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Q9ES88

- S13A2_MOUSE

UniProt

Q9ES88 - S13A2_MOUSE

Protein

Solute carrier family 13 member 2

Gene

Slc13a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Cotransport of sodium ions and dicarboxylates such as succinate and citrate.

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. sodium ion transport Source: UniProtKB-KW

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 13 member 2
    Alternative name(s):
    Na(+)/dicarboxylate cotransporter 1
    Short name:
    NaDC-1
    Renal sodium/dicarboxylate cotransporter
    Gene namesi
    Name:Slc13a2
    Synonyms:Nadc1, Sdct1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1276558. Slc13a2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 586586Solute carrier family 13 member 2PRO_0000172489Add
    BLAST

    Proteomic databases

    PRIDEiQ9ES88.

    PTM databases

    PhosphoSiteiQ9ES88.

    Expressioni

    Tissue specificityi

    Highly expressed in kidney and small intestine. Not detectable in brain, heart, stomach and skeletal muscle.

    Gene expression databases

    BgeeiQ9ES88.
    GenevestigatoriQ9ES88.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ES88.
    SMRiQ9ES88. Positions 42-276, 402-545.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei86 – 10621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei215 – 23521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei264 – 28421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei319 – 33921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei366 – 38621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei445 – 46521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei478 – 49821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei506 – 52621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei535 – 55521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0471.
    GeneTreeiENSGT00550000074480.
    HOGENOMiHOG000278432.
    HOVERGENiHBG055339.
    InParanoidiQ9ES88.
    KOiK14445.
    OMAiMFIIPSK.
    OrthoDBiEOG7G1V5S.
    PhylomeDBiQ9ES88.
    TreeFamiTF312913.

    Family and domain databases

    InterProiIPR001898. Na/sul_symport.
    [Graphical view]
    PfamiPF00939. Na_sulph_symp. 1 hit.
    [Graphical view]
    PROSITEiPS01271. NA_SULFATE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ES88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATCWQALWA YRSYLIVLCL PIFLLPLPLI VQTKEAYCAY SIILMALLWC    50
    TEALPLAVTA LFPIILFPLM GIMEASKVCL EYFKDTNILF VGGLMVAIAV 100
    EHWNLHKRIA LGVLLIIGVR PALLLLGFML VTAFLSMWIS NTATTAMMLP 150
    IGYAVLEQLQ GSQKDVEEGN SNPSFELQEA SPQKEETKLD NGQAVSVSSE 200
    PRAQKTKEHH RFSQGLSLCI CYSASIGGIA TLTGTTPNLV LQGQVNSIFP 250
    ENSNVVNFAS WFGFAFPTMV ILLLLAWLWL QVLFLGVNFR KNFGFGEGEE 300
    ERKQAAFQVI KTQHRLLGPM SFAEKAVTFL FVLLVVLWFT REPGFFPGWG 350
    DTAFANKKGQ SMVSDGTVAI FISLIMFIIP SKIPGLTEDP KKPGKLKAPP 400
    AILTWKTVND KMPWNILILL GGGFALAKGS EESGLSKWLG DKLTPLQHVP 450
    PSATVLILSL LVAIFTECTS NVATTTLFLP ILASMAQAIC LHPLYVMLPC 500
    TLAASLAFML PVATPPNAIV FSFGGLKVSD MARAGFLLNI IGVLTITLSI 550
    NSWSIPIFKL DTFPTWAYSN TSQCLLNPPN STVPGH 586
    Length:586
    Mass (Da):64,111
    Last modified:March 1, 2001 - v1
    Checksum:i56EEAE21532833EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF201903 mRNA. Translation: AAG15426.1.
    BC013493 mRNA. Translation: AAH13493.1.
    CCDSiCCDS25103.1.
    RefSeqiNP_071856.1. NM_022411.3.
    UniGeneiMm.274058.

    Genome annotation databases

    EnsembliENSMUST00000001122; ENSMUSP00000001122; ENSMUSG00000001095.
    GeneIDi20500.
    KEGGimmu:20500.
    UCSCiuc007kjf.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF201903 mRNA. Translation: AAG15426.1 .
    BC013493 mRNA. Translation: AAH13493.1 .
    CCDSi CCDS25103.1.
    RefSeqi NP_071856.1. NM_022411.3.
    UniGenei Mm.274058.

    3D structure databases

    ProteinModelPortali Q9ES88.
    SMRi Q9ES88. Positions 42-276, 402-545.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9ES88.

    Proteomic databases

    PRIDEi Q9ES88.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001122 ; ENSMUSP00000001122 ; ENSMUSG00000001095 .
    GeneIDi 20500.
    KEGGi mmu:20500.
    UCSCi uc007kjf.1. mouse.

    Organism-specific databases

    CTDi 9058.
    MGIi MGI:1276558. Slc13a2.

    Phylogenomic databases

    eggNOGi COG0471.
    GeneTreei ENSGT00550000074480.
    HOGENOMi HOG000278432.
    HOVERGENi HBG055339.
    InParanoidi Q9ES88.
    KOi K14445.
    OMAi MFIIPSK.
    OrthoDBi EOG7G1V5S.
    PhylomeDBi Q9ES88.
    TreeFami TF312913.

    Miscellaneous databases

    NextBioi 298667.
    PROi Q9ES88.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ES88.
    Genevestigatori Q9ES88.

    Family and domain databases

    InterProi IPR001898. Na/sul_symport.
    [Graphical view ]
    Pfami PF00939. Na_sulph_symp. 1 hit.
    [Graphical view ]
    PROSITEi PS01271. NA_SULFATE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning, chromosomal organization and functional characterization of a sodium/dicarboxylate cotransporter from mouse kidney."
      Pajor A.M., Sun N.N.
      Am. J. Physiol. 279:F482-F490(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Colon.

    Entry informationi

    Entry nameiS13A2_MOUSE
    AccessioniPrimary (citable) accession number: Q9ES88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3