Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 13 member 2

Gene

Slc13a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cotransport of sodium ions and dicarboxylates such as succinate and citrate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 13 member 2
Alternative name(s):
Na(+)/dicarboxylate cotransporter 1
Short name:
NaDC-1
Renal sodium/dicarboxylate cotransporter
Gene namesi
Name:Slc13a2
Synonyms:Nadc1, Sdct1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1276558 Slc13a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Transmembranei86 – 106HelicalSequence analysisAdd BLAST21
Transmembranei215 – 235HelicalSequence analysisAdd BLAST21
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Transmembranei319 – 339HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei407 – 427HelicalSequence analysisAdd BLAST21
Transmembranei445 – 465HelicalSequence analysisAdd BLAST21
Transmembranei478 – 498HelicalSequence analysisAdd BLAST21
Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Transmembranei535 – 555HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001724891 – 586Solute carrier family 13 member 2Add BLAST586

Proteomic databases

PaxDbiQ9ES88
PRIDEiQ9ES88

PTM databases

iPTMnetiQ9ES88
PhosphoSitePlusiQ9ES88

Expressioni

Tissue specificityi

Highly expressed in kidney and small intestine. Not detectable in brain, heart, stomach and skeletal muscle.

Gene expression databases

BgeeiENSMUSG00000001095
GenevisibleiQ9ES88 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000001122

Structurei

3D structure databases

ProteinModelPortaliQ9ES88
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1281 Eukaryota
COG0471 LUCA
GeneTreeiENSGT00550000074480
HOGENOMiHOG000278432
HOVERGENiHBG055339
InParanoidiQ9ES88
KOiK14445
OMAiIWWMTEA
OrthoDBiEOG091G092X
PhylomeDBiQ9ES88
TreeFamiTF312913

Family and domain databases

InterProiView protein in InterPro
IPR031312 Na/sul_symport_CS
IPR001898 SLC13A/DASS
PfamiView protein in Pfam
PF00939 Na_sulph_symp, 1 hit
PROSITEiView protein in PROSITE
PS01271 NA_SULFATE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ES88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATCWQALWA YRSYLIVLCL PIFLLPLPLI VQTKEAYCAY SIILMALLWC
60 70 80 90 100
TEALPLAVTA LFPIILFPLM GIMEASKVCL EYFKDTNILF VGGLMVAIAV
110 120 130 140 150
EHWNLHKRIA LGVLLIIGVR PALLLLGFML VTAFLSMWIS NTATTAMMLP
160 170 180 190 200
IGYAVLEQLQ GSQKDVEEGN SNPSFELQEA SPQKEETKLD NGQAVSVSSE
210 220 230 240 250
PRAQKTKEHH RFSQGLSLCI CYSASIGGIA TLTGTTPNLV LQGQVNSIFP
260 270 280 290 300
ENSNVVNFAS WFGFAFPTMV ILLLLAWLWL QVLFLGVNFR KNFGFGEGEE
310 320 330 340 350
ERKQAAFQVI KTQHRLLGPM SFAEKAVTFL FVLLVVLWFT REPGFFPGWG
360 370 380 390 400
DTAFANKKGQ SMVSDGTVAI FISLIMFIIP SKIPGLTEDP KKPGKLKAPP
410 420 430 440 450
AILTWKTVND KMPWNILILL GGGFALAKGS EESGLSKWLG DKLTPLQHVP
460 470 480 490 500
PSATVLILSL LVAIFTECTS NVATTTLFLP ILASMAQAIC LHPLYVMLPC
510 520 530 540 550
TLAASLAFML PVATPPNAIV FSFGGLKVSD MARAGFLLNI IGVLTITLSI
560 570 580
NSWSIPIFKL DTFPTWAYSN TSQCLLNPPN STVPGH
Length:586
Mass (Da):64,111
Last modified:March 1, 2001 - v1
Checksum:i56EEAE21532833EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF201903 mRNA Translation: AAG15426.1
BC013493 mRNA Translation: AAH13493.1
CCDSiCCDS25103.1
RefSeqiNP_071856.1, NM_022411.3
UniGeneiMm.274058

Genome annotation databases

EnsembliENSMUST00000001122; ENSMUSP00000001122; ENSMUSG00000001095
GeneIDi20500
KEGGimmu:20500
UCSCiuc007kjf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiS13A2_MOUSE
AccessioniPrimary (citable) accession number: Q9ES88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: March 1, 2001
Last modified: March 28, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health