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Protein

Popeye domain-containing protein 3

Gene

Popdc3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the maintenance of heart function mediated, at least in part, through cAMP-binding.2 Publications

GO - Molecular functioni

  • cAMP binding Source: UniProtKB

GO - Biological processi

  • regulation of membrane potential Source: MGI
Complete GO annotation...

Keywords - Ligandi

cAMP, cAMP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Popeye domain-containing protein 3
Short name:
Popeye protein 3
Gene namesi
Name:Popdc3
Synonyms:Pop3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1930153. Popdc3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei27 – 4418HelicalSequence analysisAdd
BLAST
Transmembranei48 – 7023HelicalSequence analysisAdd
BLAST
Transmembranei77 – 9923HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291Popeye domain-containing protein 3PRO_0000046796Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ES81.
PRIDEiQ9ES81.

PTM databases

iPTMnetiQ9ES81.
PhosphoSiteiQ9ES81.

Expressioni

Tissue specificityi

Expressed in cardiac and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000019848.
CleanExiMM_POPDC3.
ExpressionAtlasiQ9ES81. baseline and differential.
GenevisibleiQ9ES81. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019994.

Structurei

3D structure databases

ProteinModelPortaliQ9ES81.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the popeye family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGHK. Eukaryota.
ENOG410ZTIT. LUCA.
GeneTreeiENSGT00390000002563.
HOGENOMiHOG000050233.
HOVERGENiHBG053639.
InParanoidiQ9ES81.
OMAiHYIYPFQ.
OrthoDBiEOG091G0CVO.
PhylomeDBiQ9ES81.
TreeFamiTF326644.

Family and domain databases

InterProiIPR018490. cNMP-bd-like.
IPR006916. Popeye_prot.
[Graphical view]
PANTHERiPTHR12101. PTHR12101. 1 hit.
PfamiPF04831. Popeye. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ES81-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKNSSLWKS LVTEHPLCTT WKQEAEGAIY HLASILFVVG FMGGSGFFGL
60 70 80 90 100
LYVFSLLGLG FLSSAVWAWV DICAADIFSW NFVLFVICFM QFVHIAYQVH
110 120 130 140 150
SITFARDFHV LYSSLFKPLG IPLPVFRTIA LSSEVVSLEK EHCYAMQGKT
160 170 180 190 200
SIDRLSVLIS GRIRVTVDGE FLHYISPFQF LDSPEWDSLR PTEEGIFQVT
210 220 230 240 250
LTADTDCRYV SWRRKKLYLL FAQHRYISRL FSVLIGSDIA DKLYALNDRV
260 270 280 290
YIGKKHHYDI RLPNYYHMST PDLSRSPLTE QFRNSRQHCN K
Length:291
Mass (Da):33,612
Last modified:March 1, 2001 - v1
Checksum:i8AC6BFE107AEEE12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204176 mRNA. Translation: AAG23409.1.
AK052325 mRNA. Translation: BAC34938.1.
BC114993 mRNA. Translation: AAI14994.1.
CCDSiCCDS23827.1.
RefSeqiNP_077248.1. NM_024286.1.
UniGeneiMm.24748.

Genome annotation databases

EnsembliENSMUST00000019994; ENSMUSP00000019994; ENSMUSG00000019848.
GeneIDi78977.
KEGGimmu:78977.
UCSCiuc007ezy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF204176 mRNA. Translation: AAG23409.1.
AK052325 mRNA. Translation: BAC34938.1.
BC114993 mRNA. Translation: AAI14994.1.
CCDSiCCDS23827.1.
RefSeqiNP_077248.1. NM_024286.1.
UniGeneiMm.24748.

3D structure databases

ProteinModelPortaliQ9ES81.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019994.

PTM databases

iPTMnetiQ9ES81.
PhosphoSiteiQ9ES81.

Proteomic databases

PaxDbiQ9ES81.
PRIDEiQ9ES81.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019994; ENSMUSP00000019994; ENSMUSG00000019848.
GeneIDi78977.
KEGGimmu:78977.
UCSCiuc007ezy.1. mouse.

Organism-specific databases

CTDi64208.
MGIiMGI:1930153. Popdc3.

Phylogenomic databases

eggNOGiENOG410IGHK. Eukaryota.
ENOG410ZTIT. LUCA.
GeneTreeiENSGT00390000002563.
HOGENOMiHOG000050233.
HOVERGENiHBG053639.
InParanoidiQ9ES81.
OMAiHYIYPFQ.
OrthoDBiEOG091G0CVO.
PhylomeDBiQ9ES81.
TreeFamiTF326644.

Miscellaneous databases

PROiQ9ES81.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019848.
CleanExiMM_POPDC3.
ExpressionAtlasiQ9ES81. baseline and differential.
GenevisibleiQ9ES81. MM.

Family and domain databases

InterProiIPR018490. cNMP-bd-like.
IPR006916. Popeye_prot.
[Graphical view]
PANTHERiPTHR12101. PTHR12101. 1 hit.
PfamiPF04831. Popeye. 1 hit.
[Graphical view]
SUPFAMiSSF51206. SSF51206. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPOPD3_MOUSE
AccessioniPrimary (citable) accession number: Q9ES81
Secondary accession number(s): Q1RME0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.