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Q9ESB5

- NECA1_RAT

UniProt

Q9ESB5 - NECA1_RAT

Protein

N-terminal EF-hand calcium-binding protein 1

Gene

Necab1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi39 – 50121PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-terminal EF-hand calcium-binding protein 1
    Short name:
    EF-hand calcium-binding protein 1
    Alternative name(s):
    Neuronal calcium-binding protein 1
    Synaptotagmin-interacting protein 1
    Short name:
    Stip-1
    Gene namesi
    Name:Necab1
    Synonyms:Efcbp1, Stip
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi708548. Necab1.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352N-terminal EF-hand calcium-binding protein 1PRO_0000282612Add
    BLAST

    Proteomic databases

    PaxDbiQ9ESB5.
    PRIDEiQ9ESB5.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ESB5.

    Interactioni

    Subunit structurei

    Interacts with STX1 and CPNE6.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ESB5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 6136EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini60 – 9536EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini252 – 34089ABMAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili135 – 16329Sequence AnalysisAdd
    BLAST
    Coiled coili209 – 27567Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ABM domain.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG27099.
    GeneTreeiENSGT00390000009734.
    HOGENOMiHOG000008120.
    HOVERGENiHBG050433.
    InParanoidiQ9ESB5.
    OMAiSHIMIVQ.
    OrthoDBiEOG7BS49N.
    PhylomeDBiQ9ESB5.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR007138. ABM-like.
    IPR011008. Dimeric_a/b-barrel.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF03992. ABM. 1 hit.
    PF13202. EF-hand_5. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    SUPFAMiSSF54909. SSF54909. 1 hit.
    PROSITEiPS51725. ABM. 1 hit.
    PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ESB5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEDSRETSPS SNNSSEELSS ALQLSKGMSI FLDILRRADK NDDGKLSFEE    50
    FKAYFADGVL SGEELHELFH TIDTHNTNNL DTEELCEYFS QHLGEYENVL 100
    AALEDLNLSI LKAMGKTKKD YQEASNLEQF VTRFLLKETL NQLQSLQNSL 150
    ECAMETTEEQ TRQERQGPSK PEVLSIQWPG KRSSRRVQRH NSFSPNSPQF 200
    NVSSPALLEE DNQWMTQINR LQKLIDRLEK KDLKLEPLEE EVIEENTKPH 250
    IMLVQRQMSV TEEDLEEFQL ALKHYVESAS AQSGCLRISI QKLSNESRYM 300
    IYEFWENSSV WNRHLQTNYS KTFQRSNVDF LETPELTSTM LVPASWWILK 350
    NN 352
    Length:352
    Mass (Da):40,904
    Last modified:March 1, 2001 - v1
    Checksum:i17D589374638F858
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193755 mRNA. Translation: AAG28411.1.
    RefSeqiNP_071638.1. NM_022302.1.
    UniGeneiRn.64485.

    Genome annotation databases

    EnsembliENSRNOT00000009718; ENSRNOP00000009718; ENSRNOG00000007256.
    GeneIDi64169.
    KEGGirno:64169.
    UCSCiRGD:708548. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF193755 mRNA. Translation: AAG28411.1 .
    RefSeqi NP_071638.1. NM_022302.1.
    UniGenei Rn.64485.

    3D structure databases

    ProteinModelPortali Q9ESB5.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q9ESB5.
    PRIDEi Q9ESB5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009718 ; ENSRNOP00000009718 ; ENSRNOG00000007256 .
    GeneIDi 64169.
    KEGGi rno:64169.
    UCSCi RGD:708548. rat.

    Organism-specific databases

    CTDi 64168.
    RGDi 708548. Necab1.

    Phylogenomic databases

    eggNOGi NOG27099.
    GeneTreei ENSGT00390000009734.
    HOGENOMi HOG000008120.
    HOVERGENi HBG050433.
    InParanoidi Q9ESB5.
    OMAi SHIMIVQ.
    OrthoDBi EOG7BS49N.
    PhylomeDBi Q9ESB5.

    Miscellaneous databases

    NextBioi 612816.
    PROi Q9ESB5.

    Gene expression databases

    Genevestigatori Q9ESB5.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR007138. ABM-like.
    IPR011008. Dimeric_a/b-barrel.
    IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF03992. ABM. 1 hit.
    PF13202. EF-hand_5. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    SUPFAMi SSF54909. SSF54909. 1 hit.
    PROSITEi PS51725. ABM. 1 hit.
    PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern."
      Sugita S., Ho A., Suedhof T.C.
      Neuroscience 112:51-63(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 315-321, INTERACTION WITH STX1 AND CPNE6.
      Tissue: Brain.

    Entry informationi

    Entry nameiNECA1_RAT
    AccessioniPrimary (citable) accession number: Q9ESB5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3