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Protein

Ubiquitin carboxyl-terminal hydrolase 29

Gene

Usp29

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei298 – 2981NucleophilePROSITE-ProRule annotation
Active sitei781 – 7811Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: GO_Central
  2. ubiquitin-specific protease activity Source: GO_Central
  3. ubiquitin thiolesterase activity Source: GO_Central

GO - Biological processi

  1. proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
  2. protein deubiquitination Source: GO_Central
  3. regulation of proteasomal protein catabolic process Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Protein family/group databases

MEROPSiC19.043.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 29 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 29
Ubiquitin thioesterase 29
Ubiquitin-specific-processing protease 29
Gene namesi
Name:Usp29
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1888998. Usp29.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: GO_Central
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 869869Ubiquitin carboxyl-terminal hydrolase 29PRO_0000080661Add
BLAST

Proteomic databases

MaxQBiQ9ES63.
PaxDbiQ9ES63.
PRIDEiQ9ES63.

PTM databases

PhosphoSiteiQ9ES63.

Expressioni

Tissue specificityi

Highest expression levels in adult brain, especially in the cerebral cortex and hippocampus, and in the forebrain, face, and limb buds of midgestation mouse embryos.

Gene expression databases

BgeeiQ9ES63.
CleanExiMM_USP29.
ExpressionAtlasiQ9ES63. baseline.
GenevestigatoriQ9ES63.

Structurei

3D structure databases

ProteinModelPortaliQ9ES63.
SMRiQ9ES63. Positions 4-104, 290-544.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini289 – 826538USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiNOG279142.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiQ9ES63.
KOiK11850.
OMAiGFIQIWS.
OrthoDBiEOG7HMS09.
TreeFamiTF323032.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ES63-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAHLKINGLV QIRSTNRSKH TRASQWKEAV IEIVERKQKV NLVVSFKLEE
60 70 80 90 100
RRRVFQLGDN VTGVVVSGEL GLYHLDLTLR DDTSLLIDKL SSADVEHLKS
110 120 130 140 150
FLDSSTPCES QQPMEPMSSQ DDLESSDPFC GEHQEAACGS LNTTPESGTP
160 170 180 190 200
LSRKMPLSMS NTTGGQKRGE KQGRKRKTEP SSSSAEVNKD IPKENTPDQK
210 220 230 240 250
KKSRRYYSRN RGGKAEKAVT LREQEKRSNW KLEPAFNSKS YGRANLDGTI
260 270 280 290 300
LPIATCSDDR DVSIFGLEII THNGVQSLPD PYLNQLKREG FPNLGNTCYM
310 320 330 340 350
NSILQSVFGI PTFAKDLLTQ GIPWEKVSYD DLIMPLSQLL VLKDIRDVEI
360 370 380 390 400
KGELLTSVKK SISTVADTFS GNEQNDAHEF LSLCLDQLKL NMEKVNAMWD
410 420 430 440 450
TERRNTCAGS AGTKRFVCPV GANFEFELHS SIICEGCGEA TIKTEVSNYL
460 470 480 490 500
SIDLHHGTKT HPLSIQKSFD LFFTPEKIEH NCEKCKNKNS VLKYTLRRLP
510 520 530 540 550
RVLIVHLKRY QVTTDLLPVK SEQPVEISKY LNISSHCHEN RKLPFPLANT
560 570 580 590 600
SPDVSQGMMP GIFNQSMLSK KVISESCDPM VLQVGSSVDA EIQSFQIMYE
610 620 630 640 650
DEDASEEQQQ RGLESGSMLE PELVKTENRI LRQKTSLATD SMMGDGYSFL
660 670 680 690 700
PMLCEPLSIQ DPGLAEMGLQ EVPENPEFKN YEKINIYGKS DGRTNTELSK
710 720 730 740 750
LYQNHGSRIK GLFLPASLAS VSSQEDPEKD LSRSPELQED DPHSFAFGSD
760 770 780 790 800
DSKDGEMGDD LQNYRLVSVV SHFGSSPNSG HYVSDVYDFQ KQAWLLYSDV
810 820 830 840 850
QVFESSDPSI QENRLNSGYI FFYMHNEIFE ELLKKASECK VLSTSKEEKR
860
DIDYFSTLLN GLTYILEEF
Length:869
Mass (Da):97,823
Last modified:July 27, 2011 - v2
Checksum:i4B661AD187BCA966
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti568 – 5681L → S in AAG14415. (PubMed:10958632)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229257 mRNA. Translation: AAG14415.1.
EU233992 mRNA. Translation: ACD47025.1.
CCDSiCCDS20784.1.
RefSeqiNP_001277923.1. NM_001290994.1.
NP_067298.2. NM_021323.3.
UniGeneiMm.394138.
Mm.40752.

Genome annotation databases

EnsembliENSMUST00000054055; ENSMUSP00000062349; ENSMUSG00000051527.
GeneIDi57775.
KEGGimmu:57775.
UCSCiuc009fcb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229257 mRNA. Translation: AAG14415.1.
EU233992 mRNA. Translation: ACD47025.1.
CCDSiCCDS20784.1.
RefSeqiNP_001277923.1. NM_001290994.1.
NP_067298.2. NM_021323.3.
UniGeneiMm.394138.
Mm.40752.

3D structure databases

ProteinModelPortaliQ9ES63.
SMRiQ9ES63. Positions 4-104, 290-544.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC19.043.

PTM databases

PhosphoSiteiQ9ES63.

Proteomic databases

MaxQBiQ9ES63.
PaxDbiQ9ES63.
PRIDEiQ9ES63.

Protocols and materials databases

DNASUi57775.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054055; ENSMUSP00000062349; ENSMUSG00000051527.
GeneIDi57775.
KEGGimmu:57775.
UCSCiuc009fcb.1. mouse.

Organism-specific databases

CTDi57663.
MGIiMGI:1888998. Usp29.

Phylogenomic databases

eggNOGiNOG279142.
GeneTreeiENSGT00440000033542.
HOGENOMiHOG000060197.
HOVERGENiHBG055893.
InParanoidiQ9ES63.
KOiK11850.
OMAiGFIQIWS.
OrthoDBiEOG7HMS09.
TreeFamiTF323032.

Miscellaneous databases

NextBioi313944.
PROiQ9ES63.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ES63.
CleanExiMM_USP29.
ExpressionAtlasiQ9ES63. baseline.
GenevestigatoriQ9ES63.

Family and domain databases

InterProiIPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4."
    Kim J., Noskov V.N., Lu X., Bergmann A., Ren X., Warth T., Richardson P., Kouprina N., Stubbs L.
    Genome Res. 10:1138-1147(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
  2. "An active antisense promoter in mouse L1 retrotransposons has implications for fusion gene expression and epigenetic control."
    Li J., Symer D.E.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiUBP29_MOUSE
AccessioniPrimary (citable) accession number: Q9ES63
Secondary accession number(s): C6EQG1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: July 27, 2011
Last modified: February 4, 2015
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.