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Protein

Lipopolysaccharide-responsive and beige-like anchor protein

Gene

Lrba

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules.1 Publication

GO - Molecular functioni

GO - Biological processi

  • endosomal transport Source: MGI
  • protein localization Source: MGI
  • signal transduction Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Lipopolysaccharide-responsive and beige-like anchor protein
Alternative name(s):
Beige-like protein
Gene namesi
Name:Lrba
Synonyms:Bgl, Lba
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1933162. Lrba.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1529 – 154517HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasmic, membrane-bounded vesicle Source: MGI
  • endoplasmic reticulum Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • lysosome Source: UniProtKB
  • membrane Source: MGI
  • plasma membrane Source: UniProtKB
  • trans-Golgi network Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Golgi apparatus, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 28562855Lipopolysaccharide-responsive and beige-like anchor proteinPRO_0000386545Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei10 – 101PhosphoserineBy similarity
Modified residuei979 – 9791PhosphoserineCombined sources
Modified residuei1003 – 10031PhosphoserineCombined sources
Modified residuei1097 – 10971PhosphoserineBy similarity
Modified residuei1132 – 11321PhosphoserineBy similarity
Modified residuei1136 – 11361PhosphoserineBy similarity
Modified residuei1219 – 12191PhosphoserineCombined sources
Modified residuei1221 – 12211PhosphoserineCombined sources
Modified residuei1228 – 12281PhosphoserineCombined sources
Modified residuei1244 – 12441PhosphoserineBy similarity
Modified residuei1258 – 12581PhosphoserineBy similarity
Modified residuei1487 – 14871PhosphoserineBy similarity
Modified residuei1497 – 14971PhosphoserineBy similarity
Modified residuei1608 – 16081PhosphoserineBy similarity
Modified residuei1770 – 17701PhosphoserineCombined sources
Modified residuei1773 – 17731PhosphoserineCombined sources
Modified residuei2057 – 20571PhosphoserineBy similarity
Modified residuei2489 – 24891PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9ESE1.
MaxQBiQ9ESE1.
PaxDbiQ9ESE1.
PeptideAtlasiQ9ESE1.
PRIDEiQ9ESE1.

PTM databases

iPTMnetiQ9ESE1.
PhosphoSiteiQ9ESE1.

Expressioni

Tissue specificityi

Isoform 1 is expressed in the brain, is absent from the lung and the bone marrow and is less abundant in the spleen. Isoform 2 is expressed in the spleen, lung, brain and bone marrow. Isoform 3 is expressed in the brain, is absent from the bone marrow and is less abundant in the spleen and lung.1 Publication

Inductioni

By lipopolysaccharide (LPS).1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9ESE1. 2 interactions.
MINTiMINT-1866542.
STRINGi10090.ENSMUSP00000103261.

Structurei

3D structure databases

ProteinModelPortaliQ9ESE1.
SMRiQ9ESE1. Positions 2069-2482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati1298 – 134043WD 1Add
BLAST
Domaini2066 – 2174109BEACH-type PHPROSITE-ProRule annotationAdd
BLAST
Domaini2193 – 2482290BEACHPROSITE-ProRule annotationAdd
BLAST
Repeati2584 – 262643WD 2Add
BLAST
Repeati2629 – 267244WD 3Add
BLAST
Repeati2688 – 272841WD 4Add
BLAST
Repeati2770 – 280940WD 5Add
BLAST
Repeati2812 – 285140WD 6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1994 – 19985Poly-Arg

Sequence similaritiesi

Contains 1 BEACH domain.PROSITE-ProRule annotation
Contains 1 BEACH-type PH domain.PROSITE-ProRule annotation
Contains 6 WD repeats.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, WD repeat

Phylogenomic databases

eggNOGiKOG1786. Eukaryota.
ENOG410XNQC. LUCA.
HOGENOMiHOG000082375.
InParanoidiQ9ESE1.
PhylomeDBiQ9ESE1.

Family and domain databases

Gene3Di1.10.1540.10. 1 hit.
1.25.10.10. 4 hits.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR010508. DUF1088.
IPR031570. DUF4704.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF06469. DUF1088. 1 hit.
PF15787. DUF4704. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ESE1-1) [UniParc]FASTAAdd to basket

Also known as: lba-alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASEDNRAPS RPPTGDDGGG GGKEETPTEG GALSLKPGLP IRGIRMKFAV
60 70 80 90 100
LTGLVEVGEV SNRDIVETVF NLLVGGQFDL EMNFIIQEGE SIMCMVELLE
110 120 130 140 150
KCDVTCQAEV WSMFTAILKK SIRNLQVCTE VGLVEKVLGK IEKVDSMIAD
160 170 180 190 200
LLVDMLGVLA SYNLTVRELK LFFSKLQGDK GQWPPHAGKL LSVLKHMPQK
210 220 230 240 250
YGPDAFFNFP GKSAAAIALP PIARWPYQNG FTFHTWLRMD PVNNINVDKD
260 270 280 290 300
KPYLYCFRTS KGLGYSAHFV GGCLIITSIK SKGKGFQHCV KFDFKPQKWY
310 320 330 340 350
MVTIVHIYNR WKNSELRCYV NGELASYGEI TWFVNTSDTF DKCFLGSSET
360 370 380 390 400
ADANRVFCGQ MTAVYLFSDA LNAAQIFAIY QLGLGYKGTF KFKAESDLFL
410 420 430 440 450
AEHHKLLLYD GKLSSAIAFM YNPRATDAQL CLESSPKDNP SIFVHSPHAL
460 470 480 490 500
MLQDVKAVLT HSIQSAMHSI GGVQVLFPLF AQLDYKQYLS DEVDLTICTT
510 520 530 540 550
LLAFIMELLK NSIAMQEQML ACKGFLVIGY SLEKSSKSHV SRAVLELCLA
560 570 580 590 600
FSKYLSNLQN GMPLLKQLCD HILLNPAVWI HTPAKVQLML YTYLSTEFIG
610 620 630 640 650
TVNIYNTIRR VGTVLLIMHT LKYYYWAVNP QDRSGITPKG LDGPRPNQKE
660 670 680 690 700
ILSLRAFLLM FIKQLVMKDS GVKEDELQAI LNYLLTMHED DNLMDVLQLL
710 720 730 740 750
VALMAEHPNS MIPAFDQRNG LRVIYKLLAS KSEGIRVQAL KALGYFLKHL
760 770 780 790 800
APKRKAEVML GHGLFSLLAE RLMLQTNLIT MTMYNVLFEI LIEQICTQVI
810 820 830 840 850
HKQHPDPDST VKIQNPQILK VIATLLRNSP QCPESMEVRR AFLSDMIKLF
860 870 880 890 900
NNSRENRRSL LQCSVWQEWM LSLCYFNPKN SDEQKITEMV YAIFRILLYH
910 920 930 940 950
AVKYEWGGWR VWVDTLSITH SKVTFEIHKE NLANIFREEQ RKGDEETGPC
960 970 980 990 1000
SSSLVPEGTG ATRGVDVSVG SQHEDRKDSP ISPHFTRNSD ENSSIGRASS
1010 1020 1030 1040 1050
IDSASNTELQ THDMSSDEKK VERENQELLD QATVEETATN GAKDDLETSS
1060 1070 1080 1090 1100
DAAEPVTINS NSLEPGKDTV TISEVSASIS SPSEEDAAEM PELLEKSGVE
1110 1120 1130 1140 1150
EKEDDDYVEL KVEGSPTEEA GLPTELQGEG LSVAASGGRE EPDMCGHGCE
1160 1170 1180 1190 1200
VQVEAPITKI HNDPETTDSE DSRFPTVATA GSLATSSEVP VPQATVQSDS
1210 1220 1230 1240 1250
HEMLDGGMKA TNLAGETESV SDCADNVSEA PATSEQKITK LDVSSVASDT
1260 1270 1280 1290 1300
ERFELKASTS TEAPQPQRHG LEISRQQEQT AQGTAPDAVD QQRRDSRSTM
1310 1320 1330 1340 1350
FRIPEFKWSQ MHQRLLTDLL FSIETDIQMW RSHSTKTVMD FVNSSDNVIF
1360 1370 1380 1390 1400
VHNTIHLISQ VMDNMVMACG GILPLLSAAT SATHELENIE PTQGLSIEAS
1410 1420 1430 1440 1450
VTFLQRLISL VDVLIFASSL GFTEIEAEKN MSSGGILRQC LRLVCAVAVR
1460 1470 1480 1490 1500
NCLECQQHSQ LKARGDTAKS SKTIHSLIPM GKSAAKSPVD IVTGGISSVR
1510 1520 1530 1540 1550
DLDRLPARTW TLIGLRAVVF RDIEDSKQAQ FLALAVVYFI SVLMVSKYRD
1560 1570 1580 1590 1600
ILEPQDERHS QSLKETSSDN GNASLPDAEN TPAEFSSLTL SSVEESLEGT
1610 1620 1630 1640 1650
SCTRRRDSGL GEETASGLGS GLSVASPAAP LGVSAGPDAI SEVLCTLSLE
1660 1670 1680 1690 1700
VNKSQETRID GGNELDRKVT PSVPVSKNVN VKDILRSLVN MPADGVTVDP
1710 1720 1730 1740 1750
ALLPPACLGA LGDLSVDPPM QFRSFDRSVI IATKKSSVLP SALTTSAPSS
1760 1770 1780 1790 1800
AVSVVSSVDP THASDTGGES PGSRSPKCKT ALSCKQLAPS HKTPAAHMSI
1810 1820 1830 1840 1850
TERLEHALEK AAPLLREIFV DFAPFLSRTL LGSHGQELLI EGTSLVCMKS
1860 1870 1880 1890 1900
SSSVVELVML LCSQEWQNSI QKNAGLAFIE LVNEGRLLSQ TMKDHLVRVA
1910 1920 1930 1940 1950
NEAEFILSRQ RAEDIHRHAE FESLCAQYSA DKREEEKMCD HLIRAAKYRD
1960 1970 1980 1990 2000
HVTATQLIQK IINLLTDKHG AWGSSAVSRP REFWRLDYWE DDLRRRRRFV
2010 2020 2030 2040 2050
RNPLGSTHPE ATLKTAVEHA ADEDILAKGK QSIKSQALGN QNSENEALLE
2060 2070 2080 2090 2100
GDDDTLSSVD EKDLENLAGP VSLSTPAQLV APSVVVKGTL SVTSSELYFE
2110 2120 2130 2140 2150
VDEEDPNFKK IDPKILAYTE GLHGKWLFTE IRSIFSRRYL LQNTALEIFM
2160 2170 2180 2190 2200
ANRVAVMFNF PDPATVKKVV NYLPRVGVGT SFGLPQTRRI SLATPRQLFK
2210 2220 2230 2240 2250
ASNMTQRWQH REISNFEYLM FLNTIAGRSY NDLNQYPVFP WVITNYESEE
2260 2270 2280 2290 2300
LDLTLPSNFR DLSKPIGALN PKRAAFFAER FESWEDDQVP KFHYGTHYST
2310 2320 2330 2340 2350
ASFVLAWLLR IEPFTTYFLN LQGGKFDHAD RTFSSVSRAW RNSQRDTSDI
2360 2370 2380 2390 2400
KELIPEFYYL PEMFVNFNNY NLGVMDDGTV VSDVELPPWA KTSEEFVRIN
2410 2420 2430 2440 2450
RLALESEFVS CQLHQWIDLI FGYKQQGPEA VRALNVFYYL TYEGAVNLNS
2460 2470 2480 2490 2500
ITDPVLREAV EAQIRSFGQT PSQLLIEPHP PRGSAMQASP LMFTDQAQQD
2510 2520 2530 2540 2550
VIMVLKFPSN SPVTHVAANT QPGLAMPAVI TVTANRLFAV NKWHNLPAHQ
2560 2570 2580 2590 2600
GAVQDQPYQL PVEIDPLIAC GTGTHRRQVT DLLDQSIQVH SQCFVITSDN
2610 2620 2630 2640 2650
RYILVCGFWD KSFRVYSTDT GKLIQVVFGH WDVVTCLARS ESYIGGNCYI
2660 2670 2680 2690 2700
LSGSRDATLL LWYWNGKSSG IGDNPGGETA TPRAILTGHD YEITCAAVCA
2710 2720 2730 2740 2750
ELGLVLSGSQ EGPCLIHSMN GDLLRTLEGP ENCLKPKLIQ ASREGHCVIF
2760 2770 2780 2790 2800
YENGCFCTFS VNGKLQATVE TDDHIRAIQL SRDGQYLLTG GDNGVVIVRQ
2810 2820 2830 2840 2850
VSDLKQLFAY PGCDAGIRAM ALSFDQRCII SGMASGSIVL FYNDFNRWHH

EYQTRY
Length:2,856
Mass (Da):317,064
Last modified:March 1, 2001 - v1
Checksum:i6E7C5DD865384BEA
GO
Isoform 2 (identifier: Q9ESE1-2) [UniParc]FASTAAdd to basket

Also known as: lba-beta

The sequence of this isoform differs from the canonical sequence as follows:
     2777-2792: AIQLSRDGQYLLTGGD → VSAVGSTLFLLLGSSK
     2793-2856: Missing.

Show »
Length:2,792
Mass (Da):309,623
Checksum:i734FB37825AE405B
GO
Isoform 3 (identifier: Q9ESE1-3) [UniParc]FASTAAdd to basket

Also known as: lba-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     2569-2579: ACGTGTHRRQV → GLPLLSLFAIH
     2580-2856: Missing.

Show »
Length:2,579
Mass (Da):286,453
Checksum:i5733D4AC76C7C3B8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei2569 – 257911ACGTGTHRRQV → GLPLLSLFAIH in isoform 3. 1 PublicationVSP_038227Add
BLAST
Alternative sequencei2580 – 2856277Missing in isoform 3. 1 PublicationVSP_038228Add
BLAST
Alternative sequencei2777 – 279216AIQLS…LTGGD → VSAVGSTLFLLLGSSK in isoform 2. 1 PublicationVSP_038229Add
BLAST
Alternative sequencei2793 – 285664Missing in isoform 2. 1 PublicationVSP_038230Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187731 mRNA. Translation: AAG14003.1.
AF188506 mRNA. Translation: AAG15400.1.
AF188507 mRNA. Translation: AAG15401.1.
RefSeqiNP_001071155.1. NM_001077687.1.
NP_001071156.1. NM_001077688.1.
NP_109620.2. NM_030695.2.
UniGeneiMm.439825.

Genome annotation databases

GeneIDi80877.
KEGGimmu:80877.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF187731 mRNA. Translation: AAG14003.1.
AF188506 mRNA. Translation: AAG15400.1.
AF188507 mRNA. Translation: AAG15401.1.
RefSeqiNP_001071155.1. NM_001077687.1.
NP_001071156.1. NM_001077688.1.
NP_109620.2. NM_030695.2.
UniGeneiMm.439825.

3D structure databases

ProteinModelPortaliQ9ESE1.
SMRiQ9ESE1. Positions 2069-2482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9ESE1. 2 interactions.
MINTiMINT-1866542.
STRINGi10090.ENSMUSP00000103261.

PTM databases

iPTMnetiQ9ESE1.
PhosphoSiteiQ9ESE1.

Proteomic databases

EPDiQ9ESE1.
MaxQBiQ9ESE1.
PaxDbiQ9ESE1.
PeptideAtlasiQ9ESE1.
PRIDEiQ9ESE1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi80877.
KEGGimmu:80877.

Organism-specific databases

CTDi987.
MGIiMGI:1933162. Lrba.

Phylogenomic databases

eggNOGiKOG1786. Eukaryota.
ENOG410XNQC. LUCA.
HOGENOMiHOG000082375.
InParanoidiQ9ESE1.
PhylomeDBiQ9ESE1.

Miscellaneous databases

ChiTaRSiLrba. mouse.
PROiQ9ESE1.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.1540.10. 1 hit.
1.25.10.10. 4 hits.
2.130.10.10. 1 hit.
2.30.29.40. 1 hit.
2.60.120.200. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000409. BEACH_dom.
IPR013320. ConA-like_dom.
IPR010508. DUF1088.
IPR031570. DUF4704.
IPR023362. PH-BEACH_dom.
IPR011993. PH_dom-like.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02138. Beach. 1 hit.
PF06469. DUF1088. 1 hit.
PF15787. DUF4704. 1 hit.
PF14844. PH_BEACH. 1 hit.
[Graphical view]
SMARTiSM01026. Beach. 1 hit.
SM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF50978. SSF50978. 1 hit.
SSF81837. SSF81837. 1 hit.
PROSITEiPS50197. BEACH. 1 hit.
PS51783. PH_BEACH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel lipopolysaccharide-inducible gene with key features of both A kinase anchor proteins and chs1/beige proteins."
    Wang J.-W., Howson J., Haller E., Kerr W.G.
    J. Immunol. 166:4586-4595(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), FUNCTION, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Liver.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-979; SER-1003; SER-1219; SER-1221; SER-1228; SER-1770 AND SER-1773, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiLRBA_MOUSE
AccessioniPrimary (citable) accession number: Q9ESE1
Secondary accession number(s): Q9ESD3, Q9ESD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.