Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cell surface glycoprotein CD200 receptor 1

Gene

Cd200r1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface glycoprotein CD200 receptor 1
Alternative name(s):
CD200 cell surface glycoprotein receptor
Cell surface glycoprotein OX2 receptor 1
OX102 antigen
Gene namesi
Name:Cd200r1
Synonyms:Mox2r, Ox2r
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi61837. Cd200r1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 239ExtracellularSequence analysisAdd BLAST216
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 327CytoplasmicSequence analysisAdd BLAST67

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000001513024 – 327Cell surface glycoprotein CD200 receptor 1Add BLAST304

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)1
Glycosylationi34N-linked (GlcNAc...)1
Glycosylationi43N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi58 ↔ 129PROSITE-ProRule annotation
Disulfide bondi81 ↔ 97PROSITE-ProRule annotation
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi164 ↔ 213PROSITE-ProRule annotation
Disulfide bondi183 ↔ 201PROSITE-ProRule annotation
Glycosylationi187N-linked (GlcNAc...)Sequence analysis1
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi222N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylated on tyrosine residues.
Highly N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9ES58.
PRIDEiQ9ES58.

Expressioni

Tissue specificityi

Restricted to cells of the myeloid lineage.1 Publication

Gene expression databases

BgeeiENSRNOG00000039048.
GenevisibleiQ9ES58. RN.

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002799.

Structurei

3D structure databases

ProteinModelPortaliQ9ES58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 145Ig-like V-typeAdd BLAST120
Domaini147 – 226Ig-like C2-typeAdd BLAST80

Sequence similaritiesi

Belongs to the CD200R family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUJX. Eukaryota.
ENOG4112DF0. LUCA.
GeneTreeiENSGT00390000014496.
HOGENOMiHOG000113622.
HOVERGENiHBG108141.
InParanoidiQ9ES58.
OMAiLCPWRTA.
OrthoDBiEOG091G0IYA.
PhylomeDBiQ9ES58.
TreeFamiTF335960.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9ES58-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLCFWRTSHV AVLLIWGVFA AESSCPDKNQ TMQNNSSTMT EVNTTVFVQM
60 70 80 90 100
GKKALLCCPS ISLTKVILIT WTITLRGQPS CIISYKADTR ETHESNCSDR
110 120 130 140 150
SITWASTPDL APDLQISAVA LQHEGRYSCD IAVPDGNFQN IYDLQVLVPP
160 170 180 190 200
EVTHFPGENR TAVCEAIAGK PAAQISWTPD GDCVAKNESH SNGTVTVRST
210 220 230 240 250
CHWEQSHVSV VFCVVSHLTT GNQSLSIELG RGGDQLLGSY IQYIIPSIII
260 270 280 290 300
LIIIGCICLL KISGCRKCKL PKSGATPDIE EDEMQPYASY TEKSNPLYDT
310 320
VTTTEAHPAS QGKVNGTDCL TLSAMGI
Length:327
Mass (Da):35,534
Last modified:March 1, 2001 - v1
Checksum:iBA06E7FFC778610C
GO
Isoform 2 (identifier: Q9ES58-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-149: VP → GK
     150-327: Missing.

Show »
Length:149
Mass (Da):16,504
Checksum:iDB04F0EEBA23045D
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034998148 – 149VP → GK in isoform 2. 1 Publication2
Alternative sequenceiVSP_034999150 – 327Missing in isoform 2. 1 PublicationAdd BLAST178

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231392 Genomic DNA. Translation: AAF98555.1.
AY583211 mRNA. Translation: AAS90843.1.
RefSeqiNP_076443.1. NM_023953.1. [Q9ES58-1]
UniGeneiRn.124439.

Genome annotation databases

EnsembliENSRNOT00000002799; ENSRNOP00000002799; ENSRNOG00000039048. [Q9ES58-1]
GeneIDi64357.
KEGGirno:64357.
UCSCiRGD:61837. rat. [Q9ES58-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231392 Genomic DNA. Translation: AAF98555.1.
AY583211 mRNA. Translation: AAS90843.1.
RefSeqiNP_076443.1. NM_023953.1. [Q9ES58-1]
UniGeneiRn.124439.

3D structure databases

ProteinModelPortaliQ9ES58.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000002799.

Proteomic databases

PaxDbiQ9ES58.
PRIDEiQ9ES58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000002799; ENSRNOP00000002799; ENSRNOG00000039048. [Q9ES58-1]
GeneIDi64357.
KEGGirno:64357.
UCSCiRGD:61837. rat. [Q9ES58-1]

Organism-specific databases

CTDi131450.
RGDi61837. Cd200r1.

Phylogenomic databases

eggNOGiENOG410IUJX. Eukaryota.
ENOG4112DF0. LUCA.
GeneTreeiENSGT00390000014496.
HOGENOMiHOG000113622.
HOVERGENiHBG108141.
InParanoidiQ9ES58.
OMAiLCPWRTA.
OrthoDBiEOG091G0IYA.
PhylomeDBiQ9ES58.
TreeFamiTF335960.

Enzyme and pathway databases

ReactomeiR-RNO-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

PROiQ9ES58.

Gene expression databases

BgeeiENSRNOG00000039048.
GenevisibleiQ9ES58. RN.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMO2R1_RAT
AccessioniPrimary (citable) accession number: Q9ES58
Secondary accession number(s): Q6PS97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.