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Protein

CKLF-like MARVEL transmembrane domain-containing protein 7

Gene

Cmtm7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • B-1a B cell differentiation Source: MGI
  • chemotaxis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
CKLF-like MARVEL transmembrane domain-containing protein 7
Alternative name(s):
Chemokine-like factor superfamily member 7
LNV
Gene namesi
Name:Cmtm7
Synonyms:Cklfsf7, Lnv
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:2447166. Cmtm7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei35 – 5521HelicalSequence analysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Transmembranei102 – 12221HelicalSequence analysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 167167CKLF-like MARVEL transmembrane domain-containing protein 7PRO_0000186111Add
BLAST

Proteomic databases

MaxQBiQ9ESD6.
PaxDbiQ9ESD6.
PRIDEiQ9ESD6.

PTM databases

PhosphoSiteiQ9ESD6.
SwissPalmiQ9ESD6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000032436.
GenevisibleiQ9ESD6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035009.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 158127MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the chemokine-like factor family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00510000048725.
HOGENOMiHOG000111751.
HOVERGENiHBG050981.
InParanoidiQ9ESD6.
OMAiICVRSSV.
OrthoDBiEOG091G0SAJ.
PhylomeDBiQ9ESD6.
TreeFamiTF317387.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ESD6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSHGSGLVRT TCSSGGALGP GQPSEGLLDR VYPLTHGALF KVAQMVTLLI
60 70 80 90 100
AFICVRSSVP IDYGAHSFFE VVTMCDLIMI LIFYLVHLFR FYRVLTCISW
110 120 130 140 150
PLSELLHYLI GTLLLLIASI VIASKSYNQS GLVAGAIFGF LASFLCLASL
160
WLSYKITCIT QSSDASA
Length:167
Mass (Da):18,105
Last modified:March 1, 2001 - v1
Checksum:i1F97D2D03626975E
GO
Isoform 2 (identifier: Q9ESD6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-136: Missing.

Note: No experimental confirmation available.
Show »
Length:134
Mass (Da):14,681
Checksum:i4DE335D842B2B212
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei104 – 13633Missing in isoform 2. 1 PublicationVSP_008267Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188504 mRNA. Translation: AAG15398.1.
AY241869 mRNA. Translation: AAP33491.1.
BC038633 mRNA. Translation: AAH38633.1.
CCDSiCCDS57709.1. [Q9ESD6-2]
CCDS57710.1. [Q9ESD6-1]
RefSeqiNP_001239408.1. NM_001252479.1. [Q9ESD6-2]
NP_598739.1. NM_133978.2. [Q9ESD6-1]
UniGeneiMm.35600.

Genome annotation databases

EnsembliENSMUST00000035009; ENSMUSP00000035009; ENSMUSG00000032436. [Q9ESD6-1]
ENSMUST00000084867; ENSMUSP00000081927; ENSMUSG00000032436. [Q9ESD6-2]
GeneIDi102545.
KEGGimmu:102545.
UCSCiuc009ryc.2. mouse. [Q9ESD6-1]
uc009ryd.2. mouse. [Q9ESD6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188504 mRNA. Translation: AAG15398.1.
AY241869 mRNA. Translation: AAP33491.1.
BC038633 mRNA. Translation: AAH38633.1.
CCDSiCCDS57709.1. [Q9ESD6-2]
CCDS57710.1. [Q9ESD6-1]
RefSeqiNP_001239408.1. NM_001252479.1. [Q9ESD6-2]
NP_598739.1. NM_133978.2. [Q9ESD6-1]
UniGeneiMm.35600.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035009.

PTM databases

PhosphoSiteiQ9ESD6.
SwissPalmiQ9ESD6.

Proteomic databases

MaxQBiQ9ESD6.
PaxDbiQ9ESD6.
PRIDEiQ9ESD6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035009; ENSMUSP00000035009; ENSMUSG00000032436. [Q9ESD6-1]
ENSMUST00000084867; ENSMUSP00000081927; ENSMUSG00000032436. [Q9ESD6-2]
GeneIDi102545.
KEGGimmu:102545.
UCSCiuc009ryc.2. mouse. [Q9ESD6-1]
uc009ryd.2. mouse. [Q9ESD6-2]

Organism-specific databases

CTDi112616.
MGIiMGI:2447166. Cmtm7.

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00510000048725.
HOGENOMiHOG000111751.
HOVERGENiHBG050981.
InParanoidiQ9ESD6.
OMAiICVRSSV.
OrthoDBiEOG091G0SAJ.
PhylomeDBiQ9ESD6.
TreeFamiTF317387.

Miscellaneous databases

PROiQ9ESD6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032436.
GenevisibleiQ9ESD6. MM.

Family and domain databases

InterProiIPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCKLF7_MOUSE
AccessioniPrimary (citable) accession number: Q9ESD6
Secondary accession number(s): Q8CHW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.