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Protein

Protein CYR61

Gene

Cyr61

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 (By similarity). CYR61-mediated gene regulation is dependent on heparin-binding (By similarity). Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 (By similarity). Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 (By similarity).By similarity

GO - Molecular functioni

  • heparin binding Source: RGD
  • insulin-like growth factor binding Source: InterPro
  • integrin binding Source: GO_Central

GO - Biological processi

  • cell adhesion Source: RGD
  • cell-cell signaling Source: GO_Central
  • chemotaxis Source: RGD
  • negative regulation of cell death Source: GO_Central
  • positive regulation of angiogenesis Source: RGD
  • positive regulation of cell migration Source: RGD
  • regulation of cell growth Source: InterPro
  • signal transduction Source: GO_Central

Keywordsi

Molecular functionGrowth factor binding, Heparin-binding
Biological processCell adhesion, Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CYR61
Alternative name(s):
CCN family member 1
Cysteine-rich angiogenic inducer 61
Insulin-like growth factor-binding protein 10
Short name:
IBP-10
Short name:
IGF-binding protein 10
Short name:
IGFBP-10
Gene namesi
Name:Cyr61
Synonyms:Ccn1, Igfbp10
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620763. Cyr61.

Subcellular locationi

GO - Cellular componenti

  • proteinaceous extracellular matrix Source: RGD

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001440025 – 379Protein CYR61Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184PhosphoserineBy similarity1
Disulfide bondi284 ↔ 321By similarity
Disulfide bondi301 ↔ 335By similarity
Disulfide bondi312 ↔ 351By similarity
Disulfide bondi315 ↔ 353By similarity
Disulfide bondi320 ↔ 357By similarity

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiQ9ES72.
PRIDEiQ9ES72.

Interactioni

Subunit structurei

Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9ES72. 1 interactor.
STRINGi10116.ENSRNOP00000019501.

Structurei

3D structure databases

SMRiQ9ES72.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 94IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST70
Domaini98 – 164VWFCPROSITE-ProRule annotationAdd BLAST67
Domaini226 – 271TSP type-1PROSITE-ProRule annotationAdd BLAST46
Domaini284 – 358CTCKPROSITE-ProRule annotationAdd BLAST75

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni277 – 313Heparin-bindingBy similarityAdd BLAST37

Sequence similaritiesi

Belongs to the CCN family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IIY0. Eukaryota.
ENOG41119KZ. LUCA.
HOGENOMiHOG000231462.
HOVERGENiHBG000635.
InParanoidiQ9ES72.
KOiK06829.
PhylomeDBiQ9ES72.

Family and domain databases

InterProiView protein in InterPro
IPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. TSP1_rpt.
IPR001007. VWF_dom.
PfamiView protein in Pfam
PF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00093. VWC. 1 hit.
PIRSFiPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTiView protein in SMART
SM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEiView protein in PROSITE
PS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ES72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSTIKTLA VAVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC
60 70 80 90 100
GCCKVCAKQL NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC
110 120 130 140 150
EYNSRIYQNG ESFQPNCKHQ CTCIDGAVGC IPLCPQELSL PNLGCPNPRL
160 170 180 190 200
VKVSGQCCEE WVCDEDSIKD SLDDQDDLLG FDASEVELTR NNELIAIGKG
210 220 230 240 250
SSLKRLPVFG TEPRVLYNPL HAHGQKCIVQ TTSWSQCSKS CGTGISTRVT
260 270 280 290 300
NDNSECRLVK ETRICEVRPC GQPVYSSLKK GKKCSKTKKS PEPVRFTYAG
310 320 330 340 350
CSSVKKYRPK YCGSCVDGRC CTPLQTRTVK MRFRCEDGEM FSKNVMMIQS
360 370
CKCNYNCPHP NEASFRLYSL FNDIHKFRD
Length:379
Mass (Da):41,687
Last modified:March 1, 2001 - v1
Checksum:i62BF0BBA4C5AFDE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218568 mRNA. Translation: AAG14964.1.
RefSeqiNP_112617.2. NM_031327.2.
UniGeneiRn.22129.

Genome annotation databases

GeneIDi83476.
KEGGirno:83476.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCYR61_RAT
AccessioniPrimary (citable) accession number: Q9ES72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2001
Last modified: July 5, 2017
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families