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Protein

Potassium channel subfamily K member 9

Gene

Kcnk9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

pH-dependent, voltage-insensitive, background potassium channel protein.2 Publications

GO - Molecular functioni

  • potassium ion leak channel activity Source: GO_Central
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • voltage-gated potassium channel activity Source: Ensembl

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiR-RNO-1299316. TWIK-releated acid-sensitive K+ channel (TASK).

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 9
Alternative name(s):
Acid-sensitive potassium channel protein TASK-3
TWIK-related acid-sensitive K(+) channel 3
Two pore potassium channel KT3.2
Short name:
Two pore K(+) channel KT3.2
Gene namesi
Name:Kcnk9
Synonyms:Task3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621451. Kcnk9.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 88ExtracellularSequence analysisAdd BLAST59
Intramembranei89 – 101Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST13
Topological domaini102 – 107ExtracellularSequence analysis6
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 158CytoplasmicSequence analysisAdd BLAST30
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 194ExtracellularSequence analysisAdd BLAST15
Intramembranei195 – 207Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST13
Topological domaini208 – 218ExtracellularSequence analysisAdd BLAST11
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 396CytoplasmicSequence analysisAdd BLAST157

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: RGD
  • synaptic vesicle Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi98H → D: Reduces sensitivity to alterations in external pH. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017561 – 396Potassium channel subfamily K member 9Add BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ES08.

Expressioni

Tissue specificityi

Highly expressed in the CNS and at lower levels in the colon, kidney, liver, lung, spleen, stomach and skeletal muscle. The highest expression was found in the olfactory nuclei, piriform cortex, cerebellum, antedorsal thalmic nucleus, pontine nucleus, dorsal raphe and several nuclei in the medulla. Shows a non-homogeneous distribution in the hippocampus. Expressed at highest levels in the lateral posterior and inferior portions and at medium levels in neocortex.4 Publications

Gene expression databases

BgeeiENSRNOG00000009265.
GenevisibleiQ9ES08. RN.

Interactioni

Subunit structurei

Homodimer. Heterodimer with KCNK1.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

DIPiDIP-61122N.
STRINGi10116.ENSRNOP00000012408.

Structurei

3D structure databases

ProteinModelPortaliQ9ES08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ9ES08.
KOiK04919.
OMAiIEREHEI.
OrthoDBiEOG091G08DH.
PhylomeDBiQ9ES08.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
IPR005407. KCNK9.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01585. TASK3CHANNEL.
PR01095. TASKCHANNEL.

Sequencei

Sequence statusi: Complete.

Q9ES08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQNVRTLS LIACTFTYLL VGAAVFDALE SDHEMREEEK LKAEEVRLRG
60 70 80 90 100
KYNISSDDYQ QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PGTDAGKAFC MFYAVLGIPL TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR
160 170 180 190 200
NTEVSMENMV TVGFFSCMGT LCLGAAAFSQ CEDWSFFHAY YYCFITLTTI
210 220 230 240 250
GFGDFVALQS KGALQRKPFY VAFSFMYILV GLTVIGAFLN LVVLRFLTMN
260 270 280 290 300
TDEDLLEGEV AQILAGNPRR VVVRVPQSRK RHHPMYFLRK YGRTLCYLCF
310 320 330 340 350
PGANWGDDDD DDDDAVENVV VTTPVPPAVA AAAAAATPGP STRNVRATVH
360 370 380 390
SVSCRVEEIP PDVLRNTYFR SPFGAIPPGM HTCGENHRLH IRRKSI
Length:396
Mass (Da):44,357
Last modified:January 10, 2006 - v2
Checksum:i734EB0EEA1ED1828
GO

Sequence cautioni

The sequence AAF60229 differs from that shown. Reason: Frameshift at positions 170, 171 and 175.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192366 mRNA. Translation: AAF60229.1. Frameshift.
AF391084 mRNA. Translation: AAK69764.1.
AF257082 mRNA. Translation: AAG33128.1.
RefSeqiNP_445857.2. NM_053405.2.
XP_017450625.1. XM_017595136.1.
UniGeneiRn.48796.

Genome annotation databases

EnsembliENSRNOT00000012408; ENSRNOP00000012408; ENSRNOG00000009265.
GeneIDi84429.
KEGGirno:84429.
UCSCiRGD:621451. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192366 mRNA. Translation: AAF60229.1. Frameshift.
AF391084 mRNA. Translation: AAK69764.1.
AF257082 mRNA. Translation: AAG33128.1.
RefSeqiNP_445857.2. NM_053405.2.
XP_017450625.1. XM_017595136.1.
UniGeneiRn.48796.

3D structure databases

ProteinModelPortaliQ9ES08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61122N.
STRINGi10116.ENSRNOP00000012408.

Proteomic databases

PaxDbiQ9ES08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000012408; ENSRNOP00000012408; ENSRNOG00000009265.
GeneIDi84429.
KEGGirno:84429.
UCSCiRGD:621451. rat.

Organism-specific databases

CTDi51305.
RGDi621451. Kcnk9.

Phylogenomic databases

eggNOGiKOG4404. Eukaryota.
ENOG410XRZJ. LUCA.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000231463.
HOVERGENiHBG052239.
InParanoidiQ9ES08.
KOiK04919.
OMAiIEREHEI.
OrthoDBiEOG091G08DH.
PhylomeDBiQ9ES08.
TreeFamiTF313947.

Enzyme and pathway databases

ReactomeiR-RNO-1299316. TWIK-releated acid-sensitive K+ channel (TASK).

Miscellaneous databases

PROiQ9ES08.

Gene expression databases

BgeeiENSRNOG00000009265.
GenevisibleiQ9ES08. RN.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR013099. K_chnl_dom.
IPR005407. KCNK9.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PRINTSiPR01333. 2POREKCHANEL.
PR01585. TASK3CHANNEL.
PR01095. TASKCHANNEL.
ProtoNetiSearch...

Entry informationi

Entry nameiKCNK9_RAT
AccessioniPrimary (citable) accession number: Q9ES08
Secondary accession number(s): Q923V6, Q9JLD4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 10, 2006
Last modified: November 30, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.