Protein CYR61 precursor - Rattus norvegicus (Rat)

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Q9ES72 (CYR61_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 82. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein CYR61

Alternative name(s):
CCN family member 1
Cysteine-rich angiogenic inducer 61
Insulin-like growth factor-binding protein 10
Short name=IBP-10
Short name=IGF-binding protein 10
Short name=IGFBP-10

Gene names

Name:	Cyr61
Synonyms:	Ccn1, Igfbp10

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	379 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 By similarity. CYR61-mediated gene regulation is dependent on heparin-binding By similarity. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 By similarity. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 By similarity.
Subunit structure	Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion By similarity.
Subcellular location	Secreted.
Sequence similarities	Belongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Contains 1 VWFC domain.

Ontologies

Keywords
Biological process	Cell adhesion Chemotaxis
Cellular component	Secreted
Domain	Signal
Ligand	Growth factor binding Heparin-binding
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell adhesion Inferred from direct assay PubMed 11897702. Source: RGD chemotaxis Inferred from direct assay PubMed 11897702. Source: RGD positive regulation of angiogenesis Traceable author statement PubMed 11897702. Source: RGD positive regulation of cell migration Traceable author statement PubMed 11897702. Source: RGD regulation of cell growth Inferred from electronic annotation. Source: InterPro
Cellular_component	proteinaceous extracellular matrix Traceable author statement PubMed 11897702. Source: RGD
Molecular_function	heparin binding Traceable author statement PubMed 11897702. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

Potential

Chain

25 – 379

355

Protein CYR61

PRO_0000014400

Regions

Domain

25 – 94

IGFBP N-terminal

Domain

98 – 164

VWFC

Domain

226 – 271

TSP type-1

Domain

284 – 358

CTCK

Region

277 – 313

Heparin-binding By similarity

Amino acid modifications

Disulfide bond

284 ↔ 321

By similarity

Disulfide bond

301 ↔ 335

By similarity

Disulfide bond

312 ↔ 351

By similarity

Disulfide bond

315 ↔ 353

By similarity

Disulfide bond

320 ↔ 357

By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q9ES72 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 62BF0BBA4C5AFDE9
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FASTA

379

41,687

        10         20         30         40         50         60 
MSSSTIKTLA VAVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC GCCKVCAKQL 

        70         80         90        100        110        120 
NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC EYNSRIYQNG ESFQPNCKHQ 

       130        140        150        160        170        180 
CTCIDGAVGC IPLCPQELSL PNLGCPNPRL VKVSGQCCEE WVCDEDSIKD SLDDQDDLLG 

       190        200        210        220        230        240 
FDASEVELTR NNELIAIGKG SSLKRLPVFG TEPRVLYNPL HAHGQKCIVQ TTSWSQCSKS 

       250        260        270        280        290        300 
CGTGISTRVT NDNSECRLVK ETRICEVRPC GQPVYSSLKK GKKCSKTKKS PEPVRFTYAG 

       310        320        330        340        350        360 
CSSVKKYRPK YCGSCVDGRC CTPLQTRTVK MRFRCEDGEM FSKNVMMIQS CKCNYNCPHP 

       370 
NEASFRLYSL FNDIHKFRD

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References

[1]	"Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61." Albrecht C., von Der Kammer H., Mayhaus M., Klaudiny J., Schweizer M., Nitsch R.M. J. Biol. Chem. 275:28929-28936(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF218568 mRNA. Translation: AAG14964.1.
IPI	IPI00551794.
RefSeq	NP_112617.2. NM_031327.2.
UniGene	Rn.22129.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9ES72. 1 interaction.
STRING	10116.ENSRNOP00000019501.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	83476.
KEGG	rno:83476.
Organism-specific databases
CTD	3491.
RGD	620763. Cyr61.
Phylogenomic databases
eggNOG	NOG82014.
HOGENOM	HOG000231462.
HOVERGEN	HBG000635.
InParanoid	Q9ES72.
KO	K06829.
OrthoDB	EOG4J3WH3.
Gene expression databases
ArrayExpress	Q9ES72.
Genevestigator	Q9ES72.
GermOnline	ENSRNOG00000014350. Rattus norvegicus.
Family and domain databases
InterPro	IPR006208. Cys_knot. IPR006207. Cys_knot_C. IPR000867. IGFBP-like. IPR012395. IGFBP_CNN. IPR017891. Insulin_GF-bd_Cys-rich_CS. IPR000884. Thrombospondin_1_rpt. IPR001007. VWF_C. [Graphical view]
Pfam	PF00007. Cys_knot. 1 hit. PF00219. IGFBP. 1 hit. PF00090. TSP_1. 1 hit. PF00093. VWC. 1 hit. [Graphical view]
PIRSF	PIRSF036495. IGFBP_rP_CNN. 1 hit.
SMART	SM00041. CT. 1 hit. SM00121. IB. 1 hit. SM00209. TSP1. 1 hit. SM00214. VWC. 1 hit. [Graphical view]
SUPFAM	SSF82895. TSP1. 1 hit.
PROSITE	PS01185. CTCK_1. 1 hit. PS01225. CTCK_2. 1 hit. PS00222. IGFBP_N_1. 1 hit. PS51323. IGFBP_N_2. 1 hit. PS50092. TSP1. 1 hit. PS01208. VWFC_1. 1 hit. PS50184. VWFC_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	615893.

Entry information

Entry name

CYR61_RAT

Accession

Primary (citable) accession number: Q9ES72

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents