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Q9ES92

- Q9ES92_MOUSE

UniProt

Q9ES92 - Q9ES92_MOUSE

Protein
Submitted name:

Fc gamma receptor III

Gene

Fcgr3

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. IgG binding Source: MGI
    2. IgG receptor activity Source: MGI

    GO - Biological processi

    1. antibody-dependent cellular cytotoxicity Source: MGI
    2. antigen processing and presentation of exogenous peptide antigen via MHC class I Source: MGI
    3. cell surface receptor signaling pathway Source: MGI
    4. Fc-gamma receptor signaling pathway Source: GOC
    5. mast cell activation Source: MGI
    6. neutrophil chemotaxis Source: MGI
    7. phagocytosis, engulfment Source: MGI
    8. phagocytosis, recognition Source: MGI
    9. positive regulation of phagocytosis Source: MGI
    10. positive regulation of tumor necrosis factor biosynthetic process Source: MGI
    11. positive regulation of type I hypersensitivity Source: MGI
    12. positive regulation of type IIa hypersensitivity Source: MGI
    13. positive regulation of type III hypersensitivity Source: MGI
    14. regulation of immune response Source: MGI
    15. serotonin secretion Source: MGI

    Keywords - Molecular functioni

    ReceptorImported

    Enzyme and pathway databases

    ReactomeiREACT_196487. FCGR activation.
    REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
    REACT_210240. Role of phospholipids in phagocytosis.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Fc gamma receptor IIIImported
    Gene namesi
    Name:Fcgr3Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:95500. Fcgr3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ES92.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000027964.

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG051602.
    InParanoidiQ9ES92.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ES92-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFQNAHSGSQ WLLPPLTILL LFAFADRQSA ALPKAVVKLD PPWIQVLKED    50
    MVTLMCEGTH NPGNSSTQWF HNWSSIRSQV QSSYTFKATV NDSGEYRCQM 100
    EQTRLSDPVD LGVISDWLLL QTPQRVFLEG ETITLRCHSW RNKLLNRISF 150
    FHNEKSVRYH HYKSNFSIPK ANHSHSGDYY CKGSLGSTQH QSKPVTITVQ 200
    DPATTSSISL VWYHTAFSLV MCLLFAVDTG LYFYVRRNLQ TPRDYWRKSL 250
    SIRKHQAPQD K 261
    Length:261
    Mass (Da):30,098
    Last modified:March 1, 2001 - v1
    Checksum:i9C8570E032F94730
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF197930 mRNA. Translation: AAG28520.1.
    AY897419 mRNA. Translation: AAX13974.1.
    AY897420 mRNA. Translation: AAX13975.1.
    AK077227 mRNA. Translation: BAC36696.1.
    UniGeneiMm.22119.

    Genome annotation databases

    UCSCiuc007dmy.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF197930 mRNA. Translation: AAG28520.1 .
    AY897419 mRNA. Translation: AAX13974.1 .
    AY897420 mRNA. Translation: AAX13975.1 .
    AK077227 mRNA. Translation: BAC36696.1 .
    UniGenei Mm.22119.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000027964.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc007dmy.2. mouse.

    Organism-specific databases

    MGIi MGI:95500. Fcgr3.

    Phylogenomic databases

    HOVERGENi HBG051602.
    InParanoidi Q9ES92.

    Enzyme and pathway databases

    Reactomei REACT_196487. FCGR activation.
    REACT_198374. Regulation of actin dynamics for phagocytic cup formation.
    REACT_210240. Role of phospholipids in phagocytosis.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q9ES92.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "High-efficiency full-length cDNA cloning."
      Carninci P., Hayashizaki Y.
      Methods Enzymol. 303:19-44(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    2. "Mouse Fc gamma RIII: identification and characterization of a new allele in C57BL/6 mice."
      Fossati Jimack L., Boucrot E., Izui S.
      Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6Imported.
    3. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    4. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    5. "Functional annotation of a full-length mouse cDNA collection."
      The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium
      Nature 409:685-690(2001)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    6. "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs."
      The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team
      Nature 420:563-573(2002)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    7. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    8. "The Transcriptional Landscape of the Mammalian Genome."
      The FANTOM Consortium, Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group)
      Science 309:1559-1563(2005)
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    9. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
      Tissue: Ovary and uterusImported.
    10. "Involvement of IgG Fc receptor polymorphisms and C5 in susceptibility to collagen-induced arthritis."
      Andren M., Johanneson B., Alarcon-Riquelme M.E., Kleinau S.
      Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/10Imported and C57BL/6Imported.

    Entry informationi

    Entry nameiQ9ES92_MOUSE
    AccessioniPrimary (citable) accession number: Q9ES92
    Entry historyi
    Integrated into UniProtKB/TrEMBL: March 1, 2001
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)