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Q9ES63 (UBP29_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 29

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 29
Ubiquitin thioesterase 29
Ubiquitin-specific-processing protease 29
Gene names
Name:Usp29
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length869 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Tissue specificity

Highest expression levels in adult brain, especially in the cerebral cortex and hippocampus, and in the forebrain, face, and limb buds of midgestation mouse embryos.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 USP domain.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processubiquitin-dependent protein catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 869869Ubiquitin carboxyl-terminal hydrolase 29
PRO_0000080661

Regions

Domain289 – 826538USP

Sites

Active site2981Nucleophile By similarity
Active site7811Proton acceptor By similarity

Experimental info

Sequence conflict5681L → S in AAG14415. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9ES63 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 4B661AD187BCA966

FASTA86997,823
        10         20         30         40         50         60 
MAHLKINGLV QIRSTNRSKH TRASQWKEAV IEIVERKQKV NLVVSFKLEE RRRVFQLGDN 

        70         80         90        100        110        120 
VTGVVVSGEL GLYHLDLTLR DDTSLLIDKL SSADVEHLKS FLDSSTPCES QQPMEPMSSQ 

       130        140        150        160        170        180 
DDLESSDPFC GEHQEAACGS LNTTPESGTP LSRKMPLSMS NTTGGQKRGE KQGRKRKTEP 

       190        200        210        220        230        240 
SSSSAEVNKD IPKENTPDQK KKSRRYYSRN RGGKAEKAVT LREQEKRSNW KLEPAFNSKS 

       250        260        270        280        290        300 
YGRANLDGTI LPIATCSDDR DVSIFGLEII THNGVQSLPD PYLNQLKREG FPNLGNTCYM 

       310        320        330        340        350        360 
NSILQSVFGI PTFAKDLLTQ GIPWEKVSYD DLIMPLSQLL VLKDIRDVEI KGELLTSVKK 

       370        380        390        400        410        420 
SISTVADTFS GNEQNDAHEF LSLCLDQLKL NMEKVNAMWD TERRNTCAGS AGTKRFVCPV 

       430        440        450        460        470        480 
GANFEFELHS SIICEGCGEA TIKTEVSNYL SIDLHHGTKT HPLSIQKSFD LFFTPEKIEH 

       490        500        510        520        530        540 
NCEKCKNKNS VLKYTLRRLP RVLIVHLKRY QVTTDLLPVK SEQPVEISKY LNISSHCHEN 

       550        560        570        580        590        600 
RKLPFPLANT SPDVSQGMMP GIFNQSMLSK KVISESCDPM VLQVGSSVDA EIQSFQIMYE 

       610        620        630        640        650        660 
DEDASEEQQQ RGLESGSMLE PELVKTENRI LRQKTSLATD SMMGDGYSFL PMLCEPLSIQ 

       670        680        690        700        710        720 
DPGLAEMGLQ EVPENPEFKN YEKINIYGKS DGRTNTELSK LYQNHGSRIK GLFLPASLAS 

       730        740        750        760        770        780 
VSSQEDPEKD LSRSPELQED DPHSFAFGSD DSKDGEMGDD LQNYRLVSVV SHFGSSPNSG 

       790        800        810        820        830        840 
HYVSDVYDFQ KQAWLLYSDV QVFESSDPSI QENRLNSGYI FFYMHNEIFE ELLKKASECK 

       850        860 
VLSTSKEEKR DIDYFSTLLN GLTYILEEF 

« Hide

References

[1]"Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4."
Kim J., Noskov V.N., Lu X., Bergmann A., Ren X., Warth T., Richardson P., Kouprina N., Stubbs L.
Genome Res. 10:1138-1147(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/SvJ.
[2]"An active antisense promoter in mouse L1 retrotransposons has implications for fusion gene expression and epigenetic control."
Li J., Symer D.E.
Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF229257 mRNA. Translation: AAG14415.1.
EU233992 mRNA. Translation: ACD47025.1.
RefSeqNP_067298.2. NM_021323.2.
UniGeneMm.394138.
Mm.40752.

3D structure databases

ProteinModelPortalQ9ES63.
SMRQ9ES63. Positions 4-104, 290-544.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC19.043.

PTM databases

PhosphoSiteQ9ES63.

Proteomic databases

PaxDbQ9ES63.
PRIDEQ9ES63.

Protocols and materials databases

DNASU57775.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054055; ENSMUSP00000062349; ENSMUSG00000051527.
GeneID57775.
KEGGmmu:57775.
UCSCuc009fcb.1. mouse.

Organism-specific databases

CTD57663.
MGIMGI:1888998. Usp29.

Phylogenomic databases

eggNOGNOG279142.
GeneTreeENSGT00440000033542.
HOGENOMHOG000060197.
HOVERGENHBG055893.
InParanoidQ9ES63.
KOK11850.
OMATEREADD.
OrthoDBEOG7HMS09.
TreeFamTF323032.

Gene expression databases

BgeeQ9ES63.
CleanExMM_USP29.
GenevestigatorQ9ES63.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
[Graphical view]
PfamPF00443. UCH. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio313944.
PROQ9ES63.
SOURCESearch...

Entry information

Entry nameUBP29_MOUSE
AccessionPrimary (citable) accession number: Q9ES63
Secondary accession number(s): C6EQG1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot