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Protein

Ubiquitin-protein ligase E3B

Gene

Ube3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1038 – 10381Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-protein ligase E3B (EC:6.3.2.-)
Gene namesi
Name:Ube3b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1891295. Ube3b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10701070Ubiquitin-protein ligase E3BPRO_0000281883Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei421 – 4211PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9ES34.
PaxDbiQ9ES34.
PeptideAtlasiQ9ES34.
PRIDEiQ9ES34.

PTM databases

iPTMnetiQ9ES34.
PhosphoSiteiQ9ES34.

Expressioni

Tissue specificityi

Widely expressed. High expression is observed in developing central nervous system.2 Publications

Gene expression databases

BgeeiENSMUSG00000029577.
CleanExiMM_UBE3B.
ExpressionAtlasiQ9ES34. baseline and differential.
GenevisibleiQ9ES34. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073652.

Structurei

3D structure databases

ProteinModelPortaliQ9ES34.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 5830IQPROSITE-ProRule annotationAdd
BLAST
Domaini704 – 1070367HECTPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.PROSITE-ProRule annotation
Contains 1 IQ domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0942. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00550000074668.
HOGENOMiHOG000232154.
HOVERGENiHBG108644.
InParanoidiQ9ES34.
KOiK10588.
OMAiFQSVHGW.
OrthoDBiEOG091G029A.
PhylomeDBiQ9ES34.
TreeFamiTF313215.

Family and domain databases

InterProiIPR000569. HECT_dom.
IPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
PF00612. IQ. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ES34-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFTVSQTSRA WFIDRARQAR EERLVQKERE RSAVTIQALV RSFLCRRRLH
60 70 80 90 100
RDIRKEIDEF FSADESGSSK RSALCIFKIA RRLLFICKTT EDSERLEKLC
110 120 130 140 150
RSILNSMDAE NEPKVWYVSL ALSKDLTLLW IKQIKSILWH CCELLGQLKP
160 170 180 190 200
EILQDSRLIT LYLTMLVTFT DTSTWKILRG KGESLRPALN HICANIMGHL
210 220 230 240 250
NQRGLYSVLQ VLLTRGLARP RPCLSKGMLT AAFSLALRPV VAAQFSDNLM
260 270 280 290 300
RPFIIHVMSV PALVAHLSTV APERLGVLES HDMLRKFIVF LRDRDRCRDA
310 320 330 340 350
CESLEGCHTL CLMGNLLHLG SLSLRLLEEE MDGFVSALTQ MLCYCQKYVA
360 370 380 390 400
QKKSNLTHWH PVLGWFSQPV DYGLNDSMYL ITKQLQFLWA VPLIRILFSD
410 420 430 440 450
ILSRKLLEHA EPAPVQPQPS SPQTVLPVKS LLKRAFQKSA SVRNILRPVG
460 470 480 490 500
GRRVDSAEVR KVCNICVLYQ TSLTTLTQIR LQILTGLTYL DDLLPKLWAF
510 520 530 540 550
ICELGPHGGL KLFLECLNND TGESKQLLAM LMLFCDCSRH LITILDDIEV
560 570 580 590 600
YEEQISFKLE ELVTISSFLN SFVFKMIWDG IVENAKGETL ELFQSVHGWL
610 620 630 640 650
MVLYERDCRR RFAPEDHWLR RDLKPGVLFQ ELDKDRRRAQ LVLQHIPHVV
660 670 680 690 700
PHKNRVLLFR NMVIKEKEKL GLVETSSASP HVTHITIRRS RMLEDGYEQL
710 720 730 740 750
RQLSQHAMKG VIRVKFVNDL GVDEAGIDQD GVFKEFLEEI IKRVFDPALN
760 770 780 790 800
LFKTTSGDER LYPSPTSYIH ENYLQLFEFV GKMLGKAVYE GIVVDVPFAS
810 820 830 840 850
FFLSQMLGHH HSVFYSSVDE LPSLDSEFYK NLTSIKRYDG DIADLGLTLS
860 870 880 890 900
YDEDVMGQLV CHELVPGGKT IPVTDENKIS YIHLMAHFRM HTQIKNQTAA
910 920 930 940 950
LISGFRSIIK PEWIRMFSTP ELQRLISGDN AEIDLEDLKK HTVYYGGFHG
960 970 980 990 1000
SHRVIIWLWD ILASDFTPEE RAMFLKFVTS CSRPPLLGFA YLKPPFSIRC
1010 1020 1030 1040 1050
VEVSDDQDTG DTLGSVLRGF FTIRKREPGG RLPTSSTCFN LLKLPNYSKK
1060 1070
SVLREKLRYA ISMNTGFELS
Length:1,070
Mass (Da):122,762
Last modified:October 1, 2002 - v3
Checksum:iAEC9A7F4232A434E
GO

Sequence cautioni

The sequence AAH34059 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244362 mRNA. Translation: AAG16783.3.
BC023956 mRNA. Translation: AAH23956.1.
BC034059 mRNA. Translation: AAH34059.1. Different initiation.
BC096743 mRNA. Translation: AAH96743.1.
CCDSiCCDS19564.1.
RefSeqiNP_473434.2. NM_054093.2.
XP_006530188.1. XM_006530125.1.
UniGeneiMm.28792.

Genome annotation databases

EnsembliENSMUST00000074002; ENSMUSP00000073652; ENSMUSG00000029577.
GeneIDi117146.
KEGGimmu:117146.
UCSCiuc008yzn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF244362 mRNA. Translation: AAG16783.3.
BC023956 mRNA. Translation: AAH23956.1.
BC034059 mRNA. Translation: AAH34059.1. Different initiation.
BC096743 mRNA. Translation: AAH96743.1.
CCDSiCCDS19564.1.
RefSeqiNP_473434.2. NM_054093.2.
XP_006530188.1. XM_006530125.1.
UniGeneiMm.28792.

3D structure databases

ProteinModelPortaliQ9ES34.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000073652.

PTM databases

iPTMnetiQ9ES34.
PhosphoSiteiQ9ES34.

Proteomic databases

MaxQBiQ9ES34.
PaxDbiQ9ES34.
PeptideAtlasiQ9ES34.
PRIDEiQ9ES34.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074002; ENSMUSP00000073652; ENSMUSG00000029577.
GeneIDi117146.
KEGGimmu:117146.
UCSCiuc008yzn.1. mouse.

Organism-specific databases

CTDi89910.
MGIiMGI:1891295. Ube3b.

Phylogenomic databases

eggNOGiKOG0942. Eukaryota.
COG5021. LUCA.
GeneTreeiENSGT00550000074668.
HOGENOMiHOG000232154.
HOVERGENiHBG108644.
InParanoidiQ9ES34.
KOiK10588.
OMAiFQSVHGW.
OrthoDBiEOG091G029A.
PhylomeDBiQ9ES34.
TreeFamiTF313215.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiUbe3b. mouse.
PROiQ9ES34.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029577.
CleanExiMM_UBE3B.
ExpressionAtlasiQ9ES34. baseline and differential.
GenevisibleiQ9ES34. MM.

Family and domain databases

InterProiIPR000569. HECT_dom.
IPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamiPF00632. HECT. 1 hit.
PF00612. IQ. 1 hit.
[Graphical view]
SMARTiSM00119. HECTc. 1 hit.
[Graphical view]
SUPFAMiSSF56204. SSF56204. 1 hit.
PROSITEiPS50237. HECT. 1 hit.
PS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUBE3B_MOUSE
AccessioniPrimary (citable) accession number: Q9ES34
Secondary accession number(s): Q8K068
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.