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Protein

Beta-parvin

Gene

Parvb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding
Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-parvin
Gene namesi
Name:Parvb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2153063. Parvb.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001215841 – 365Beta-parvinAdd BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by ILK.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9ES46.
PaxDbiQ9ES46.
PRIDEiQ9ES46.

PTM databases

iPTMnetiQ9ES46.
PhosphoSitePlusiQ9ES46.

Expressioni

Tissue specificityi

Expressed predominantly in heart and moderately in spleen, lung and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000022438.
CleanExiMM_PARVB.
ExpressionAtlasiQ9ES46. baseline and differential.
GenevisibleiQ9ES46. MM.

Interactioni

Subunit structurei

Interacts with ILK, ARHGEF6, PXN (via LD motifs), ACTN2 and actin (By similarity). Interacts with DYSF.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-57659N.
IntActiQ9ES46. 2 interactors.
MINTiMINT-7978697.
STRINGi10090.ENSMUSP00000023072.

Structurei

3D structure databases

ProteinModelPortaliQ9ES46.
SMRiQ9ES46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini88 – 195Calponin-homology 1PROSITE-ProRule annotationAdd BLAST108
Domaini255 – 362Calponin-homology 2PROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the parvin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3631. Eukaryota.
ENOG410XQWH. LUCA.
GeneTreeiENSGT00390000009673.
HOGENOMiHOG000247027.
HOVERGENiHBG053517.
InParanoidiQ9ES46.
KOiK06275.
OMAiHGWALRW.
OrthoDBiEOG091G0ULB.
PhylomeDBiQ9ES46.
TreeFamiTF314025.

Family and domain databases

Gene3Di1.10.418.10. 2 hits.
InterProiView protein in InterPro
IPR001715. CH-domain.
IPR028433. Parvin.
PANTHERiPTHR12114. PTHR12114. 1 hit.
PfamiView protein in Pfam
PF00307. CH. 2 hits.
PIRSFiPIRSF039131. Parvin. 1 hit.
SMARTiView protein in SMART
SM00033. CH. 2 hits.
SUPFAMiSSF47576. SSF47576. 2 hits.
PROSITEiView protein in PROSITE
PS50021. CH. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9ES46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAPPRSPT PRAPKMKKDE SFLGKLGGTL ARKKKTREVT DLQEEGKSAI
60 70 80 90 100
NSPMAPALVD IHPEDTQLEE NEERTMIDPT SREDPKFKEL VKVLLDWIND
110 120 130 140 150
VLAEERIIVK QLEEDLYDGQ VLQKLLEKLA HCKLNVAEVT QSEIGQKQKL
160 170 180 190 200
QTVLEAVQDL LRPHGWPLRW NVDSIHGKNL VAILHLLVSL AMHFRAPIHL
210 220 230 240 250
PEHVTVQVVV VRKREGLLHS SHISEELTTT TEIMMGRFER DAFDTLFDHA
260 270 280 290 300
PDKLNLVKKS LITFVNKHLN KLNLEVTDLE TQFADGVYLV LLLGLLEDYF
310 320 330 340 350
VPLHNFYLTP DSFDQKVHNV AFAFELMLDG GLKKPKARPE DVVNLDLKST
360
LRVLYTLFTK YKDVE
Length:365
Mass (Da):41,669
Last modified:March 1, 2001 - v1
Checksum:iA3C6B8B3D5875CEA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237770 mRNA. Translation: AAG27172.1.
CCDSiCCDS37167.1.
RefSeqiNP_573395.1. NM_133167.3.
UniGeneiMm.323892.

Genome annotation databases

EnsembliENSMUST00000023072; ENSMUSP00000023072; ENSMUSG00000022438.
GeneIDi170736.
KEGGimmu:170736.
UCSCiuc007xby.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPARVB_MOUSE
AccessioniPrimary (citable) accession number: Q9ES46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: July 5, 2017
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families