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Protein

Ubiquitin fusion degradation protein 1 homolog

Gene

Ufd1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures (By similarity).By similarity

Pathwayi: proteasomal ubiquitin-dependent pathway

This protein is involved in the pathway proteasomal ubiquitin-dependent pathway, which is part of Protein degradation.By similarity
View all proteins of this organism that are known to be involved in the pathway proteasomal ubiquitin-dependent pathway and in Protein degradation.

GO - Molecular functioni

  • ATPase binding Source: ParkinsonsUK-UCL
  • protein complex binding Source: RGD
  • receptor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-RNO-110320. Translesion Synthesis by POLH.
R-RNO-5689880. Ub-specific processing proteases.
UniPathwayiUPA00144.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin fusion degradation protein 1 homologBy similarity
Short name:
UB fusion protein 1By similarity
Gene namesi
Name:Ufd1lImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi619822. Ufd1l.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB-SubCell
  • nucleus Source: UniProtKB-SubCell
  • UFD1-NPL4 complex Source: ParkinsonsUK-UCL
  • VCP-NPL4-UFD1 AAA ATPase complex Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003712291 – 307Ubiquitin fusion degradation protein 1 homologAdd BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei129PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei247PhosphoserineBy similarity1
Modified residuei299PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9ES53.
PRIDEiQ9ES53.

PTM databases

iPTMnetiQ9ES53.
PhosphoSitePlusiQ9ES53.

Expressioni

Gene expression databases

BgeeiENSRNOG00000047394.
GenevisibleiQ9ES53. RN.

Interactioni

Subunit structurei

Interacts with USP13 (By similarity). Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Nploc4Q9ES546EBI-399031,EBI-1993990

GO - Molecular functioni

  • ATPase binding Source: ParkinsonsUK-UCL
  • protein complex binding Source: RGD
  • receptor binding Source: RGD

Protein-protein interaction databases

BioGridi249978. 4 interactors.
IntActiQ9ES53. 5 interactors.
STRINGi10116.ENSRNOP00000067081.

Structurei

3D structure databases

ProteinModelPortaliQ9ES53.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UFD1 family.Sequence analysis

Phylogenomic databases

eggNOGiKOG1816. Eukaryota.
COG5140. LUCA.
GeneTreeiENSGT00390000002408.
InParanoidiQ9ES53.
KOiK14016.
OMAiADHSSYA.
OrthoDBiEOG091G0KO7.
PhylomeDBiQ9ES53.

Family and domain databases

InterProiIPR004854. UFD1.
[Graphical view]
PANTHERiPTHR12555. PTHR12555. 1 hit.
PfamiPF03152. UFD1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ES53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP
60 70 80 90 100
SALDQLSRLN ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ
110 120 130 140 150
NLLLEEGGLV QVESVNLQVA TYSKFQPQSP DFLDITNPKA VLENALRNFA
160 170 180 190 200
CLTTGDVIAI NYNEKIYELR VMETKPDKAV SIIECDMNVD FDAPLGYKEP
210 220 230 240 250
ERPVQHEESI EGEADHSGYA GEVGFRAFSG SGNRLDGKKK GVEPSPSPIK
260 270 280 290 300
PGDIKRGIPN YEFKLGKITF IRNSRPMVKK VEEDEAGGRF VAFSGEGQSL

RKKGRKP
Length:307
Mass (Da):34,485
Last modified:March 1, 2001 - v1
Checksum:iC482D6B1B910494D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF234601 mRNA. Translation: AAG27535.1.
CH473999 Genomic DNA. Translation: EDL77960.1.
BC161818 mRNA. Translation: AAI61818.1.
RefSeqiNP_445870.1. NM_053418.2.
UniGeneiRn.11946.

Genome annotation databases

EnsembliENSRNOT00000071493; ENSRNOP00000067081; ENSRNOG00000047394.
GeneIDi84478.
KEGGirno:84478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF234601 mRNA. Translation: AAG27535.1.
CH473999 Genomic DNA. Translation: EDL77960.1.
BC161818 mRNA. Translation: AAI61818.1.
RefSeqiNP_445870.1. NM_053418.2.
UniGeneiRn.11946.

3D structure databases

ProteinModelPortaliQ9ES53.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249978. 4 interactors.
IntActiQ9ES53. 5 interactors.
STRINGi10116.ENSRNOP00000067081.

PTM databases

iPTMnetiQ9ES53.
PhosphoSitePlusiQ9ES53.

Proteomic databases

PaxDbiQ9ES53.
PRIDEiQ9ES53.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071493; ENSRNOP00000067081; ENSRNOG00000047394.
GeneIDi84478.
KEGGirno:84478.

Organism-specific databases

CTDi7353.
RGDi619822. Ufd1l.

Phylogenomic databases

eggNOGiKOG1816. Eukaryota.
COG5140. LUCA.
GeneTreeiENSGT00390000002408.
InParanoidiQ9ES53.
KOiK14016.
OMAiADHSSYA.
OrthoDBiEOG091G0KO7.
PhylomeDBiQ9ES53.

Enzyme and pathway databases

UniPathwayiUPA00144.
ReactomeiR-RNO-110320. Translesion Synthesis by POLH.
R-RNO-5689880. Ub-specific processing proteases.

Miscellaneous databases

PROiQ9ES53.

Gene expression databases

BgeeiENSRNOG00000047394.
GenevisibleiQ9ES53. RN.

Family and domain databases

InterProiIPR004854. UFD1.
[Graphical view]
PANTHERiPTHR12555. PTHR12555. 1 hit.
PfamiPF03152. UFD1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUFD1_RAT
AccessioniPrimary (citable) accession number: Q9ES53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: March 1, 2001
Last modified: November 30, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.