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Protein

Potassium channel subfamily K member 9

Gene

Kcnk9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

pH-dependent, voltage-insensitive, background potassium channel protein.2 Publications

GO - Molecular functioni

  • potassium ion leak channel activity Source: GO_Central
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • voltage-gated potassium channel activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

ReactomeiR-RNO-1299316 TWIK-releated acid-sensitive K+ channel (TASK)
R-RNO-5576886 Phase 4 - resting membrane potential

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 9
Alternative name(s):
Acid-sensitive potassium channel protein TASK-3
TWIK-related acid-sensitive K(+) channel 3
Two pore potassium channel KT3.2
Short name:
Two pore K(+) channel KT3.2
Gene namesi
Name:Kcnk9
Synonyms:Task3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi621451 Kcnk9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 29HelicalSequence analysisAdd BLAST21
Topological domaini30 – 88ExtracellularSequence analysisAdd BLAST59
Intramembranei89 – 101Pore-forming; Name=Pore-forming 1Sequence analysisAdd BLAST13
Topological domaini102 – 107ExtracellularSequence analysis6
Transmembranei108 – 128HelicalSequence analysisAdd BLAST21
Topological domaini129 – 158CytoplasmicSequence analysisAdd BLAST30
Transmembranei159 – 179HelicalSequence analysisAdd BLAST21
Topological domaini180 – 194ExtracellularSequence analysisAdd BLAST15
Intramembranei195 – 207Pore-forming; Name=Pore-forming 2Sequence analysisAdd BLAST13
Topological domaini208 – 218ExtracellularSequence analysisAdd BLAST11
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Topological domaini240 – 396CytoplasmicSequence analysisAdd BLAST157

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi98H → D: Reduces sensitivity to alterations in external pH. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001017561 – 396Potassium channel subfamily K member 9Add BLAST396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9ES08
PRIDEiQ9ES08

Expressioni

Tissue specificityi

Highly expressed in the CNS and at lower levels in the colon, kidney, liver, lung, spleen, stomach and skeletal muscle. The highest expression was found in the olfactory nuclei, piriform cortex, cerebellum, antedorsal thalmic nucleus, pontine nucleus, dorsal raphe and several nuclei in the medulla. Shows a non-homogeneous distribution in the hippocampus. Expressed at highest levels in the lateral posterior and inferior portions and at medium levels in neocortex.4 Publications

Gene expression databases

BgeeiENSRNOG00000009265
GenevisibleiQ9ES08 RN

Interactioni

Subunit structurei

Homodimer. Heterodimer with KCNK1.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

DIPiDIP-61122N
IntActiQ9ES08, 1 interactor
STRINGi10116.ENSRNOP00000012408

Structurei

3D structure databases

ProteinModelPortaliQ9ES08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4404 Eukaryota
ENOG410XRZJ LUCA
GeneTreeiENSGT00760000118858
HOGENOMiHOG000231463
HOVERGENiHBG052239
InParanoidiQ9ES08
KOiK04919
OMAiGMRNTEV
OrthoDBiEOG091G08DH
PhylomeDBiQ9ES08
TreeFamiTF313947

Family and domain databases

InterProiView protein in InterPro
IPR003280 2pore_dom_K_chnl
IPR003092 2pore_dom_K_chnl_TASK
IPR013099 K_chnl_dom
IPR005407 KCNK9
PfamiView protein in Pfam
PF07885 Ion_trans_2, 2 hits
PRINTSiPR01333 2POREKCHANEL
PR01585 TASK3CHANNEL
PR01095 TASKCHANNEL

Sequencei

Sequence statusi: Complete.

Q9ES08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKRQNVRTLS LIACTFTYLL VGAAVFDALE SDHEMREEEK LKAEEVRLRG
60 70 80 90 100
KYNISSDDYQ QLELVILQSE PHRAGVQWKF AGSFYFAITV ITTIGYGHAA
110 120 130 140 150
PGTDAGKAFC MFYAVLGIPL TLVMFQSLGE RMNTFVRYLL KRIKKCCGMR
160 170 180 190 200
NTEVSMENMV TVGFFSCMGT LCLGAAAFSQ CEDWSFFHAY YYCFITLTTI
210 220 230 240 250
GFGDFVALQS KGALQRKPFY VAFSFMYILV GLTVIGAFLN LVVLRFLTMN
260 270 280 290 300
TDEDLLEGEV AQILAGNPRR VVVRVPQSRK RHHPMYFLRK YGRTLCYLCF
310 320 330 340 350
PGANWGDDDD DDDDAVENVV VTTPVPPAVA AAAAAATPGP STRNVRATVH
360 370 380 390
SVSCRVEEIP PDVLRNTYFR SPFGAIPPGM HTCGENHRLH IRRKSI
Length:396
Mass (Da):44,357
Last modified:January 10, 2006 - v2
Checksum:i734EB0EEA1ED1828
GO

Sequence cautioni

The sequence AAF60229 differs from that shown. Reason: Frameshift at positions 170, 171 and 175.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF192366 mRNA Translation: AAF60229.1 Frameshift.
AF391084 mRNA Translation: AAK69764.1
AF257082 mRNA Translation: AAG33128.1
RefSeqiNP_445857.2, NM_053405.2
XP_017450625.1, XM_017595136.1
UniGeneiRn.48796

Genome annotation databases

EnsembliENSRNOT00000012408; ENSRNOP00000012408; ENSRNOG00000009265
GeneIDi84429
KEGGirno:84429
UCSCiRGD:621451 rat

Similar proteinsi

Entry informationi

Entry nameiKCNK9_RAT
AccessioniPrimary (citable) accession number: Q9ES08
Secondary accession number(s): Q923V6, Q9JLD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: January 10, 2006
Last modified: May 23, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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