_057149.1.
    UniGenei Rn.217570.
    Rn.64517.

    3D structure databases

    ProteinModelPortali Q9ESE2.
    SMRi Q9ESE2. Positions 163-318.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9ESE2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 117516.
    KEGGi rno:117516.
    UCSCi RGD:620784. rat.

    Organism-specific databases

    CTDi 8600.
    RGDi 620784. Tnfsf11.

    Phylogenomic databases

    eggNOGi NOG40842.
    HOGENOMi HOG000132981.
    HOVERGENi HBG054257.
    InParanoidi Q9ESE2.
    KOi K05473.
    PhylomeDBi Q9ESE2.

    Miscellaneous databases

    NextBioi 620273.
    PROi Q9ESE2.

    Gene expression databases

    Genevestigatori Q9ESE2.

    Family and domain databases

    Gene3Di 2.60.120.40. 1 hit.
    InterProi IPR006052. TNF_dom.
    IPR017355. TNF_ligand_10/11.
    IPR008983. Tumour_necrosis_fac-like_dom.
    [Graphical view ]
    Pfami PF00229. TNF. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038013. TNF10_TNF11. 1 hit.
    SMARTi SM00207. TNF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49842. SSF49842. 1 hit.
    PROSITEi PS50049. TNF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequence and functional characterization of the rat homologue of receptor activator of NF-kB ligand."
      Xu J.K., Tan J.K., Huang L., Gao X.H., Laird R., Liu D., Wysocki S., Zheng M.H.
      J. Bone Miner. Res. 15:2178-2186(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Tibial bone.
    2. "Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene."
      Odgren P.R., Kim N., van Wesenbeeck L., MacKay C., Mason-Savas A., Safadi F.F., Popoff S.N., Lengner C., van-Hul W., Choi Y., Marks S.C. Jr.
      Int. J. Dev. Biol. 45:853-859(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 266-318.
      Strain: Fischer 344.

    Entry informationi

    Entry nameiTNF11_RAT
    AccessioniPrimary (citable) accession number: Q9ESE2
    Secondary accession number(s): Q91ZI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 6, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3