Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositide phosphatase SAC1

Gene

Sacm1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Phosphoinositide phosphatase that hydrolyzes phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 4-phosphate (PtdIns4P) (By similarity). Has low activity towards PtdIns(3,5)P2 (PubMed:10887188).By similarity1 Publication

GO - Molecular functioni

  • phosphatase activity Source: UniProtKB
  • phosphatidylinositol-3-phosphatase activity Source: RGD
  • phosphatidylinositol-4-phosphate phosphatase activity Source: RGD
  • phosphatidylinositol bisphosphate phosphatase activity Source: RGD

GO - Biological processi

  • phosphatidylinositol dephosphorylation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-RNO-1483248. Synthesis of PIPs at the ER membrane.
R-RNO-1660514. Synthesis of PIPs at the Golgi membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositide phosphatase SAC1 (EC:3.1.3.-)
Alternative name(s):
Suppressor of actin mutations 1-like protein
Gene namesi
Name:Sacm1l
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi69223. Sacm1l.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei56 – 7621HelicalSequence analysisAdd
BLAST
Transmembranei521 – 54121HelicalSequence analysisAdd
BLAST
Transmembranei549 – 56921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • AMPA glutamate receptor complex Source: Ensembl
  • endoplasmic reticulum membrane Source: UniProtKB
  • Golgi apparatus Source: Ensembl
  • integral component of endoplasmic reticulum membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi391 – 3911D → N: Reduces phosphatase activity towards PtdIns(4)P, but not towards PtdIns(3)P or PtdIns(3,5)P2. 1 Publication
Mutagenesisi442 – 4421A → V: Reduces phosphatase activity towards PtdIns(4)P, but not towards PtdIns(3)P or PtdIns(3,5)P2. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Phosphatidylinositide phosphatase SAC1PRO_0000317174Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei456 – 4561N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9ES21.
PRIDEiQ9ES21.

PTM databases

iPTMnetiQ9ES21.
PhosphoSiteiQ9ES21.

Expressioni

Tissue specificityi

Detected in spleen, lung, liver, skeletal muscle, kidney, testis and in cerebellar Purkinje cells (at protein level). Ubiquitous. Highly expressed in brain, spleen, liver and kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000005149.
GenevisibleiQ9ES21. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007223.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini122 – 451330SACPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SAC domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1889. Eukaryota.
COG5329. LUCA.
GeneTreeiENSGT00530000063393.
HOGENOMiHOG000189112.
HOVERGENiHBG108454.
InParanoidiQ9ES21.
OMAiYFATDYD.
OrthoDBiEOG091G03I1.
PhylomeDBiQ9ES21.
TreeFamiTF313543.

Family and domain databases

InterProiIPR002013. SAC_dom.
[Graphical view]
PfamiPF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEiPS50275. SAC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9ES21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATAYEHLK LHITPEKFYV EACDDGADDV LIIDRVSTEV TLAVKKDVPP
60 70 80 90 100
SAVTRPIYGI MGTIHLVAGN YLVVITKKMK VGEFFNHVIW KATDFDVLSY
110 120 130 140 150
KKTMLHLTDI QLQDNKTFLA MLNHVLSTDG FYFSTTYDLT HTLQRLSNTS
160 170 180 190 200
PEFQEMSLLE RADQRFVWNG HLLRELSAQP EVHRFALPVL HGFITMHSCS
210 220 230 240 250
INGKYFDWIL ISRRSCFRAG VRYYVRGIDS EGHAANFVET EQIVHYSGNR
260 270 280 290 300
ASFVQTRGSI PVFWSQRPNL KYKPDPQINK VANHMDGFQR HFDSQVIIYG
310 320 330 340 350
KQVIINLVNH KGSEKPLEQT FAKMVSSLGS GMIRYIAFDF HKECKNMRWD
360 370 380 390 400
RLSILLDQVA EMQDELSYFL VDSAGKVVTN QEGVFRSNCM DCLDRTNVIQ
410 420 430 440 450
SLLARRSLQA QLQRLGVLHV GQKLEEQDEF EKIYKNAWAD NANACAKQYA
460 470 480 490 500
GTGALKTDFT RTGKRTQLGL VMDGFNSLLR YYKNNFSDGF RQDSIDLFLG
510 520 530 540 550
NYSVDELDSH SPLSVPRDWK FLALPIIMVV AFSMCIICLL MAGDTWTETL
560 570 580
AYVLFWGVAS IGTFFIILYN GKDFVDAPRL VQKEKID
Length:587
Mass (Da):67,039
Last modified:March 1, 2001 - v1
Checksum:i77C29FFB08F54FF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251186 mRNA. Translation: AAG29810.1.
RefSeqiNP_446250.1. NM_053798.2.
UniGeneiRn.161978.

Genome annotation databases

EnsembliENSRNOT00000007223; ENSRNOP00000007223; ENSRNOG00000005149.
GeneIDi116482.
KEGGirno:116482.
UCSCiRGD:69223. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF251186 mRNA. Translation: AAG29810.1.
RefSeqiNP_446250.1. NM_053798.2.
UniGeneiRn.161978.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007223.

PTM databases

iPTMnetiQ9ES21.
PhosphoSiteiQ9ES21.

Proteomic databases

PaxDbiQ9ES21.
PRIDEiQ9ES21.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007223; ENSRNOP00000007223; ENSRNOG00000005149.
GeneIDi116482.
KEGGirno:116482.
UCSCiRGD:69223. rat.

Organism-specific databases

CTDi22908.
RGDi69223. Sacm1l.

Phylogenomic databases

eggNOGiKOG1889. Eukaryota.
COG5329. LUCA.
GeneTreeiENSGT00530000063393.
HOGENOMiHOG000189112.
HOVERGENiHBG108454.
InParanoidiQ9ES21.
OMAiYFATDYD.
OrthoDBiEOG091G03I1.
PhylomeDBiQ9ES21.
TreeFamiTF313543.

Enzyme and pathway databases

ReactomeiR-RNO-1483248. Synthesis of PIPs at the ER membrane.
R-RNO-1660514. Synthesis of PIPs at the Golgi membrane.

Miscellaneous databases

PROiQ9ES21.

Gene expression databases

BgeeiENSRNOG00000005149.
GenevisibleiQ9ES21. RN.

Family and domain databases

InterProiIPR002013. SAC_dom.
[Graphical view]
PfamiPF02383. Syja_N. 1 hit.
[Graphical view]
PROSITEiPS50275. SAC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAC1_RAT
AccessioniPrimary (citable) accession number: Q9ES21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: March 1, 2001
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.