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Protein

Beta-parvin

Gene

Parvb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration (By similarity).By similarity

GO - Biological processi

  1. actin cytoskeleton reorganization Source: UniProtKB
  2. cell adhesion Source: UniProtKB-KW
  3. cell projection assembly Source: UniProtKB
  4. establishment or maintenance of cell polarity regulating cell shape Source: UniProtKB
  5. lamellipodium assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiREACT_302398. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.
REACT_320343. Cell-extracellular matrix interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-parvin
Gene namesi
Name:Parvb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2153063. Parvb.

Subcellular locationi

  1. Cell junctionfocal adhesion
  2. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
  3. Cytoplasmcytoskeleton By similarity
  4. Cell projectionlamellipodium By similarity
  5. Cytoplasmmyofibrilsarcomere By similarity
  6. CytoplasmmyofibrilsarcomereZ line By similarity

  7. Note: Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia (By similarity).By similarity

GO - Cellular componenti

  1. cytoskeleton Source: UniProtKB-SubCell
  2. focal adhesion Source: UniProtKB
  3. lamellipodium Source: UniProtKB
  4. plasma membrane Source: UniProtKB-SubCell
  5. Z disc Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 365365Beta-parvinPRO_0000121584Add
BLAST

Post-translational modificationi

Phosphorylated by ILK.By similarity

Proteomic databases

MaxQBiQ9ES46.
PaxDbiQ9ES46.
PRIDEiQ9ES46.

PTM databases

PhosphoSiteiQ9ES46.

Expressioni

Tissue specificityi

Expressed predominantly in heart and moderately in spleen, lung and skeletal muscle.1 Publication

Gene expression databases

BgeeiQ9ES46.
CleanExiMM_PARVB.
ExpressionAtlasiQ9ES46. baseline and differential.
GenevestigatoriQ9ES46.

Interactioni

Subunit structurei

Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin (By similarity). Interacts with DYSF.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Arhgef7Q9ES282EBI-6914996,EBI-642580
IlkO552222EBI-6914996,EBI-6690138

Protein-protein interaction databases

DIPiDIP-57659N.
IntActiQ9ES46. 2 interactions.
MINTiMINT-7978697.

Structurei

3D structure databases

ProteinModelPortaliQ9ES46.
SMRiQ9ES46. Positions 236-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 195108CH 1PROSITE-ProRule annotationAdd
BLAST
Domaini255 – 362108CH 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the parvin family.Curated
Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG303418.
GeneTreeiENSGT00390000009673.
HOGENOMiHOG000247027.
HOVERGENiHBG053517.
InParanoidiQ9ES46.
KOiK06275.
OMAiLAMHFQA.
OrthoDBiEOG70KGPW.
PhylomeDBiQ9ES46.
TreeFamiTF314025.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR028433. Parvin.
[Graphical view]
PANTHERiPTHR12114. PTHR12114. 1 hit.
PfamiPF00307. CH. 2 hits.
[Graphical view]
PIRSFiPIRSF039131. Parvin. 1 hit.
SMARTiSM00033. CH. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS50021. CH. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ES46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPPRSPT PRAPKMKKDE SFLGKLGGTL ARKKKTREVT DLQEEGKSAI
60 70 80 90 100
NSPMAPALVD IHPEDTQLEE NEERTMIDPT SREDPKFKEL VKVLLDWIND
110 120 130 140 150
VLAEERIIVK QLEEDLYDGQ VLQKLLEKLA HCKLNVAEVT QSEIGQKQKL
160 170 180 190 200
QTVLEAVQDL LRPHGWPLRW NVDSIHGKNL VAILHLLVSL AMHFRAPIHL
210 220 230 240 250
PEHVTVQVVV VRKREGLLHS SHISEELTTT TEIMMGRFER DAFDTLFDHA
260 270 280 290 300
PDKLNLVKKS LITFVNKHLN KLNLEVTDLE TQFADGVYLV LLLGLLEDYF
310 320 330 340 350
VPLHNFYLTP DSFDQKVHNV AFAFELMLDG GLKKPKARPE DVVNLDLKST
360
LRVLYTLFTK YKDVE
Length:365
Mass (Da):41,669
Last modified:March 1, 2001 - v1
Checksum:iA3C6B8B3D5875CEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237770 mRNA. Translation: AAG27172.1.
CCDSiCCDS37167.1.
RefSeqiNP_573395.1. NM_133167.3.
UniGeneiMm.323892.

Genome annotation databases

EnsembliENSMUST00000023072; ENSMUSP00000023072; ENSMUSG00000022438.
GeneIDi170736.
KEGGimmu:170736.
UCSCiuc007xby.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237770 mRNA. Translation: AAG27172.1.
CCDSiCCDS37167.1.
RefSeqiNP_573395.1. NM_133167.3.
UniGeneiMm.323892.

3D structure databases

ProteinModelPortaliQ9ES46.
SMRiQ9ES46. Positions 236-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-57659N.
IntActiQ9ES46. 2 interactions.
MINTiMINT-7978697.

PTM databases

PhosphoSiteiQ9ES46.

Proteomic databases

MaxQBiQ9ES46.
PaxDbiQ9ES46.
PRIDEiQ9ES46.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023072; ENSMUSP00000023072; ENSMUSG00000022438.
GeneIDi170736.
KEGGimmu:170736.
UCSCiuc007xby.1. mouse.

Organism-specific databases

CTDi29780.
MGIiMGI:2153063. Parvb.

Phylogenomic databases

eggNOGiNOG303418.
GeneTreeiENSGT00390000009673.
HOGENOMiHOG000247027.
HOVERGENiHBG053517.
InParanoidiQ9ES46.
KOiK06275.
OMAiLAMHFQA.
OrthoDBiEOG70KGPW.
PhylomeDBiQ9ES46.
TreeFamiTF314025.

Enzyme and pathway databases

ReactomeiREACT_302398. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.
REACT_320343. Cell-extracellular matrix interactions.

Miscellaneous databases

NextBioi370282.
PROiQ9ES46.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ES46.
CleanExiMM_PARVB.
ExpressionAtlasiQ9ES46. baseline and differential.
GenevestigatoriQ9ES46.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiIPR001715. CH-domain.
IPR028433. Parvin.
[Graphical view]
PANTHERiPTHR12114. PTHR12114. 1 hit.
PfamiPF00307. CH. 2 hits.
[Graphical view]
PIRSFiPIRSF039131. Parvin. 1 hit.
SMARTiSM00033. CH. 2 hits.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiPS50021. CH. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily."
    Olski T.M., Noegel A.A., Korenbaum E.
    J. Cell Sci. 114:525-538(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans."
    Korenbaum E., Olski T.M., Noegel A.A.
    Gene 279:69-79(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  3. "Dysferlin interacts with affixin (beta-parvin) at the sarcolemma."
    Matsuda C., Kameyama K., Tagawa K., Ogawa M., Suzuki A., Yamaji S., Okamoto H., Nishino I., Hayashi Y.K.
    J. Neuropathol. Exp. Neurol. 64:334-340(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DYSF.

Entry informationi

Entry nameiPARVB_MOUSE
AccessioniPrimary (citable) accession number: Q9ES46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: April 1, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.