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Protein

Gamma-aminobutyric acid receptor subunit epsilon

Gene

Gabre

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.By similarity

GO - Molecular functioni

GO - Biological processi

  • chloride transport Source: RGD
  • gamma-aminobutyric acid signaling pathway Source: RGD
  • response to drug Source: RGD

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit epsilon
Alternative name(s):
GABA(A) receptor subunit epsilon
Gene namesi
Name:Gabre
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68320 Gabre

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 254ExtracellularCuratedAdd BLAST232
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Transmembranei282 – 302HelicalSequence analysisAdd BLAST21
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Topological domaini366 – 485CytoplasmicCuratedAdd BLAST120
Transmembranei486 – 506HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1907607

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000000047223 – 506Gamma-aminobutyric acid receptor subunit epsilonAdd BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi196 ↔ 210By similarity
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ES14
PRIDEiQ9ES14

Interactioni

Subunit structurei

Generally pentameric. Associates with alpha and beta subunits (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022431

Structurei

3D structure databases

ProteinModelPortaliQ9ES14
SMRiQ9ES14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
HOVERGENiHBG051707
InParanoidiQ9ES14

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR008099 GABAAe_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01723 GABAAREPSLON
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ES14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPKVLLMLL NMFLALQWRV GPHIKLENKP PAQDKVVFGP QPQPSGKKLP
60 70 80 90 100
ARETELTADH TTERPRGKLT RASQILNTIL SNYDHKLRPS IGEKPTVVTV
110 120 130 140 150
KVFVNSLGPI SILDMEYSID IIFYQTWYDE RLRYNDTFET LILHGNVVSQ
160 170 180 190 200
LWIPDTFFRN SKRTQEYDIT IPNQMALIHK DGKVLYTVRM TIDARCSLHM
210 220 230 240 250
LNFPMDSHSC PLSFSSFSYD EHEMIYKWEN FKLKIDAKNT WKLLEFDFTG
260 270 280 290 300
VNNKTEIIST PVGDFMVMTF FFNVSRRFGF IVFQNYIPSS VTTMLSWVSF
310 320 330 340 350
WIKIEAAAAR ASVGVSSVLT MATLGTFSRK NFPRVSYLTA LDFYIAICFV
360 370 380 390 400
LCFCTLLEFT VLNFLTYNNI ERQASPKFYQ FPTNSRANAR TRARARTRAR
410 420 430 440 450
ARARARQQQE VFVCEIVTYE ENAEEGYQWS PRSRRPQCPW RRCGRSYVCF
460 470 480 490 500
RVLRKYFCMV PGCEGNNWQR GRICIHVYRL DNYSRVLFPI TFFFFNVVYW

VICLNL
Length:506
Mass (Da):59,219
Last modified:March 1, 2001 - v1
Checksum:i8C2FBECF10686E57
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133R → C in AAB93879 (Ref. 2) Curated1
Sequence conflicti467N → S in AAB93879 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255612 mRNA Translation: AAG17631.1
U92284 Genomic DNA Translation: AAB93879.1
UniGeneiRn.54455

Similar proteinsi

Entry informationi

Entry nameiGBRE_RAT
AccessioniPrimary (citable) accession number: Q9ES14
Secondary accession number(s): O55209
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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