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Q9ESB5

- NECA1_RAT

UniProt

Q9ESB5 - NECA1_RAT

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Protein
N-terminal EF-hand calcium-binding protein 1
Gene
Necab1, Efcbp1, Stip
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi39 – 50121 Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
N-terminal EF-hand calcium-binding protein 1
Short name:
EF-hand calcium-binding protein 1
Alternative name(s):
Neuronal calcium-binding protein 1
Synaptotagmin-interacting protein 1
Short name:
Stip-1
Gene namesi
Name:Necab1
Synonyms:Efcbp1, Stip
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi708548. Necab1.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: RGD
  2. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352N-terminal EF-hand calcium-binding protein 1
PRO_0000282612Add
BLAST

Proteomic databases

PaxDbiQ9ESB5.
PRIDEiQ9ESB5.

Expressioni

Gene expression databases

GenevestigatoriQ9ESB5.

Interactioni

Subunit structurei

Interacts with STX1 and CPNE6.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9ESB5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 6136EF-hand 1
Add
BLAST
Domaini60 – 9536EF-hand 2
Add
BLAST
Domaini260 – 32263ABM
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili135 – 16329 Reviewed prediction
Add
BLAST
Coiled coili209 – 27567 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Contains 1 ABM domain.
Contains 2 EF-hand domains.

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG27099.
GeneTreeiENSGT00390000009734.
HOGENOMiHOG000008120.
HOVERGENiHBG050433.
InParanoidiQ9ESB5.
OMAiSHIMIVQ.
OrthoDBiEOG7BS49N.
PhylomeDBiQ9ESB5.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR007138. ABM-like.
IPR011008. Dimeric_a/b-barrel.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF03992. ABM. 1 hit.
PF13202. EF-hand_5. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF54909. SSF54909. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ESB5-1 [UniParc]FASTAAdd to Basket

« Hide

MEDSRETSPS SNNSSEELSS ALQLSKGMSI FLDILRRADK NDDGKLSFEE    50
FKAYFADGVL SGEELHELFH TIDTHNTNNL DTEELCEYFS QHLGEYENVL 100
AALEDLNLSI LKAMGKTKKD YQEASNLEQF VTRFLLKETL NQLQSLQNSL 150
ECAMETTEEQ TRQERQGPSK PEVLSIQWPG KRSSRRVQRH NSFSPNSPQF 200
NVSSPALLEE DNQWMTQINR LQKLIDRLEK KDLKLEPLEE EVIEENTKPH 250
IMLVQRQMSV TEEDLEEFQL ALKHYVESAS AQSGCLRISI QKLSNESRYM 300
IYEFWENSSV WNRHLQTNYS KTFQRSNVDF LETPELTSTM LVPASWWILK 350
NN 352
Length:352
Mass (Da):40,904
Last modified:March 1, 2001 - v1
Checksum:i17D589374638F858
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF193755 mRNA. Translation: AAG28411.1.
RefSeqiNP_071638.1. NM_022302.1.
UniGeneiRn.64485.

Genome annotation databases

EnsembliENSRNOT00000009718; ENSRNOP00000009718; ENSRNOG00000007256.
GeneIDi64169.
KEGGirno:64169.
UCSCiRGD:708548. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF193755 mRNA. Translation: AAG28411.1 .
RefSeqi NP_071638.1. NM_022302.1.
UniGenei Rn.64485.

3D structure databases

ProteinModelPortali Q9ESB5.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q9ESB5.
PRIDEi Q9ESB5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000009718 ; ENSRNOP00000009718 ; ENSRNOG00000007256 .
GeneIDi 64169.
KEGGi rno:64169.
UCSCi RGD:708548. rat.

Organism-specific databases

CTDi 64168.
RGDi 708548. Necab1.

Phylogenomic databases

eggNOGi NOG27099.
GeneTreei ENSGT00390000009734.
HOGENOMi HOG000008120.
HOVERGENi HBG050433.
InParanoidi Q9ESB5.
OMAi SHIMIVQ.
OrthoDBi EOG7BS49N.
PhylomeDBi Q9ESB5.

Miscellaneous databases

NextBioi 612816.
PROi Q9ESB5.

Gene expression databases

Genevestigatori Q9ESB5.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR007138. ABM-like.
IPR011008. Dimeric_a/b-barrel.
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF03992. ABM. 1 hit.
PF13202. EF-hand_5. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
SUPFAMi SSF54909. SSF54909. 1 hit.
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern."
    Sugita S., Ho A., Suedhof T.C.
    Neuroscience 112:51-63(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 315-321, INTERACTION WITH STX1 AND CPNE6.
    Tissue: Brain.

Entry informationi

Entry nameiNECA1_RAT
AccessioniPrimary (citable) accession number: Q9ESB5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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