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Q9ES88

- S13A2_MOUSE

UniProt

Q9ES88 - S13A2_MOUSE

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Protein

Solute carrier family 13 member 2

Gene

Slc13a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cotransport of sodium ions and dicarboxylates such as succinate and citrate.

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 2
Alternative name(s):
Na(+)/dicarboxylate cotransporter 1
Short name:
NaDC-1
Renal sodium/dicarboxylate cotransporter
Gene namesi
Name:Slc13a2
Synonyms:Nadc1, Sdct1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1276558. Slc13a2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Solute carrier family 13 member 2PRO_0000172489Add
BLAST

Proteomic databases

PRIDEiQ9ES88.

PTM databases

PhosphoSiteiQ9ES88.

Expressioni

Tissue specificityi

Highly expressed in kidney and small intestine. Not detectable in brain, heart, stomach and skeletal muscle.

Gene expression databases

BgeeiQ9ES88.
GenevestigatoriQ9ES88.

Structurei

3D structure databases

ProteinModelPortaliQ9ES88.
SMRiQ9ES88. Positions 42-276, 402-545.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Transmembranei319 – 33921HelicalSequence AnalysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence AnalysisAdd
BLAST
Transmembranei407 – 42721HelicalSequence AnalysisAdd
BLAST
Transmembranei445 – 46521HelicalSequence AnalysisAdd
BLAST
Transmembranei478 – 49821HelicalSequence AnalysisAdd
BLAST
Transmembranei506 – 52621HelicalSequence AnalysisAdd
BLAST
Transmembranei535 – 55521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0471.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ9ES88.
KOiK14445.
OMAiMFIIPSK.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ9ES88.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ES88 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATCWQALWA YRSYLIVLCL PIFLLPLPLI VQTKEAYCAY SIILMALLWC
60 70 80 90 100
TEALPLAVTA LFPIILFPLM GIMEASKVCL EYFKDTNILF VGGLMVAIAV
110 120 130 140 150
EHWNLHKRIA LGVLLIIGVR PALLLLGFML VTAFLSMWIS NTATTAMMLP
160 170 180 190 200
IGYAVLEQLQ GSQKDVEEGN SNPSFELQEA SPQKEETKLD NGQAVSVSSE
210 220 230 240 250
PRAQKTKEHH RFSQGLSLCI CYSASIGGIA TLTGTTPNLV LQGQVNSIFP
260 270 280 290 300
ENSNVVNFAS WFGFAFPTMV ILLLLAWLWL QVLFLGVNFR KNFGFGEGEE
310 320 330 340 350
ERKQAAFQVI KTQHRLLGPM SFAEKAVTFL FVLLVVLWFT REPGFFPGWG
360 370 380 390 400
DTAFANKKGQ SMVSDGTVAI FISLIMFIIP SKIPGLTEDP KKPGKLKAPP
410 420 430 440 450
AILTWKTVND KMPWNILILL GGGFALAKGS EESGLSKWLG DKLTPLQHVP
460 470 480 490 500
PSATVLILSL LVAIFTECTS NVATTTLFLP ILASMAQAIC LHPLYVMLPC
510 520 530 540 550
TLAASLAFML PVATPPNAIV FSFGGLKVSD MARAGFLLNI IGVLTITLSI
560 570 580
NSWSIPIFKL DTFPTWAYSN TSQCLLNPPN STVPGH
Length:586
Mass (Da):64,111
Last modified:March 1, 2001 - v1
Checksum:i56EEAE21532833EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF201903 mRNA. Translation: AAG15426.1.
BC013493 mRNA. Translation: AAH13493.1.
CCDSiCCDS25103.1.
RefSeqiNP_071856.1. NM_022411.3.
UniGeneiMm.274058.

Genome annotation databases

EnsembliENSMUST00000001122; ENSMUSP00000001122; ENSMUSG00000001095.
GeneIDi20500.
KEGGimmu:20500.
UCSCiuc007kjf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF201903 mRNA. Translation: AAG15426.1 .
BC013493 mRNA. Translation: AAH13493.1 .
CCDSi CCDS25103.1.
RefSeqi NP_071856.1. NM_022411.3.
UniGenei Mm.274058.

3D structure databases

ProteinModelPortali Q9ES88.
SMRi Q9ES88. Positions 42-276, 402-545.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q9ES88.

Proteomic databases

PRIDEi Q9ES88.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001122 ; ENSMUSP00000001122 ; ENSMUSG00000001095 .
GeneIDi 20500.
KEGGi mmu:20500.
UCSCi uc007kjf.1. mouse.

Organism-specific databases

CTDi 9058.
MGIi MGI:1276558. Slc13a2.

Phylogenomic databases

eggNOGi COG0471.
GeneTreei ENSGT00550000074480.
HOGENOMi HOG000278432.
HOVERGENi HBG055339.
InParanoidi Q9ES88.
KOi K14445.
OMAi MFIIPSK.
OrthoDBi EOG7G1V5S.
PhylomeDBi Q9ES88.
TreeFami TF312913.

Miscellaneous databases

NextBioi 298667.
PROi Q9ES88.
SOURCEi Search...

Gene expression databases

Bgeei Q9ES88.
Genevestigatori Q9ES88.

Family and domain databases

InterProi IPR001898. Na/sul_symport.
[Graphical view ]
Pfami PF00939. Na_sulph_symp. 1 hit.
[Graphical view ]
PROSITEi PS01271. NA_SULFATE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, chromosomal organization and functional characterization of a sodium/dicarboxylate cotransporter from mouse kidney."
    Pajor A.M., Sun N.N.
    Am. J. Physiol. 279:F482-F490(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiS13A2_MOUSE
AccessioniPrimary (citable) accession number: Q9ES88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: October 1, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3