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Q9ES17

- IL21_MOUSE

UniProt

Q9ES17 - IL21_MOUSE

Protein

Interleukin-21

Gene

Il21

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells By similarity. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.By similarity3 Publications

    GO - Molecular functioni

    1. cytokine receptor binding Source: MGI

    GO - Biological processi

    1. B cell apoptotic process Source: UniProtKB
    2. cell maturation Source: Ensembl
    3. immune response Source: InterPro
    4. positive regulation of B cell differentiation Source: UniProtKB
    5. positive regulation of B cell proliferation Source: Ensembl
    6. positive regulation of interferon-gamma biosynthetic process Source: MGI
    7. positive regulation of interleukin-10 production Source: MGI
    8. positive regulation of interleukin-17 production Source: Ensembl
    9. positive regulation of natural killer cell cytokine production Source: MGI
    10. positive regulation of natural killer cell differentiation Source: MGI
    11. positive regulation of natural killer cell mediated cytotoxicity Source: MGI
    12. positive regulation of T cell proliferation Source: Ensembl
    13. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    14. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-21
    Short name:
    IL-21
    Gene namesi
    Name:Il21
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1890474. Il21.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 146129Interleukin-21PRO_0000015506Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi64 ↔ 115Sequence Analysis
    Disulfide bondi71 ↔ 118Sequence Analysis
    Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Gene expression databases

    ArrayExpressiQ9ES17.
    BgeeiQ9ES17.
    CleanExiMM_IL21.
    GenevestigatoriQ9ES17.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000029273.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9ES17.
    SMRiQ9ES17. Positions 23-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-15/IL-21 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40525.
    GeneTreeiENSGT00390000010494.
    HOGENOMiHOG000113039.
    HOVERGENiHBG052106.
    InParanoidiQ9ES17.
    KOiK05434.
    OrthoDBiEOG7M98JN.
    PhylomeDBiQ9ES17.
    TreeFamiTF336380.

    Family and domain databases

    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR003443. IL-15/IL-21_fam.
    IPR028151. IL-21.
    [Graphical view]
    PANTHERiPTHR14356. PTHR14356. 1 hit.
    PfamiPF02372. IL15. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9ES17-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERTLVCLVV IFLGTVAHKS SPQGPDRLLI RLRHLIDIVE QLKIYENDLD    50
    PELLSAPQDV KGHCEHAAFA CFQKAKLKPS NPGNNKTFII DLVAQLRRRL 100
    PARRGGKKQK HIAKCPSCDS YEKRTPKEFL ERLKWLLQKM IHQHLS 146
    Length:146
    Mass (Da):16,811
    Last modified:March 1, 2001 - v1
    Checksum:iD2527ED95BA15194
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254070 mRNA. Translation: AAG29349.1.
    AY428162 mRNA. Translation: AAR06254.1.
    CCDSiCCDS17317.1.
    RefSeqiNP_068554.1. NM_021782.3.
    UniGeneiMm.157689.

    Genome annotation databases

    EnsembliENSMUST00000029273; ENSMUSP00000029273; ENSMUSG00000027718.
    GeneIDi60505.
    KEGGimmu:60505.
    UCSCiuc008paj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254070 mRNA. Translation: AAG29349.1 .
    AY428162 mRNA. Translation: AAR06254.1 .
    CCDSi CCDS17317.1.
    RefSeqi NP_068554.1. NM_021782.3.
    UniGenei Mm.157689.

    3D structure databases

    ProteinModelPortali Q9ES17.
    SMRi Q9ES17. Positions 23-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000029273.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000029273 ; ENSMUSP00000029273 ; ENSMUSG00000027718 .
    GeneIDi 60505.
    KEGGi mmu:60505.
    UCSCi uc008paj.1. mouse.

    Organism-specific databases

    CTDi 59067.
    MGIi MGI:1890474. Il21.

    Phylogenomic databases

    eggNOGi NOG40525.
    GeneTreei ENSGT00390000010494.
    HOGENOMi HOG000113039.
    HOVERGENi HBG052106.
    InParanoidi Q9ES17.
    KOi K05434.
    OrthoDBi EOG7M98JN.
    PhylomeDBi Q9ES17.
    TreeFami TF336380.

    Miscellaneous databases

    NextBioi 314909.
    PROi Q9ES17.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9ES17.
    Bgeei Q9ES17.
    CleanExi MM_IL21.
    Genevestigatori Q9ES17.

    Family and domain databases

    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR003443. IL-15/IL-21_fam.
    IPR028151. IL-21.
    [Graphical view ]
    PANTHERi PTHR14356. PTHR14356. 1 hit.
    Pfami PF02372. IL15. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "Mouse interleukin 21 can improve the anti-tumor effect of LAK cells."
      Guobing C., Jun D., Junsong C., Fenshu Z.
      Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity."
      Kasaian M.T., Whitters M.J., Carter L.L., Lowe L.D., Jussif J.M., Deng B., Johnson K.A., Witek J.S., Senices M., Konz R.F., Wurster A.L., Donaldson D.D., Collins M., Young D.A., Grusby M.J.
      Immunity 16:559-569(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    4. "Interleukin-21 inhibits dendritic cell activation and maturation."
      Brandt K., Bulfone-Paus S., Foster D.C., Rueckert R.
      Blood 102:4090-4098(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells."
      Pene J., Gauchat J.-F., Lecart S., Drouet E., Guglielmi P., Boulay V., Delwail A., Foster D., Lecron J.C., Yssel H.
      J. Immunol. 172:5154-5157(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiIL21_MOUSE
    AccessioniPrimary (citable) accession number: Q9ES17
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: March 1, 2001
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3