Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gamma-aminobutyric acid receptor subunit epsilon

Gene

Gabre

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.By similarity

GO - Molecular functioni

GO - Biological processi

  • chloride transport Source: RGD
  • gamma-aminobutyric acid signaling pathway Source: RGD
  • response to drug Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Chloride

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit epsilon
Alternative name(s):
GABA(A) receptor subunit epsilon
Gene namesi
Name:Gabre
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi68320. Gabre.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 254232ExtracellularCuratedAdd
BLAST
Transmembranei255 – 27521HelicalSequence analysisAdd
BLAST
Transmembranei282 – 30221HelicalSequence analysisAdd
BLAST
Transmembranei345 – 36521HelicalSequence analysisAdd
BLAST
Topological domaini366 – 485120CytoplasmicCuratedAdd
BLAST
Transmembranei486 – 50621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1907607.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence analysisAdd
BLAST
Chaini23 – 506484Gamma-aminobutyric acid receptor subunit epsilonPRO_0000000472Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi135 – 1351N-linked (GlcNAc...)Sequence analysis
Disulfide bondi196 ↔ 210By similarity
Glycosylationi253 – 2531N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9ES14.
PRIDEiQ9ES14.

Interactioni

Subunit structurei

Generally pentameric. Associates with alpha and beta subunits (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022431.

Structurei

3D structure databases

ProteinModelPortaliQ9ES14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
HOVERGENiHBG051707.
InParanoidiQ9ES14.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008099. GABAAe_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01723. GABAAREPSLON.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9ES14-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLPKVLLMLL NMFLALQWRV GPHIKLENKP PAQDKVVFGP QPQPSGKKLP
60 70 80 90 100
ARETELTADH TTERPRGKLT RASQILNTIL SNYDHKLRPS IGEKPTVVTV
110 120 130 140 150
KVFVNSLGPI SILDMEYSID IIFYQTWYDE RLRYNDTFET LILHGNVVSQ
160 170 180 190 200
LWIPDTFFRN SKRTQEYDIT IPNQMALIHK DGKVLYTVRM TIDARCSLHM
210 220 230 240 250
LNFPMDSHSC PLSFSSFSYD EHEMIYKWEN FKLKIDAKNT WKLLEFDFTG
260 270 280 290 300
VNNKTEIIST PVGDFMVMTF FFNVSRRFGF IVFQNYIPSS VTTMLSWVSF
310 320 330 340 350
WIKIEAAAAR ASVGVSSVLT MATLGTFSRK NFPRVSYLTA LDFYIAICFV
360 370 380 390 400
LCFCTLLEFT VLNFLTYNNI ERQASPKFYQ FPTNSRANAR TRARARTRAR
410 420 430 440 450
ARARARQQQE VFVCEIVTYE ENAEEGYQWS PRSRRPQCPW RRCGRSYVCF
460 470 480 490 500
RVLRKYFCMV PGCEGNNWQR GRICIHVYRL DNYSRVLFPI TFFFFNVVYW

VICLNL
Length:506
Mass (Da):59,219
Last modified:March 1, 2001 - v1
Checksum:i8C2FBECF10686E57
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331R → C in AAB93879 (Ref. 2) Curated
Sequence conflicti467 – 4671N → S in AAB93879 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255612 mRNA. Translation: AAG17631.1.
U92284 Genomic DNA. Translation: AAB93879.1.
UniGeneiRn.54455.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255612 mRNA. Translation: AAG17631.1.
U92284 Genomic DNA. Translation: AAB93879.1.
UniGeneiRn.54455.

3D structure databases

ProteinModelPortaliQ9ES14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022431.

Chemistry

ChEMBLiCHEMBL1907607.

Proteomic databases

PaxDbiQ9ES14.
PRIDEiQ9ES14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi68320. Gabre.

Phylogenomic databases

eggNOGiKOG3642. Eukaryota.
ENOG410XNQG. LUCA.
HOVERGENiHBG051707.
InParanoidiQ9ES14.

Miscellaneous databases

PROiQ9ES14.

Family and domain databases

Gene3Di2.70.170.10. 1 hit.
InterProiIPR006028. GABAA/Glycine_rcpt.
IPR008099. GABAAe_rcpt.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00253. GABAARECEPTR.
PR01723. GABAAREPSLON.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning and expression of a gamma-aminobutyric acid A receptor epsilon-subunit in rat brain."
    Moragues N., Ciofi P., Lafon P., Odessa M.F., Tramu G., Garret M.
    Eur. J. Neurosci. 12:4318-4330(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Alternative transcripts of a gene encoding the GABA-A receptor epsilon subunit on chromosome Xq28."
    Hanna M.C., Hales T.G., Kirkness E.F.
    Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 123-506.

Entry informationi

Entry nameiGBRE_RAT
AccessioniPrimary (citable) accession number: Q9ES14
Secondary accession number(s): O55209
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: March 1, 2001
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.