ID   Q9ESC5_MOUSE            Unreviewed;       331 AA.
AC   Q9ESC5;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 131.
DE   RecName: Full=GTPase Era, mitochondrial {ECO:0000256|ARBA:ARBA00019149};
DE   AltName: Full=ERA-like protein 1 {ECO:0000256|ARBA:ARBA00030975};
GN   Name=Eral1 {ECO:0000313|MGI:MGI:1889295};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAG17176.1};
RN   [1] {ECO:0000313|EMBL:AAG17176.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J {ECO:0000313|EMBL:AAG17176.1};
RC   TISSUE=Whole embryo {ECO:0000313|EMBL:AAG17176.1};
RA   Chen S.-M., Court D.L.;
RT   "Mus musculus Era GTPase W protein (MERA-W) mRNA sequence.";
RL   Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable GTPase that plays a role in the mitochondrial
CC       ribosomal small subunit assembly. Specifically binds the 12S
CC       mitochondrial rRNA (12S mt-rRNA) to a 33 nucleotide section delineating
CC       the 3' terminal stem-loop region. May act as a chaperone that protects
CC       the 12S mt-rRNA on the 28S mitoribosomal subunit during ribosomal small
CC       subunit assembly. {ECO:0000256|ARBA:ARBA00025227}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004170};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004170}.
CC       Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00004637};
CC       Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004637}.
CC       Mitochondrion matrix {ECO:0000256|ARBA:ARBA00004305}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC       GTPase superfamily. Era GTPase family. {ECO:0000256|ARBA:ARBA00007921,
CC       ECO:0000256|PROSITE-ProRule:PRU01050}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF190730; AAG17176.1; -; mRNA.
DR   RefSeq; NP_071708.2; NM_022313.2.
DR   AlphaFoldDB; Q9ESC5; -.
DR   PeptideAtlas; Q9ESC5; -.
DR   DNASU; 57837; -.
DR   GeneID; 57837; -.
DR   KEGG; mmu:57837; -.
DR   AGR; MGI:1889295; -.
DR   CTD; 26284; -.
DR   MGI; MGI:1889295; Eral1.
DR   OrthoDB; 5490026at2759; -.
DR   BioGRID-ORCS; 57837; 25 hits in 77 CRISPR screens.
DR   ChiTaRS; Eral1; mouse.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   CDD; cd04163; Era; 1.
DR   CDD; cd22534; KH-II_Era; 1.
DR   Gene3D; 3.30.300.20; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   HAMAP; MF_00367; GTPase_Era; 1.
DR   InterPro; IPR030388; G_ERA_dom.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR005662; GTPase_Era.
DR   InterPro; IPR015946; KH_dom-like_a/b.
DR   InterPro; IPR004044; KH_dom_type_2.
DR   InterPro; IPR009019; KH_sf_prok-type.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   NCBIfam; TIGR00231; small_GTP; 1.
DR   PANTHER; PTHR42698; GTPASE ERA; 1.
DR   PANTHER; PTHR42698:SF4; GTPASE ERA, MITOCHONDRIAL; 1.
DR   Pfam; PF07650; KH_2; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF54814; Prokaryotic type KH domain (KH-domain type II); 1.
DR   PROSITE; PS51713; G_ERA; 1.
DR   Genevisible; Q9ESC5; MM.
PE   2: Evidence at transcript level;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|PROSITE-
KW   ProRule:PRU01050}; Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU01050}; RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          6..224
FT                   /note="Era-type G"
FT                   /evidence="ECO:0000259|PROSITE:PS51713"
FT   REGION          14..21
FT                   /note="G1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT   REGION          40..44
FT                   /note="G2"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT   REGION          61..64
FT                   /note="G3"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT   REGION          130..133
FT                   /note="G4"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
FT   REGION          164..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          202..204
FT                   /note="G5"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01050"
SQ   SEQUENCE   331 AA;  37091 MW;  811FEAF6FA1ACEFF CRC64;
     MPENPRVLRV VLLGAPNAGK STLSNQLVGR KVFPVSKKVH TTRCQALGVI TEKETQVILL
     DTPGIISPVK QKRHHLERSL LEDPWTSMES ADLVVVLVDV SDKWNKNRLN PQVLQCLTKF
     SQVPSILVLN KVDCLKQKSV LLELTAALTE GVVNGKKLNI KQALRSRSST HCPGPETEGP
     NAHSVRNPQR IGWPYFQEIF MLSALNNKDV NTLKQYLLTQ AQPGPWEFHS GVLTSQTPEE
     ICANKIREKL LEYLPEEVPY GVQQKTVIWE EGPSGELVIQ QNLLVPKESH VRILIGQKGL
     LISQIAQEVG RDLMDIFHCD VLIRLSVKLL K
//