Q9ES17 (IL21_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-21
Short name=IL-21

Gene names

Name:

Il21

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells By similarity. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Ref.3 Ref.4 Ref.5
Subcellular location	Secreted Ref.3.
Sequence similarities	Belongs to the IL-15/IL-21 family.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Cytokine
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	B cell apoptotic process Non-traceable author statement PubMed 15494482. Source: UniProtKB cell maturation Inferred from electronic annotation. Source: Compara immune response Inferred from electronic annotation. Source: InterPro positive regulation of B cell differentiation Non-traceable author statement PubMed 15494482. Source: UniProtKB positive regulation of T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of interferon-gamma biosynthetic process Inferred from direct assay PubMed 14764669. Source: MGI positive regulation of interleukin-10 production Inferred from direct assay PubMed 14764669. Source: MGI positive regulation of interleukin-17 production Inferred from electronic annotation. Source: Compara positive regulation of natural killer cell cytokine production Inferred from direct assay PubMed 14764669. Source: MGI positive regulation of natural killer cell differentiation Inferred from direct assay PubMed 14764669. Source: MGI positive regulation of natural killer cell mediated cytotoxicity Inferred from direct assay PubMed 14764669. Source: MGI
Cellular_component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	cytokine receptor binding Inferred from direct assay Ref.1. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 146	129	Interleukin-21		PRO_0000015506
Amino acid modifications
	Glycosylation	85	1	N-linked (GlcNAc...) Potential
	Disulfide bond	64 ↔ 115		Potential
	Disulfide bond	71 ↔ 118		Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9ES17 [UniParc]. Last modified March 1, 2001. Version 1. Checksum: D2527ED95BA15194	FASTA	146	16,811
	10 20 30 40 50 60 MERTLVCLVV IFLGTVAHKS SPQGPDRLLI RLRHLIDIVE QLKIYENDLD PELLSAPQDV 70 80 90 100 110 120 KGHCEHAAFA CFQKAKLKPS NPGNNKTFII DLVAQLRRRL PARRGGKKQK HIAKCPSCDS 130 140 YEKRTPKEFL ERLKWLLQKM IHQHLS

References

[1]	"Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function." Parrish-Novak J., Dillon S.R., Nelson A., Hammond A., Sprecher C., Gross J.A., Johnston J., Madden K., Xu W., West J., Schrader S., Burkhead S., Heipel M., Brandt C., Kuijper J.L., Kramer J., Conklin D., Presnell S.R. , Berry J., Shiota F., Bort S., Hambly K., Mudri S., Clegg C., Moore M., Grant F.J., Lofton-Day C., Gilbert T., Raymond F., Ching A., Yao L., Smith D., Webster P., Whitmore T., Maurer M., Kaushansky K., Holly R.D., Foster D. Nature 408:57-63(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"Mouse interleukin 21 can improve the anti-tumor effect of LAK cells." Guobing C., Jun D., Junsong C., Fenshu Z. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[3]	"IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity." Kasaian M.T., Whitters M.J., Carter L.L., Lowe L.D., Jussif J.M., Deng B., Johnson K.A., Witek J.S., Senices M., Konz R.F., Wurster A.L., Donaldson D.D., Collins M., Young D.A., Grusby M.J. Immunity 16:559-569(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]	"Interleukin-21 inhibits dendritic cell activation and maturation." Brandt K., Bulfone-Paus S., Foster D.C., Rueckert R. Blood 102:4090-4098(2003) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[5]	"IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells." Pene J., Gauchat J.-F., Lecart S., Drouet E., Guglielmi P., Boulay V., Delwail A., Foster D., Lecron J.C., Yssel H. J. Immunol. 172:5154-5157(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF254070 mRNA. Translation: AAG29349.1. AY428162 mRNA. Translation: AAR06254.1.
IPI	IPI00112642.
RefSeq	NP_068554.1. NM_021782.2.
UniGene	Mm.157689.
3D structure databases
ProteinModelPortal	Q9ES17.
SMR	Q9ES17. Positions 23-146.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000029273.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000029273; ENSMUSP00000029273; ENSMUSG00000027718.
GeneID	60505.
KEGG	mmu:60505.
Organism-specific databases
CTD	59067.
MGI	MGI:1890474. Il21.
Phylogenomic databases
eggNOG	NOG40525.
GeneTree	ENSGT00390000010494.
HOGENOM	HOG000113039.
HOVERGEN	HBG052106.
InParanoid	Q9ES17.
KO	K05434.
OrthoDB	EOG4DJJXM.
Gene expression databases
ArrayExpress	Q9ES17.
Bgee	Q9ES17.
CleanEx	MM_IL21.
Genevestigator	Q9ES17.
GermOnline	ENSMUSG00000027718. Mus musculus.
Family and domain databases
InterPro	IPR003443. Interleukin_15-like. [Graphical view]
Pfam	PF02372. IL15. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	314909.
SOURCE	Search...

Entry information

Entry name

IL21_MOUSE

Accession

Primary (citable) accession number: Q9ES17

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 23, 2004
Last sequence update:	March 1, 2001
Last modified:	April 3, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program