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Protein

Solute carrier family 13 member 2

Gene

Slc13a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cotransport of sodium ions and dicarboxylates such as succinate and citrate.

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiREACT_256568. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 2
Alternative name(s):
Na(+)/dicarboxylate cotransporter 1
Short name:
NaDC-1
Renal sodium/dicarboxylate cotransporter
Gene namesi
Name:Slc13a2
Synonyms:Nadc1, Sdct1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1276558. Slc13a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Transmembranei86 – 10621HelicalSequence AnalysisAdd
BLAST
Transmembranei215 – 23521HelicalSequence AnalysisAdd
BLAST
Transmembranei264 – 28421HelicalSequence AnalysisAdd
BLAST
Transmembranei319 – 33921HelicalSequence AnalysisAdd
BLAST
Transmembranei366 – 38621HelicalSequence AnalysisAdd
BLAST
Transmembranei407 – 42721HelicalSequence AnalysisAdd
BLAST
Transmembranei445 – 46521HelicalSequence AnalysisAdd
BLAST
Transmembranei478 – 49821HelicalSequence AnalysisAdd
BLAST
Transmembranei506 – 52621HelicalSequence AnalysisAdd
BLAST
Transmembranei535 – 55521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 586586Solute carrier family 13 member 2PRO_0000172489Add
BLAST

Proteomic databases

PRIDEiQ9ES88.

PTM databases

PhosphoSiteiQ9ES88.

Expressioni

Tissue specificityi

Highly expressed in kidney and small intestine. Not detectable in brain, heart, stomach and skeletal muscle.

Gene expression databases

BgeeiQ9ES88.
GenevestigatoriQ9ES88.

Structurei

3D structure databases

ProteinModelPortaliQ9ES88.
SMRiQ9ES88. Positions 42-276, 402-545.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0471.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ9ES88.
KOiK14445.
OMAiMFIIPSK.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ9ES88.
TreeFamiTF312913.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ES88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCWQALWA YRSYLIVLCL PIFLLPLPLI VQTKEAYCAY SIILMALLWC
60 70 80 90 100
TEALPLAVTA LFPIILFPLM GIMEASKVCL EYFKDTNILF VGGLMVAIAV
110 120 130 140 150
EHWNLHKRIA LGVLLIIGVR PALLLLGFML VTAFLSMWIS NTATTAMMLP
160 170 180 190 200
IGYAVLEQLQ GSQKDVEEGN SNPSFELQEA SPQKEETKLD NGQAVSVSSE
210 220 230 240 250
PRAQKTKEHH RFSQGLSLCI CYSASIGGIA TLTGTTPNLV LQGQVNSIFP
260 270 280 290 300
ENSNVVNFAS WFGFAFPTMV ILLLLAWLWL QVLFLGVNFR KNFGFGEGEE
310 320 330 340 350
ERKQAAFQVI KTQHRLLGPM SFAEKAVTFL FVLLVVLWFT REPGFFPGWG
360 370 380 390 400
DTAFANKKGQ SMVSDGTVAI FISLIMFIIP SKIPGLTEDP KKPGKLKAPP
410 420 430 440 450
AILTWKTVND KMPWNILILL GGGFALAKGS EESGLSKWLG DKLTPLQHVP
460 470 480 490 500
PSATVLILSL LVAIFTECTS NVATTTLFLP ILASMAQAIC LHPLYVMLPC
510 520 530 540 550
TLAASLAFML PVATPPNAIV FSFGGLKVSD MARAGFLLNI IGVLTITLSI
560 570 580
NSWSIPIFKL DTFPTWAYSN TSQCLLNPPN STVPGH
Length:586
Mass (Da):64,111
Last modified:March 1, 2001 - v1
Checksum:i56EEAE21532833EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201903 mRNA. Translation: AAG15426.1.
BC013493 mRNA. Translation: AAH13493.1.
CCDSiCCDS25103.1.
RefSeqiNP_071856.1. NM_022411.3.
UniGeneiMm.274058.

Genome annotation databases

EnsembliENSMUST00000001122; ENSMUSP00000001122; ENSMUSG00000001095.
GeneIDi20500.
KEGGimmu:20500.
UCSCiuc007kjf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201903 mRNA. Translation: AAG15426.1.
BC013493 mRNA. Translation: AAH13493.1.
CCDSiCCDS25103.1.
RefSeqiNP_071856.1. NM_022411.3.
UniGeneiMm.274058.

3D structure databases

ProteinModelPortaliQ9ES88.
SMRiQ9ES88. Positions 42-276, 402-545.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ9ES88.

Proteomic databases

PRIDEiQ9ES88.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001122; ENSMUSP00000001122; ENSMUSG00000001095.
GeneIDi20500.
KEGGimmu:20500.
UCSCiuc007kjf.1. mouse.

Organism-specific databases

CTDi9058.
MGIiMGI:1276558. Slc13a2.

Phylogenomic databases

eggNOGiCOG0471.
GeneTreeiENSGT00550000074480.
HOGENOMiHOG000278432.
HOVERGENiHBG055339.
InParanoidiQ9ES88.
KOiK14445.
OMAiMFIIPSK.
OrthoDBiEOG7G1V5S.
PhylomeDBiQ9ES88.
TreeFamiTF312913.

Enzyme and pathway databases

ReactomeiREACT_256568. Sodium-coupled sulphate, di- and tri-carboxylate transporters.

Miscellaneous databases

NextBioi298667.
PROiQ9ES88.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ES88.
GenevestigatoriQ9ES88.

Family and domain databases

InterProiIPR001898. Na/sul_symport.
[Graphical view]
PfamiPF00939. Na_sulph_symp. 1 hit.
[Graphical view]
PROSITEiPS01271. NA_SULFATE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning, chromosomal organization and functional characterization of a sodium/dicarboxylate cotransporter from mouse kidney."
    Pajor A.M., Sun N.N.
    Am. J. Physiol. 279:F482-F490(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon.

Entry informationi

Entry nameiS13A2_MOUSE
AccessioniPrimary (citable) accession number: Q9ES88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: February 4, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.