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Protein

Ubiquitin recognition factor in ER-associated degradation protein 1

Gene

Ufd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (PubMed:10811609). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity).By similarity1 Publication

Pathwayi: proteasomal ubiquitin-dependent pathway

This protein is involved in the pathway proteasomal ubiquitin-dependent pathway, which is part of Protein degradation.1 Publication
View all proteins of this organism that are known to be involved in the pathway proteasomal ubiquitin-dependent pathway and in Protein degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-110320 Translesion Synthesis by POLH
R-RNO-5689880 Ub-specific processing proteases
UniPathwayiUPA00144

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin recognition factor in ER-associated degradation protein 1
Alternative name(s):
Ubiquitin fusion degradation protein 1 homolog
Short name:
UB fusion protein 1
Gene namesi
Name:Ufd1Imported
Synonyms:Ufd1lImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi619822 Ufd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003712291 – 307Ubiquitin recognition factor in ER-associated degradation protein 1Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei129PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei299PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9ES53
PRIDEiQ9ES53

PTM databases

iPTMnetiQ9ES53
PhosphoSitePlusiQ9ES53

Expressioni

Gene expression databases

BgeeiENSRNOG00000047394
GenevisibleiQ9ES53 RN

Interactioni

Subunit structurei

Interacts with USP13 (By similarity). Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion (PubMed:10811609). Interacts with ZFAND2B; probably through VCP (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Nploc4Q9ES546EBI-399031,EBI-1993990

GO - Molecular functioni

Protein-protein interaction databases

BioGridi249978, 4 interactors
CORUMiQ9ES53
IntActiQ9ES53, 6 interactors
MINTiQ9ES53
STRINGi10116.ENSRNOP00000067081

Structurei

3D structure databases

ProteinModelPortaliQ9ES53
SMRiQ9ES53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UFD1 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG1816 Eukaryota
COG5140 LUCA
GeneTreeiENSGT00390000002408
InParanoidiQ9ES53
KOiK14016
OMAiKDHSETQ
OrthoDBiEOG091G0KO7
PhylomeDBiQ9ES53

Family and domain databases

InterProiView protein in InterPro
IPR004854 Ufd1-like
PANTHERiPTHR12555 PTHR12555, 1 hit
PfamiView protein in Pfam
PF03152 UFD1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9ES53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP
60 70 80 90 100
SALDQLSRLN ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ
110 120 130 140 150
NLLLEEGGLV QVESVNLQVA TYSKFQPQSP DFLDITNPKA VLENALRNFA
160 170 180 190 200
CLTTGDVIAI NYNEKIYELR VMETKPDKAV SIIECDMNVD FDAPLGYKEP
210 220 230 240 250
ERPVQHEESI EGEADHSGYA GEVGFRAFSG SGNRLDGKKK GVEPSPSPIK
260 270 280 290 300
PGDIKRGIPN YEFKLGKITF IRNSRPMVKK VEEDEAGGRF VAFSGEGQSL

RKKGRKP
Length:307
Mass (Da):34,485
Last modified:March 1, 2001 - v1
Checksum:iC482D6B1B910494D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF234601 mRNA Translation: AAG27535.1
CH473999 Genomic DNA Translation: EDL77960.1
BC161818 mRNA Translation: AAI61818.1
RefSeqiNP_445870.1, NM_053418.2
UniGeneiRn.11946

Genome annotation databases

EnsembliENSRNOT00000071493; ENSRNOP00000067081; ENSRNOG00000047394
GeneIDi84478
KEGGirno:84478

Similar proteinsi

Entry informationi

Entry nameiUFD1_RAT
AccessioniPrimary (citable) accession number: Q9ES53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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