Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9ES63

- UBP29_MOUSE

UniProt

Q9ES63 - UBP29_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase 29

Gene

Usp29

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei298 – 2981NucleophilePROSITE-ProRule annotation
    Active sitei781 – 7811Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Protein family/group databases

    MEROPSiC19.043.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 29 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 29
    Ubiquitin thioesterase 29
    Ubiquitin-specific-processing protease 29
    Gene namesi
    Name:Usp29
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1888998. Usp29.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 869869Ubiquitin carboxyl-terminal hydrolase 29PRO_0000080661Add
    BLAST

    Proteomic databases

    PaxDbiQ9ES63.
    PRIDEiQ9ES63.

    PTM databases

    PhosphoSiteiQ9ES63.

    Expressioni

    Tissue specificityi

    Highest expression levels in adult brain, especially in the cerebral cortex and hippocampus, and in the forebrain, face, and limb buds of midgestation mouse embryos.

    Gene expression databases

    BgeeiQ9ES63.
    CleanExiMM_USP29.
    GenevestigatoriQ9ES63.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ES63.
    SMRiQ9ES63. Positions 4-104, 290-544.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini289 – 826538USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiNOG279142.
    GeneTreeiENSGT00440000033542.
    HOGENOMiHOG000060197.
    HOVERGENiHBG055893.
    InParanoidiQ9ES63.
    KOiK11850.
    OMAiTEREADD.
    OrthoDBiEOG7HMS09.
    TreeFamiTF323032.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ES63-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHLKINGLV QIRSTNRSKH TRASQWKEAV IEIVERKQKV NLVVSFKLEE    50
    RRRVFQLGDN VTGVVVSGEL GLYHLDLTLR DDTSLLIDKL SSADVEHLKS 100
    FLDSSTPCES QQPMEPMSSQ DDLESSDPFC GEHQEAACGS LNTTPESGTP 150
    LSRKMPLSMS NTTGGQKRGE KQGRKRKTEP SSSSAEVNKD IPKENTPDQK 200
    KKSRRYYSRN RGGKAEKAVT LREQEKRSNW KLEPAFNSKS YGRANLDGTI 250
    LPIATCSDDR DVSIFGLEII THNGVQSLPD PYLNQLKREG FPNLGNTCYM 300
    NSILQSVFGI PTFAKDLLTQ GIPWEKVSYD DLIMPLSQLL VLKDIRDVEI 350
    KGELLTSVKK SISTVADTFS GNEQNDAHEF LSLCLDQLKL NMEKVNAMWD 400
    TERRNTCAGS AGTKRFVCPV GANFEFELHS SIICEGCGEA TIKTEVSNYL 450
    SIDLHHGTKT HPLSIQKSFD LFFTPEKIEH NCEKCKNKNS VLKYTLRRLP 500
    RVLIVHLKRY QVTTDLLPVK SEQPVEISKY LNISSHCHEN RKLPFPLANT 550
    SPDVSQGMMP GIFNQSMLSK KVISESCDPM VLQVGSSVDA EIQSFQIMYE 600
    DEDASEEQQQ RGLESGSMLE PELVKTENRI LRQKTSLATD SMMGDGYSFL 650
    PMLCEPLSIQ DPGLAEMGLQ EVPENPEFKN YEKINIYGKS DGRTNTELSK 700
    LYQNHGSRIK GLFLPASLAS VSSQEDPEKD LSRSPELQED DPHSFAFGSD 750
    DSKDGEMGDD LQNYRLVSVV SHFGSSPNSG HYVSDVYDFQ KQAWLLYSDV 800
    QVFESSDPSI QENRLNSGYI FFYMHNEIFE ELLKKASECK VLSTSKEEKR 850
    DIDYFSTLLN GLTYILEEF 869
    Length:869
    Mass (Da):97,823
    Last modified:July 27, 2011 - v2
    Checksum:i4B661AD187BCA966
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti568 – 5681L → S in AAG14415. (PubMed:10958632)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229257 mRNA. Translation: AAG14415.1.
    EU233992 mRNA. Translation: ACD47025.1.
    CCDSiCCDS20784.1.
    RefSeqiNP_001277923.1. NM_001290994.1.
    NP_067298.2. NM_021323.3.
    UniGeneiMm.394138.
    Mm.40752.

    Genome annotation databases

    EnsembliENSMUST00000054055; ENSMUSP00000062349; ENSMUSG00000051527.
    GeneIDi57775.
    KEGGimmu:57775.
    UCSCiuc009fcb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229257 mRNA. Translation: AAG14415.1 .
    EU233992 mRNA. Translation: ACD47025.1 .
    CCDSi CCDS20784.1.
    RefSeqi NP_001277923.1. NM_001290994.1.
    NP_067298.2. NM_021323.3.
    UniGenei Mm.394138.
    Mm.40752.

    3D structure databases

    ProteinModelPortali Q9ES63.
    SMRi Q9ES63. Positions 4-104, 290-544.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.043.

    PTM databases

    PhosphoSitei Q9ES63.

    Proteomic databases

    PaxDbi Q9ES63.
    PRIDEi Q9ES63.

    Protocols and materials databases

    DNASUi 57775.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054055 ; ENSMUSP00000062349 ; ENSMUSG00000051527 .
    GeneIDi 57775.
    KEGGi mmu:57775.
    UCSCi uc009fcb.1. mouse.

    Organism-specific databases

    CTDi 57663.
    MGIi MGI:1888998. Usp29.

    Phylogenomic databases

    eggNOGi NOG279142.
    GeneTreei ENSGT00440000033542.
    HOGENOMi HOG000060197.
    HOVERGENi HBG055893.
    InParanoidi Q9ES63.
    KOi K11850.
    OMAi TEREADD.
    OrthoDBi EOG7HMS09.
    TreeFami TF323032.

    Miscellaneous databases

    NextBioi 313944.
    PROi Q9ES63.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9ES63.
    CleanExi MM_USP29.
    Genevestigatori Q9ES63.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4."
      Kim J., Noskov V.N., Lu X., Bergmann A., Ren X., Warth T., Richardson P., Kouprina N., Stubbs L.
      Genome Res. 10:1138-1147(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvJ.
    2. "An active antisense promoter in mouse L1 retrotransposons has implications for fusion gene expression and epigenetic control."
      Li J., Symer D.E.
      Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiUBP29_MOUSE
    AccessioniPrimary (citable) accession number: Q9ES63
    Secondary accession number(s): C6EQG1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2002
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 94 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3