Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ubiquitin recognition factor in ER-associated degradation protein 1

Gene

Ufd1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (PubMed:10811609). Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (By similarity).By similarity1 Publication

Pathwayi: proteasomal ubiquitin-dependent pathway

This protein is involved in the pathway proteasomal ubiquitin-dependent pathway, which is part of Protein degradation.1 Publication
View all proteins of this organism that are known to be involved in the pathway proteasomal ubiquitin-dependent pathway and in Protein degradation.

GO - Molecular functioni

  • ATPase binding Source: ParkinsonsUK-UCL
  • K48-linked polyubiquitin binding Source: Ensembl
  • protein complex binding Source: RGD
  • receptor binding Source: RGD

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-110320. Translesion Synthesis by POLH.
R-RNO-5689880. Ub-specific processing proteases.
UniPathwayiUPA00144.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin recognition factor in ER-associated degradation protein 1
Alternative name(s):
Ubiquitin fusion degradation protein 1 homolog
Short name:
UB fusion protein 1
Gene namesi
Name:Ufd1Imported
Synonyms:Ufd1lImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi619822. Ufd1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • UFD1-NPL4 complex Source: ParkinsonsUK-UCL
  • VCP-NPL4-UFD1 AAA ATPase complex Source: ParkinsonsUK-UCL

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003712291 – 307Ubiquitin recognition factor in ER-associated degradation protein 1Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei129PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei299PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9ES53.
PRIDEiQ9ES53.

PTM databases

iPTMnetiQ9ES53.
PhosphoSitePlusiQ9ES53.

Expressioni

Gene expression databases

BgeeiENSRNOG00000047394.
GenevisibleiQ9ES53. RN.

Interactioni

Subunit structurei

Interacts with USP13 (By similarity). Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion (PubMed:10811609).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Nploc4Q9ES546EBI-399031,EBI-1993990

GO - Molecular functioni

  • ATPase binding Source: ParkinsonsUK-UCL
  • K48-linked polyubiquitin binding Source: Ensembl
  • protein complex binding Source: RGD
  • receptor binding Source: RGD

Protein-protein interaction databases

BioGridi249978. 4 interactors.
IntActiQ9ES53. 5 interactors.
STRINGi10116.ENSRNOP00000067081.

Structurei

3D structure databases

ProteinModelPortaliQ9ES53.
SMRiQ9ES53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UFD1 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG1816. Eukaryota.
COG5140. LUCA.
GeneTreeiENSGT00390000002408.
InParanoidiQ9ES53.
KOiK14016.
OMAiKDHSETQ.
OrthoDBiEOG091G0KO7.
PhylomeDBiQ9ES53.

Family and domain databases

InterProiView protein in InterPro
IPR004854. UFD1.
PANTHERiPTHR12555. PTHR12555. 1 hit.
PfamiView protein in Pfam
PF03152. UFD1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9ES53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP
60 70 80 90 100
SALDQLSRLN ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ
110 120 130 140 150
NLLLEEGGLV QVESVNLQVA TYSKFQPQSP DFLDITNPKA VLENALRNFA
160 170 180 190 200
CLTTGDVIAI NYNEKIYELR VMETKPDKAV SIIECDMNVD FDAPLGYKEP
210 220 230 240 250
ERPVQHEESI EGEADHSGYA GEVGFRAFSG SGNRLDGKKK GVEPSPSPIK
260 270 280 290 300
PGDIKRGIPN YEFKLGKITF IRNSRPMVKK VEEDEAGGRF VAFSGEGQSL

RKKGRKP
Length:307
Mass (Da):34,485
Last modified:March 1, 2001 - v1
Checksum:iC482D6B1B910494D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF234601 mRNA. Translation: AAG27535.1.
CH473999 Genomic DNA. Translation: EDL77960.1.
BC161818 mRNA. Translation: AAI61818.1.
RefSeqiNP_445870.1. NM_053418.2.
UniGeneiRn.11946.

Genome annotation databases

EnsembliENSRNOT00000071493; ENSRNOP00000067081; ENSRNOG00000047394.
GeneIDi84478.
KEGGirno:84478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF234601 mRNA. Translation: AAG27535.1.
CH473999 Genomic DNA. Translation: EDL77960.1.
BC161818 mRNA. Translation: AAI61818.1.
RefSeqiNP_445870.1. NM_053418.2.
UniGeneiRn.11946.

3D structure databases

ProteinModelPortaliQ9ES53.
SMRiQ9ES53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249978. 4 interactors.
IntActiQ9ES53. 5 interactors.
STRINGi10116.ENSRNOP00000067081.

PTM databases

iPTMnetiQ9ES53.
PhosphoSitePlusiQ9ES53.

Proteomic databases

PaxDbiQ9ES53.
PRIDEiQ9ES53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071493; ENSRNOP00000067081; ENSRNOG00000047394.
GeneIDi84478.
KEGGirno:84478.

Organism-specific databases

CTDi7353.
RGDi619822. Ufd1.

Phylogenomic databases

eggNOGiKOG1816. Eukaryota.
COG5140. LUCA.
GeneTreeiENSGT00390000002408.
InParanoidiQ9ES53.
KOiK14016.
OMAiKDHSETQ.
OrthoDBiEOG091G0KO7.
PhylomeDBiQ9ES53.

Enzyme and pathway databases

UniPathwayiUPA00144.
ReactomeiR-RNO-110320. Translesion Synthesis by POLH.
R-RNO-5689880. Ub-specific processing proteases.

Miscellaneous databases

PROiPR:Q9ES53.

Gene expression databases

BgeeiENSRNOG00000047394.
GenevisibleiQ9ES53. RN.

Family and domain databases

InterProiView protein in InterPro
IPR004854. UFD1.
PANTHERiPTHR12555. PTHR12555. 1 hit.
PfamiView protein in Pfam
PF03152. UFD1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUFD1_RAT
AccessioniPrimary (citable) accession number: Q9ES53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: March 1, 2001
Last modified: June 7, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.