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Q9ES71 (GNPAT_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dihydroxyacetone phosphate acyltransferase

Short name=DAP-AT
Short name=DHAP-AT
EC=2.3.1.42
Alternative name(s):
Acyl-CoA:dihydroxyacetonephosphateacyltransferase
Glycerone-phosphate O-acyltransferase
Gene names
Name:Gnpat
Synonyms:Dhapat
OrganismRattus norvegicus (Rat)
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length678 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate.

Pathway

Membrane lipid metabolism; glycerophospholipid metabolism.

Subunit structure

May be part of an heterotrimeric complex composed of DAP-AT, ADAP-S and a modified form of DAP-AT By similarity.

Subcellular location

Peroxisome membrane; Peripheral membrane protein; Matrix side By similarity. Note: Exclusively localized to the lumenal side of the peroxisomal membrane By similarity.

Domain

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate By similarity.

Sequence similarities

Belongs to the GPAT/DAPAT family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 678678Dihydroxyacetone phosphate acyltransferase
PRO_0000195248

Regions

Motif161 – 1666HXXXXD motif
Motif676 – 6783Microbody targeting signal Potential
Compositional bias5 – 95Poly-Ser

Amino acid modifications

Modified residue6411N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9ES71 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: F825A2728D534B68

FASTA67877,076
        10         20         30         40         50         60 
MDVPSSSSSR FSVGSASPSS VLLYAKDLKK WDEFEDLLEE RRQVSDFKFA MKCYTPPLYR 

        70         80         90        100        110        120 
GITPCKPSDI KSIVLNSEEI NYVIKQLSRE SLTGVDVLRE EANEILEEMS HKLRIGAIRF 

       130        140        150        160        170        180 
FAFVLSKVFK QIFSKVCVNE EGIQKLQRAI QEHPVILLPS HRSYIDFLML SFVLYNYDLP 

       190        200        210        220        230        240 
VPVIAAGMDF LGMRVVSELL RMSGAFFMRR TFGGNKLYWA VFSEYVKTML RSGYAPVEFF 

       250        260        270        280        290        300 
LEGTRSRAAK TLTPKFGLLN IVMEPFFKRE VFDTYFVPIS ISYDKILEES LYAYELLGIP 

       310        320        330        340        350        360 
KPKESTTGLL KARRILSENF GSIHVYFGDP VSLRSLAAGR LSRNTYNLVP RCIPQKQPED 

       370        380        390        400        410        420 
VQAFVTEVAY KMQLLQIENL ALSPWLLVVA ILLQNQLCMD FDALVEKTLW LKGLTQVFGG 

       430        440        450        460        470        480 
FLLWPDNKLP EEVVQSSILL HSNLATLVKD QVVLKVDSES SQMVNGLVPQ HIAFLMCSAY 

       490        500        510        520        530        540 
RNQLLNVFAR PSLVAVALHM TPGLRKEDVF SCFSFLRNVF SDEFIFLPGN TLRDFEEGCY 

       550        560        570        580        590        600 
LLCKTEVMQM TGKDIILTDK GNAVLQFLTG LFKPFVESYQ ILSKCLLHEE DYFSEKEYLV 

       610        620        630        640        650        660 
TARKFTRQLL DQDASQCYDA LSSELQKNAL AAFVRLGVVE KNKVDSKYVY YVNGPATSKL 

       670 
EEMLGCKKPI GKPATAKL 

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References

[1]"cDNA encoding rat dihydroxyacetonephosphate acyltransferase (DHAP-AT)."
Ofman R., Lajmir S., Wanders R.J.A.
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF218826 mRNA. Translation: AAG17548.1.
IPIIPI00191554.
RefSeqNP_445862.1. NM_053410.1.
UniGeneRn.1739.

3D structure databases

ProteinModelPortalQ9ES71.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9ES71.

PTM databases

PhosphoSiteQ9ES71.

Proteomic databases

PRIDEQ9ES71.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000026617; ENSRNOP00000026617; ENSRNOG00000019205.
GeneID84470.
KEGGrno:84470.
NMPDRfig|10116.3.peg.15208.
UCSCBC061805. rat.

Organism-specific databases

CTD8443.
RGD620179. Gnpat.

Phylogenomic databases

eggNOGroNOG08043.
GeneTreeENSGT00520000055570.
HOVERGENHBG051749.
InParanoidQ9ES71.
OMAPRYIPQK.
OrthoDBEOG4DJJW5.
PhylomeDBQ9ES71.

Enzyme and pathway databases

BRENDA2.3.1.42. 5301.

Gene expression databases

ArrayExpressQ9ES71.
GenevestigatorQ9ES71.
GermOnlineENSRNOG00000019205. Rattus norvegicus.

Family and domain databases

InterProIPR002123. Acyltransferase.
IPR022284. G3P_O-AcylTrfase.
[Graphical view]
KOK00649.
PfamPF01553. Acyltransferase. 1 hit.
[Graphical view]
PIRSFPIRSF000437. GPAT_DHAPAT. 1 hit.
SMARTSM00563. PlsC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio616952.

Entry information

Entry nameGNPAT_RAT
AccessionPrimary (citable) accession number: Q9ES71
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: March 1, 2001
Last modified: November 16, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families