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Q9ES72 (CYR61_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein CYR61
Alternative name(s):
CCN family member 1
Cysteine-rich angiogenic inducer 61
Insulin-like growth factor-binding protein 10
Short name=IBP-10
Short name=IGF-binding protein 10
Short name=IGFBP-10
Gene names
Name:Cyr61
Synonyms:Ccn1, Igfbp10
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5 By similarity. CYR61-mediated gene regulation is dependent on heparin-binding By similarity. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1 By similarity. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-1/beta-5 and cell proliferation through integrin alpha-v/beta-3 By similarity.

Subunit structure

Interaction with integrins is heparin- and cell-type-dependent and promotes cell adhesion By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the CCN family.

Contains 1 CTCK (C-terminal cystine knot-like) domain.

Contains 1 IGFBP N-terminal domain.

Contains 1 TSP type-1 domain.

Contains 1 VWFC domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 379355Protein CYR61
PRO_0000014400

Regions

Domain25 – 9470IGFBP N-terminal
Domain98 – 16467VWFC
Domain226 – 27146TSP type-1
Domain284 – 35875CTCK
Region277 – 31337Heparin-binding By similarity

Amino acid modifications

Disulfide bond284 ↔ 321 By similarity
Disulfide bond301 ↔ 335 By similarity
Disulfide bond312 ↔ 351 By similarity
Disulfide bond315 ↔ 353 By similarity
Disulfide bond320 ↔ 357 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ES72 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: 62BF0BBA4C5AFDE9

FASTA37941,687
        10         20         30         40         50         60 
MSSSTIKTLA VAVTLLHLTR LALSTCPAAC HCPLEAPKCA PGVGLVRDGC GCCKVCAKQL 

        70         80         90        100        110        120 
NEDCSKTQPC DHTKGLECNF GASSTALKGI CRAQSEGRPC EYNSRIYQNG ESFQPNCKHQ 

       130        140        150        160        170        180 
CTCIDGAVGC IPLCPQELSL PNLGCPNPRL VKVSGQCCEE WVCDEDSIKD SLDDQDDLLG 

       190        200        210        220        230        240 
FDASEVELTR NNELIAIGKG SSLKRLPVFG TEPRVLYNPL HAHGQKCIVQ TTSWSQCSKS 

       250        260        270        280        290        300 
CGTGISTRVT NDNSECRLVK ETRICEVRPC GQPVYSSLKK GKKCSKTKKS PEPVRFTYAG 

       310        320        330        340        350        360 
CSSVKKYRPK YCGSCVDGRC CTPLQTRTVK MRFRCEDGEM FSKNVMMIQS CKCNYNCPHP 

       370 
NEASFRLYSL FNDIHKFRD 

« Hide

References

[1]"Muscarinic acetylcholine receptors induce the expression of the immediate early growth regulatory gene CYR61."
Albrecht C., von Der Kammer H., Mayhaus M., Klaudiny J., Schweizer M., Nitsch R.M.
J. Biol. Chem. 275:28929-28936(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF218568 mRNA. Translation: AAG14964.1.
RefSeqNP_112617.2. NM_031327.2.
UniGeneRn.22129.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9ES72. 1 interaction.
STRING10116.ENSRNOP00000019501.

Proteomic databases

PRIDEQ9ES72.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID83476.
KEGGrno:83476.

Organism-specific databases

CTD3491.
RGD620763. Cyr61.

Phylogenomic databases

eggNOGNOG82014.
HOGENOMHOG000231462.
HOVERGENHBG000635.
InParanoidQ9ES72.
KOK06829.
PhylomeDBQ9ES72.

Gene expression databases

GenevestigatorQ9ES72.

Family and domain databases

InterProIPR006207. Cys_knot_C.
IPR006208. Glyco_hormone_CN.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000867. IGFBP-like.
IPR012395. IGFBP_CNN.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000884. Thrombospondin_1_rpt.
IPR001007. VWF_C.
[Graphical view]
PfamPF00007. Cys_knot. 1 hit.
PF00219. IGFBP. 1 hit.
PF00090. TSP_1. 1 hit.
PF00093. VWC. 1 hit.
[Graphical view]
PIRSFPIRSF036495. IGFBP_rP_CNN. 1 hit.
SMARTSM00041. CT. 1 hit.
SM00121. IB. 1 hit.
SM00209. TSP1. 1 hit.
SM00214. VWC. 1 hit.
[Graphical view]
SUPFAMSSF57184. SSF57184. 1 hit.
SSF82895. SSF82895. 1 hit.
PROSITEPS01185. CTCK_1. 1 hit.
PS01225. CTCK_2. 1 hit.
PS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS50092. TSP1. 1 hit.
PS01208. VWFC_1. 1 hit.
PS50184. VWFC_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio615893.
PROQ9ES72.

Entry information

Entry nameCYR61_RAT
AccessionPrimary (citable) accession number: Q9ES72
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families