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Q9ES88 (S13A2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 13 member 2
Alternative name(s):
Na(+)/dicarboxylate cotransporter 1
Short name=NaDC-1
Renal sodium/dicarboxylate cotransporter
Gene names
Name:Slc13a2
Synonyms:Nadc1, Sdct1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length586 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cotransport of sodium ions and dicarboxylates such as succinate and citrate.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Highly expressed in kidney and small intestine. Not detectable in brain, heart, stomach and skeletal muscle.

Sequence similarities

Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Sodium transport
Symport
Transport
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandSodium
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsodium ion transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionsymporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 586586Solute carrier family 13 member 2
PRO_0000172489

Regions

Transmembrane13 – 3321Helical; Potential
Transmembrane53 – 7321Helical; Potential
Transmembrane86 – 10621Helical; Potential
Transmembrane215 – 23521Helical; Potential
Transmembrane264 – 28421Helical; Potential
Transmembrane319 – 33921Helical; Potential
Transmembrane366 – 38621Helical; Potential
Transmembrane407 – 42721Helical; Potential
Transmembrane445 – 46521Helical; Potential
Transmembrane478 – 49821Helical; Potential
Transmembrane506 – 52621Helical; Potential
Transmembrane535 – 55521Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ES88 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 56EEAE21532833EE

FASTA58664,111
        10         20         30         40         50         60 
MATCWQALWA YRSYLIVLCL PIFLLPLPLI VQTKEAYCAY SIILMALLWC TEALPLAVTA 

        70         80         90        100        110        120 
LFPIILFPLM GIMEASKVCL EYFKDTNILF VGGLMVAIAV EHWNLHKRIA LGVLLIIGVR 

       130        140        150        160        170        180 
PALLLLGFML VTAFLSMWIS NTATTAMMLP IGYAVLEQLQ GSQKDVEEGN SNPSFELQEA 

       190        200        210        220        230        240 
SPQKEETKLD NGQAVSVSSE PRAQKTKEHH RFSQGLSLCI CYSASIGGIA TLTGTTPNLV 

       250        260        270        280        290        300 
LQGQVNSIFP ENSNVVNFAS WFGFAFPTMV ILLLLAWLWL QVLFLGVNFR KNFGFGEGEE 

       310        320        330        340        350        360 
ERKQAAFQVI KTQHRLLGPM SFAEKAVTFL FVLLVVLWFT REPGFFPGWG DTAFANKKGQ 

       370        380        390        400        410        420 
SMVSDGTVAI FISLIMFIIP SKIPGLTEDP KKPGKLKAPP AILTWKTVND KMPWNILILL 

       430        440        450        460        470        480 
GGGFALAKGS EESGLSKWLG DKLTPLQHVP PSATVLILSL LVAIFTECTS NVATTTLFLP 

       490        500        510        520        530        540 
ILASMAQAIC LHPLYVMLPC TLAASLAFML PVATPPNAIV FSFGGLKVSD MARAGFLLNI 

       550        560        570        580 
IGVLTITLSI NSWSIPIFKL DTFPTWAYSN TSQCLLNPPN STVPGH 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning, chromosomal organization and functional characterization of a sodium/dicarboxylate cotransporter from mouse kidney."
Pajor A.M., Sun N.N.
Am. J. Physiol. 279:F482-F490(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF201903 mRNA. Translation: AAG15426.1.
BC013493 mRNA. Translation: AAH13493.1.
CCDSCCDS25103.1.
RefSeqNP_071856.1. NM_022411.3.
UniGeneMm.274058.

3D structure databases

ProteinModelPortalQ9ES88.
SMRQ9ES88. Positions 42-276, 402-545.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9ES88.

Proteomic databases

PRIDEQ9ES88.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001122; ENSMUSP00000001122; ENSMUSG00000001095.
GeneID20500.
KEGGmmu:20500.
UCSCuc007kjf.1. mouse.

Organism-specific databases

CTD9058.
MGIMGI:1276558. Slc13a2.

Phylogenomic databases

eggNOGCOG0471.
GeneTreeENSGT00550000074480.
HOGENOMHOG000278432.
HOVERGENHBG055339.
InParanoidQ9ES88.
KOK14445.
OMAMFIIPSK.
OrthoDBEOG7G1V5S.
PhylomeDBQ9ES88.
TreeFamTF312913.

Gene expression databases

BgeeQ9ES88.
GenevestigatorQ9ES88.

Family and domain databases

InterProIPR001898. Na/sul_symport.
[Graphical view]
PfamPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEPS01271. NA_SULFATE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298667.
PROQ9ES88.
SOURCESearch...

Entry information

Entry nameS13A2_MOUSE
AccessionPrimary (citable) accession number: Q9ES88
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: July 9, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot