Skip Header

 
Contribute Send feedback
Read comments (1) or add your own

Reviewed, UniProtKB/Swiss-Prot Q9ES71 (GNPAT_RAT)

Last modified June 16, 2009. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Dihydroxyacetone phosphate acyltransferase
      Short name=DHAP-AT
      Short name=DAP-AT
    EC=2.3.1.42
Alternative name(s):
    Glycerone-phosphate O-acyltransferase
    Acyl-CoA:dihydroxyacetonephosphateacyltransferase
Gene names
Name: Gnpat
Synonyms: Dhapat
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length678 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Catalytic activity

Acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate.

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Subunit structure

May be part of an heterotrimeric complex composed of DAP-AT, ADAP-S and a modified form of DAP-AT By similarity.

Subcellular location

Peroxisome membrane; Peripheral membrane protein; Matrix side By similarity. Note: Exclusively localized to the lumenal side of the peroxisomal membrane By similarity.

Domain

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.

Sequence similarities

Belongs to the GPAT/DAPAT family.

Ontologies

Keywords
   Cellular componentMembrane
Peroxisome
   Molecular functionAcyltransferase
Transferase
Gene Ontology (GO)
   Biological processmetabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentperoxisomal membrane

Traceable author statement. Source: RGD

   Molecular functionglycerone-phosphate O-acyltransferase activity

Traceable author statement. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 678678Dihydroxyacetone phosphate acyltransferase
PRO_0000195248

Regions

Motif161 – 1666HXXXXD motif
Motif676 – 6783Microbody targeting signal Potential
Compositional bias5 – 95Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
Q9ES71-1 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: F825A2728D534B68

FASTA67877,076
        10         20         30         40         50         60 
MDVPSSSSSR FSVGSASPSS VLLYAKDLKK WDEFEDLLEE RRQVSDFKFA MKCYTPPLYR 

        70         80         90        100        110        120 
GITPCKPSDI KSIVLNSEEI NYVIKQLSRE SLTGVDVLRE EANEILEEMS HKLRIGAIRF 

       130        140        150        160        170        180 
FAFVLSKVFK QIFSKVCVNE EGIQKLQRAI QEHPVILLPS HRSYIDFLML SFVLYNYDLP 

       190        200        210        220        230        240 
VPVIAAGMDF LGMRVVSELL RMSGAFFMRR TFGGNKLYWA VFSEYVKTML RSGYAPVEFF 

       250        260        270        280        290        300 
LEGTRSRAAK TLTPKFGLLN IVMEPFFKRE VFDTYFVPIS ISYDKILEES LYAYELLGIP 

       310        320        330        340        350        360 
KPKESTTGLL KARRILSENF GSIHVYFGDP VSLRSLAAGR LSRNTYNLVP RCIPQKQPED 

       370        380        390        400        410        420 
VQAFVTEVAY KMQLLQIENL ALSPWLLVVA ILLQNQLCMD FDALVEKTLW LKGLTQVFGG 

       430        440        450        460        470        480 
FLLWPDNKLP EEVVQSSILL HSNLATLVKD QVVLKVDSES SQMVNGLVPQ HIAFLMCSAY 

       490        500        510        520        530        540 
RNQLLNVFAR PSLVAVALHM TPGLRKEDVF SCFSFLRNVF SDEFIFLPGN TLRDFEEGCY 

       550        560        570        580        590        600 
LLCKTEVMQM TGKDIILTDK GNAVLQFLTG LFKPFVESYQ ILSKCLLHEE DYFSEKEYLV 

       610        620        630        640        650        660 
TARKFTRQLL DQDASQCYDA LSSELQKNAL AAFVRLGVVE KNKVDSKYVY YVNGPATSKL 

       670 
EEMLGCKKPI GKPATAKL 

« Hide

References

[1]"cDNA encoding rat dihydroxyacetonephosphate acyltransferase (DHAP-AT)."
Ofman R., Lajmir S., Wanders R.J.A.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

AF218826 mRNA. Translation: AAG17548.1.
IPIIPI00191554.
RefSeqNP_445862.1.
UniGeneRn.1739

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ9ES71.

Genome annotation databases

EnsemblENSRNOG00000019205. Rattus norvegicus. [Contig view]
GeneID84470.
KEGGrno:84470.
NMPDRfig|10116.3.peg.15208.

Organism-specific databases

RGD620179. Gnpat.

Phylogenomic databases

HOVERGENQ9ES71.
OMAQ9ES71. GSIHVYF.

Enzyme and pathway databases

BRENDA2.3.1.42. 248.

Gene expression databases

ArrayExpressQ9ES71.
GermOnlineENSRNOG00000019205. Rattus norvegicus.

Family and domain databases

InterProIPR002123. Acyltransferase.
[Graphical view]
PfamPF01553. Acyltransferase. 1 hit.
[Graphical view]
SMARTSM00563. PlsC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio616952.

Entry information

Entry nameGNPAT_RAT
AccessionPrimary (citable) accession number: Q9ES71
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: June 16, 2009
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents