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Protein

Melanoma-associated antigen D1

Gene

Maged1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as ARNTL/BMAL1 and NFIL3, induced, or NR1D1, repressed.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Tumor antigen

Keywords - Biological processi

Biological rhythms, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-193648. NRAGE signals death through JNK.

Names & Taxonomyi

Protein namesi
Recommended name:
Melanoma-associated antigen D1
Alternative name(s):
MAGE-D1 antigen
Neurotrophin receptor-interacting MAGE homolog
Sertoli cell necdin-related gene protein 1
Short name:
SNERG-1
Gene namesi
Name:Maged1
Synonyms:Nrage
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi70898. Maged1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001567261 – 775Melanoma-associated antigen D1Add BLAST775

Proteomic databases

PaxDbiQ9ES73.
PRIDEiQ9ES73.

PTM databases

iPTMnetiQ9ES73.
PhosphoSitePlusiQ9ES73.

Expressioni

Tissue specificityi

Ubiquitous and in the seminiferous tubules expressed in Sertoli cells but not in germ cells. Expression decreases in all tissues with increased age and is detectable only in brain cortex and lung.

Developmental stagei

Expressed at low levels throughout the embryo and is enriched in the developing brain and spinal cord.

Inductioni

Follitropin decreased expression while lutropin and prolactin stimulated expression.

Gene expression databases

BgeeiENSRNOG00000006756.
ExpressionAtlasiQ9ES73. baseline and differential.
GenevisibleiQ9ES73. RN.

Interactioni

Subunit structurei

Interacts with DLX5, DLX7 and MSX2 and forms homomultimers. Interacts with UNC5A. Interacts with TRIM28 and PJA1. Interacts with NGFR/p75NTR and RORA.2 Publications

Protein-protein interaction databases

BioGridi249969. 1 interactor.
STRINGi10116.ENSRNOP00000009870.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati293 – 29816
Repeati299 – 30426
Repeati305 – 31036
Repeati329 – 33446
Repeati335 – 34056
Repeati341 – 34666
Repeati347 – 35276
Repeati353 – 35886
Repeati359 – 36496
Repeati365 – 370106
Repeati371 – 376116
Repeati377 – 382126
Repeati383 – 388136
Repeati389 – 394146
Repeati395 – 400156
Repeati401 – 406166
Repeati407 – 412176
Repeati413 – 418186
Repeati419 – 424196
Repeati425 – 42920; approximate5
Repeati430 – 435216
Repeati436 – 441226
Domaini468 – 666MAGEPROSITE-ProRule annotationAdd BLAST199

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni293 – 44122 X 6 AA tandem repeats of W-[PQ]-X-P-X-XAdd BLAST149

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi276 – 462Pro-richAdd BLAST187

Sequence similaritiesi

Contains 1 MAGE domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000049038.
HOVERGENiHBG003714.
InParanoidiQ9ES73.
KOiK12464.
OMAiWQNPVIW.
OrthoDBiEOG091G09D3.
PhylomeDBiQ9ES73.

Family and domain databases

InterProiIPR030083. MAGED1.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF28. PTHR11736:SF28. 1 hit.
PfamiPF01454. MAGE. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ES73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQKPDGGAG LRGFQAEASV EDSALLVQTL MEAIQISEAP PTSQATAAAS
60 70 80 90 100
GPNASPQSSQ PPTANEKADT EVSAAAARPK TGFKAQNTTT KGPNDYSQAR
110 120 130 140 150
NAKEMPKNQP KVAFKSQNAT SKGPHAASDF SHAASTGKSA AKKSEMAFKG
160 170 180 190 200
QNTTTKAGPS ATYNFTQSPS ANEMTNNQPK TAKAWNDTTK IPGADAQTQN
210 220 230 240 250
VNQAKMADVG TSAGISETDG AAAQTSADGS QAQNVESRTI IRGKRTRKIN
260 270 280 290 300
NLNVEENSNG DQRRASLASG NWRSAPVPVT TQNPPGAPPN VLWQTPLAWQ
310 320 330 340 350
NPSGWQNQTA RQTPPARQSP PARQTPSAWQ NPVAWQNPVI WPNPVIWQNP
360 370 380 390 400
VIWPNPIVWP GPIVWPNPMA WQSTPGWQSP PSWQAPPSWQ SPQDWQGPPD
410 420 430 440 450
WQLPPDWSMP PDWSFPSDWP FPPDWIPADW PIPPDWQNLR PSPNLRSSPN
460 470 480 490 500
SRASQNQGPP QPRDVALLQE RANKLVKYLM LKDYTKVPIK RSEMLRDIIR
510 520 530 540 550
EYTDVYPEII ERACFVLEKK FGIQLKEIDK EEHLYILIST PESLAGILGT
560 570 580 590 600
TKDTPKLGLL LVILGIIFMN GNRATEAVLW EALRKMGLRP GVRHPLLGDL
610 620 630 640 650
RKLLTYEFVK QKYLDYRRVP NSNPPEYEFL WGLRSYHETS KMKVLRFIAE
660 670 680 690 700
VQKRDPRDWT AQFMEAADEA LDALDAAAAE AEARAEARNR MGIGDEAVSG
710 720 730 740 750
PWSWDDIEFE LLTWDEEGDF GDPWSRIPFT FWARYHQNAR SRFPQAFTGP
760 770
IIGPSGTATA NFAANFGAIG FFWVE
Length:775
Mass (Da):85,798
Last modified:May 1, 2007 - v3
Checksum:iF8BF3B170B8A3742
GO

Sequence cautioni

The sequence CAB65381 differs from that shown. Reason: Frameshift at position 726.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178Q → R in AAF75283 (Ref. 4) Curated1
Sequence conflicti425 – 427WIP → CIL in CAB65381 (PubMed:11014239).Curated3
Sequence conflicti425 – 427WIP → CIL in AAF75283 (Ref. 4) Curated3
Sequence conflicti693 – 699IGDEAVS → LETELCL in CAB65381 (PubMed:11014239).Curated7
Sequence conflicti693 – 699IGDEAVS → LETELCL in AAF75283 (Ref. 4) Curated7
Sequence conflicti724 – 725WS → GP in AAF75283 (Ref. 4) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217964 mRNA. Translation: AAG09705.1.
BC081756 mRNA. Translation: AAH81756.1.
AJ133038 mRNA. Translation: CAB65381.1. Frameshift.
AF274043 mRNA. Translation: AAF75283.1.
RefSeqiNP_445861.1. NM_053409.2.
UniGeneiRn.54596.

Genome annotation databases

EnsembliENSRNOT00000009870; ENSRNOP00000009870; ENSRNOG00000006756.
GeneIDi84469.
KEGGirno:84469.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF217964 mRNA. Translation: AAG09705.1.
BC081756 mRNA. Translation: AAH81756.1.
AJ133038 mRNA. Translation: CAB65381.1. Frameshift.
AF274043 mRNA. Translation: AAF75283.1.
RefSeqiNP_445861.1. NM_053409.2.
UniGeneiRn.54596.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249969. 1 interactor.
STRINGi10116.ENSRNOP00000009870.

PTM databases

iPTMnetiQ9ES73.
PhosphoSitePlusiQ9ES73.

Proteomic databases

PaxDbiQ9ES73.
PRIDEiQ9ES73.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009870; ENSRNOP00000009870; ENSRNOG00000006756.
GeneIDi84469.
KEGGirno:84469.

Organism-specific databases

CTDi9500.
RGDi70898. Maged1.

Phylogenomic databases

eggNOGiKOG4562. Eukaryota.
ENOG4111S70. LUCA.
GeneTreeiENSGT00760000118824.
HOGENOMiHOG000049038.
HOVERGENiHBG003714.
InParanoidiQ9ES73.
KOiK12464.
OMAiWQNPVIW.
OrthoDBiEOG091G09D3.
PhylomeDBiQ9ES73.

Enzyme and pathway databases

ReactomeiR-RNO-193648. NRAGE signals death through JNK.

Miscellaneous databases

PROiQ9ES73.

Gene expression databases

BgeeiENSRNOG00000006756.
ExpressionAtlasiQ9ES73. baseline and differential.
GenevisibleiQ9ES73. RN.

Family and domain databases

InterProiIPR030083. MAGED1.
IPR002190. MHD_dom.
[Graphical view]
PANTHERiPTHR11736:SF28. PTHR11736:SF28. 1 hit.
PfamiPF01454. MAGE. 1 hit.
[Graphical view]
SMARTiSM01373. MAGE. 1 hit.
[Graphical view]
PROSITEiPS50838. MAGE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMAGD1_RAT
AccessioniPrimary (citable) accession number: Q9ES73
Secondary accession number(s): Q66HP3, Q9JHZ6, Q9QX92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: May 1, 2007
Last modified: November 2, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.