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Q9ES17 (IL21_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-21

Short name=IL-21
Gene names
Name:Il21
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length146 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells By similarity. During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation. Ref.3 Ref.4 Ref.5

Subcellular location

Secreted Ref.3.

Sequence similarities

Belongs to the IL-15/IL-21 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processB cell apoptotic process

Non-traceable author statement PubMed 15494482. Source: UniProtKB

cell maturation

Inferred from electronic annotation. Source: Ensembl

immune response

Inferred from electronic annotation. Source: InterPro

positive regulation of B cell differentiation

Non-traceable author statement PubMed 15494482. Source: UniProtKB

positive regulation of B cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of interferon-gamma biosynthetic process

Inferred from direct assay PubMed 14764669. Source: MGI

positive regulation of interleukin-10 production

Inferred from direct assay PubMed 14764669. Source: MGI

positive regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of natural killer cell cytokine production

Inferred from direct assay PubMed 14764669. Source: MGI

positive regulation of natural killer cell differentiation

Inferred from direct assay PubMed 14764669. Source: MGI

positive regulation of natural killer cell mediated cytotoxicity

Inferred from direct assay PubMed 14764669. Source: MGI

positive regulation of tyrosine phosphorylation of Stat1 protein

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat3 protein

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncytokine receptor binding

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 146129Interleukin-21
PRO_0000015506

Amino acid modifications

Glycosylation851N-linked (GlcNAc...) Potential
Disulfide bond64 ↔ 115 Potential
Disulfide bond71 ↔ 118 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9ES17 [UniParc].

Last modified March 1, 2001. Version 1.
Checksum: D2527ED95BA15194

FASTA14616,811
        10         20         30         40         50         60 
MERTLVCLVV IFLGTVAHKS SPQGPDRLLI RLRHLIDIVE QLKIYENDLD PELLSAPQDV 

        70         80         90        100        110        120 
KGHCEHAAFA CFQKAKLKPS NPGNNKTFII DLVAQLRRRL PARRGGKKQK HIAKCPSCDS 

       130        140 
YEKRTPKEFL ERLKWLLQKM IHQHLS 

« Hide

References

[1]"Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function."
Parrish-Novak J., Dillon S.R., Nelson A., Hammond A., Sprecher C., Gross J.A., Johnston J., Madden K., Xu W., West J., Schrader S., Burkhead S., Heipel M., Brandt C., Kuijper J.L., Kramer J., Conklin D., Presnell S.R. expand/collapse author list , Berry J., Shiota F., Bort S., Hambly K., Mudri S., Clegg C., Moore M., Grant F.J., Lofton-Day C., Gilbert T., Raymond F., Ching A., Yao L., Smith D., Webster P., Whitmore T., Maurer M., Kaushansky K., Holly R.D., Foster D.
Nature 408:57-63(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"Mouse interleukin 21 can improve the anti-tumor effect of LAK cells."
Guobing C., Jun D., Junsong C., Fenshu Z.
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[3]"IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity."
Kasaian M.T., Whitters M.J., Carter L.L., Lowe L.D., Jussif J.M., Deng B., Johnson K.A., Witek J.S., Senices M., Konz R.F., Wurster A.L., Donaldson D.D., Collins M., Young D.A., Grusby M.J.
Immunity 16:559-569(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
[4]"Interleukin-21 inhibits dendritic cell activation and maturation."
Brandt K., Bulfone-Paus S., Foster D.C., Rueckert R.
Blood 102:4090-4098(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells."
Pene J., Gauchat J.-F., Lecart S., Drouet E., Guglielmi P., Boulay V., Delwail A., Foster D., Lecron J.C., Yssel H.
J. Immunol. 172:5154-5157(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF254070 mRNA. Translation: AAG29349.1.
AY428162 mRNA. Translation: AAR06254.1.
RefSeqNP_068554.1. NM_021782.2.
UniGeneMm.157689.

3D structure databases

ProteinModelPortalQ9ES17.
SMRQ9ES17. Positions 23-146.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000029273.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000029273; ENSMUSP00000029273; ENSMUSG00000027718.
GeneID60505.
KEGGmmu:60505.
UCSCuc008paj.1. mouse.

Organism-specific databases

CTD59067.
MGIMGI:1890474. Il21.

Phylogenomic databases

eggNOGNOG40525.
GeneTreeENSGT00390000010494.
HOGENOMHOG000113039.
HOVERGENHBG052106.
InParanoidQ9ES17.
KOK05434.
OrthoDBEOG7M98JN.
PhylomeDBQ9ES17.
TreeFamTF336380.

Gene expression databases

ArrayExpressQ9ES17.
BgeeQ9ES17.
CleanExMM_IL21.
GenevestigatorQ9ES17.

Family and domain databases

InterProIPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view]
PANTHERPTHR14356:SF0. PTHR14356:SF0. 1 hit.
PfamPF02372. IL15. 1 hit.
[Graphical view]
SUPFAMSSF47266. SSF47266. 1 hit.
ProtoNetSearch...

Other

NextBio314909.
PROQ9ES17.
SOURCESearch...

Entry information

Entry nameIL21_MOUSE
AccessionPrimary (citable) accession number: Q9ES17
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2001
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot