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Q9ESB5 (NECA1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-terminal EF-hand calcium-binding protein 1

Short name=EF-hand calcium-binding protein 1
Alternative name(s):
Neuronal calcium-binding protein 1
Synaptotagmin-interacting protein 1
Short name=Stip-1
Gene names
Name:Necab1
Synonyms:Efcbp1, Stip
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Interacts with STX1 and CPNE6. Ref.1

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Contains 1 ABM domain.

Contains 2 EF-hand domains.

Ontologies

Keywords
   Cellular componentCytoplasm
   DomainCoiled coil
Repeat
   LigandCalcium
Metal-binding
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from direct assay Ref.1. Source: RGD

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352N-terminal EF-hand calcium-binding protein 1
PRO_0000282612

Regions

Domain26 – 6136EF-hand 1
Domain60 – 9536EF-hand 2
Domain260 – 32263ABM
Calcium binding39 – 50121 Potential
Coiled coil135 – 16329 Potential
Coiled coil209 – 27567 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ESB5 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 17D589374638F858

FASTA35240,904
        10         20         30         40         50         60 
MEDSRETSPS SNNSSEELSS ALQLSKGMSI FLDILRRADK NDDGKLSFEE FKAYFADGVL 

        70         80         90        100        110        120 
SGEELHELFH TIDTHNTNNL DTEELCEYFS QHLGEYENVL AALEDLNLSI LKAMGKTKKD 

       130        140        150        160        170        180 
YQEASNLEQF VTRFLLKETL NQLQSLQNSL ECAMETTEEQ TRQERQGPSK PEVLSIQWPG 

       190        200        210        220        230        240 
KRSSRRVQRH NSFSPNSPQF NVSSPALLEE DNQWMTQINR LQKLIDRLEK KDLKLEPLEE 

       250        260        270        280        290        300 
EVIEENTKPH IMLVQRQMSV TEEDLEEFQL ALKHYVESAS AQSGCLRISI QKLSNESRYM 

       310        320        330        340        350 
IYEFWENSSV WNRHLQTNYS KTFQRSNVDF LETPELTSTM LVPASWWILK NN 

« Hide

References

[1]"NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern."
Sugita S., Ho A., Suedhof T.C.
Neuroscience 112:51-63(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 315-321, INTERACTION WITH STX1 AND CPNE6.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF193755 mRNA. Translation: AAG28411.1.
RefSeqNP_071638.1. NM_022302.1.
UniGeneRn.64485.

3D structure databases

ProteinModelPortalQ9ESB5.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ9ESB5.
PRIDEQ9ESB5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009718; ENSRNOP00000009718; ENSRNOG00000007256.
GeneID64169.
KEGGrno:64169.
UCSCRGD:708548. rat.

Organism-specific databases

CTD64168.
RGD708548. Necab1.

Phylogenomic databases

eggNOGNOG27099.
GeneTreeENSGT00390000009734.
HOGENOMHOG000008120.
HOVERGENHBG050433.
InParanoidQ9ESB5.
OMAKKGMSIF.
OrthoDBEOG7BS49N.
PhylomeDBQ9ESB5.

Gene expression databases

GenevestigatorQ9ESB5.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR007138. Antibiotic_mOase.
IPR011008. Dimeric_a/b-barrel.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF03992. ABM. 1 hit.
PF13202. EF-hand_5. 1 hit.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMSSF54909. SSF54909. 1 hit.
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio612816.
PROQ9ESB5.

Entry information

Entry nameNECA1_RAT
AccessionPrimary (citable) accession number: Q9ESB5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families