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Protein

Trafficking protein particle complex subunit 4

Gene

Trappc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in vesicular transport from endoplasmic reticulum to Golgi. May play a role in dendrite postsynaptic membrane trafficking.

GO - Biological processi

  • dendrite development Source: UniProtKB
  • ER to Golgi vesicle-mediated transport Source: InterPro
  • neurotransmitter receptor biosynthetic process Source: UniProtKB
  • vesicle-mediated transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 4
Alternative name(s):
Synbindin
TRS23 homolog
Gene namesi
Name:Trappc4
Synonyms:Sbdn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1926211. Trappc4.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • cis-Golgi network Source: InterPro
  • dendrite Source: UniProtKB
  • endoplasmic reticulum Source: UniProtKB-SubCell
  • Golgi stack Source: UniProtKB
  • plasma membrane Source: Reactome
  • postsynaptic membrane Source: UniProtKB-SubCell
  • synapse Source: UniProtKB
  • synaptic vesicle Source: UniProtKB
  • TRAPP complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Endoplasmic reticulum, Golgi apparatus, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 219219Trafficking protein particle complex subunit 4PRO_0000211570Add
BLAST

Proteomic databases

EPDiQ9ES56.
MaxQBiQ9ES56.
PaxDbiQ9ES56.
PRIDEiQ9ES56.

PTM databases

iPTMnetiQ9ES56.
PhosphoSiteiQ9ES56.

Expressioni

Tissue specificityi

Widely expressed.

Gene expression databases

BgeeiQ9ES56.
CleanExiMM_TRAPPC4.
ExpressionAtlasiQ9ES56. baseline and differential.
GenevisibleiQ9ES56. MM.

Interactioni

Subunit structurei

Component of the multisubunit TRAPP (transport protein particle) complex, which includes at least TRAPPC2, TRAPPC2L, TRAPPC3, TRAPPC3L, TRAPPC4, TRAPPC5, TRAPPC8, TRAPPC9, TRAPPC10, TRAPPC11 and TRAPPC12 (By similarity). Interacts with SDC2.By similarity1 Publication

Protein-protein interaction databases

BioGridi208560. 1 interaction.
IntActiQ9ES56. 1 interaction.
STRINGi10090.ENSMUSP00000034623.

Structurei

3D structure databases

ProteinModelPortaliQ9ES56.
SMRiQ9ES56. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3369. Eukaryota.
COG5122. LUCA.
GeneTreeiENSGT00510000047061.
HOGENOMiHOG000165618.
HOVERGENiHBG054226.
InParanoidiQ9ES56.
OMAiDPRQSGI.
OrthoDBiEOG7FJH1J.
PhylomeDBiQ9ES56.
TreeFamiTF314561.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR007233. TRAPPC.
[Graphical view]
PANTHERiPTHR23249. PTHR23249. 2 hits.
PfamiPF04099. Sybindin. 1 hit.
[Graphical view]
SMARTiSM01399. Sybindin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9ES56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIFSVYVVN KAGGLIYQWD SYSPRAEAEK TFSYPLDLLL KLHDERVLVA
60 70 80 90 100
FGQRDGIRVG HAVLAINGMD VNGKYTADGK EVLEYLGNPA NYPVSIRFGR
110 120 130 140 150
PRLTSNEKLM LASMFHSLFA IGSQLSPEQG SSGIEMLETD TFKLHCFQTL
160 170 180 190 200
TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF ALKNPFYSLE MPIRCELFDQ
210
NLKLALEVAE KAGTFGPGS
Length:219
Mass (Da):24,385
Last modified:March 1, 2001 - v1
Checksum:i7B03F1E772857E92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233340 mRNA. Translation: AAG24950.1.
BC038898 mRNA. Translation: AAH38898.1.
AK005276 mRNA. No translation available.
CCDSiCCDS23109.1.
RefSeqiNP_068561.1. NM_021789.2.
UniGeneiMm.29814.

Genome annotation databases

EnsembliENSMUST00000034623; ENSMUSP00000034623; ENSMUSG00000032112.
GeneIDi60409.
KEGGimmu:60409.
UCSCiuc009pdk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF233340 mRNA. Translation: AAG24950.1.
BC038898 mRNA. Translation: AAH38898.1.
AK005276 mRNA. No translation available.
CCDSiCCDS23109.1.
RefSeqiNP_068561.1. NM_021789.2.
UniGeneiMm.29814.

3D structure databases

ProteinModelPortaliQ9ES56.
SMRiQ9ES56. Positions 2-215.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi208560. 1 interaction.
IntActiQ9ES56. 1 interaction.
STRINGi10090.ENSMUSP00000034623.

PTM databases

iPTMnetiQ9ES56.
PhosphoSiteiQ9ES56.

Proteomic databases

EPDiQ9ES56.
MaxQBiQ9ES56.
PaxDbiQ9ES56.
PRIDEiQ9ES56.

Protocols and materials databases

DNASUi60409.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034623; ENSMUSP00000034623; ENSMUSG00000032112.
GeneIDi60409.
KEGGimmu:60409.
UCSCiuc009pdk.1. mouse.

Organism-specific databases

CTDi51399.
MGIiMGI:1926211. Trappc4.

Phylogenomic databases

eggNOGiKOG3369. Eukaryota.
COG5122. LUCA.
GeneTreeiENSGT00510000047061.
HOGENOMiHOG000165618.
HOVERGENiHBG054226.
InParanoidiQ9ES56.
OMAiDPRQSGI.
OrthoDBiEOG7FJH1J.
PhylomeDBiQ9ES56.
TreeFamiTF314561.

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.

Miscellaneous databases

PROiQ9ES56.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ES56.
CleanExiMM_TRAPPC4.
ExpressionAtlasiQ9ES56. baseline and differential.
GenevisibleiQ9ES56. MM.

Family and domain databases

InterProiIPR011012. Longin-like_dom.
IPR007233. TRAPPC.
[Graphical view]
PANTHERiPTHR23249. PTHR23249. 2 hits.
PfamiPF04099. Sybindin. 1 hit.
[Graphical view]
SMARTiSM01399. Sybindin. 1 hit.
[Graphical view]
SUPFAMiSSF64356. SSF64356. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Synbindin, a novel syndecan-2-binding protein in neuronal dendritic spines."
    Ethell I.M., Hagihara K., Miura Y., Irie F., Yamaguchi Y.
    J. Cell Biol. 151:53-68(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SDC2.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Retina.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-194.
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiTPPC4_MOUSE
AccessioniPrimary (citable) accession number: Q9ES56
Secondary accession number(s): Q9DB31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: March 1, 2001
Last modified: June 8, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.