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Protein

G-protein coupled receptor 35

Gene

Gpr35

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 35
Alternative name(s):
Kynurenic acid receptor
Short name:
KYNA receptor
Gene namesi
Name:Gpr35
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1929509. Gpr35.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818ExtracellularSequence analysisAdd
BLAST
Transmembranei19 – 3921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini40 – 5314CytoplasmicSequence analysisAdd
BLAST
Transmembranei54 – 7421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini75 – 8814ExtracellularSequence analysisAdd
BLAST
Transmembranei89 – 11022Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini111 – 12919CytoplasmicSequence analysisAdd
BLAST
Transmembranei130 – 15021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini151 – 17626ExtracellularSequence analysisAdd
BLAST
Transmembranei177 – 19721Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini198 – 21720CytoplasmicSequence analysisAdd
BLAST
Transmembranei218 – 23821Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini239 – 25719ExtracellularSequence analysisAdd
BLAST
Transmembranei258 – 27821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini279 – 30729CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2390813.
GuidetoPHARMACOLOGYi102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307G-protein coupled receptor 35PRO_0000069564Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi7 – 71N-linked (GlcNAc...)Sequence analysis
Disulfide bondi87 ↔ 160PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ES90.
PRIDEiQ9ES90.

PTM databases

PhosphoSiteiQ9ES90.

Expressioni

Tissue specificityi

Predominantly expressed in immune and gastrointestinal tissues.1 Publication

Gene expression databases

BgeeiQ9ES90.
CleanExiMM_GPR35.
ExpressionAtlasiQ9ES90. baseline and differential.
GenevisibleiQ9ES90. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027489.

Chemistry

BindingDBiQ9ES90.

Structurei

3D structure databases

ProteinModelPortaliQ9ES90.
SMRiQ9ES90. Positions 22-283.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE2J. Eukaryota.
ENOG4111JSA. LUCA.
GeneTreeiENSGT00730000110768.
HOGENOMiHOG000112791.
HOVERGENiHBG101122.
InParanoidiQ9ES90.
KOiK04276.
OMAiDANCCLD.
OrthoDBiEOG7WDN33.
PhylomeDBiQ9ES90.
TreeFamiTF335578.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ES90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSTTCNSTL TWPASVNNFF IIYSALLLVL GLLLNSVALW VFCYRMHQWT
60 70 80 90 100
ETRIYMTNLA VADLCLLCSL PFVLYSLKYS SSDTPVCQLS QGIYLANRYM
110 120 130 140 150
SISLVTAIAV DRYVAVRHPL RARELRSPRQ AAAVCVALWV IVVTSLVVRW
160 170 180 190 200
RLGMQEGGFC FSSQTRRNFS TTAFSLLGFY LPLAIVVFCS LQVVTVLSRR
210 220 230 240 250
PAADVGQAEA TQKATHMVWA NLAVFVICFL PLHVVLTVQV SLNLNTCAAR
260 270 280 290 300
DTFSRALSIT GKLSDTNCCL DAICYYYMAR EFQEASKPAT SSNTPHKSQD

SQILSLT
Length:307
Mass (Da):34,152
Last modified:March 1, 2001 - v1
Checksum:i0B3D02CECB16710D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200349 mRNA. Translation: AAG18487.1.
BC027429 mRNA. Translation: AAH27429.1.
CCDSiCCDS15182.1.
RefSeqiNP_001097999.1. NM_001104529.1.
NP_001258695.1. NM_001271766.1.
NP_071715.3. NM_022320.4.
XP_006529842.1. XM_006529779.2.
XP_006529843.1. XM_006529780.2.
XP_006529844.1. XM_006529781.2.
XP_011246355.1. XM_011248053.1.
UniGeneiMm.152780.

Genome annotation databases

EnsembliENSMUST00000064480; ENSMUSP00000070832; ENSMUSG00000026271.
ENSMUST00000169198; ENSMUSP00000126914; ENSMUSG00000026271.
ENSMUST00000186298; ENSMUSP00000139648; ENSMUSG00000026271.
GeneIDi64095.
KEGGimmu:64095.
UCSCiuc007cbz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF200349 mRNA. Translation: AAG18487.1.
BC027429 mRNA. Translation: AAH27429.1.
CCDSiCCDS15182.1.
RefSeqiNP_001097999.1. NM_001104529.1.
NP_001258695.1. NM_001271766.1.
NP_071715.3. NM_022320.4.
XP_006529842.1. XM_006529779.2.
XP_006529843.1. XM_006529780.2.
XP_006529844.1. XM_006529781.2.
XP_011246355.1. XM_011248053.1.
UniGeneiMm.152780.

3D structure databases

ProteinModelPortaliQ9ES90.
SMRiQ9ES90. Positions 22-283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000027489.

Chemistry

BindingDBiQ9ES90.
ChEMBLiCHEMBL2390813.
GuidetoPHARMACOLOGYi102.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9ES90.

Proteomic databases

PaxDbiQ9ES90.
PRIDEiQ9ES90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064480; ENSMUSP00000070832; ENSMUSG00000026271.
ENSMUST00000169198; ENSMUSP00000126914; ENSMUSG00000026271.
ENSMUST00000186298; ENSMUSP00000139648; ENSMUSG00000026271.
GeneIDi64095.
KEGGimmu:64095.
UCSCiuc007cbz.2. mouse.

Organism-specific databases

CTDi2859.
MGIiMGI:1929509. Gpr35.

Phylogenomic databases

eggNOGiENOG410IE2J. Eukaryota.
ENOG4111JSA. LUCA.
GeneTreeiENSGT00730000110768.
HOGENOMiHOG000112791.
HOVERGENiHBG101122.
InParanoidiQ9ES90.
KOiK04276.
OMAiDANCCLD.
OrthoDBiEOG7WDN33.
PhylomeDBiQ9ES90.
TreeFamiTF335578.

Miscellaneous databases

NextBioi319905.
PROiQ9ES90.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ES90.
CleanExiMM_GPR35.
ExpressionAtlasiQ9ES90. baseline and differential.
GenevisibleiQ9ES90. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  3. "Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35."
    Wang J., Simonavicius N., Wu X., Swaminath G., Reagan J., Tian H., Ling L.
    J. Biol. Chem. 281:22021-22028(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGPR35_MOUSE
AccessioniPrimary (citable) accession number: Q9ES90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: March 1, 2001
Last modified: May 11, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.