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Q9ES46

- PARVB_MOUSE

UniProt

Q9ES46 - PARVB_MOUSE

Protein

Beta-parvin

Gene

Parvb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Mar 2001)
      Previous versions | rss
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    Functioni

    Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. actin cytoskeleton reorganization Source: UniProtKB
    2. cell adhesion Source: UniProtKB-KW
    3. cell projection assembly Source: UniProtKB
    4. establishment or maintenance of cell polarity regulating cell shape Source: UniProtKB
    5. lamellipodium assembly Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-parvin
    Gene namesi
    Name:Parvb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2153063. Parvb.

    Subcellular locationi

    Cell junctionfocal adhesion. Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity. Cytoplasmcytoskeleton By similarity. Cell projectionlamellipodium By similarity. Cytoplasmmyofibrilsarcomere By similarity. CytoplasmmyofibrilsarcomereZ line By similarity
    Note: Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia By similarity.By similarity

    GO - Cellular componenti

    1. cytoskeleton Source: UniProtKB-SubCell
    2. focal adhesion Source: UniProtKB
    3. lamellipodium Source: UniProtKB
    4. plasma membrane Source: UniProtKB-SubCell
    5. Z disc Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 365365Beta-parvinPRO_0000121584Add
    BLAST

    Post-translational modificationi

    Phosphorylated by ILK.By similarity

    Proteomic databases

    MaxQBiQ9ES46.
    PaxDbiQ9ES46.
    PRIDEiQ9ES46.

    PTM databases

    PhosphoSiteiQ9ES46.

    Expressioni

    Tissue specificityi

    Expressed predominantly in heart and moderately in spleen, lung and skeletal muscle.1 Publication

    Gene expression databases

    ArrayExpressiQ9ES46.
    BgeeiQ9ES46.
    CleanExiMM_PARVB.
    GenevestigatoriQ9ES46.

    Interactioni

    Subunit structurei

    Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin By similarity. Interacts with DYSF.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Arhgef7Q9ES282EBI-6914996,EBI-642580
    IlkO552222EBI-6914996,EBI-6690138

    Protein-protein interaction databases

    DIPiDIP-57659N.
    IntActiQ9ES46. 2 interactions.
    MINTiMINT-7978697.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ES46.
    SMRiQ9ES46. Positions 236-365.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini88 – 195108CH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini255 – 362108CH 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the parvin family.Curated
    Contains 2 CH (calponin-homology) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG303418.
    GeneTreeiENSGT00390000009673.
    HOGENOMiHOG000247027.
    HOVERGENiHBG053517.
    InParanoidiQ9ES46.
    KOiK06275.
    OMAiLAMHFQA.
    OrthoDBiEOG70KGPW.
    PhylomeDBiQ9ES46.
    TreeFamiTF314025.

    Family and domain databases

    Gene3Di1.10.418.10. 2 hits.
    InterProiIPR001715. CH-domain.
    IPR028433. Parvin.
    [Graphical view]
    PANTHERiPTHR12114. PTHR12114. 1 hit.
    PfamiPF00307. CH. 2 hits.
    [Graphical view]
    SMARTiSM00033. CH. 2 hits.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 2 hits.
    PROSITEiPS50021. CH. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9ES46-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAPPRSPT PRAPKMKKDE SFLGKLGGTL ARKKKTREVT DLQEEGKSAI    50
    NSPMAPALVD IHPEDTQLEE NEERTMIDPT SREDPKFKEL VKVLLDWIND 100
    VLAEERIIVK QLEEDLYDGQ VLQKLLEKLA HCKLNVAEVT QSEIGQKQKL 150
    QTVLEAVQDL LRPHGWPLRW NVDSIHGKNL VAILHLLVSL AMHFRAPIHL 200
    PEHVTVQVVV VRKREGLLHS SHISEELTTT TEIMMGRFER DAFDTLFDHA 250
    PDKLNLVKKS LITFVNKHLN KLNLEVTDLE TQFADGVYLV LLLGLLEDYF 300
    VPLHNFYLTP DSFDQKVHNV AFAFELMLDG GLKKPKARPE DVVNLDLKST 350
    LRVLYTLFTK YKDVE 365
    Length:365
    Mass (Da):41,669
    Last modified:March 1, 2001 - v1
    Checksum:iA3C6B8B3D5875CEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF237770 mRNA. Translation: AAG27172.1.
    CCDSiCCDS37167.1.
    RefSeqiNP_573395.1. NM_133167.3.
    UniGeneiMm.323892.

    Genome annotation databases

    EnsembliENSMUST00000023072; ENSMUSP00000023072; ENSMUSG00000022438.
    GeneIDi170736.
    KEGGimmu:170736.
    UCSCiuc007xby.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF237770 mRNA. Translation: AAG27172.1 .
    CCDSi CCDS37167.1.
    RefSeqi NP_573395.1. NM_133167.3.
    UniGenei Mm.323892.

    3D structure databases

    ProteinModelPortali Q9ES46.
    SMRi Q9ES46. Positions 236-365.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-57659N.
    IntActi Q9ES46. 2 interactions.
    MINTi MINT-7978697.

    PTM databases

    PhosphoSitei Q9ES46.

    Proteomic databases

    MaxQBi Q9ES46.
    PaxDbi Q9ES46.
    PRIDEi Q9ES46.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023072 ; ENSMUSP00000023072 ; ENSMUSG00000022438 .
    GeneIDi 170736.
    KEGGi mmu:170736.
    UCSCi uc007xby.1. mouse.

    Organism-specific databases

    CTDi 29780.
    MGIi MGI:2153063. Parvb.

    Phylogenomic databases

    eggNOGi NOG303418.
    GeneTreei ENSGT00390000009673.
    HOGENOMi HOG000247027.
    HOVERGENi HBG053517.
    InParanoidi Q9ES46.
    KOi K06275.
    OMAi LAMHFQA.
    OrthoDBi EOG70KGPW.
    PhylomeDBi Q9ES46.
    TreeFami TF314025.

    Miscellaneous databases

    NextBioi 370282.
    PROi Q9ES46.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ES46.
    Bgeei Q9ES46.
    CleanExi MM_PARVB.
    Genevestigatori Q9ES46.

    Family and domain databases

    Gene3Di 1.10.418.10. 2 hits.
    InterProi IPR001715. CH-domain.
    IPR028433. Parvin.
    [Graphical view ]
    PANTHERi PTHR12114. PTHR12114. 1 hit.
    Pfami PF00307. CH. 2 hits.
    [Graphical view ]
    SMARTi SM00033. CH. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 2 hits.
    PROSITEi PS50021. CH. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily."
      Olski T.M., Noegel A.A., Korenbaum E.
      J. Cell Sci. 114:525-538(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans."
      Korenbaum E., Olski T.M., Noegel A.A.
      Gene 279:69-79(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    3. "Dysferlin interacts with affixin (beta-parvin) at the sarcolemma."
      Matsuda C., Kameyama K., Tagawa K., Ogawa M., Suzuki A., Yamaji S., Okamoto H., Nishino I., Hayashi Y.K.
      J. Neuropathol. Exp. Neurol. 64:334-340(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DYSF.

    Entry informationi

    Entry nameiPARVB_MOUSE
    AccessioniPrimary (citable) accession number: Q9ES46
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3