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Q9ES72

- CYR61_RAT

UniProt

Q9ES72 - CYR61_RAT

Protein

Protein CYR61

Gene

Cyr61

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 By similarity. CYR61-mediated gene regulation is dependent on heparin-binding By similarity. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 By similarity. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 By similarity.By similarity

    GO - Molecular functioni

    1. heparin binding Source: RGD

    GO - Biological processi

    1. cell adhesion Source: RGD
    2. chemotaxis Source: RGD
    3. positive regulation of angiogenesis Source: RGD
    4. positive regulation of cell migration Source: RGD
    5. regulation of cell growth Source: InterPro

    Keywords - Biological processi

    Cell adhesion, Chemotaxis

    Keywords - Ligandi

    Growth factor binding, Heparin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein CYR61
    Alternative name(s):
    CCN family member 1
    Cysteine-rich angiogenic inducer 61
    Insulin-like growth factor-binding protein 10
    Short name:
    IBP-10
    Short name:
    IGF-binding protein 10
    Short name:
    IGFBP-10
    Gene namesi
    Name:Cyr61
    Synonyms:Ccn1, Igfbp10
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi620763. Cyr61.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 379355Protein CYR61PRO_0000014400Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi284 ↔ 321By similarity
    Disulfide bondi301 ↔ 335By similarity
    Disulfide bondi312 ↔ 351By similarity
    Disulfide bondi315 ↔ 353By similarity
    Disulfide bondi320 ↔ 357By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiQ9ES72.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9ES72.

    Interactioni

    Subunit structurei

    Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion.By similarity

    Protein-protein interaction databases

    IntActiQ9ES72. 1 interaction.
    STRINGi10116.ENSRNOP00000019501.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini25 – 9470IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini98 – 16467VWFCPROSITE-ProRule annotationAdd
    BLAST
    Domaini226 – 27146TSP type-1PROSITE-ProRule annotationAdd
    BLAST
    Domaini284 – 35875CTCKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni277 – 31337Heparin-bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCN family.Curated
    Contains 1 CTCK (C-terminal cystine knot-like) domain.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 1 TSP type-1 domain.PROSITE-ProRule annotation
    Contains 1 VWFC domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG82014.
    HOGENOMiHOG000231462.
    HOVERGENiHBG000635.
    InParanoidiQ9ES72.
    KOiK06829.
    PhylomeDBiQ9ES72.

    Family and domain databases

    InterProiIPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTiSM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEiPS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ES72-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSTIKTLA VAVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC    50
    GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC 100
    EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL 150
    VKVSGQCCEE WVCDEDSIKD SLDDQDDLLG FDASEVELTR NNELIAIGKG 200
    SSLKRLPVFG TEPRVLYNPL HAHGQKCIVQ TTSWSQCSKS CGTGISTRVT 250
    NDNSECRLVK ETRICEVRPC GQPVYSSLKK GKKCSKTKKS PEPVRFTYAG 300
    CSSVKKYRPK YCGSCVDGRC CTPLQTRTVK MRFRCEDGEM FSKNVMMIQS 350
    CKCNYNCPHP NEASFRLYSL FNDIHKFRD 379
    Length:379
    Mass (Da):41,687
    Last modified:March 1, 2001 - v1
    Checksum:i62BF0BBA4C5AFDE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218568 mRNA. Translation: AAG14964.1.
    RefSeqiNP_112617.2. NM_031327.2.
    UniGeneiRn.22129.

    Genome annotation databases

    GeneIDi83476.
    KEGGirno:83476.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF218568 mRNA. Translation: AAG14964.1 .
    RefSeqi NP_112617.2. NM_031327.2.
    UniGenei Rn.22129.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9ES72. 1 interaction.
    STRINGi 10116.ENSRNOP00000019501.

    Proteomic databases

    PRIDEi Q9ES72.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 83476.
    KEGGi rno:83476.

    Organism-specific databases

    CTDi 3491.
    RGDi 620763. Cyr61.

    Phylogenomic databases

    eggNOGi NOG82014.
    HOGENOMi HOG000231462.
    HOVERGENi HBG000635.
    InParanoidi Q9ES72.
    KOi K06829.
    PhylomeDBi Q9ES72.

    Miscellaneous databases

    NextBioi 615893.
    PROi Q9ES72.

    Gene expression databases

    Genevestigatori Q9ES72.

    Family and domain databases

    InterProi IPR006207. Cys_knot_C.
    IPR006208. Glyco_hormone_CN.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000867. IGFBP-like.
    IPR012395. IGFBP_CNN.
    IPR017891. Insulin_GF-bd_Cys-rich_CS.
    IPR000884. Thrombospondin_1_rpt.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF00007. Cys_knot. 1 hit.
    PF00219. IGFBP. 1 hit.
    PF00090. TSP_1. 1 hit.
    PF00093. VWC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036495. IGFBP_rP_CNN. 1 hit.
    SMARTi SM00041. CT. 1 hit.
    SM00121. IB. 1 hit.
    SM00209. TSP1. 1 hit.
    SM00214. VWC. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF82895. SSF82895. 1 hit.
    PROSITEi PS01185. CTCK_1. 1 hit.
    PS01225. CTCK_2. 1 hit.
    PS00222. IGFBP_N_1. 1 hit.
    PS51323. IGFBP_N_2. 1 hit.
    PS50092. TSP1. 1 hit.
    PS01208. VWFC_1. 1 hit.
    PS50184. VWFC_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61."
      Albrecht C., von Der Kammer H., Mayhaus M., Klaudiny J., Schweizer M., Nitsch R.M.
      J. Biol. Chem. 275:28929-28936(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.

    Entry informationi

    Entry nameiCYR61_RAT
    AccessioniPrimary (citable) accession number: Q9ES72
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3