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Q9ESE2 (TNF11_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tumor necrosis factor ligand superfamily member 11
Alternative name(s):
Osteoclast differentiation factor
Short name=ODF
Osteoprotegerin ligand
Short name=OPGL
Receptor activator of nuclear factor kappa-B ligand
Short name=RANKL
TNF-related activation-induced cytokine
Short name=TRANCE
CD_antigen=CD254
Gene names
Name:Tnfsf11
Synonyms:Opgl, Rankl, Trance
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Subunit structure

Homotrimer. Interacts with TNFRSF11A and TNFRSF11B By similarity.

Subcellular location

Cell membrane; Single-pass type II membrane protein By similarity.

Tumor necrosis factor ligand superfamily member 11, soluble form: Secreted By similarity.

Tissue specificity

Highly expressed in thymus and bone tissues.

Post-translational modification

The soluble form derives from the membrane form by proteolytic processing By similarity.

Sequence similarities

Belongs to the tumor necrosis factor family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Tumor necrosis factor ligand superfamily member 11, membrane form
PRO_0000034518
Chain141 – 318178Tumor necrosis factor ligand superfamily member 11, soluble form
PRO_0000034519

Regions

Topological domain1 – 4747Cytoplasmic Potential
Transmembrane48 – 6821Helical; Signal-anchor for type II membrane protein; Potential
Topological domain69 – 318250Extracellular Potential

Sites

Site140 – 1412Cleavage By similarity

Amino acid modifications

Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation2641N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict3171I → M in AAL23963. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9ESE2 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 4B87A4D706AD098F

FASTA31835,370
        10         20         30         40         50         60 
MRRANRDYGK YLRGSEEMGS CPGVPHEGPL HPAPSAPAPA PPPAASRFMF LALLGLGLGQ 

        70         80         90        100        110        120 
VVCSIALFLY FRAQMDPNRI SEDSTRCFYR ILRLRENTGL QDSTLESEDT EALPDSCRRM 

       130        140        150        160        170        180 
KQAFQGAVQR ELQHIVGPQR FSGVPAMMEG SWLDVARRGK PEAQPFAHLT INAADIPSGS 

       190        200        210        220        230        240 
HKVSLSSWYH DRGWAKISNM TLSNGKLRVN QDGFYYLYAN ICFRHHETSG SVPADYLQLM 

       250        260        270        280        290        300 
VYVVKTSIKI PSSHNLMKGG STKNWSGNSE FHFYSINVGG FFKLRAGEEI SVQVSNPSLL 

       310 
DPDQDATYFG AFKVQDID 

« Hide

References

[1]"Cloning, sequence and functional characterization of the rat homologue of receptor activator of NF-kB ligand."
Xu J.K., Tan J.K., Huang L., Gao X.H., Laird R., Liu D., Wysocki S., Zheng M.H.
J. Bone Miner. Res. 15:2178-2186(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Tibial bone.
[2]"Evidence that the rat osteopetrotic mutation toothless (tl) is not in the TNFSF11 (TRANCE, RANKL, ODF, OPGL) gene."
Odgren P.R., Kim N., van Wesenbeeck L., MacKay C., Mason-Savas A., Safadi F.F., Popoff S.N., Lengner C., van-Hul W., Choi Y., Marks S.C. Jr.
Int. J. Dev. Biol. 45:853-859(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 266-318.
Strain: Fischer 344.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF187319 mRNA. Translation: AAG17031.1.
AF425669 mRNA. Translation: AAL23963.1.
RefSeqNP_476490.1. NM_057149.1.
UniGeneRn.217570.
Rn.64517.

3D structure databases

ProteinModelPortalQ9ESE2.
SMRQ9ESE2. Positions 163-318.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9ESE2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID117516.
KEGGrno:117516.
UCSCRGD:620784. rat.

Organism-specific databases

CTD8600.
RGD620784. Tnfsf11.

Phylogenomic databases

eggNOGNOG40842.
HOGENOMHOG000132981.
HOVERGENHBG054257.
InParanoidQ9ESE2.
KOK05473.
PhylomeDBQ9ESE2.

Gene expression databases

GenevestigatorQ9ESE2.

Family and domain databases

Gene3D2.60.120.40. 1 hit.
InterProIPR006052. TNF_dom.
IPR017355. TNF_ligand_10/11.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamPF00229. TNF. 1 hit.
[Graphical view]
PIRSFPIRSF038013. TNF10_TNF11. 1 hit.
SMARTSM00207. TNF. 1 hit.
[Graphical view]
SUPFAMSSF49842. SSF49842. 1 hit.
PROSITEPS50049. TNF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio620273.
PROQ9ESE2.

Entry information

Entry nameTNF11_RAT
AccessionPrimary (citable) accession number: Q9ESE2
Secondary accession number(s): Q91ZI9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families