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Protein

Cell surface glycoprotein CD200 receptor 1

Gene

Cd200r1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of proinflammatory molecules including TNF-alpha, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli.2 Publications

GO - Molecular functioni

  • receptor activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell surface glycoprotein CD200 receptor 1
Alternative name(s):
CD200 cell surface glycoprotein receptor
Cell surface glycoprotein OX2 receptor 1
Gene namesi
Name:Cd200r1
Synonyms:Mox2r, Ox2r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1889024. Cd200r1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 238ExtracellularSequence analysisAdd BLAST213
Transmembranei239 – 259HelicalSequence analysisAdd BLAST21
Topological domaini260 – 326CytoplasmicSequence analysisAdd BLAST67

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi138F → L: 7-fold reduction in binding to CD200. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001512926 – 326Cell surface glycoprotein CD200 receptor 1Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Glycosylationi35N-linked (GlcNAc...)Sequence analysis1
Glycosylationi44N-linked (GlcNAc...)1 Publication1
Disulfide bondi58 ↔ 129PROSITE-ProRule annotation1 Publication
Disulfide bondi82 ↔ 97PROSITE-ProRule annotation1 Publication
Glycosylationi93N-linked (GlcNAc...)1 Publication1
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1
Glycosylationi159N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi164 ↔ 213PROSITE-ProRule annotation1 Publication
Disulfide bondi183 ↔ 201PROSITE-ProRule annotation1 Publication
Glycosylationi192N-linked (GlcNAc...)1 Publication1
Glycosylationi207N-linked (GlcNAc...)Sequence analysis1
Glycosylationi221N-linked (GlcNAc...)Sequence analysis1
Glycosylationi233N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9ES57.
PaxDbiQ9ES57.
PeptideAtlasiQ9ES57.
PRIDEiQ9ES57.

PTM databases

iPTMnetiQ9ES57.
PhosphoSitePlusiQ9ES57.

Expressioni

Tissue specificityi

Expressed in granulocytes, monocytes, most T-cells and a subset of NK, NKT and B-cells (at protein level). Expressed in the spleen, lung, liver, testis, bone marrow, lymph nodes, spinal cord, kidney, uterus and small intestine. Expressed in mast and dendritic cells. Expressed in the lung of N. brasiliensis-infected mice.4 Publications

Gene expression databases

BgeeiENSMUSG00000022667.
CleanExiMM_CD200R1.
ExpressionAtlasiQ9ES57. baseline and differential.
GenevisibleiQ9ES57. MM.

Interactioni

Subunit structurei

CD200 and CD200R1 interact via their respective N-terminal Ig-like domains.1 Publication

Protein-protein interaction databases

BioGridi208327. 1 interactor.
DIPiDIP-60159N.
STRINGi10090.ENSMUSP00000053822.

Structurei

Secondary structure

1326
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi41 – 50Combined sources10
Beta strandi55 – 57Combined sources3
Beta strandi59 – 62Combined sources4
Turni64 – 66Combined sources3
Beta strandi68 – 76Combined sources9
Beta strandi82 – 87Combined sources6
Turni88 – 91Combined sources4
Beta strandi92 – 95Combined sources4
Turni98 – 101Combined sources4
Beta strandi102 – 104Combined sources3
Beta strandi114 – 118Combined sources5
Helixi121 – 123Combined sources3
Beta strandi125 – 133Combined sources9
Beta strandi136 – 148Combined sources13
Beta strandi151 – 157Combined sources7
Turni158 – 160Combined sources3
Beta strandi161 – 171Combined sources11
Beta strandi174 – 179Combined sources6
Beta strandi182 – 189Combined sources8
Beta strandi195 – 202Combined sources8
Beta strandi205 – 207Combined sources3
Beta strandi210 – 216Combined sources7
Beta strandi222 – 227Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BFGX-ray2.08A26-228[»]
4BFIX-ray3.22A26-228[»]
ProteinModelPortaliQ9ES57.
SMRiQ9ES57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 136Ig-like V-typeAdd BLAST86
Domaini138 – 229Ig-like C2-typeAdd BLAST92

Sequence similaritiesi

Belongs to the CD200R family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUJX. Eukaryota.
ENOG4112DF0. LUCA.
GeneTreeiENSGT00390000014496.
HOGENOMiHOG000113622.
HOVERGENiHBG108141.
InParanoidiQ9ES57.
OMAiLCPWRTA.
OrthoDBiEOG091G0IYA.
PhylomeDBiQ9ES57.
TreeFamiTF335960.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ES57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFCFWRTSAL AVLLIWGVFV AGSSCTDKNQ TTQNNSSSPL TQVNTTVSVQ
60 70 80 90 100
IGTKALLCCF SIPLTKAVLI TWIIKLRGLP SCTIAYKVDT KTNETSCLGR
110 120 130 140 150
NITWASTPDH SPELQISAVT LQHEGTYTCE TVTPEGNFEK NYDLQVLVPP
160 170 180 190 200
EVTYFPEKNR SAVCEAMAGK PAAQISWSPD GDCVTTSESH SNGTVTVRST
210 220 230 240 250
CHWEQNNVSD VSCIVSHLTG NQSLSIELSR GGNQSLRPYI PYIIPSIIIL
260 270 280 290 300
IIIGCICLLK ISGFRKCKLP KLEATSAIEE DEMQPYASYT EKSNPLYDTV
310 320
TKVEAFPVSQ GEVNGTDCLT LSAIGI
Length:326
Mass (Da):35,505
Last modified:March 1, 2001 - v1
Checksum:i025B3959602F82A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231393 Genomic DNA. Translation: AAF98556.1.
BC052682 mRNA. Translation: AAH52682.1.
CCDSiCCDS28189.1.
RefSeqiNP_067300.1. NM_021325.3.
UniGeneiMm.416152.

Genome annotation databases

EnsembliENSMUST00000057488; ENSMUSP00000053822; ENSMUSG00000022667.
GeneIDi57781.
KEGGimmu:57781.
UCSCiuc007zhr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF231393 Genomic DNA. Translation: AAF98556.1.
BC052682 mRNA. Translation: AAH52682.1.
CCDSiCCDS28189.1.
RefSeqiNP_067300.1. NM_021325.3.
UniGeneiMm.416152.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BFGX-ray2.08A26-228[»]
4BFIX-ray3.22A26-228[»]
ProteinModelPortaliQ9ES57.
SMRiQ9ES57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208327. 1 interactor.
DIPiDIP-60159N.
STRINGi10090.ENSMUSP00000053822.

PTM databases

iPTMnetiQ9ES57.
PhosphoSitePlusiQ9ES57.

Proteomic databases

MaxQBiQ9ES57.
PaxDbiQ9ES57.
PeptideAtlasiQ9ES57.
PRIDEiQ9ES57.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057488; ENSMUSP00000053822; ENSMUSG00000022667.
GeneIDi57781.
KEGGimmu:57781.
UCSCiuc007zhr.2. mouse.

Organism-specific databases

CTDi131450.
MGIiMGI:1889024. Cd200r1.

Phylogenomic databases

eggNOGiENOG410IUJX. Eukaryota.
ENOG4112DF0. LUCA.
GeneTreeiENSGT00390000014496.
HOGENOMiHOG000113622.
HOVERGENiHBG108141.
InParanoidiQ9ES57.
OMAiLCPWRTA.
OrthoDBiEOG091G0IYA.
PhylomeDBiQ9ES57.
TreeFamiTF335960.

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

PROiQ9ES57.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022667.
CleanExiMM_CD200R1.
ExpressionAtlasiQ9ES57. baseline and differential.
GenevisibleiQ9ES57. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMO2R1_MOUSE
AccessioniPrimary (citable) accession number: Q9ES57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

May be expressed in adult splenic cells (PubMed:15187158), as the antibody used could not discriminate between CD200R1 and CD200R4. May be expressed in uterus at 12.5 dpc (at protein level) (PubMed:15274657), as the antibody used could not discriminate between CD200R1 and CD200R4.2 Publications

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.