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Q9ES17

- IL21_MOUSE

UniProt

Q9ES17 - IL21_MOUSE

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Protein

Interleukin-21

Gene

Il21

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG1 and IgG3 in B-cells. May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15. May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation.By similarity3 Publications

GO - Molecular functioni

  1. cytokine receptor binding Source: MGI

GO - Biological processi

  1. B cell apoptotic process Source: UniProtKB
  2. cell maturation Source: Ensembl
  3. immune response Source: InterPro
  4. positive regulation of B cell differentiation Source: UniProtKB
  5. positive regulation of B cell proliferation Source: Ensembl
  6. positive regulation of interferon-gamma biosynthetic process Source: MGI
  7. positive regulation of interleukin-10 production Source: MGI
  8. positive regulation of interleukin-17 production Source: Ensembl
  9. positive regulation of natural killer cell cytokine production Source: MGI
  10. positive regulation of natural killer cell differentiation Source: MGI
  11. positive regulation of natural killer cell mediated cytotoxicity Source: MGI
  12. positive regulation of T cell proliferation Source: Ensembl
  13. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
  14. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-21
Short name:
IL-21
Gene namesi
Name:Il21
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1890474. Il21.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 146129Interleukin-21PRO_0000015506Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi64 ↔ 115Sequence Analysis
Disulfide bondi71 ↔ 118Sequence Analysis
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Gene expression databases

BgeeiQ9ES17.
CleanExiMM_IL21.
ExpressionAtlasiQ9ES17. baseline and differential.
GenevestigatoriQ9ES17.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029273.

Structurei

3D structure databases

ProteinModelPortaliQ9ES17.
SMRiQ9ES17. Positions 23-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-15/IL-21 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG40525.
GeneTreeiENSGT00390000010494.
HOGENOMiHOG000113039.
HOVERGENiHBG052106.
InParanoidiQ9ES17.
KOiK05434.
OrthoDBiEOG7M98JN.
PhylomeDBiQ9ES17.
TreeFamiTF336380.

Family and domain databases

InterProiIPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view]
PANTHERiPTHR14356. PTHR14356. 1 hit.
PfamiPF02372. IL15. 1 hit.
[Graphical view]
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ES17-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MERTLVCLVV IFLGTVAHKS SPQGPDRLLI RLRHLIDIVE QLKIYENDLD
60 70 80 90 100
PELLSAPQDV KGHCEHAAFA CFQKAKLKPS NPGNNKTFII DLVAQLRRRL
110 120 130 140
PARRGGKKQK HIAKCPSCDS YEKRTPKEFL ERLKWLLQKM IHQHLS
Length:146
Mass (Da):16,811
Last modified:March 1, 2001 - v1
Checksum:iD2527ED95BA15194
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF254070 mRNA. Translation: AAG29349.1.
AY428162 mRNA. Translation: AAR06254.1.
CCDSiCCDS17317.1.
RefSeqiNP_068554.1. NM_021782.3.
UniGeneiMm.157689.

Genome annotation databases

EnsembliENSMUST00000029273; ENSMUSP00000029273; ENSMUSG00000027718.
GeneIDi60505.
KEGGimmu:60505.
UCSCiuc008paj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF254070 mRNA. Translation: AAG29349.1 .
AY428162 mRNA. Translation: AAR06254.1 .
CCDSi CCDS17317.1.
RefSeqi NP_068554.1. NM_021782.3.
UniGenei Mm.157689.

3D structure databases

ProteinModelPortali Q9ES17.
SMRi Q9ES17. Positions 23-146.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000029273.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000029273 ; ENSMUSP00000029273 ; ENSMUSG00000027718 .
GeneIDi 60505.
KEGGi mmu:60505.
UCSCi uc008paj.1. mouse.

Organism-specific databases

CTDi 59067.
MGIi MGI:1890474. Il21.

Phylogenomic databases

eggNOGi NOG40525.
GeneTreei ENSGT00390000010494.
HOGENOMi HOG000113039.
HOVERGENi HBG052106.
InParanoidi Q9ES17.
KOi K05434.
OrthoDBi EOG7M98JN.
PhylomeDBi Q9ES17.
TreeFami TF336380.

Miscellaneous databases

NextBioi 314909.
PROi Q9ES17.
SOURCEi Search...

Gene expression databases

Bgeei Q9ES17.
CleanExi MM_IL21.
ExpressionAtlasi Q9ES17. baseline and differential.
Genevestigatori Q9ES17.

Family and domain databases

InterProi IPR009079. 4_helix_cytokine-like_core.
IPR003443. IL-15/IL-21_fam.
IPR028151. IL-21.
[Graphical view ]
PANTHERi PTHR14356. PTHR14356. 1 hit.
Pfami PF02372. IL15. 1 hit.
[Graphical view ]
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  2. "Mouse interleukin 21 can improve the anti-tumor effect of LAK cells."
    Guobing C., Jun D., Junsong C., Fenshu Z.
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "IL-21 limits NK cell responses and promotes antigen-specific T cell activation: a mediator of the transition from innate to adaptive immunity."
    Kasaian M.T., Whitters M.J., Carter L.L., Lowe L.D., Jussif J.M., Deng B., Johnson K.A., Witek J.S., Senices M., Konz R.F., Wurster A.L., Donaldson D.D., Collins M., Young D.A., Grusby M.J.
    Immunity 16:559-569(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  4. "Interleukin-21 inhibits dendritic cell activation and maturation."
    Brandt K., Bulfone-Paus S., Foster D.C., Rueckert R.
    Blood 102:4090-4098(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "IL-21 is a switch factor for the production of IgG1 and IgG3 by human B cells."
    Pene J., Gauchat J.-F., Lecart S., Drouet E., Guglielmi P., Boulay V., Delwail A., Foster D., Lecron J.C., Yssel H.
    J. Immunol. 172:5154-5157(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiIL21_MOUSE
AccessioniPrimary (citable) accession number: Q9ES17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 1, 2001
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3