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Protein

Cell surface glycoprotein CD200 receptor 1

Gene

Cd200r1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli (By similarity).By similarity

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-RNO-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface glycoprotein CD200 receptor 1
Alternative name(s):
CD200 cell surface glycoprotein receptor
Cell surface glycoprotein OX2 receptor 1
OX102 antigen
Gene namesi
Name:Cd200r1
Synonyms:Mox2r, Ox2r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi61837 Cd200r1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 239ExtracellularSequence analysisAdd BLAST216
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 327CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001513024 – 327Cell surface glycoprotein CD200 receptor 1Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagine1
Glycosylationi34N-linked (GlcNAc...) asparagine1
Glycosylationi43N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi58 ↔ 129PROSITE-ProRule annotation
Disulfide bondi81 ↔ 97PROSITE-ProRule annotation
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi164 ↔ 213PROSITE-ProRule annotation
Disulfide bondi183 ↔ 201PROSITE-ProRule annotation
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi192N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylated on tyrosine residues.
Highly N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ES58
PRIDEiQ9ES58

Expressioni

Tissue specificityi

Restricted to cells of the myeloid lineage.1 Publication

Gene expression databases

BgeeiENSRNOG00000039048
GenevisibleiQ9ES58 RN

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002799

Structurei

3D structure databases

ProteinModelPortaliQ9ES58
SMRiQ9ES58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 145Ig-like V-typeAdd BLAST120
Domaini147 – 226Ig-like C2-typeAdd BLAST80

Sequence similaritiesi

Belongs to the CD200R family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUJX Eukaryota
ENOG4112DF0 LUCA
GeneTreeiENSGT00390000014496
HOGENOMiHOG000113622
HOVERGENiHBG108141
InParanoidiQ9ES58
KOiK21668
OMAiLCPWRTA
OrthoDBiEOG091G0IYA
PhylomeDBiQ9ES58
TreeFamiTF335960

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR013162 CD80_C2-set
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF08205 C2-set_2, 1 hit
PF07686 V-set, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ES58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCFWRTSHV AVLLIWGVFA AESSCPDKNQ TMQNNSSTMT EVNTTVFVQM
60 70 80 90 100
GKKALLCCPS ISLTKVILIT WTITLRGQPS CIISYKADTR ETHESNCSDR
110 120 130 140 150
SITWASTPDL APDLQISAVA LQHEGRYSCD IAVPDGNFQN IYDLQVLVPP
160 170 180 190 200
EVTHFPGENR TAVCEAIAGK PAAQISWTPD GDCVAKNESH SNGTVTVRST
210 220 230 240 250
CHWEQSHVSV VFCVVSHLTT GNQSLSIELG RGGDQLLGSY IQYIIPSIII
260 270 280 290 300
LIIIGCICLL KISGCRKCKL PKSGATPDIE EDEMQPYASY TEKSNPLYDT
310 320
VTTTEAHPAS QGKVNGTDCL TLSAMGI
Length:327
Mass (Da):35,534
Last modified:March 1, 2001 - v1
Checksum:iBA06E7FFC778610C
GO
Isoform 2 (identifier: Q9ES58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-149: VP → GK
     150-327: Missing.

Show »
Length:149
Mass (Da):16,504
Checksum:iDB04F0EEBA23045D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034998148 – 149VP → GK in isoform 2. 1 Publication2
Alternative sequenceiVSP_034999150 – 327Missing in isoform 2. 1 PublicationAdd BLAST178

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231392 Genomic DNA Translation: AAF98555.1
AY583211 mRNA Translation: AAS90843.1
RefSeqiNP_076443.1, NM_023953.1 [Q9ES58-1]
UniGeneiRn.124439

Genome annotation databases

EnsembliENSRNOT00000002799; ENSRNOP00000002799; ENSRNOG00000039048 [Q9ES58-1]
GeneIDi64357
KEGGirno:64357
UCSCiRGD:61837 rat [Q9ES58-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMO2R1_RAT
AccessioniPrimary (citable) accession number: Q9ES58
Secondary accession number(s): Q6PS97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health