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Protein

N-terminal EF-hand calcium-binding protein 1

Gene

Necab1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi39 – 50121PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
N-terminal EF-hand calcium-binding protein 1
Short name:
EF-hand calcium-binding protein 1
Alternative name(s):
Neuronal calcium-binding protein 1
Synaptotagmin-interacting protein 1
Short name:
Stip-1
Gene namesi
Name:Necab1
Synonyms:Efcbp1, Stip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi708548. Necab1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352N-terminal EF-hand calcium-binding protein 1PRO_0000282612Add
BLAST

Proteomic databases

PaxDbiQ9ESB5.
PRIDEiQ9ESB5.

Expressioni

Gene expression databases

GenevestigatoriQ9ESB5.

Interactioni

Subunit structurei

Interacts with STX1 and CPNE6.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9ESB5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 6136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini252 – 34089ABMAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili135 – 16329Sequence AnalysisAdd
BLAST
Coiled coili209 – 27567Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 ABM domain.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG27099.
GeneTreeiENSGT00390000009734.
HOGENOMiHOG000008120.
HOVERGENiHBG050433.
InParanoidiQ9ESB5.
OMAiSHIMIVQ.
OrthoDBiEOG7BS49N.
PhylomeDBiQ9ESB5.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR007138. ABM-like.
IPR011008. Dimeric_a/b-barrel.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF03992. ABM. 1 hit.
PF13202. EF-hand_5. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 1 hit.
PROSITEiPS51725. ABM. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDSRETSPS SNNSSEELSS ALQLSKGMSI FLDILRRADK NDDGKLSFEE
60 70 80 90 100
FKAYFADGVL SGEELHELFH TIDTHNTNNL DTEELCEYFS QHLGEYENVL
110 120 130 140 150
AALEDLNLSI LKAMGKTKKD YQEASNLEQF VTRFLLKETL NQLQSLQNSL
160 170 180 190 200
ECAMETTEEQ TRQERQGPSK PEVLSIQWPG KRSSRRVQRH NSFSPNSPQF
210 220 230 240 250
NVSSPALLEE DNQWMTQINR LQKLIDRLEK KDLKLEPLEE EVIEENTKPH
260 270 280 290 300
IMLVQRQMSV TEEDLEEFQL ALKHYVESAS AQSGCLRISI QKLSNESRYM
310 320 330 340 350
IYEFWENSSV WNRHLQTNYS KTFQRSNVDF LETPELTSTM LVPASWWILK

NN
Length:352
Mass (Da):40,904
Last modified:March 1, 2001 - v1
Checksum:i17D589374638F858
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193755 mRNA. Translation: AAG28411.1.
RefSeqiNP_071638.1. NM_022302.1.
UniGeneiRn.64485.

Genome annotation databases

EnsembliENSRNOT00000009718; ENSRNOP00000009718; ENSRNOG00000007256.
GeneIDi64169.
KEGGirno:64169.
UCSCiRGD:708548. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF193755 mRNA. Translation: AAG28411.1.
RefSeqiNP_071638.1. NM_022302.1.
UniGeneiRn.64485.

3D structure databases

ProteinModelPortaliQ9ESB5.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9ESB5.
PRIDEiQ9ESB5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009718; ENSRNOP00000009718; ENSRNOG00000007256.
GeneIDi64169.
KEGGirno:64169.
UCSCiRGD:708548. rat.

Organism-specific databases

CTDi64168.
RGDi708548. Necab1.

Phylogenomic databases

eggNOGiNOG27099.
GeneTreeiENSGT00390000009734.
HOGENOMiHOG000008120.
HOVERGENiHBG050433.
InParanoidiQ9ESB5.
OMAiSHIMIVQ.
OrthoDBiEOG7BS49N.
PhylomeDBiQ9ESB5.

Miscellaneous databases

NextBioi612816.
PROiQ9ESB5.

Gene expression databases

GenevestigatoriQ9ESB5.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR007138. ABM-like.
IPR011008. Dimeric_a/b-barrel.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF03992. ABM. 1 hit.
PF13202. EF-hand_5. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 1 hit.
PROSITEiPS51725. ABM. 1 hit.
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern."
    Sugita S., Ho A., Suedhof T.C.
    Neuroscience 112:51-63(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 315-321, INTERACTION WITH STX1 AND CPNE6.
    Tissue: Brain.

Entry informationi

Entry nameiNECA1_RAT
AccessioniPrimary (citable) accession number: Q9ESB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: January 7, 2015
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.