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Protein

Interleukin-21

Gene

Il21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.By similarity3 Publications

GO - Molecular functioni

  1. cytokine receptor binding Source: MGI
  2. interleukin-2 receptor binding Source: MGI

GO - Biological processi

  1. B cell apoptotic process Source: UniProtKB
  2. cell maturation Source: MGI
  3. immune response Source: InterPro
  4. positive regulation of B cell differentiation Source: UniProtKB
  5. positive regulation of B cell proliferation Source: MGI
  6. positive regulation of cell proliferation Source: MGI
  7. positive regulation of interferon-gamma biosynthetic process Source: MGI
  8. positive regulation of interleukin-10 production Source: MGI
  9. positive regulation of interleukin-17 production Source: MGI
  10. positive regulation of natural killer cell cytokine production Source: MGI
  11. positive regulation of natural killer cell differentiation Source: MGI
  12. positive regulation of natural killer cell mediated cytotoxicity Source: MGI
  13. positive regulation of T cell proliferation Source: MGI
  14. positive regulation of tyrosine phosphorylation of Stat1 protein Source: MGI
  15. positive regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-21
Short name:
IL-21
Gene namesi
Name:Il21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1890474. Il21.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 146129Interleukin-21PRO_0000015506Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 115Sequence Analysis
Disulfide bondi71 ↔ 118Sequence Analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiQ9ES17.
CleanExiMM_IL21.
ExpressionAtlasiQ9ES17. baseline and differential.
GenevestigatoriQ9ES17.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029273.

Structurei

3D structure databases

SMRiQ9ES17. Positions 23-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40525.
GeneTreeiENSGT00390000010494.
HOGENOMiHOG000113039.
HOVERGENiHBG052106.
InParanoidiQ9ES17.
KOiK05434.
OrthoDBiEOG7M98JN.
PhylomeDBiQ9ES17.
TreeFamiTF336380.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view]
PANTHERiPTHR14356. PTHR14356. 1 hit.
PfamiPF02372. IL15. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ES17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTLVCLVV IFLGTVAHKS SPQGPDRLLI RLRHLIDIVE QLKIYENDLD
60 70 80 90 100
PELLSAPQDV KGHCEHAAFA CFQKAKLKPS NPGNNKTFII DLVAQLRRRL
110 120 130 140
PARRGGKKQK HIAKCPSCDS YEKRTPKEFL ERLKWLLQKM IHQHLS
Length:146
Mass (Da):16,811
Last modified:February 28, 2001 - v1
Checksum:iD2527ED95BA15194
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254070 mRNA. Translation: AAG29349.1.
AY428162 mRNA. Translation: AAR06254.1.
CCDSiCCDS17317.1.
RefSeqiNP_068554.1. NM_021782.3.
UniGeneiMm.157689.

Genome annotation databases

EnsembliENSMUST00000029273; ENSMUSP00000029273; ENSMUSG00000027718.
GeneIDi60505.
KEGGimmu:60505.
UCSCiuc008paj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254070 mRNA. Translation: AAG29349.1.
AY428162 mRNA. Translation: AAR06254.1.
CCDSiCCDS17317.1.
RefSeqiNP_068554.1. NM_021782.3.
UniGeneiMm.157689.

3D structure databases

SMRiQ9ES17. Positions 23-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029273.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029273; ENSMUSP00000029273; ENSMUSG00000027718.
GeneIDi60505.
KEGGimmu:60505.
UCSCiuc008paj.1. mouse.

Organism-specific databases

CTDi59067.
MGIiMGI:1890474. Il21.

Phylogenomic databases

eggNOGiNOG40525.
GeneTreeiENSGT00390000010494.
HOGENOMiHOG000113039.
HOVERGENiHBG052106.
InParanoidiQ9ES17.
KOiK05434.
OrthoDBiEOG7M98JN.
PhylomeDBiQ9ES17.
TreeFamiTF336380.

Miscellaneous databases

NextBioi314909.
PROiQ9ES17.
SOURCEiSearch...

Gene expression databases

BgeeiQ9ES17.
CleanExiMM_IL21.
ExpressionAtlasiQ9ES17. baseline and differential.
GenevestigatoriQ9ES17.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view]
PANTHERiPTHR14356. PTHR14356. 1 hit.
PfamiPF02372. IL15. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Mouse interleukin 21 can improve the anti-tumor effect of LAK cells."
    Guobing C., Jun D., Junsong C., Fenshu Z.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity."
    Kasaian M.T., Whitters M.J., Carter L.L., Lowe L.D., Jussif J.M., Deng B., Johnson K.A., Witek J.S., Senices M., Konz R.F., Wurster A.L., Donaldson D.D., Collins M., Young D.A., Grusby M.J.
    Immunity 16:559-569(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "Interleukin-21 inhibits dendritic cell activation and maturation."
    Brandt K., Bulfone-Paus S., Foster D.C., Rueckert R.
    Blood 102:4090-4098(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells."
    Pene J., Gauchat J.-F., Lecart S., Drouet E., Guglielmi P., Boulay V., Delwail A., Foster D., Lecron J.C., Yssel H.
    J. Immunol. 172:5154-5157(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiIL21_MOUSE
AccessioniPrimary (citable) accession number: Q9ES17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2004
Last sequence update: February 28, 2001
Last modified: March 31, 2015
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.